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Know Thy Neighbor: A Survey of Diseases and Complex Syndromes that Map to Chromosomal Regions Encoding TRP Channels

  • J. Abramowitz
  • L. Birnbaumer
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 179)

Abstract

On the basis of their ever-expanding roles, not only in sensory signaling but also in a plethora of other, often Ca2+-mediated actions in cell and whole body homeostasis, it is suggested that mutations in TRP channel genes not only cause disease states but also contribute in more subtle ways to simple and complex diseases. A survey is therefore presented of diseases and syndromes that map to one or multiple chromosomal loci containing TRP channel genes. A visual map of the chromosomal locations of TRP channel genes in man and mouse is also presented.

Keywords

TRP Channels Genetic diseases 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • J. Abramowitz
    • 1
  • L. Birnbaumer
    • 1
  1. 1.Transmembrane Signaling Group, Laboratory of Signal Transduction, Division of Intramural Research, National Institutes of Environmental Health SciencesNational Institutes of Health, Department of Health and Human ServicesResearch Triangle ParkUSA

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