Abstract
Canonical transient receptor potential 7 (TRPC7) is the seventh identified member of the mammalian TRPC channel family, comprising nonselective cation channels activated through the phospholipase C (PLC) signaling pathway. TRPC7 is directly activated by diacylglycerol (DAG), one of the PLC products, having high sequence homology with TRPC3 and TRPC6, which are also activated by DAG. TRPC7 shows unique properties of activation, such as constitutive activity and susceptibility to negative regulation by extracellular Ca2+. Although the physiological importance of TRPC7 in the native environment remains elusive, TRPC7 would play important roles in Ca2+ signaling pathway through these characteristic features.
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References
Babich LG, Ku CY, Young HW, Huang H, Blackburn MR, Sanborn BM (2004) Expression of capacitative calcium TrpC proteins in rat myometrium during pregnancy. Biol Reprod 70:919–924
Buniel MC, Schilling WP, Kunze DL (2003) Distribution of transient receptor potential channels in the rat carotid chemosensory pathway. J Comp Neurol 464:404–413
Cai S, Fatherazi S, Presland RB, Belton CM, Izutsu KT (2005) TRPC channel expression during calcium-induced differentiation of human gingival keratinocytes. J Dermatol Sci 40:21–28
Dalrymple A, Slater DM, Poston L, Tribe RM (2004) Physiological induction of transient receptor potential canonical proteins, calcium entry channels, in human myometrium: influence of pregnancy, labor, and interleukin-1 beta. J Clin Endocrinol Metab 89:1291–1300
Goel M, Sinkins WG, Schilling WP (2002) Selective association of TRPC channel subunits in rat brain synaptosomes. J Biol Chem 277:48303–48310
Inoue R, Okada T, Onoue H, Hara Y, Shimizu S, Naitoh S, Ito Y, Mori Y (2001) The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca2+-permeable cation channel. Circ Res 88:325–332
Lievremont JP, Bird GS, Putney JW Jr (2004) Canonical transient receptor potential TRPC7 can function as both a receptor-and store-operated channel in HEK-293 cells. Am J Physiol Cell Physiol 287:C1709–C1716
Lievremont JP, Bird GS, Putney JW Jr (2005a) Mechanism of inhibition of TRPC cation channels by 2-aminoethoxydiphenylborane. Mol Pharmacol 68:758–762
Lievremont JP, Numaga T, Vazquez G, Lemonnier L, Hara Y, Mori E, Trebak M, Moss SE, Bird GS, Mori Y, Putney JW Jr (2005b) The role of canonical transient receptor potential 7 in B-cell receptor-activated channels. J Biol Chem 280:35346–35351
Montell C, Birnbaumer L, Flockerzi V, Bindels RJ, Bruford EA, Caterina MJ, Clapham DE, Harteneck C, Heller S, Julius D, Kojima I, Mori Y, Penner R, Prawitt D, Scharenberg AM, Schultz G, Shimizu N, Zhu MX (2002) A unified nomenclature for the superfamily of TRP cation channels. Mol Cell 9:229–231
Nagamine K, Kudoh J, Minoshima S, Kawasaki K, Asakawa S, Ito F, Shimizu N (1998) Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain. Genomics 54:124–131
Okada T, Inoue R, Yamazaki K, Maeda A, Kurosaki T, Yamakuni T, Tanaka I, Shimizu S, Ikenaka K, Imoto K, Mori Y (1999) Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca2+-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J Biol Chem 274:27359–27370
Riccio A, Mattei C, Kelsell RE, Medhurst AD, Calver AR, Randall AD, Davis JB, Benham CD, Pangalos MN (2002a) Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx. J Biol Chem 277:12302–12309
Riccio A, Medhurst AD, Mattei C, Kelsell RE, Calver AR, Randall AD, Benham CD, Pangalos MN (2002b) mRNA distribution analysis of human TRPC family in CNS and peripheral tissues. Brain Res Mol Brain Res 109:95–104
Shi J, Mori E, Mori Y, Mori M, Li J, Ito Y, Inoue R (2004) Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells. J Physiol 561:415–432
Walker RL, Hume JR, Horowitz B (2001) Differential expression and alternative splicing of TRP channel genes in smooth muscles. Am J Physiol Cell Physiol 280:C1184–C1192
Wang Q, Hogg RC, Large WA (1993) A monovalent ion-selective cation current activated by noradrenaline in smooth muscle cells of rabbit ear artery. Pflugers Arch 423:28–33
Wu X, Zagranichnaya TK, Gurda GT, Eves EM, Villereal ML (2004) A TRPC1/TRPC3-mediated increase in store-operated calcium entry is required for differentiation of H19-7 hippocampal neuronal cells. J Biol Chem 279:43392–43402
Yang M, Gupta A, Shlykov SG, Corrigan R, Tsujimoto S, Sanborn BM (2002) Multiple Trp isoforms implicated in capacitative calcium entry are expressed in human pregnant myometrium and myometrial cells. Biol Reprod 67:988–994
Yip H, Chan WY, Leung PC, Kwan HY, Liu C, Huang Y, Michel V, Yew DT, Yao X (2004) Expression of TRPC homologs in endothelial cells and smooth muscle layers of human arteries. Histochem Cell Biol 122:553–561
Zagranichnaya TK, Wu X, Villereal ML (2005a) Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells. J Biol Chem 280:29559–29569
Zagranichnaya TK, Wu X, Danos AM, Villereal ML (2005b) Gene expression profiles in HEK-293 cells with low or high store-operated calcium entry: can regulatory as well as regulated genes be identified? Physiol Genomics 21:14–33
Zitt C, Obukhov AG, Strubing C, Zobel A, Kalkbrenner F, Luckhoff A, Schultz G (1997) Expression of TRPC3 in Chinese hamster ovary cells results in calcium-activated cation currents not related to store depletion. J Cell Biol 138:1333–1341
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© 2007 Springer-Verlag Berlin Heidelberg
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Numaga, T., Wakamori, M., Mori, Y. (2007). TRPC7. In: Flockerzi, V., Nilius, B. (eds) Transient Receptor Potential (TRP) Channels. Handbook of Experimental Pharmacology, vol 179. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-34891-7_8
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DOI: https://doi.org/10.1007/978-3-540-34891-7_8
Publisher Name: Springer, Berlin, Heidelberg
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