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Development of the Enteric Nervous System

  • Chapter
Hirschsprung's Disease and Allied Disorders

Abstract

The enteric nervous system (ENS) is the largest and the most complex division of the peripheral nervous system [1]. The ENS contains more neurons than the spinal cord and is capable of mediating reflex activity in the absence of central nervous system. About 80–100 million enteric neurons can be classified into functional distinct subpopulations, including intrinsic primary neurons, interneurons, motor neurons, secretomotor and vasomotor neurons [2]. The ENS plays a crucial role in normal gastrointestinal motility. Therefore insights into the development of the gastrointestinal tract and the ENS are relevant for the understanding of the pathophysiology and treatment of infants and children with motility disorders.

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Authors and Affiliations

  1. Children’s Research Centre, Our Lady’s Children’s Hospital, University College of Dublin, Crumlin, Dublin 12, Ireland

    P. Puri

  2. Department of Paediatric Surgery, University of Leipzig, 04103, Leipzig, Germany

    U. Rolle

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  1. P. Puri
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  1. Immenzaun 6a, 51429, Bergisch Gladbach, Germany

    Alexander Matthias Holschneider

  2. The Children’s Hospital of Cologne, Amsterdamerstr. 59, 50735 , Cologne, Germany

    Alexander Matthias Holschneider

  3. Our Lady’s Children’s Hospital, Children’s Research Centre, University College of Dublin, Crumlin, Dublin 12, Ireland

    Prem Puri

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Puri, P., Rolle, U. (2008). Development of the Enteric Nervous System. In: Holschneider, A., Puri, P. (eds) Hirschsprung's Disease and Allied Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-33935-9_2

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  • DOI: https://doi.org/10.1007/978-3-540-33935-9_2

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