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Myogenesis: A Cell Lineage Interpretation

  • Chapter
Cell Cycle and Cell Differentiation

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 7))

Abstract

This review is based on four interrelated assumptions: (1) The central problem in differentiation is understanding how coupled bits of information unavailable in a mother cell become available in daughter cells (Holtzer et al., 1973); (2) The genetic controls regulating rates of synthesis of constitutive molecules such as glucose-6-phosphatase or RNA polymerases, or organelles such as mitochondria or ribosomes are, for the most part, independent of the regulatory controls for differentiation; (3) All embryonic cells—zygote, blastula, gastrula, stem-cells, etc.—exist as differentiated cell types, each committed to a unique and limited program of synthesis (Holtzer, 1968, 1970); and (4) The number of options for transition in a developmental program available to any one cell, whether from an embryo or mature organism, is never greater than two (Abbott et al., 1974).

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Authors and Affiliations

  1. Departments of Biology and Anatomy, University of Pennsylvania, Philadelphia, PA, USA

    S. R. Dienstman & H. Holtzer

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  1. S. R. Dienstman
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  2. H. Holtzer
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  1. Department of Anatomy, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Howard Holtzer

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Dienstman, S.R., Holtzer, H. (1975). Myogenesis: A Cell Lineage Interpretation. In: Reinert, J., Holtzer, H. (eds) Cell Cycle and Cell Differentiation. Results and Problems in Cell Differentiation, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-37390-2_1

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  • DOI: https://doi.org/10.1007/978-3-540-37390-2_1

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