TRPC Channels: Interacting Proteins

  • K. Kiselyov
  • D. M. Shin
  • J. -Y. Kim
  • J. P. Yuan
  • S. Muallem
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 179)


TRP channels, in particular the TRPC and TRPV subfamilies, have emerged as important constituents of the receptor-activated Ca2+ influx mechanism triggered by hormones, growth factors, and neurotransmitters through activation of phospholipase C (PLC). Several TRPC channels are also activated by passive depletion of endoplasmic reticulum (ER) Ca2+. Although in several studies the native TRP channels faithfully reproduce the respective recombinant channels, more often the properties of Ca2+ entry and/or the store-operated current are strikingly different from that of the TRP channels expressed in the same cells. The present review aims to discuss this disparity in the context of interaction of TRPC channels with auxiliary proteins that may alter the permeation and regulation of TRPC channels.


TRP channels Receptor-induced Ca2+ influx Scaffold proteins Homer Junctate 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • K. Kiselyov
    • 1
  • D. M. Shin
    • 2
  • J. -Y. Kim
    • 3
  • J. P. Yuan
    • 3
  • S. Muallem
    • 3
  1. 1.Department of Biological SciencesUniversity of PittsburghPittsburghUSA
  2. 2.Department of Oral Biology, Oral Science Research Center, Brain Korea 21 Project for Medical ScienceYonsei University College of DentistrySeoulKorea
  3. 3.Department of PhysiologyUniversity of Texas Southwestern Medical Center at DallasDallasUSA

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