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Decompression Surgery for Thyroid-Related Orbitopathy: Status of the Art and Unresolved Issues

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Oculoplastics and Orbit

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

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Abstract

The autoimmune process at the root of thyroid orbitopathy (TRO) leads to accumulation of complex carbohydrates called glycosaminoglycans and collagen within the extraocular muscles and orbital fat. The consequent edema and fi- brosis lead to marked swelling of the soft tissues confined within the boundary of the bony orbit with an increase in intraorbital pressure. Rarely, the increased intraorbital pressure is a cause of potentially sight-threatening conditions such as optic neuropathy or exposure keratopathy, but more frequently it leads to different degrees of venous congestion, strabismus, eyelid swelling, retraction, and exophthalmos. The latter four are principally responsible for the major aesthetic changes affecting patients with TRO.

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References

  1. Adenis JP, Rober PY, Lasudry JGH, Dalloul Z (1998) Treatment of proptosis with fat removal orbital decompression in Graves’ ophthalmopathy. Eur J Ophthalmol 8:246–252

    PubMed  CAS  Google Scholar 

  2. Bahn RS (2003) Pathophysiology of Graves’ ophthalmopathy: the cycle of disease. J Clin Endocrinol Metab 88:1939–1946

    Article  PubMed  CAS  Google Scholar 

  3. Baldeschi L, MacAndie K, Hintschich C, et al. (2005) The removal of the deep lateral wall in decompression surgery: its contribution to exophthalmos reduction and influence on consecutive diplopia. Am J Ophthalmol 140:642–647

    PubMed  Google Scholar 

  4. Baldeschi L, Wakelkamp IMMJ, Lindeboom R, et al. (2006) Early versus late orbital decompression in Graves’ orbitopathy: a retrospective study in 125 patients

    Google Scholar 

  5. Ophthalmology 113:874–878

    Google Scholar 

  6. Baldeschi L, Lupetti A, Vu P, et al. (2007) Reactivation of Graves’ orbitopathy after rehabilitative orbital decompression. Ophthalmology 114:1395–402

    Article  PubMed  Google Scholar 

  7. Baldeschi L, MacAndie K, Koetsier E, Blank LE, Wiersinga WM (2007) The influence of previous orbital irradiation on the outcome of rehabilitative decompression surgery in Graves orbitopathy. Am J Ophthalmol, submitted

    Google Scholar 

  8. Bartalena L, Pinchera A, Marcocci C (2000) Management of Graves’ ophthalmopathy: reality and perspectives. Endocr Rev 21:168–199

    Article  PubMed  CAS  Google Scholar 

  9. Bartley GB, Fatourechi V, Kadrmas EF, et al. (1996) Clinical features of Graves’ ophthalmopathy in an incidence cohort. Am J Ophthalmol 121:284–290

    PubMed  CAS  Google Scholar 

  10. Ben Simon GJ, Schwarcz RM, Mansury AM, et al. (2005) Minimally invasive orbital decompression: local anesthesia and hand-carved bone. Arch Ophthalmol 123:1671–1675

    Article  PubMed  Google Scholar 

  11. Carrasco JR, Castillo I, Bilyk JR, et al. (2005) Incidence of infraorbital hypesthesia and sinusitis after orbital decompression for thyroid-related orbitopathy: a comparison of surgical techniques. Ophthal Plast Reconstr Surg 21:188–191

    Article  PubMed  Google Scholar 

  12. De Santo LW (1984) Transantral orbital decompression. In: Gorman CA, Waller RR, Dyer JA (eds) The eye and orbit in thyroid disease. Raven, New York, pp 231–251

    Google Scholar 

  13. Dollinger J (1911) Die Druckentlastung der Augenhöhle durch Entfernung der äußeren Orbitawand bei hochgradigem Exophthalmos (Morbus Basedowii) und konsekutiver Hauterkrankung. Dtsch Med Wochenschr 37:1888–1890

    Article  Google Scholar 

  14. Eckstein AK, Finkenrath A, Heiligenhaus A, et al. (2004) Dry eye syndrome in thyroid-associated ophthalmopathy: lacrimal expression of TSH receptor suggests involvement of TSHR-specific autoantibodies. Acta Ophthalmol Scand 82:291–297

    Article  PubMed  CAS  Google Scholar 

  15. European Group on Graves’ Orbitopathy consortium www.eugogo.org

    Google Scholar 

  16. Gilbard JP, Farris RL (1983) Ocular surface drying and ocular tear film osmolarity in thyroid eye disease. Acta Ophthalmol (Copenh) 61:108–116

    Article  CAS  Google Scholar 

  17. Goldberg RA (1998) The evolving paradigm of orbital decompression surgery. Arch Ophthalmol 116:95–96

    PubMed  CAS  Google Scholar 

  18. Goldberg RA, Christenbury JD, Shorr N (1988) Medial entropion following orbital decompression for dysthyroid ophthalmopathy. Ophthal Plast Reconstr Surg 4:81–85

