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New Aspects on the Pathogenesis of Conjunctival Melanoma

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Cornea and External Eye Disease

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

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Abstract

■ Conjunctival melanoma is very rare, but occurs more frequently in white than in black individuals

■ Conjunctival melanoma often occurs in the setting of primary acquired melanosis (PAM) with atypia and is less often associated with a conjunctival nevus

■ Conjunctival melanoma shares many clinical, epidemiological and molecular features with cutaneous but not uveal melanoma

■ It is plausible that the presence of clinically atypical nevus of the skin (particularly when in a familial setting and in association with cutaneous melanoma) is etiologically linked to conjunctival melanoma

■ There is substantial evidence implicating ultraviolet radiation (UVR) as inducing conjunctival melanoma, probably through the mitogen-activated protein kinase pathway

■ Because conjunctival melanoma occasionally arises in parts of the conjunctiva protected from UVR exposure, alternative pathways may exist

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    Thomas Seregard & Eugenio Triay

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Seregard, T., Triay, E. (2008). New Aspects on the Pathogenesis of Conjunctival Melanoma. In: Reinhard, T., Larkin, F. (eds) Cornea and External Eye Disease. Essentials in Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-33681-5_11

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