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Acute Promyelocytic Leukemia pp 31–48Cite as

The PLZF Gene of t(11;17)-Associated APL

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 313))

Abstract

The PLZF gene is one of five partners fused to the retinoic acid receptor αin acute promyelocytic leukemia. PLZF encodes a DNA-binding transcriptional repressor and the PLZF-RARα fusion protein like other RARα fusions can inhibit the genet program mediated by the wild tpe retinoic acid receptor. However an increasing body of literature indicates an important role for the PLZF gene in growth control and development. This information suggests that loss of PLZF function might also contribute to leukemogenesis.

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Authors and Affiliations

  1. Division of Hematology/Oncology, Northwestern University, Feinberg School of Medicine, 303 E Superior St, Chicago, IL, 60611, USA

    M. J. McConnell & J. D. Licht

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  1. M. J. McConnell
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  2. J. D. Licht
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  1. Memorial Sloan-Kettering Cancer Center, Sloan-Kettering-Institute, 1275 York Avenue, New York, New York, 10021, USA

    Pier Paolo Pandolfi MD, Ph.D.

  2. The Scripps Research Institute, 10550 North Torreye Pines Road, La Jolla, CA, 92037, USA

    Peter K. Vogt Ph.D.

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McConnell, M.J., Licht, J.D. (2007). The PLZF Gene of t(11;17)-Associated APL. In: Pandolfi, P.P., Vogt, P.K. (eds) Acute Promyelocytic Leukemia. Current Topics in Microbiology and Immunology, vol 313. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-34594-7_3

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