    Article  PubMed  CAS  Google Scholar 

  19. Goldberg RA, Weinberg DA, Shorr N, Wirta D (1997) Maximal three-wall orbital decompression through a coronal approach. Ophthalmic Surg Lasers 28:832–843

    PubMed  CAS  Google Scholar 

  20. Goldberg RA, Kim AJ, Kerivan KM (1998) The lacrimal keyhole, orbital door jamb, and basin of the inferior orbital fissure. Three areas of deep bone in the lateral orbit. Arch Ophthalmol 116:1618–1624

    PubMed  CAS  Google Scholar 

  21. Goldberg RA, Perry JD, Hortoleza V, Tong JT (2000) Strabismus after balanced medial plus lateral wall versus lateral wall only orbital decompression for dysthyroid orbitopathy. Ophthal Plast Reconstr Surg 16:271–277

    Article  PubMed  CAS  Google Scholar 

  22. Heinz C, Eckstein A, Steuhl KP, Meller D (2004) Amniotic membrane transplantation for reconstruction of corneal ulcer in Graves’ ophthalmopathy. Cornea 23:524–526

    Article  PubMed  Google Scholar 

  23. Hirsch VO, Urbanek I (1930) Behandlung eines excessiven Exophthalmus (Basedow) durch Entfernung von Orbitafett von der Kieferhöhle aus. Monatsschr Ohrenheilk Laryngorhinol 64:212–213

    Google Scholar 

  24. Jorge R, Scott IU, Akaishi PM, et al. (2003) Resolution of choroidal folds and improvement in visual acuity after orbital decompression for graves orbitopathy. Retina 23:563–565

    Article  PubMed  Google Scholar 

  25. Kazim M, Trokel SL, Acaroglu G, Elliot A (2000) Reversal of dysthyroid optic neuropathy following orbital fat decompression. Br J Ophthalmol 84:600–605

    Article  PubMed  CAS  Google Scholar 

  26. Kennedy DW, Goldstein ML, Miller NR, Zinreich SJ (1990) Endoscopic transnasal orbital decompression. Arch Otolaryngol Head Neck Surg 116:275–282

    PubMed  CAS  Google Scholar 

  27. Leone CR, Piest KL, Newman RJ (1989) Medial and lateral wall decompression for thyroid ophthalmopathy. Am J Ophthalmol 108:160–166

    PubMed  Google Scholar 

  28. Liao SL, Chang TC, Lin LL (2006) Transcaruncular orbital decompression: an alternate procedure for Graves ophthalmopathy with compressive optic neuropathy. Am J Ophthalmol 141:810–818

    Article  PubMed  Google Scholar 

  29. Ljunggren JG (1983) Who was the man behind the syndrome: Ismail al-Jurjani, Testa, Flagani, Parry, Graves or Basedow? Use the term hyperthyreosis instead. Lakartidningen 80:2902

    PubMed  CAS  Google Scholar 

  30. Martinelli M (2005) Demone di Sarteano. Una Patologia? (Demon of Sarteno. Was it a disease?). Archeologia Viva. Giunti, Florence

    Google Scholar 

  31. McCann JD, Goldberg RA, Anderson RL, et al. (2006) Medial wall decompression for optic neuropathy but lateral wall decompression with fat removal for non vision-threatening indications. Am J Ophthalmol 141:916–917

    Article  PubMed  Google Scholar 

  32. McCord CD (1981) Orbital decompression for Graves’ disease: exposure through lateral canthal and inferior fornix incision. Ophthalmology 88:533–541

    PubMed  Google Scholar 

  33. McCord CD (1985) Current trends in orbital decompression. Ophthalmology 92:21–33

    PubMed  Google Scholar 

  34. McCormick CD, Bearden WH, Hunts JH, Anderson RL (2004) Cerebral vasospasm and is­chemia after orbital decompression for Graves ophthalmopathy. Ophthal Plast Reconstr Surg 20:347–351

    Article  PubMed  Google Scholar 

  35. Moore RF (1920) Exophthalmos and limitation of eye movements of Graves’ disease. Lancet 2:701

    Google Scholar 

  36. Mourits MP, Koornneef L, Wiersinga WM, et al. (1990) Orbital decompression for Graves’ ophthalmopathy by inferomedial, by inferomedial plus lateral, and by coronal approach. Ophthalmology 97:636–641

    PubMed  CAS  Google Scholar 

  37. Mourits MP, Rose GE, Garrity JA, et al. (2000) Surgical management of Graves’ ophthalmopathy. In: Prummel MF (ed) Recent developments in Graves’ ophthalmopathy. Kluwer, Dordrecht, pp 133–169

    Google Scholar 

  38. Naffziger HC (1931) Progressive exophthalmos following thyroidectomy; its pathology and treatment. Ann Surg 94:582–586

    PubMed  CAS  Google Scholar 

  39. Nunery WR (1991) Ophthalmic Graves’ disease: a dual theory of pathogenesis. Ophthalmol Clin North Am 4:73–87

    Google Scholar 

  40. Olivari N (1988) [Transpalpebral decompression operation in endocrine orbitopathy (exophthalmos)]. Wien Med Wochenschr 18:138–142

    Google Scholar 

  41. Paridaens D, Hans K, van Buiten S, Mourits MP (1998) The incidence of diplopia following coronal and trans lid orbital decompression in Graves’ orbitopathy. Eye 12:800–805

    PubMed  Google Scholar 

  42. Perros P, Baldeschi L, Boboridis K, et al. (2006) A questionnaire survey on the management of Graves’ orbitopathy in Europe.

