According to the original description by Tieche [33], to which little can be added, blue nevus is a dermal-based, benign melanocytic lesion histopathologically made up by variable proportions of oval/spindle and bipolar, usually heavily pigmented dendritic cells (G. Ferrara et al., submitted) [37, 40]. The aggregation of oval/spindle melanocytes with pale cytoplasm into discrete expansile nodules features a “cellular” blue nevus [23, 37].


Nodular Lesion Cardiac Myxoma Atrial Myxoma Clear Cell Sarcoma Blue Nevus 
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  1. Ackerman AB, Cerroni L, Kerl K. Pifalls in the diagnosis of malignant melanoma. Philadelphia: Lea and Febiger, 1994Google Scholar
  2. Argenziano G, Soyer HP, Giorgi V de, et al. Interactive atlas of dermoscopy (Book and CD-ROM). Milan: Edra Medical Publishing and New Media, 2000Google Scholar
  3. Ariyanayagam-Baksh SM, Baksh FK, Finkelstein SD, Swalsky PA, Abernethy J, Barnes EL. Malignant blue nevus: a case report and molecular analysis. Am J Dermatopathol 2003;25:21–27PubMedCrossRefGoogle Scholar
  4. Aroni K, Georgala S, Papachatzaki E. Coexistence of plaque-type blue nevus and congenital melanocytic nevi. J Dermatol 1996;23:325–328PubMedGoogle Scholar
  5. Avidor I, Kessler E. “Atypical” blue nevus: a benign variant of cellular blue nevus. Presentation of three cases. Dermatologica 1977;154:39–44PubMedCrossRefGoogle Scholar
  6. Bhawan J, Cao S-L. Amelanotic blue nevus: a variant of blue nevus. Am J Dermatopathol 1999;21:225–228PubMedCrossRefGoogle Scholar
  7. Busam KJ. Metastatic melanoma to the skin simulating blue nevus. Am J Surg Pathol 1999;23:276–282PubMedCrossRefGoogle Scholar
  8. Busam K, Woodruff JM, Erlandson PRA. Large plaque-type blue nevus with subcutaneous cellular nodules. Am J Surg Pathol 2000;20:527–530Google Scholar
  9. Carney JA, Ferreiro JA. The epithelioid blue nevus. A multicentric familial tumor with important associations, including cardiac myxoma and psammomatous melanotic schwannoma. Am J Surg Pathol 1996;20:259–272PubMedCrossRefGoogle Scholar
  10. Carr S, See J, Wilkinson B, Kossard S. Hypopigmented common blue nevus. J Cutan Pathol 1997;24:494–498PubMedCrossRefGoogle Scholar
  11. Cooper PH. Deep penetrating (plexiform spindle cell) nevus. A frequent participant in combined nevus. J Cutan Pathol 1992;19:172–180PubMedCrossRefGoogle Scholar
  12. Giorgi V de, Massi D, Salvini C, Trez E, Mannone F, Carli P. Dermoscopic features of combined melanocytic nevi. J Cutan Pathol 2004;31:600–604CrossRefGoogle Scholar
  13. Deyrup AT, Althof P, Zhou M, Morgan M, Solomon AR, Bridge JA, Weiss SW. Paraganglioma-like dermal melanocytic tumor: a unique entity distict from cellular blue nevus, clear cell sarcoma, and cutaneous melanoma. Am J Surg Pathol 2004;28:1579–1586PubMedCrossRefGoogle Scholar
  14. Ferrara G, Argenziano G, Zgavec B, Bartenjev I, Staibano S, Rosa G de, Soyer HP. “Compound blue nevus”: a reappraisal of “superficial blue nevus with prominent intraepidermal dendritic melanocytes” with emphasis on dermoscopic and histopathologic features. J Am Acad Dermatol 2002;46:85–89PubMedCrossRefGoogle Scholar
  15. Ferrara G, Boscaino A, Rosa G de. Bronchial blue nevus: a previously unreported entity. Histopathology 1995;26:581–583PubMedCrossRefGoogle Scholar
  16. Gricknik JM. Dermoscopy of melanocytic neoplasms. Sclerotic blue nevi. Arch Dermatol 2003;139:1522CrossRefGoogle Scholar
  17. Groben PA, Harvell JD, White WL. Epithelioid blue nevus. Neoplasm sui generis or variation on a theme? Am J Dermatopathol 2000;22:473–488PubMedCrossRefGoogle Scholar
  18. Guadagni M, Nazzari G. Clinical and dermoscopic features of an evolving deep-penetrating nevus. Arch Dermatol 2005;141:1490PubMedCrossRefGoogle Scholar
  19. Harvell JD, White WL. Persistent and recurrent blue nevi. Am J Dermatopathol 1999;21:506–517PubMedCrossRefGoogle Scholar
