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Nociception and TRP Channels

  • M. Tominaga
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 179)

Abstract

Pain is initiated when noxious stimuli excite the peripheral terminals of specialized primary afferent neurons called nociceptors. Many molecules are involved in conversion of the noxious stimuli to the electrical signals in the nociceptor endings. Among them, TRP channels play important roles in detecting noxious stimuli.

Keywords

Noci-TRPs Capsaicin Analgesic Thermo-TRPs Heat perception Cold perception 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • M. Tominaga
    • 1
  1. 1.Section of Cell Signaling, Okazaki Institute for Integrative BioscienceNational Institutes of Natural SciencesOkazakiJapan

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