    Google Scholar 

  43. Eur J Endocrinol 155:207–211

    Google Scholar 

  44. Prummel MF (1999) Medical treatment of thyroid-associated orbitopathy. Exp Clin Endocrinol Diabetes 107:198–200

    Article  Google Scholar 

  45. Prummel MF, Mourits MP, Koornneef L, et al. (1989) Prednisone and cyclosporine in the treatment of severe Graves’ ophthalmopathy. N Engl J Med 321:1353–1359

    Article  PubMed  CAS  Google Scholar 

  46. Prummel MF, Wiersinga WM, Mourits MP, et al. (1990) Effect of abnormal thyroid function on the severity of Graves’ ophthalmopathy. Arch Intern Med 150:1098–1101

    Article  PubMed  CAS  Google Scholar 

  47. Rose GE, Lund VJ (2003) Clinical features and treatment of late enophthalmos after orbital decompression: a condition suggesting cause for idiopathic “imploding antrum” (silent sinus) syndrome. Ophthalmology 110:819–826

    Article  PubMed  Google Scholar 

  48. Rubin PAD, Watkins LM, Rumelt S, et al. (1998) Orbital computed tomographic characteristics of globe subluxation in thyroid orbitopathy. Ophthalmology 105:2061–2064

    Article  PubMed  CAS  Google Scholar 

  49. Sewall EC (1936) Operative control of progressive exophthalmos. Arch Otolaryngol 24:621–624

    Google Scholar 

  50. Soares-Welch CV, Fatourechi V, Bartley GB, et al. (2003) Optic neuropathy of Graves disease: results of transantral orbital decompression and long-term follow-up in 215 patients. Am J Ophthalmol 136:433–441

    Article  PubMed  Google Scholar 

  51. Terwee CB, Dekker FW, Mourits MP, et al. (2001) Interpretation and validity of changes in scores on the Graves’ ophthalmopathy quality of life questionnaire (GO-QOL) after different treatments.

    Google Scholar 

  52. Clin Endocrinol (Oxf) 54:391–398

    Google Scholar 

  53. Terwee CB, Dekker FW, Bonsel GJ, et al. (2003) Facial disfigurement: is it in the eye of the beholder? A study in patients with Graves’ ophthalmopathy. Clin Endocrinol (Oxf) 58:192–198

    Article  Google Scholar 

  54. Trokel S, Kazim M, Moore S (1993) Orbital fat removal, decompression for Graves ophthalmopathy. Ophthalmology 100:674–682

    PubMed  CAS  Google Scholar 

  55. Wakelkamp IMMJ, Baldeschi L, Saeed P, et al. (2005) Surgical or medical decompression as a first line treatment of optic neuropathy in Graves’ ophthalmopathy? A randomized controlled trial. Clin Endocrinol (Oxf) 63:323–328

    Article  CAS  Google Scholar 

  56. Walsch TE, Ogura JH (1957) Transantral orbital decompression for malignant exophthalmos. Laryngoscope 67:544–568

    Google Scholar 

  57. Wiersinga WM, Prummel MF (2000) An evidence-based approach to the treatment of Graves’ ophthalmopathy. Endocrinol Metab Clin North Am 29:297–319

    Article  PubMed  CAS  Google Scholar 

  58. Wiersinga WM, Perros P, Kahaly GJ, et al. (2006) Clinical assessment of patients with Graves’ orbitopathy: the European group for Graves’ orbitopathy recommendations to generalists, specialists and clinical researchers.

    Google Scholar 

  59. Eur J Endocrinol 155:387–389

    Google Scholar 

  60. Wilson WB, Manke WF (1991) Orbital decompression in Graves’ disease: the predictability of reduction of proptosis. Arch Ophthalmol 109:343–345

    PubMed  CAS  Google Scholar 

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Rudolf Guthoff James Katowitz

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(2007). Decompression Surgery for Thyroid-Related Orbitopathy: Status of the Art and Unresolved Issues. In: Guthoff, R., Katowitz, J. (eds) Oculoplastics and Orbit. Essentials in Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-33677-8_9

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  • DOI: https://doi.org/10.1007/978-3-540-33677-8_9

  • Publisher Name: Springer, Berlin, Heidelberg

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