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20.5 Literatur
Altman DG, Matthews JNS. Interaction 1: Heterogeneity of effects. British Medical Journal 1996; 313:486.
Assmann SF, Pocock SJ, Enos LE, Kasten LE. Subgroup analysis and other (mis)uses of baseline data in clinical trials. Lancet 2000; 355:1064–1069.
Bland JM, Altman DG. Multiple significance tests: The Bonferroni method. British Medical Journal 1995; 310:170.
Gail M, Simon R. Testing for qualitative interactions between treatment effects and patient subsets. Biometrics 1985; 41:361–372.
Horn M, Vollandt R. Multiple Tests und Auswahlverfahren. Stuttgart: Gustav Fischer Verlag, 1995
Horwitz RI, Singer BH, Makuch RW, Viscoli CM. Can treatment that is helpful on average be harmful to some patients? A study of conflicting information needs of clinical enquiry and drug regulation. Journal of Clinical Epidemiology 1996; 49:395–400.
Ingelfinger JA, Mosteller F, Thibodeau LA, Ware JH. Biostatistics in clinical medicine. New York: Macmillian, 1983.
Lee KL, McNeer JF, Starmer CF, Harris PJ, Rosati RA. Lessons from a simulated randomized trial in coronary artery disease. Circulation 1980; 61:508–515.
Matthew JNS, Altman DG. Interaction 2: Compare effect sizes not P values. British Medical Journal 1996; 313:808.
Matthew JNS, Altman DG. Interaction 3: How to examine heterogeneity. British Medical Journal 1996; 313:862.
Nowak R. Problems in clinical trials go far beyond misconduct. Science 1994; 264:1538–1541.
Pocock SJ, Hughes MD, Lee RJ. Statistical problems in the reporting of clinical trials: A survey of three medical journals. New England Journal of Medicine 1987; 317:426–432.
Schmoor C, Olschewski M, Schumacher M. Randomized and non-randomized patients in clinical trials: Experiences with Comprehensive Cohort Studies. Statistics in Medicine 1996; 15:263–271.
Schmoor C, Ulm K, Schumacher M. Comparison of the Cox model and the regression tree procedure in analysing a randomized clinical trial. Statistics in Medicine 1993;12:2351–2366.
Schumacher M, Bastert G, Bojar H, et al. for the German Breast Cancer Study Group (GBSG). Randomized 2×2 trial evaluating hormonal treatment and the duration of chemotherapy in node-positive breast cancer patients. Journal of Clinical Oncology 1994; 12:2086–2093.
Senn S, Harrell FE. On subgroups and grouping for significance (letter). Journal of Clinical Epidemiology 1998; 51:1367.
Simon R. Patient subsets and variation in therapeutic efficacy. British Journal of Clinical Pharmacology 1982; 14:473–482.
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Schmoor, C. (2007). Die Problematik von Subgruppenanalysen in klinischen Studien: Eine hypothetische klinische Studie beim Mammakarzinom. In: Methodik klinischer Studien. Statistik und ihre Anwendungen. Springer, Berlin, Heidelberg . https://doi.org/10.1007/978-3-540-36990-5_20
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DOI: https://doi.org/10.1007/978-3-540-36990-5_20
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