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An Introduction on TRP Channels

  • V. Flockerzi
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 179)

Abstract

The transient receptor potential (TRP) ion channels are named after the role of the channels in Drosophila phototransduction. Mammalian TRP channel subunit proteins are encoded by at least 28 genes. TRP cation channels display an extraordinary assortment of selectivities and activation mechanisms, some of which represent previously unrecognized modes of regulating ion channels. In addition, the biological roles of TRP channels appear to be equally diverse and range from roles in thermosensation and pain perception to Ca2+ and Mg2+ absorption, endothelial permeability, smooth muscle proliferation and gender-specific behaviour.

Keywords

TRP channels TRP pharmacology TRP gene mutation Thermo TRPs Store-operated channel 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • V. Flockerzi
    • 1
  1. 1.Experimentelle und Klinische Pharmakologie und ToxikologieUniversität des SaarlandesHomburgGermany

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