Skip to main content
SpringerLink
Log in

Targeting APL Fusion Proteins by Peptide Interference

  • Chapter
Acute Promyelocytic Leukemia

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 313))

  • 752 Accesses

Abstract

A significant barrier to experimental therapeutics is the ability to identify and specifically target oncogenic proteins involved in the molecular pathogenesis of disease. In acute promyelocytic leukemia (APL), aberrant transcription factors and their associated machinery play a central role in mediating the malignant phenotype. The mechanism of action of APL chimeric fusion proteins involves their ability to either self-associate or interact with different partner proteins. Thus, targeting protein-protein interactions could have a significant impact in blocking the activity of APL oncoproteins. As therapeutic targets, the interface between interacting proteins may not always be amenable to highly specific small molecule blockade. In contrast, peptides are well-suited to this purpose and can be reliably delivered when fused to cell-permeable peptide domains. Therapeutic peptides can be designed to directly target APL fusion proteins, their downstream effectors, or other potentially synergistic oncogenic mechanisms of importance in APL blasts. In addition to serving as potential therapeutic agents, such reagents could serve as powerful reagents to dissect the molecular pathogenesis of APL.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Agou F, Courtois G, Chiaravalli J, Baleux F, Coic YM, Traincard F, Israel A, Veron M (2004) Inhibition of NF-kappa B activation by peptides targeting NF-kappa B essential modulator (nemo) oligomerization. J Biol Chem 279:54248–54257

    Article  PubMed  CAS  Google Scholar 

  • Ahmad KF, Engel CK, Prive GG (1998) Crystal structure of the BTB domain from PLZF. Proc Natl Acad Sci U S A 95:12123–12128

    Article  PubMed  CAS  Google Scholar 

  • Ahmad KF, Melnick A, Lax S, Bouchard D, Liu J, Kiang CL, Mayer S, Takahashi S, Licht JD, Prive GG (2003) Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain. Mol Cell 12:1551–1564

    Article  PubMed  CAS  Google Scholar 

  • Alcalay M, Tomassoni L, Colombo E, Stoldt S, Grignani F, Fagioli M, Szekely L, Helin K, Pelicci PG (1998) The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein. Mol Cell Biol 18:1084–1093

    PubMed  CAS  Google Scholar 

  • Barka T, Gresik EW, van Der Noen H (2000) Transduction of TAT-HA-betagalactosidase fusion protein into salivary gland-derived cells and organ cultures of the developing gland, and into rat submandibular gland in vivo. J Histochem Cytochem 48:1453–1460

    PubMed  CAS  Google Scholar 

  • Barka T, Gresik ES, Henderson SC (2004) Production of cell lines secreting TAT fusion proteins. J Histochem Cytochem 52:469–477

    PubMed  CAS  Google Scholar 

  • Bashour AM, Meng JJ, Ip W, MacCollin M, Ratner N (2002) The neurofibromatosis type 2 gene product, merlin, reverses the F-actin cytoskeletal defects in primary human Schwannoma cells. Mol Cell Biol 22:1150–1157

    Article  PubMed  CAS  Google Scholar 

  • Belting M, Sandgren S, Wittrup A (2005) Nuclear delivery of macromolecules: barriers and carriers. Adv Drug Deliv Rev 57:505–527

    Article  PubMed  CAS  Google Scholar 

  • Bernassola F, Salomoni P, Oberst A, Di Como CJ, Pagano M, Melino G, Pandolfi PP (2004) Ubiquitin-dependent degradation of p73 is inhibited by PML. J Exp Med 199:1545–1557

    Article  PubMed  CAS  Google Scholar 

  • Brooks H, Lebleu B, Vives E (2005) Tat peptide-mediated cellular delivery: back to basics. Adv Drug Deliv Rev 57:559–577

    Article  PubMed  CAS  Google Scholar 

  • Callens C, Chevret S, Cayuela JM, Cassinat B, Raffoux E, de Botton S, Thomas X, Guerci A, Fegueux N, Pigneux A, Stoppa AM, Lamy T, Rigal-Huguet F, Vekhoff A, Meyer-Monard S, Ferrand A, Sanz M, Chomienne C, Fenaux P, Dombret H (2005) Prognostic implication of FLT3 and Ras gene mutations in patients with acute promyelocytic leukemia (APL): a retrospective study from the European APL Group. Leukemia 19:1153–1160

