Interactions Between HIV-1 Tat and KSHV

  • Y. Aoki
  • G. Tosato
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 312)


Since the advent of the HIV-1 pandemic, a close association between HIV-1 infection and the development of selected types of cancers has been brought to light. The discovery of Kaposi sarcoma-associated herpesvirus (KSHV) has led to significant advances in uncovering the virological and molecular mechanisms involved in the pathogenesis of AIDS-related malignancies. Extensive evidence indicates that HIV-1 trans-activating protein Tat plays an oncogenic role in the development of KSHV-associated neoplasms. Comprehensive knowledge of the functions of Tat-1 together with the KSHV genes will contribute to a better understanding of the pathogenesis of virus-associated cancers and the interaction of viruses with their hosts.


Primary Effusion Lymphoma Human Brain Microvascular Endothelial Cell KSHV Infection Multicentric Castleman Disease Primary Effusion Lymphoma Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Y. Aoki
    • 1
  • G. Tosato
    • 1
  1. 1.Development, Astellas Pharma Inc.Japan

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