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Photoneuroimmunology: Modulation of the Neuroimmune System by UV Radiation

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References

  1. Allanson M, Reeve VE (2005) Ultraviolet A (320–400nm) modulation of ultraviolet B (290–320nm) induced immune suppression is mediated by carbon monoxide. J Invest Dermatol 124:644–650

    Article  PubMed  CAS  Google Scholar 

  2. Amerio P, Toto P, Feliciani C, Suzuki H, Shivji G, Wang B, Sauder DN (2001) Rethinking the role of tumor necrosis factor-alpha in ultraviolet (UV) B-induced immunosuppression: altered immune response in UV-irradiated TNFRlR2 gene-targeted mutant mice. Br J Dermatol 144:952–957

    Article  PubMed  CAS  Google Scholar 

  3. Artuc M, Bohm M, Grutzkau A, Smorodchenko A, Zuberbier T, Lugen R, Henz BM (2006) Human mast cells in the neurohormonal network: expression of POMC, detection of precursor proteases, and evidence for IgE-dependent secretion of α-MSH. J Invest Dermatol 126:1976–1981

    Article  PubMed  CAS  Google Scholar 

  4. Asahina A, Hosoi J, Beissert S, Stratigos A, Granstein RD (1995) Inhibition of the induction of delayed-type and contact hypersensitivity by calcitonin gene-related peptide. J Immunol 154:3056–3061

    PubMed  CAS  Google Scholar 

  5. Asahina A, Moro O, Hosoi J, Lerner EA, Xu S, Takashima A, Granstein RD (1995) Specific induction of cAMP in Langerhans cells by calcitonin gene-related peptide: relevance to functional studies. Proc Natl Acad Sci USA 92:8328–8327

    Article  Google Scholar 

  6. Baron ED, Fourtanier A, Compan D, Medaisko C, Cooper KD, Stevens SR (2003) High ultraviolet A protection affords greater immune protection confirming that ultraviolet A contributes to photoimmunosuppression in humans. J Invest Dermatol 121:869–875

    Article  PubMed  CAS  Google Scholar 

  7. Beissert S, Schwarz A, Schwarz T (2006) Regulatory T cells. J Invest Dermatol 126:15–24

    Article  PubMed  CAS  Google Scholar 

  8. Benrath J, Eschenfelder C, Zimmermann M, Gillardon F (1995) Calcitonin gene-relatd peptide, substance P and nitric oxide are involved in cutaneous inflammation following ultraviolet irradiation. Eur J Pharmacol 293:87–96

    Article  PubMed  CAS  Google Scholar 

  9. Bohm M, Wolff I, Scholzen TE, Robinson SJ, Healy E, Luger TA, Schwarz T, Schwarz A (2005) α-Melanocyte-stimulating hormone protects from ultraviolet radiation-induced apoptosis and DNA damage. J Biol Chem 280:5795802

    Google Scholar 

  10. Bohm M, Luger TA, Tobin DJ, Garcia-Borron JC (2006) Melanocortin receptor ligands: new horizons for skin biology and clinical dermatology. J Invest Dermatol 126:1966–1975

    Article  PubMed  CAS  Google Scholar 

  11. Botchkarev VA, Yaar M, Peters EMJ, Raychaudhuri SP, Botchkarev NV, Marconi A, Raychaudhuri SK, Paus R, Pincelli C (2006) Neurotrophins in skin biology and pathology. J Invest Dermatol 126:1719–1727

    Article  PubMed  CAS  Google Scholar 

  12. Cocchiara R, Bongiovanni A, Albegianni G, Azzolini A, Lampiasi N, Di Blasi F, Geraci D (1997) Inhibitory effect of neuraminidase on SP-induced histamine release and TNFα mRNA in rat mast cells: evidence of a receptor-independent mechanism. J Neuroimmunol 75:9–18