    Article  PubMed  CAS  Google Scholar 

  • Chen YN, Sharma SK, Ramsey TM, Jiang L, Martin MS, Baker K, Adams PD, Bair KW, Kaelin WG Jr (1999) Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists. Proc Natl Acad Sci U S A 96:4325–4329

    Article  PubMed  CAS  Google Scholar 

  • Console S, Marty C, Garcia-Echeverria C, Schwendener R, Ballmer-Hofer K (2003) Antennapedia and HIV transactivator of transcription (TAT) “protein transduction domains” promote endocytosis of high molecular weight cargo upon binding to cell surface glycosaminoglycans. J Biol Chem 278:35109–35114

    Article  PubMed  CAS  Google Scholar 

  • Contegno F, Cioce M, Pelicci PG, Minucci S (2002) Targeting protein inactivation through an oligomerization chain reaction. Proc Natl Acad Sci U S A 99:1865–1869

    Article  PubMed  CAS  Google Scholar 

  • Crawford M, Woodman R, Ko Ferrigno P (2003) Peptide aptamers: tools for biology and drug discovery. Brief Funct Genomic Proteomic 2:72–79

    Article  PubMed  CAS  Google Scholar 

  • Datta K, Sundberg C, Karumanchi SA, Mukhopadhyay D (2001) The 104–123 amino acid sequence of the beta-domain of von Hippel-Lindau gene product is sufficient to inhibit renal tumor growth and invasion. Cancer Res 61:1768–1775

    PubMed  CAS  Google Scholar 

  • Derossi D, Joliot AH, Chassaing G, Prochiantz A (1994) The third helix of the Antennapedia homeodomain translocates through biological membranes. J Biol Chem 269:10444–10450

    PubMed  CAS  Google Scholar 

  • Di Croce L, Raker VA, Corsaro M, Fazi F, Fanelli M, Faretta M, Fuks F, Lo Coco F, Kouzarides T, Nervi C, Minucci S, Pelicci PG (2002) Identification of a zinc finger domain in the human NEIL2 (Nei-like-2) protein. Science 295:1079–1082

    Article  PubMed  Google Scholar 

  • Dong S, Stenoien DL, Qiu J, Mancini MA, Tweardy DJ (2004) Reduced intranuclear mobility of APL fusion proteins accompanies their mislocalization and results in sequestration and decreased mobility of retinoid X receptor alpha. Mol Cell Biol 24:4465–4475

    Article  PubMed  CAS  Google Scholar 

  • Duprez E, Wagner K, Koch H, Tenen DG (2003) C/EBPbeta: a major PML-RARA responsive gene in retinoic acid-induced differentiation of APL cells. EMBO J 22:5806–5816

    Article  PubMed  CAS  Google Scholar 

  • Elliott G, O’Hare P (1997) Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell 88:223–233

    Article  PubMed  CAS  Google Scholar 

  • Fazi F, Travaglini L, Carotti D, Palitti F, Diverio D, Alcalay M, McNamara S, Miller W H Jr, Lo Coco F, Pelicci PG, Nervi C (2005) Retinoic acid targets DNA-methyltransferases and histone deacetylases during APL blast differentiation in vitro and in vivo. Oncogene 24:1820–1830

    Article  PubMed  CAS  Google Scholar 

  • Ferbeyre G (2002) PML a target of translocations in APL is a regulator of cellular senescence. Leukemia 16:1918–1926

    Article  PubMed  CAS  Google Scholar 

  • Ferbeyre G, de Stanchina E, Querido E, Baptiste N, Prives C, Lowe SW (2000) PML is induced by oncogenic ras and promotes premature senescence. Genes Dev 14:2015–2027

    PubMed  CAS  Google Scholar 

  • Ferrari A, Pellegrini V, Arcangeli C, Fittipaldi A, Giacca M, Beltram F (2003) Caveolae-mediated internalization of extracellular HIV-1 tat fusion proteins visualized in real time. Mol Ther 8:284–294

    Article  PubMed  CAS  Google Scholar 

  • Fischer R, Kohler K, Fotin-Mleczek M, Brock R (2004) A stepwise dissection of the intracellular fate of cationic cell-penetrating peptides. J Biol Chem 279:12625–12635

