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Penile Tumors: Classification, Clinics and Current Therapeutic Approach

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Color Doppler US of the Penis

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

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Abstract

Penile cancer is an uncommon malignancy in developed countries. In the United States, 1,530 cases occur per year. Higher incidence rates (Narayana et al. 1982) are seen in Africa and Asia (10% to 20%), and in areas of Brazil penile cancer accounts for 17% of all malignancies in men (Ornellas et al. 1994). Penile cancer most commonly affects men between 50 and 70 years of age (Hoppmann and Fraley 1978). Younger individuals are also affected; approximately 22% of patients are less than 40 years of age.

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References

  • Agrawal A, Pai D, Ananthakrishnan N et al (2000) The histological extent of the local spread of carcinoma of the penis and its therapeutic implications. BJU Int 85:299–301

    Article  PubMed  CAS  Google Scholar 

  • Bertolotto M, Serafini G, Dogliotti L et al (2005) Primary and secondary malignancies of the penis: ultrasound features. Abdom Imaging 30:108–112

    Article  PubMed  CAS  Google Scholar 

  • Burgers JK, Badalament RA, Drago JR (1992) Penile cancer. Clinical presentation, diagnosis, and staging. Urol Clin North Am 19:247–256

    PubMed  CAS  Google Scholar 

  • Cabanas RM (1977) An approach for the treatment of penile carcinoma. Cancer 39:456–466

    Article  PubMed  CAS  Google Scholar 

  • Catalona WJ (1988) Modified inguinal lymphadenectomy for carcinoma of the penis with preservation of saphenous veins: technique and preliminary results. J Urol 140:306–310

    PubMed  CAS  Google Scholar 

  • Crook J, Grimard L, Tsihlias J et al (2002) Interstitial brachytherapy for penile cancer: an alternative to amputation. J Urol 167:506–511

    Article  PubMed  Google Scholar 

  • Daling JR, Madeleine MM, Johnson LG et al (2005) Penile cancer: importance of circumcision, human papillomavirus and smoking in in situ and invasive disease. Int J Cancer 116:606–616

    Article  PubMed  CAS  Google Scholar 

  • Ficarra V, Zattoni F, Cunico SC et al (2005) Lymphatic and vascular embolizations are independent predictive variables of inguinal lymph node involvement in patients with squamous cell carcinoma of the penis: Gruppo Uro-Oncologico del Nord Est (Northeast Uro-Oncological Group) Penile Cancer data base data. Cancer 103:2507–2516

    Article  PubMed  Google Scholar 

  • Fraley EE, Zhang G, Manivel C, Niehans GA (1989) The role of ilioinguinal lymphadenectomy and significance of histological differentiation in treatment of carcinoma of the penis. J Urol 142:1478–1482

    PubMed  CAS  Google Scholar 

  • Guerrero I, Pow-Sang M, Pow-Sang J et al (2000) Improved DNA extraction from paraffin-embedded tissue for human papillomavirus detection in penile cancer by polymerase chain reaction. Urologia Panamericana 12:20–21

    Google Scholar 

  • Guimaraes GC, Lopes A, Campos RS et al (2006) Front pattern of invasion in squamous cell carcinoma of the penis: new prognostic factor for predicting risk of lymph node metastases. Urology 68:148–153

    Article  PubMed  Google Scholar 

  • Hakenberg OW, Nippgen JB, Froehner M et al (2006) Cisplatin, methotrexate and bleomycin for treating advanced penile carcinoma. BJU Int 98:1225–1227

    Article  PubMed  CAS  Google Scholar 

  • Hizli F, Berkmen F (2006) Penile metastasis from other malignancies. A study of ten cases and review of the literature. Urol Int 76:118–121

    Article  PubMed  Google Scholar 

  • Hoppmann HJ, Fraley EE (1978) Squamous cell carcinoma of the penis. J Urol 120:393–398

    PubMed  CAS  Google Scholar 

  • Horenblas S, Jansen L, Meinhardt W et al (2000) Detection of occult metastasis in squamous cell carcinoma of the penis using a dynamic sentinel node procedure. J Urol 163:100–104

    Article  PubMed  CAS  Google Scholar 

  • Horenblas S, van Tinteren H (1994) Squamous cell carcinoma of the penis. IV. Prognostic factors of survival: analysis of tumor, nodes and metastasis classification system. J Urol 151:1239–1243

    PubMed  CAS  Google Scholar 

  • Horenblas S, Van Tinteren H, Delemarre JF et al (1991) Squamous cell carcinoma of the penis: accuracy of tumor, nodes and metastasis classification system, and role of lymphangiography, computerized tomography scan and fine needle aspiration cytology. J Urol 146:1279–1283

    PubMed  CAS  Google Scholar 

  • Horenblas S, van Tinteren H, Delemarre JF et al (1993) Squamous cell carcinoma of the penis. III. Treatment of regional lymph nodes. J Urol 149:492–497

    PubMed  CAS  Google Scholar 

  • Hungerhuber E, Schlenker B, Karl A et al (2006) Risk stratification in penile carcinoma: 25-year experience with surgical inguinal lymph node staging. Urology 68:621–625