    Article  PubMed  CAS  Google Scholar 

  13. De Fabo EC, Noonan FP (1983) Mechanism of immune suppression by ultraviolet irradiation in vivo. I. Evidence for the existence of a unique photoreceptor in skin and its role in photoimmunology. J Exp Med 157:84–98

    Article  Google Scholar 

  14. De Fabo EC, Noonan FP, Fears T, Merlino G (2004) Ultraviolet B but not Ultraviolet A radiation initiates melanoma. Cancer Res 64:6372–6376

    Article  PubMed  Google Scholar 

  15. Diffy BL (2002) Sources and measurement of ultraviolet radiation. Methods 28:4–13

    Article  CAS  Google Scholar 

  16. Egan CL, Viglione-Schneck MJ, Walsh LJ, Green B, Trojanowski JQ, Whitaker-Menezes D, Murphy GF (1998) Characterization of unmyelinated axons uniting epidermal and dermal immune cells in primate and human skin. J Cutan Pathol 25:20–29

    Article  PubMed  CAS  Google Scholar 

  17. Eschenfelder CC, Benrath J, Zimmermann M, Gillardon F (1995) Involvement of substance P in ultraviolet irradiation-induced inflammation in rat skin. Eur J Neurosci 7:1520–1526

    Article  PubMed  CAS  Google Scholar 

  18. Garssen J, Buckley TL, van Loveren H (1998) A role for neuropeptides in UVB-induced systemic immunosuppression. Photochem Photobiol 68:205–210

    Article  PubMed  CAS  Google Scholar 

  19. Garssen J, De Gruijl F, Mol D, de Klerk A, Roholl P, van Loveren H (2001) UVA exposure affects UVB and cis-urocanic acid-induced systemic suppression of immune responses in Listeria monocytogenes-infected Balb/c mice. Photochem Photobiol 73:432–438

    Article  PubMed  CAS  Google Scholar 

  20. Gillardon F, Morano I, Zimmerman M (1991) Ultraviolet irradiation of the skin attenuates calcitonin gene-related peptide mRNA expression in rat dorsal root ganglion cells. Neurosci Lett 124:144–147

    Article  PubMed  CAS  Google Scholar 

  21. Gillardon F, Moll I, Michel S, Benrath J, Weihe E, Zimmerman M (1995) Calcitonin gene-related peptide and nitric oxide are involved in ultraviolet radiation-induced immunosuppression. Eur J Pharmacol 293:395–400

    Article  PubMed  CAS  Google Scholar 

  22. Gorman S, Tan JW, Thomas JA, Townley SL, Stumbles PA, Finlay-Jones JJ, Hart PH (2005) Primary defect in UVB-induced systemic immunomodulation does not relate to immature or functionally impaired APCs in regional lymph nodes. J Immunol 174:6677–6685

    PubMed  CAS  Google Scholar 

  23. Grabbe S, Bhardwaj RS, Mahnke K, Simon MM, Schwarz T, Luger TA (1996) α-Melanocyte-stimulating hormone induces hapten-specific tolerance in mice. J Immunol 156:473–478

    PubMed  CAS  Google Scholar 

  24. Grimbaldeston MA, Simpson A, Finlay-Jones JJ, Hart PH (2003) Determinants of dermal mast cell prevalence in human skin. Br J Dermatol 148:300–306

    Article  PubMed  CAS  Google Scholar 

  25. Grutzkau A, Henz BM, Kirchhof L, Luger T, Artuc M (2000) Alpha-melanocyte stimulating hormone acts as a selective inducer of secretory functions in human mast cells. Biochem Biophys Res Commun 278:14–19

    Article  PubMed  CAS  Google Scholar 

  26. Guhl S, Lee HH, Babina M, Henz BM, Zuberbier T (2005) Evidence for a restricted rather than generalized stimulatory response of skin-derived human mast cells to substance P. J Neuroimmunol 163:92–101

    Article  PubMed  CAS  Google Scholar 

  27. Hart PH, Jaksic A, Swift GJ, Norval M, El-Ghorr AA, Finlay-Jones JJ (1997) Histamine involvement in UVB- and cis-urocanic acid-induced systemic suppression of contact hypersensitivity responses. Immunology 91:601–608