    Article  PubMed  CAS  Google Scholar 

  • Fittipaldi A, Ferrari A, Zoppe M, Arcangeli C, Pellegrini V, Beltram F, Giacca M (2003) Cell membrane lipid rafts mediate caveolar endocytosis of HIV-1 Tat fusion proteins. J Biol Chem 278:34141–34149

    Article  PubMed  CAS  Google Scholar 

  • Frankel AD, Pabo CO (1988) Cellular uptake of the tat protein from human immunodeficiency virus. Cell 55:1189–1193

    Article  PubMed  CAS  Google Scholar 

  • Fujimoto K, Hosotani R, Miyamoto Y, Doi R, Koshiba T, Otaka A, Fujii N, Beauchamp RD, Imamura M (2000) Inhibition of pRb phosphorylation and cell cycle progression by an antennapedia-p16(INK4A) fusion peptide in pancreatic cancer cells. Cancer Lett 159:151–158

    Article  PubMed  CAS  Google Scholar 

  • Fulda S, Wick W, Weller M, Debatin KM (2002) Smac agonists sensitize for Apo2L/TRAIL-or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. Nat Med 8:808–815

    PubMed  CAS  Google Scholar 

  • Futaki S, Suzuki T, Ohashi W, Yagami T, Tanaka S, Ueda K, Sugiura Y (2001) Argininerich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery. J Biol Chem 276:5836–5840

    Article  PubMed  CAS  Google Scholar 

  • Gallagher RE (2002) Retinoic acid resistance in acute promyelocytic leukemia. Leukemia 16:1940–1958

    Article  PubMed  CAS  Google Scholar 

  • Gery S, Park DJ, Vuong PT, Chih DY, Lemp N, Koeffler HP (2004) Retinoic acid regulates C/EBP homologous protein expression (CHOP), which negatively regulates myeloid target genes. Blood 104:3911–3917

    Article  PubMed  CAS  Google Scholar 

  • Green M, Loewenstein PM (1988) Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein. Cell 55:1179–1188

    Article  PubMed  CAS  Google Scholar 

  • Grignani F, De Matteis S, Nervi C, Tomassoni L, Gelmetti V, Cioce M, Fanelli M, Ruthardt M, Ferrara FF, Zamir I, Seiser C, Lazar MA, Minucci S, Pelicci PG (1998) Cloning and characterization of a novel human histone deacetylase, HDAC8. Nature 391:815–818

    Article  PubMed  CAS  Google Scholar 

  • Hayakawa F, Privalsky ML (2004) Phosphorylation of PML by mitogen-activated protein kinases plays a key role in arsenic trioxide-mediated apoptosis. Cancer Cell 5:389–401

    Article  PubMed  CAS  Google Scholar 

  • Hosotani R, Miyamoto Y, Fujimoto K, Doi R, Otaka A, Fujii N, Imamura M (2002) Trojan p16 peptide suppresses pancreatic cancer growth and prolongs survival in mice. Clin Cancer Res 8:1271–1276

    PubMed  CAS  Google Scholar 

  • Hu X, Lazar MA (1999) The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors. Nature 402:93–96

    Article  PubMed  CAS  Google Scholar 

  • Jensen K, Shiels C, Freemont PS (2001) PML protein isoforms and the RBCC/TRIM motif. Oncogene 20:7223–7233

    Article  PubMed  CAS  Google Scholar 

  • Joliot A, Prochiantz A (2004) Transduction peptides: from technology to physiology. Nat Cell Biol 6:189–196

    Article  PubMed  CAS  Google Scholar 

  • Kamashev D, Vitoux D, De The H (2004) PML-RARA-RXR oligomers mediate retinoid and rexinoid/cAMP cross-talk in acute promyelocytic leukemia cell differentiation. J Exp Med 199:1163–1174

    Article  PubMed  CAS  Google Scholar 

  • Kawasaki A, Matsumura I, Kataoka Y, Takigawa E, Nakajima K, Kanakura Y (2003) Opposing effects of PML and PML/RAR alpha on STAT3 activity. Blood 101:3668–3673

