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Placebo and Endogenous Mechanisms of Analgesia

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Book cover Analgesia

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 177))

Abstract

The discovery of the endogenous systems of analgesia has produced a large amount of research aimed at investigating their biochemical and neurophysiological mechanisms and their neuroanatomical localization. Nevertheless, the neurobiological acquisitions on these mechanisms have not been paralleled by behavioural correlates in humans—in other words, by the understanding of when and how these endogenous mechanisms of analgesia are activated. Until recent times one of the most studied behavioural correlates of endogenous analgesia was stress-induced analgesia, in which the activation of endogenous opioid systems is known to be involved. By contrast, today the placebo analgesic effect represents one of the best-described situations in which this endogenous opioid network is naturally activated in humans. Therefore, not only is placebo research helpful towards improving clinical trial design and medical practice, but it also provides us with a better understanding of the endogenous mechanisms of analgesia.

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  1. Department of Neuroscience, Clinical and Applied Physiology Programme, University of Turin Medical School, Corso Raffaello 30, 10125, Turin, Italy

    F. Benedetti

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  1. Department of Anesthesiology and Critical Care Medicine Charité — Campus Benjamin Franklin, Free University Berlin, Hindenburgdamm 30, 12200, Berlin, Germany

    Christoph Stein

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Benedetti, F. (2006). Placebo and Endogenous Mechanisms of Analgesia. In: Stein, C. (eds) Analgesia. Handbook of Experimental Pharmacology, vol 177. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-33823-9_14

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