  20. Jiji V. Blue nevus of the endocervix. Review of the literature. Arch Pathol Lab Med 1971;92:203–205Google Scholar
  21. Kamino H, Tam ST. Compound blue nevus: a variant of blue nevus with an additional junctional dendritic component. A clinical, histopathologic, and immunohistochemical study of six cases. Arch Dermatol 1990;126:1330–1333PubMedCrossRefGoogle Scholar
  22. Marano SR, Brooks RA, Spetzler RF, Rekate HL. Giant congenital cellular blue of the scalp of a newborn with an underlying skull defect and invasion of the dura mater. Neurosurgery 1986;18:85–89PubMedCrossRefGoogle Scholar
  23. Massi G, LeBoit PE. “Cellular” blue nevus. In: Massi G, LeBoit PE (eds). Histological diagnosis of nevi and melanoma. Steinkopf Verlag Darmstadt: Berlin, 2004:151–168Google Scholar
  24. Misago N, Narisawa Y, Kohda H. A combination of speckled lentiginous nevus with patch-type blue nevus. J Dermatol 1993;20:643–647PubMedGoogle Scholar
  25. Mones JM, Ackerman AB. Atypical blue nevus, malignant blue nevus, and metastasizing blue nevus: a critique in historical perspective of three concepts flawed fatally. Am J Dermatopathol 2004;26:407–430PubMedCrossRefGoogle Scholar
  26. Papanicolaou SJ, Pierrakou ED, Patsakas AJ. Intraoral blue nevus. Review of the literature and a case report. J Oral Med 1985:40:32–35Google Scholar
  27. Pearson JP, Weiss SW, Headington JT. Cutaneous malignant melanotic neurocristic tumors arising in neurocristic hamartomas. A melanocytic tumor morphologically and biologically distinct from common melanoma. Am J Surg Pathol 1996;20:665–677PubMedCrossRefGoogle Scholar
  28. Rongioletti F, Innocenzi D. Sclerosing “mucinous” blue naevus. Br J Dermatol 2003;148:1250–1252PubMedCrossRefGoogle Scholar
  29. Scolyer RA, Zhuang L, Palmer AA, Thompson JF, McCarthy SW. Combined naevus: a benign lesion frequently misdiagnosed both clinically and pathologically as melanoma. Pathology 2004;36:419–427PubMedCrossRefGoogle Scholar
  30. Seab JA Jr, Graham JH, Helwig EB. Deep penetrating nevus. Am J Surg Pathol 13:39–44Google Scholar
  31. Stolz W, Braun-Falco O, Bilek P, Landthaler M,Cognetta AB.Color atlas of dermatoscopy. Oxford: Blackwell; 1994, p. 75Google Scholar
  32. Tannenbaum M. Differential diagnosis in uropathology. III. Melanotic lesions of the prostate: blue nevus and prostatic epithelial melanosis. Urology 1974;4:617–621PubMedCrossRefGoogle Scholar
  33. Tieche M. Uber benigne Melanome (Chromatophorome) der Haut: blaue Naevi. Virchow Arch Patol Anat 1906:186:212–229Google Scholar
  34. Tran TA, Carlson JA, Basaca PC, Mihm MC. Cellular blue nevus with atypia (atypical cellular blue nevus): a clinicopathologic study of nine cases. J Cutan Pathol 1998;25:252–258PubMedCrossRefGoogle Scholar
  35. Urso C, Tinacci G. Angiomatoid cellular blue nevus: a variant of blue nevus with an angioma-like appearance. J Cutan Pathol 2005;32:385–387PubMedCrossRefGoogle Scholar
  36. Veles A, Del Rio E, Martin-de-Hijas C, Furiò V, Sanchez Yus E. Agminated blue nevi: case report and review of the literature. Dermatology 1993;186:144–148Google Scholar
  37. Weedon D. Lentigines, nevi and melanoma. In: Weedon D (ed). Skin pathology, 2nd edn. Edinburg: Churchill Livingstone; 2002, pp. 803–858Google Scholar
  38. Zembowicz A, Carney JA, Mihm CMJ. Pigmented epithelioid melanocytoma, a low grade melanoma indistinguishable from animal type melanoma and epithelioid blue nevus. Am J Surg Pathol 2004;28:31–40PubMedCrossRefGoogle Scholar
  39. Zembowicz A, Granter SR, McKee PH, Mihm MC. Amelanotic cellular blue nevus: a hypopigmented variant of cellular blue nevus: clinicopathologic analysis of 20 cases. Am J Surg Pathol 2002;26:1493–1500PubMedCrossRefGoogle Scholar
  40. Zembowicz A, Mihm MC. Dermal dendritic melanocytic proliferation: an update. Histopathology 2004;45:433–451PubMedCrossRefGoogle Scholar

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