• J. Oberwinkler
  • S. E. Philipp
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 179)


TRPM3 is the last identified member of the TRPM subfamily and is most closely related to TRPM1. Due to alternative splicing, the TRPM3 gene encodes a large number of different variants. One splice event, affecting the pore-forming region of the channel, changes its selectivity for divalent cations. Inthis review, we give an overview of the identified TRPM3 variants and compare their functional properties.


TRPM3 variants Alternative splicing Channel pore 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • J. Oberwinkler
    • 1
  • S. E. Philipp
    • 1
  1. 1.Institut für klinische und experimentelle Pharmakologie und ToxikologieUniversität des SaarlandesHomburgGermany

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