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The Use of Antiviral Drugs in the Prevention and Treatment of Kaposi Sarcoma, Multicentric Castleman Disease and Primary Effusion Lymphoma

  • C. Casper
  • A. Wald
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 312)

Abstract

Kaposi sarcoma-associated herpesvirus [KSHV, also known as human herpesvirus 8 (HHV-8)] is the most recently identified member of the human herpesvirus family. Kaposi sarcoma (KS), primary effusion lymphoma, and multicentric Castleman disease are all associated with KSHV infection. Although the incidence of KS has declined dramatically in areas with access to highly active antiretroviral therapy, it remains the most common AIDS-associated malignancy in the developed world and is one of the most common cancers in developing nations. Current treatment options for KSHV-associated disease are ineffective, unavailable, or toxic to many affected persons. A growing body of basic science, preclinical, and observational data suggests that antiviral medications may play an important role in the prevention and treatment of KSHV-associated disease.

Keywords

Primary Effusion Lymphoma Multicenter AIDS Cohort Study Lytic Replication Multicentric Castleman Disease Intravenous Cidofovir 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • C. Casper
    • 1
  • A. Wald
    • 1
  1. 1.University of Washington Virology Research ClinicSeattleUSA

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