    Article  PubMed  Google Scholar 

  • Jackson SM (1966) The treatment of carcinoma of the penis. Br J Surg 53:33–35

    Article  PubMed  CAS  Google Scholar 

  • Katona TM, Lopez-Beltran A, MacLennan GT et al (2006) Soft tissue tumors of the penis: a review. Anal Quant Cytol Histol 28:193–206

    PubMed  Google Scholar 

  • Kharchenko VP, Kaprin AD, Timova VA et al (2006) [Radiation assisted diagnosis and complex treatment of penile carcinoma]. Vopr Onkol 52:315–321

    PubMed  CAS  Google Scholar 

  • Kroon BK, Valdes Olmos RA, van Tinteren H et al (2005) Reproducibility of lymphoscintigraphy for lymphatic mapping in patients with penile carcinoma. J Urol 174:2214–2217

    Article  PubMed  Google Scholar 

  • Lont AP, Besnard AP, Gallee MP et al (2003a) A comparison of physical examination and imaging in determining the extent of primary penile carcinoma. BJU Int 91:493–495

    Article  PubMed  CAS  Google Scholar 

  • Lont AP, Gallee MP, Meinhardt W et al (2006) Penis conserving treatment for T1 and T2 penile carcinoma: clinical implications of a local recurrence. J Urol 176:575–580; discussion 580

    Article  PubMed  CAS  Google Scholar 

  • Lont AP, Horenblas S, Tanis PJ et al (2003b) Management of clinically node negative penile carcinoma: improved survival after the introduction of dynamic sentinel node biopsy. J Urol 170:783–786

    Article  PubMed  CAS  Google Scholar 

  • Lopes A, Bezerra AL, Pinto CA et al (2002) p53 as a new prognostic factor for lymph node metastasis in penile carcinoma: analysis of 82 patients treated with amputation and bilateral lymphadenectomy. J Urol 168:81–86

    Article  PubMed  Google Scholar 

  • Lopes A, Bezerra AL, Serrano SV, Hidalgo GS (2000) Iliac nodal metastases from carcinoma of the penis treated surgically. BJU Int 86:690–693

    Article  PubMed  CAS  Google Scholar 

  • Lucia MS, Miller GJ (1992) Histopathology of malignant lesions of the penis. Urol Clin North Am 19:227–246

    PubMed  CAS  Google Scholar 

  • Maiche AG (1992) Epidemiological aspects of cancer of the penis in Finland. Eur J Cancer Prev 1:153–158

    Article  PubMed  CAS  Google Scholar 

  • Minhas S, Kayes O, Hegarty P et al (2005) What surgical resection margins are required to achieve oncological control in men with primary penile cancer? BJU Int 96:1040–1043

    Article  PubMed  Google Scholar 

  • Mohs FE, Snow SN, Larson PO (1992) Mohs micrographic surgery for penile tumors. Urol Clin North Am 19:291–304

    PubMed  CAS  Google Scholar 

  • Narayana AS, Olney LE, Loening SA et al (1982) Carcinoma of the penis: analysis of 219 cases. Cancer 49:2185–2191

    Article  PubMed  CAS  Google Scholar 

  • Ornellas AA, Seixas AL, Marota A et al (1994) Surgical treatment of invasive squamous cell carcinoma of the penis: retrospective analysis of 350 cases. J Urol 151:1244–1249

    PubMed  CAS  Google Scholar 

  • Pascual A, Pariente M, Godinez JM et al (2007) High prevalence of human papillomavirus 16 in penile carcinoma. Histol Histopathol 22:177–183

    PubMed  CAS  Google Scholar 

  • Perdona S, Autorino R, Gallo L et al (2006) Role of dynamic sentinel node biopsy in penile cancer: our experience. J Surg Oncol 93:181–185

    Article  PubMed  CAS  Google Scholar 

  • Pizzocaro G, Piva L, Nicolai N (1996) [Treatment of lymphatic metastasis of squamous cell carcinoma of the penis: experience at the National Tumor Institute of Milan]. Arch Ital Urol Androl 68:169–172

    PubMed  CAS  Google Scholar 

  • Schellhammer PF, Jordan GH, Robey EL, Spaulding JT (1992) Premalignant lesions and nonsquamous malignancy of the penis and carcinoma of the scrotum. Urol Clin North Am 19:131–142

    PubMed  CAS  Google Scholar 

  • Sobin L, Wittekind C (2002) TNM classification of malignant tumors. Wiley, New York

    Google Scholar 

  • Solsona E, Iborra I, Rubio J et al (2001) Prospective validation of the association of local tumor stage and grade as a predictive factor for occult lymph node micrometastasis in patients with penile carcinoma and clinically negative inguinal lymph nodes. J Urol 165:1506–1509

    Article  PubMed  CAS  Google Scholar 

  • Tsen HF, Morgenstern H, Mack T, Peters RK (2001) Risk factors for penile cancer: results of a population-based case-control study in Los Angeles County (United States). Cancer Causes Control 12:267–277

    Article  PubMed  CAS  Google Scholar 

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Pow-Sang, M., Destéfano, V. (2008). Penile Tumors: Classification, Clinics and Current Therapeutic Approach. In: Bertolotto, M. (eds) Color Doppler US of the Penis. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-36677-5_13

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  • DOI: https://doi.org/10.1007/978-3-540-36677-5_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-36676-8

  • Online ISBN: 978-3-540-36677-5

  • eBook Packages: MedicineMedicine (R0)

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