Abstract
The PLZF gene is one of five partners fused to the retinoic acid receptor αin acute promyelocytic leukemia. PLZF encodes a DNA-binding transcriptional repressor and the PLZF-RARα fusion protein like other RARα fusions can inhibit the genet program mediated by the wild tpe retinoic acid receptor. However an increasing body of literature indicates an important role for the PLZF gene in growth control and development. This information suggests that loss of PLZF function might also contribute to leukemogenesis.
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McConnell, M.J., Licht, J.D. (2007). The PLZF Gene of t(11;17)-Associated APL. In: Pandolfi, P.P., Vogt, P.K. (eds) Acute Promyelocytic Leukemia. Current Topics in Microbiology and Immunology, vol 313. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-34594-7_3
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