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The KSHV and Other Human Herpesviral G Protein-Coupled Receptors

  • M. Cannon
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 312)

Abstract

Kaposi sarcoma-associated herpesvirus (KSHV) is a γ2-herpesvirus discovered in 1994 and is the agent responsible for Kaposi sarcoma (KS), an endothelial cell malignancy responsible for significant morbidity and mortality worldwide. Over time, KSHV has pirated many human genes whose products regulate angiogenesis, inflammation, and the cell cycle. One of these encodes for a mutated G protein-coupled receptor (GPCR) that is a homologue of the human IL-8 receptor. GPCRs are the largest family of signaling molecules and respond to a wide array of ligands. Unlike its normal counterpart, the mutations present in KSHV vGPCR result in constitutive, ligand-independent signaling activity. Signaling by the KSHV vGPCR results in the elaboration of many mitogenic and angiogenic cytokines that are vital to the biology of KS and other KSHV-driven malignancies. Several other herpesviruses also encode GPCRs, the functions of which are under ongoing investigation. In addition, several human diseases are associated with mutated mammalian GPCRs in germline or somatic cells.

Keywords

Primary Effusion Lymphoma Multicentric Castleman Disease Primary Effusion Lymphoma Cell Familial Male Precocious Puberty KSHV vGPCR 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • M. Cannon
    • 1
  1. 1.Cancer Research UK Viral Oncology GroupWolfson Institute for Biomedical Research University College LondonLondonUK

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