    Article  PubMed  CAS  Google Scholar 

  28. Hart PH, Grimbaldeston MA, Swift GJ, Jaksic A, Noonan FP, Finlay-Jones JJ (1998) Dermal mast cells determine susceptibility to ultraviolet B-induced systemic suppression of contact hypersensitivity responses in mice. J Exp Med 187:2045–2053

    Article  PubMed  CAS  Google Scholar 

  29. Hart PH, Grimbaldeston MA, Swift GJ, Sedgwick JD, Korner H, Finlay-Jones JJ (1998) TNF modulates susceptibility to UVB-induced systemic immunomodulation in mice by effects on dermal mast cell prevalence. Eur J Immunol 28:2893–2901

    Article  PubMed  CAS  Google Scholar 

  30. Hart PH, Grimbaldeston MA, Swift GJ, Hosszu EK, Finlay-Jones JJ (1999) A critical role for dermal mast cells in cis-urocanic acid-induced systemic suppression of contact hypersensitivity responses in mice. Photochem Photobiol 70:807–812

    Article  PubMed  CAS  Google Scholar 

  31. Hosoi J, Murphy GF, Egan CL, Lerner EA, Grabbe S, Asahina A, Granstein RD (1993) Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide. Nature 363:159–162

    Article  PubMed  CAS  Google Scholar 

  32. Howes RA, Halliday GM, Barnetson RStC, Friedmann AC, Damian DL (2006) Topical capsaicin reduces ultraviolet radiation-induced suppression of Mantoux reactions in humans. J Dermatol Sci 44:113–115

    Article  PubMed  CAS  Google Scholar 

  33. Kahn HS, Tatham LM, Patel AV, Thun MJ, Heath CW (1998) Increased cancer mortality following a history of nonmelanoma skin cancer. JAMA 280:910–912

    Article  PubMed  CAS  Google Scholar 

  34. Kelly DA, Seed PT, Young AR, Walker SL (2003) A commercial sunscreen’s protection against ultraviolet radiationinduced immunosuppression is more than 50% lower than protection against sunburn in humans. J Invest Dermatol 120:1–7

    Article  Google Scholar 

  35. Khalil Z, Townley SL, Grimbaldeston MA, Finlay-Jones JJ, Hart PH (2001) cis-Urocanic acid stimulates neuropeptide release from peripheral sensory nerves. J Invest Dermatol 117:886–891

    Article  PubMed  CAS  Google Scholar 

  36. Kripke ML (1984) Immunological unresponsiveness induced by ultraviolet radiation. Immunol Rev 80:87–102

    Article  PubMed  CAS  Google Scholar 

  37. Kulms D, Zeise E, Poppelmann B, Schwarz T (2002) DNA damage, death receptor activation and reactive oxygen species contribute to ultraviolet radiation-induced apoptosis in an essential and independent way. Oncogene 21:5844–5851

    Article  PubMed  CAS  Google Scholar 

  38. Laihia JK, Attila M, Neuvonen K, Pasanen P, Tuomisto L, Jansen CT (1998) Urocanic acid binds to GABA but not to histamine (H1, H2 or H3) receptors. J Invest Dermatol 111:705–706

    Article  PubMed  CAS  Google Scholar 

  39. Lambert RW, Granstein RD (1998) Neuropeptides and Langerhans cells. Exp Dermatol 7:73–80

    Article  PubMed  CAS  Google Scholar 

  40. Lee E, Koo J, Berger T (2005) UVB phototherapy and skin cancer risk: a review of the literature. Int J Dermatol 44:355–360

    Article  PubMed  Google Scholar 

  41. Legat FJ, Wolf P (2006) Photodamage to the cutaneous sensory nerves: role in photoaging and carcinogenesis of the skin? Photochem Photobiol Sci 5:170–176

