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Squamous Cell Carcinoma Including Actinic Keratosis, Bowen’s Disease, Keratoacanthoma, and Its Pigmented Variants

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Color Atlas of Melanocytic Lesions of the Skin

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Abstract

Invasive squamous cell carcinoma is the second most common skin cancer after basal cell carcinoma and causes the majority of deaths among the non-melanoma skin malignancies. When detected and treated early squamous cell carcinoma has a 95% cure rate [1]; however, if neglected, squamous cell carcinoma may cause local tissue destruction and may metastasize [2, 3]. Moreover, after the diagnosis of an initial squamous cell carcinoma, the 3-year cumulative risk for developing a second lesion is approximately 18% [4], emphasizing the need for ongoing clinical surveillance. In its pathogenesis, chronic ultraviolet (UV) irradiation plays a major role, responsible for DNA mutations (usually in the p53 tumor suppressor gene) in transformed epidermal keratinocytes [5].

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Editor information

Editors and Affiliations

  1. The Queensland Institute of Dermatology, University of Queensland, QLD 4102, Brisbane, Australia

    Hans Peter Soyer

  2. Department of Dermatology, Second University of Naples, Via Pansini 5, I-80131, Naples, Italy

    Guiseppe Argenziano

  3. Department of Dermatology, Medical University Graz, Auenbruggerplatz 8, A-8036, Graz, Austria

    Rainer Hofmann-Wellenhof

  4. Pigmented Lesion Clinic, University of Miami, School of Medicine, 33136, Miami, FL, USA

    Robert H. Johr

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© 2007 Springer-Verlag Berlin Heidelberg

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(2007). Squamous Cell Carcinoma Including Actinic Keratosis, Bowen’s Disease, Keratoacanthoma, and Its Pigmented Variants. In: Soyer, H., Argenziano, G., Hofmann-Wellenhof, R., Johr, R. (eds) Color Atlas of Melanocytic Lesions of the Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-35106-1_42

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  • DOI: https://doi.org/10.1007/978-3-540-35106-1_42

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-35105-4

  • Online ISBN: 978-3-540-35106-1

  • eBook Packages: MedicineMedicine (R0)

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