TRPM3 is the last identified member of the TRPM subfamily and is most closely related to TRPM1. Due to alternative splicing, the TRPM3 gene encodes a large number of different variants. One splice event, affecting the pore-forming region of the channel, changes its selectivity for divalent cations. Inthis review, we give an overview of the identified TRPM3 variants and compare their functional properties.
KeywordsTRPM3 variants Alternative splicing Channel pore
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- Zhu X, Jiang M, Birnbaumer L (1998) Receptor-activated Ca2+ influx via human Trp3 stably expressed in human embryonic kidney (HEK)293 cells. Evidence for a non-capacitative Ca2+ entry. J Biol Chem 273:133–142Google Scholar