    Article  PubMed  CAS  Google Scholar 

  42. Legat FJ, Jaiani LT, Wolf P, Wang M, Lang R, Abraham T, Solomon AR, Armstrong CA, Glass JD, Ansel JC (2004) The role of calcitonin gene-related peptide in cutaneous immunosuppression induced by repeated subinflammatory ultraviolet irradiation exposure. Exp Dermatol 13:242–250

    Article  PubMed  CAS  Google Scholar 

  43. Marconi A, Vaschieri C, Zanoli S, Giannetti A, Pincelli C (1999) Nerve growth factor protects human keratinocytes from UVB-induced apoptosis. J Invest Dermatol 113:920–927

    Article  PubMed  CAS  Google Scholar 

  44. Mazzoni A, Young HA, Spitzer JH, Visintin A, Segal DM (2001) Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization. J Clin Invest 108:1865–1873

    PubMed  CAS  Google Scholar 

  45. Meves A, Repacholi MH (2006) Does ultraviolet radiation affect vaccination efficacy? Int J Dermatol 45:1019–1024

    Article  PubMed  CAS  Google Scholar 

  46. Mouret S, Baudouin C, Charveron M, Favier A, Cadet J, Douki T (2006) Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation. Proc Natl Acad Sci USA 103:13765–13770

    Article  PubMed  CAS  Google Scholar 

  47. Naldi L, Fortina AB, Lovati S, Barba A, Gotti E, Tesari G, Schena S, Diociaiuti A, Nanni G, La Parola IL, Masini C, Piaserica S, Peserico A, Cainelli T, Remuzzi G (2000) Risk of nonmelanoma skin cancer in Italian organ transplant recipients: a registry-based study. Transplantation 70:1479–1484

    Article  PubMed  CAS  Google Scholar 

  48. Nghiem DX, Kazimi N, Clydesdale G, Ananthaswamy HV, Kripke ML, Ullrich SE (2001) Ultraviolet A radiation suppresses an established immune response: Implications for sunscreen design. J Invest Dermatol 117:1193–1199

    Article  PubMed  CAS  Google Scholar 

  49. Niizeki H, Alard P, Streilein JW (1997) Calcitonin generelated peptide is necessary for UVB-impaired induction of contact hypersensitivity. J Immunol 159:5183–5186

    PubMed  CAS  Google Scholar 

  50. Niizeki H, Kurimoto I, Streilein JW (1999) A substance P agonist acts as an adjuvant to promote hapten-specific skin immunity. J Invest Dermatol 112:437–442

    Article  PubMed  CAS  Google Scholar 

  51. Noonan FP, De Fabo EC (1992) Immunosuppression by ultraviolet B radiation: initiation by urocanic acid. Immunol Today 13:250–254

    Article  PubMed  CAS  Google Scholar 

  52. Peters EMJ, Ericson ME, Hosoi J, Seiffert K, Hordinsky MK, Ansel JC, Paus R, Scholzen TE (2006) Neuropeptide control mechanisms in cutaneous biology: physiological and clinical significance. J Invest Dermatol 126: 1937–1947

    Article  PubMed  CAS  Google Scholar 

  53. Redondo P, Garcia-Foncillas J, Okroujnov I, Bandres E (1998) Alpha-MSH regulates IL-10 expression by human keratinocytes. Arch Dermatol Res 290:425–428

    Article  PubMed  CAS  Google Scholar 

  54. Reeve VE, Domanski D, Slater M (2006) Radiation sources providing increased UVA/UVB ratios induce photoprotection dependent on the UVA dose in hairless mice. Photochem Photobiol 82:406–411

    Article  PubMed  CAS  Google Scholar 

  55. Sastry CM, Whitmore SE, Breysse PN, Morison WL, Strickland PT (2005) The effect of clinical UVA/B exposures on urinary urocanic acid isomer levels in individuals with Caucasian type (II/III) skin types. Dermatol Online J 11:11