    Article  PubMed  CAS  Google Scholar 

  • Kiyoi H, Naoe T, Yokota S, Nakao M, Minami S, Kuriyama K, Takeshita A, Saito K, Hasegawa S, Shimodaira S, Tamura J, Shimazaki C, Matsue K, Kobayashi H, Arima N, Suzuki R, Morishita H, Saito H, Ueda R, Ohno R (1997) Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia. Leukemia Study Group of the Ministry of Health and Welfare (Kohseisho). Leukemia 11:1447–1452

    Article  PubMed  CAS  Google Scholar 

  • Letai A, Bassik MC, Walensky LD, Sorcinelli MD, Weiler S, Korsmeyer SJ (2002) Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2:183–192

    Article  PubMed  CAS  Google Scholar 

  • Letoha T, Gaal S, Somlai C, Venkei Z, Glavinas H, Kusz E, Duda E, Czajlik A, Petak F, Penke B (2005) Investigation of penetratin peptides. Part 2 In vitro uptake of penetratin and two of its derivatives. J Pept Sci 11:805–811

    Article  PubMed  CAS  Google Scholar 

  • Lin RJ, Nagy L, Inoue S, Shao W, Miller W H Jr, Evans RM (1998) Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature 391:811–814

    Article  PubMed  CAS  Google Scholar 

  • Lin YZ, Yao SY, Veach RA, Torgerson TR, Hawiger J (1995) Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. J Biol Chem 270:14255–14258

    Article  PubMed  CAS  Google Scholar 

  • Mallette FA, Goumard S, Gaumont-Leclerc MF, Moiseeva O, Ferbeyre G (2004) Human fibroblasts require the Rb family of tumor suppressors, but not p53, for PML-induced senescence. Oncogene 23:91–99

    Article  PubMed  CAS  Google Scholar 

  • Melnick A (2005) Predicting the effect of transcription therapy in hematologic malignancies. Leukemia 19:1109–1117

    Article  PubMed  CAS  Google Scholar 

  • Melnick A, Licht JD (1999) Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia. Blood 93:3167–3215

    PubMed  CAS  Google Scholar 

  • Melnick A, Ahmad KF, Arai S, Polinger A, Ball H, Borden KL, Carlile GW, Prive GG, Licht JD (2000) In-depth mutational analysis of the promyelocytic leukemia zinc finger BTB/POZ domain reveals motifs and residues required for biological and transcriptional functions. Mol Cell Biol 20:6550–6567

    Article  PubMed  CAS  Google Scholar 

  • Melnick A, Carlile G, Ahmad KF, Kiang CL, Corcoran C, Bardwell V, Prive GG, Licht JD (2002) Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors. Mol Cell Biol 22:1804–1818

    Article  PubMed  CAS  Google Scholar 

  • Melnick AM, Adelson K, Licht JD (2005) The theoretical basis of transcriptional therapy of cancer: can it be put into practice? J Clin Oncol 23:3957–3970

    Article  PubMed  Google Scholar 

  • Michod D, Yang JY, Chen J, Bonny C, Widmann C (2004) A RasGAP-derived cell permeable peptide potently enhances genotoxin-induced cytotoxicity in tumor cells. Oncogene 23:8971–8978

    Article  PubMed  CAS  Google Scholar 

  • Minucci S, Maccarana M, Cioce M, De Luca P, Gelmetti V, Segalla S, Di Croce L, Giavara S, Matteucci C, Gobbi A, Bianchini A, Colombo E, Schiavoni I, Badaracco G, Hu X, Lazar MA, Landsberger N, Nervi C, Pelicci PG (2000) Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation. Mol Cell 5:811–820

    Article  PubMed  CAS  Google Scholar 

  • Moog-Lutz C, Peterson EJ, Lutz PG, Eliason S, Cave-Riant F, Singer A, Di Gioia Y, Dmowski S, Kamens J, Cayre YE, Koretzky G (2001) PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells. J Biol Chem 276:22375–22381

    Article  PubMed  CAS  Google Scholar 

  • Morris MC, Depollier J, Mery J, Heitz F, Divita G (2001) A peptide carrier for the delivery of biologically active proteins into mammalian cells. Nat Biotechnol 19:1173–1176

    Article  PubMed  CAS  Google Scholar 

  • Mourez M, Collier RJ (2004) Use of phage display and polyvalency to design inhibitors of protein-protein interactions. Methods Mol Biol 261:213–228

