Regulation of KSHV Lytic Gene Expression

  • H. Deng
  • Y. Liang
  • R. Sun
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 312)


The life cycle of KSHV, latency versus lytic replication, is mainly determined at the transcriptional regulation level. A viral immediate-early gene product, replication and transcription activator (RTA), has been identified as the molecular switch for initiation of the lytic gene expression program from latency. Here we review progress on two key questions: how RTA gene expression is controlled by viral proteins and cellular signals and how RTA regulates the expression of downstream viral genes. We summarize the interactions of RTA with cellular and other viral proteins. We also discuss critical issues that must be addressed in the near future.


Primary Effusion Lymphoma Lytic Replication Multicentric Castleman Disease Lytic Gene Expression Viral Lytic Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • H. Deng
    • 1
    • 2
  • Y. Liang
    • 3
  • R. Sun
    • 4
  1. 1.Center for Infection and Immunity, National Laboratory of Biomacromolecules, Institute of BiophysicsChinese Academy of SciencesBeijingP.R. China
  2. 2.School of DentistryUniversity of California at Los AngelesLos AngelesUSA
  3. 3.Department of Pathology and Laboratory MedicineEmory UniversityAtlantaUSA
  4. 4.Department of Molecular and Medical PharmacologyUniversity of California at Los AngelesLos AngelesUSA

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