    Google Scholar 

  56. Scholzen TE, Luger TA (2004) Neural endopeptidase and angiotensin-converting enzyme — key enzymes terminating the action of neuroendocrine mediators. Exp Dermatol 13(suppl 4):22–26

    Article  PubMed  CAS  Google Scholar 

  57. Scholzen TE, BrzoskaT, Kalden D-H, O’Reilly F, Armstrong CA, Luger TA, Ansel JC (1999) Effect of ultraviolet light on the release of neuropeptides and neuroendocrine hormones in the skin: Mediators of photodermatitis and cutaneous inflammation. J Invest Dermatol Proc 4:55–60

    Article  CAS  Google Scholar 

  58. Scholzen TE, Steinhoff M, Sindrilaru A, Schwarz A, Bunnett NW, Luger TA, Armstrong CA, Ansel JC (2004) Cutaneous allergic contact dermatitis responses are diminished in mice deficient in neurokinin 1 receptors and augmented by neurokinin 2 receptor blockage. FASEB J 18:1007–1009

    PubMed  CAS  Google Scholar 

  59. Seiffert KS, Granstein RD (2002) Neuropeptides and neuroendocrine hormones in ultraviolet radiation-induced immunosuppression. Methods 28:97–103

    Article  PubMed  CAS  Google Scholar 

  60. Sleijffers A, Herreilers M, van Loveren H, Garssen J (2003) Ultraviolet B radiation induces upregulation of calcitonin gene-related peptide levels in human Finn chamber skin samples. J Biochem Photobiol B: Biol 69:149–152

    Article  CAS  Google Scholar 

  61. Streilein JW, Alard P, Niizeki H (1999) Neural influences on induction of contact hypersensitivity. Ann NY Acad Sci 885:196–208

    Article  PubMed  CAS  Google Scholar 

  62. Townley SL, Grimbaldeston MA, Ferguson I, Rush RA, Zhang S-H, Zhou X-F, Conner JM, Finlay-Jones JJ, Hart PH (2002) Nerve growth factor, neuropeptides, and mast cells in ultraviolet-B-induced systemic suppression of contact hypersensitivity responses in mice. J Invest Dermatol 118:396–401

    Article  PubMed  CAS  Google Scholar 

  63. Tyrrell RM, Reeve VE (2006) Potential protection of skin by acute UVA irradiation — from cellular to animal models. Prog Biophys Mol Biol 92:86–91

    Article  PubMed  CAS  Google Scholar 

  64. Ullrich SE (2005) Mechanisms underlying UV-induced immune suppression. Mut Res 571:185–205

    CAS  Google Scholar 

  65. Van der Mei IA, Ponsonby AL, Dwyer T, Blizzard L, Simmons R, Taylor BV, Butzkueven H, Kilpatrick T (2003) Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case control study. BMJ 327:316–321

    Article  PubMed  Google Scholar 

  66. Walterscheid JP, Ullrich SE, Nghiem DX (2002) Platelet-activating factor, a molecular sensor for cellular damage, activates systemic immune suppression. J Exp Med 195:171–179

    Article  PubMed  CAS  Google Scholar 

  67. Webber LJ, Whang E, De Fabo EC (1997) The effects of UVA-I (340–100nm) and UVA-I+ II on the photoisomerization of urocanic acid in vivo. Photochem Photobiol 66:484–492

    Article  PubMed  CAS  Google Scholar 

  68. Woodward EA, Prele CM, Finlay-Jones JJ, Hart PH (2006) The receptor for cis-urocanic acid remains elusive. J Invest Dermatol 126:1191–1193

    Article  PubMed  CAS  Google Scholar 

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Correspondence to P. H. Hart , J. J. Finlay-Jones or S. Gorman .

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Hart, P.H., Finlay-Jones, J.J., Gorman, S. (2009). Photoneuroimmunology: Modulation of the Neuroimmune System by UV Radiation. In: Granstein, R.D., Luger, T.A. (eds) Neuroimmunology of the Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-35989-0_12

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