    PubMed  CAS  Google Scholar 

  • Mueller BU, Pabst T, Fos J, Petkovic V, Fey MF, Asou N, Buergi U, Tenen DG (2006) ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU. 1 expression. Blood 107:3330–3338

    Article  PubMed  CAS  Google Scholar 

  • Nagahara H, Vocero-Akbani AM, Snyder EL, Ho A, Latham DG, Lissy NA, Becker-Hapak M, Ezhevsky SA, Dowdy SF (1998) Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration. Nat Med 4:1449–1452

    Article  PubMed  CAS  Google Scholar 

  • Nagel-Wolfrum K, Buerger C, Wittig I, Butz K, Hoppe-Seyler F, Groner B (2004) The interaction of specific peptide aptamers with the DNA binding domain and the dimerization domain of the transcription factor Stat3 inhibits transactivation and induces apoptosis in tumor cells. Mol Cancer Res 2:170–182

    PubMed  CAS  Google Scholar 

  • Oehlke J, Scheller A, Wiesner B, Krause E, Beyermann M, Klauschenz E, Melzig M, Bienert M (1998) Cellular uptake of an alpha-helical amphipathic model peptide with the potential to deliver polar compounds into the cell interior nonendocytically. Biochim Biophys Acta 1414:127–139

    Article  PubMed  CAS  Google Scholar 

  • Olsnes S, Klingenberg O, Wiedlocha A (2003) Transport of exogenous growth factors and cytokines to the cytosol and to the nucleus. Physiol Rev 83:163–182

    PubMed  CAS  Google Scholar 

  • Pearson M, Carbone R, Sebastiani C, Cioce M, Fagioli M, Saito S, Higashimoto Y, Appella E, Minucci S, Pandolfi PP, Pelicci PG (2000) PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature 406:207–210

    Article  PubMed  CAS  Google Scholar 

  • Pescarolo MP, Bagnasco L, Malacarne D, Melchiori A, Valente P, Millo E, Bruno S, Basso S, Parodi S (2001) A retro-inverso peptide homologous to helix 1 of c-Myc is a potent and specific inhibitor of proliferation in different cellular systems. FASEB J 15:31–33

    PubMed  CAS  Google Scholar 

  • Polo JM, Dell’oso T, Ranuncolo SM, Cerchietti L, Beck D, DaSilva GF, Prive GG, Licht JD, Melnick A (2004) Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells. Nat Med 10:1329–1335

    Article  PubMed  CAS  Google Scholar 

  • Pooga M, Hallbrink M, Zorko M, Langel U (1998) Cell penetration by transportan. FASEB J 12:67–77

    PubMed  CAS  Google Scholar 

  • Potocky TB, Menon AK, Gellman SH (2003) Cytoplasmic and nuclear delivery of a TAT-derived peptide and a beta-peptide after endocytic uptake into HeLa cells. J Biol Chem 278:50188–50194

    Article  PubMed  CAS  Google Scholar 

  • Prochiantz A, Joliot A (2003) Can transcription factors function as cell-cell signalling molecules? Nat Rev Mol Cell Biol 4:814–819

    PubMed  CAS  Google Scholar 

  • Puccetti E, Zheng X, Brambilla D, Seshire A, Beissert T, Boehrer S, Nurnberger H, Hoelzer D, Ottmann OG, Nervi C, Ruthardt M (2005) The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARalpha. Cancer Res 65:6080–6088

    Article  PubMed  CAS  Google Scholar 

  • Racanicchi S, Maccherani C, Liberatore C, Billi M, Gelmetti V, Panigada M, Rizzo G, Nervi C, Grignani F (2005) Targeting fusion protein/corepressor contact restores differentiation response in leukemia cells. EMBO J 24:1232–1242

    Article  PubMed  CAS  Google Scholar 

  • Richard JP, Melikov K, Vives E, Ramos C, Verbeure B, Gait MJ, Chernomordik LV, Lebleu B (2003) Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake. J Biol Chem 278:585–590

    Article  PubMed  CAS  Google Scholar 

  • Richard JP, Melikov K, Brooks H, Prevot P, Lebleu B, Chernomordik LV (2005) Cellular uptake of unconjugated TAT peptide involves clathrin-dependent endocytosis and heparan sulfate receptors. J Biol Chem 280:15300–15306

