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The Stability of the Determined State in Cultures of Imaginal Disks in Drosophila

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The Biology of Imaginal Disks

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 5))

Abstract

The development of different cell types in higher organisms, arising from one cell type (the zygote), is designated as cell differentiation. Differentiation is initiated by the process of determination which programs the cells for their future developmental pathway. There is accumulating evidence that the developmental programs reside in the genome and represent sets of genes acting in a coordinate fashion. The fundamental problem of how different genes are coordinately controlled remains to be elucidated. Two major categories of determinative processes are known: one is embryonic induction which involves cell or tissue interactions by means of diffusible inducing substances, and another is cytoplasmic segregation which is based upon factors intrinsic to the differentiating cells. In the latter case differentiation may be achieved by unequal distribution during cell division of cell components acting as determinative factors. Since determination creates the first essential differences among cells, an understanding of this process might be a key to the problem of differentiation in general.

1 This is an updated and revised version of an article which appeared in Vol. 1 of this series. The more recent experiments reported in this article were supported by a grant from the Jane Coffin Childs Memorial Fund for Medical Research, and by the National Science Foundation (Grant GB-17267X2).

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  1. Department of Anatomy, Yale University, New Haven, Connecticut, USA

    Walter Gehring

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  1. Walter Gehring
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  1. Zürich, Switzerland

    H. Ursprung

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Gehring, W. (1972). The Stability of the Determined State in Cultures of Imaginal Disks in Drosophila. In: Ursprung, H., Nöthiger, R. (eds) The Biology of Imaginal Disks. Results and Problems in Cell Differentiation, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-37185-4_2

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  • DOI: https://doi.org/10.1007/978-3-540-37185-4_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22480-9

  • Online ISBN: 978-3-540-37185-4

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