    Article  PubMed  CAS  Google Scholar 

  • Schwarze SR, Ho A, Vocero-Akbani A, Dowdy SF (1999) In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 285:1569–1572

    Article  PubMed  CAS  Google Scholar 

  • Shen ZX, Shi ZZ, Fang J, Gu BW, Li JM, Zhu YM, Shi JY, Zheng PZ, Yan H, Liu YF, Chen Y, Shen Y, Wu W, Tang W, Waxman S, De The H, Wang ZY, Chen SJ, Chen Z (2004) All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. Proc Natl Acad Sci U S A 101:5328–5335

    Article  PubMed  CAS  Google Scholar 

  • Snowden AW, Zhang L, Urnov F, Dent C, Jouvenot Y, Zhong X, Rebar EJ, Jamieson AC, Zhang HS, Tan S, Case CC, Pabo CO, Wolffe AP, Gregory PD (2003) Repression of vascular endothelial growth factor A in glioblastoma cells using engineered zinc finger transcription factors. Cancer Res 63:8968–8976

    PubMed  CAS  Google Scholar 

  • Snyder EL, Meade BR, Saenz CC, Dowdy SF (2004) Treatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptide. PLoS Biol 2:E36

    Article  PubMed  Google Scholar 

  • Tallman MS (2004) Acute promyelocytic leukemia as a paradigm for targeted therapy. Semin Hematol 41:27–32

    Article  PubMed  CAS  Google Scholar 

  • Tyagi M, Rusnati M, Presta M, Giacca M (2001) Internalization of HIV-1 tat requires cell surface heparan sulfate proteoglycans. J Biol Chem 276:3254–3261

    Article  PubMed  CAS  Google Scholar 

  • Vives E, Brodin P, Lebleu B (1997) A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus. J Biol Chem 272:16010–16017

    Article  PubMed  CAS  Google Scholar 

  • Wade PA, Gegonne A, Jones PL, Ballestar E, Aubry F, Wolffe AP (1999) Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation. Nat Genet 23:62–66

    PubMed  CAS  Google Scholar 

  • Wadia JS, Dowdy SF (2005) Transmembrane delivery of protein and peptide drugs by TAT-mediated transduction in the treatment of cancer. Adv Drug Deliv Rev 57:579–596

    Article  PubMed  CAS  Google Scholar 

  • Wadia JS, Stan RV, Dowdy SF (2004) Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis. Nat Med 10:310–315

    Article  PubMed  CAS  Google Scholar 

  • Walensky LD, Kung AL, Escher I, Malia TJ, Barbuto S, Wright RD, Wagner G, Verdine GL, Korsmeyer SJ (2004) Experimental fat embolism induces urine 2,3-dinor-6-ketoprostaglandin F1alpha and 11-dehydrothromboxane B2 excretion in pigs. Science 305:1466–1470

    Article  PubMed  CAS  Google Scholar 

  • Yang L, Mashima T, Sato S, Mochizuki M, Sakamoto H, Yamori T, Oh-Hara T, Tsuruo T (2003) Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide. Cancer Res 63:831–837

    PubMed  CAS  Google Scholar 

  • Yuan J, Kramer A, Eckerdt F, Kaufmann M, Strebhardt K (2002) Efficient internalization of the polo-box of polo-like kinase 1 fused to an Antennapedia peptide results in inhibition of cancer cell proliferation. Cancer Res 62:4186–4190

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Developmental and Molecular Biology and Medical Oncology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, 10461, USA

    A. Melnick

Authors
  1. A. Melnick
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Memorial Sloan-Kettering Cancer Center, Sloan-Kettering-Institute, 1275 York Avenue, New York, New York, 10021, USA

    Pier Paolo Pandolfi MD, Ph.D.

  2. The Scripps Research Institute, 10550 North Torreye Pines Road, La Jolla, CA, 92037, USA

    Peter K. Vogt Ph.D.

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Melnick, A. (2007). Targeting APL Fusion Proteins by Peptide Interference. In: Pandolfi, P.P., Vogt, P.K. (eds) Acute Promyelocytic Leukemia. Current Topics in Microbiology and Immunology, vol 313. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-34594-7_12

Download citation

Publish with us

Policies and ethics

Search

Navigation