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A Viral Conspiracy: Hijacking the Chemokine System Through Virally Encoded Pirated Chemokine Receptors

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Chemokines and Viral Infection

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 303))

Abstract

Several herpesviruses and poxviruses contain genes encoding for G proteincoupled receptor (GPCR) proteins that are expressed on the surface of infected host cells and/or the viral envelope. Most of these membrane-associated proteins display highest homology to the subfamily of chemokine receptors known to play a key role in the immune system. Virally encoded chemokine receptors have been modified through evolutionary selection both in chemokine binding profile and signaling capacity, ultimately resulting in immune evasion and cellular reprogramming in favor of viral survival and replication. Insight in the role of virally encoded GPCRs during the viral lifecycle may reveal their potential as future drug targets.

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Authors and Affiliations

  1. Leiden/Amsterdam Center for Drug Research (LACDR), Division of Medicinal Chemistry, Faculty of Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands

    H. F. Vischer & M. J. Smit

  2. Department of Medical Microbiology, Cardiovascular Research Institute Maastricht, University of Maastricht, P. O. Box 5800, 6202 AZ, Maastricht, The Netherlands

    C. Vink

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  1. H. F. Vischer
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  2. C. Vink
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  3. M. J. Smit
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  1. Department of Molecular Biology and Biochemistry, Center for Immunology, University of California, Irvine, 3205 McGaugh Hall, Irvine, CA, 92697-3900, USA

    Thomas E. Lane Ph.D. (Associate Professor) (Associate Professor)

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Vischer, H.F., Vink, C., Smit, M.J. (2006). A Viral Conspiracy: Hijacking the Chemokine System Through Virally Encoded Pirated Chemokine Receptors. In: Lane, T.E. (eds) Chemokines and Viral Infection. Current Topics in Microbiology and Immunology, vol 303. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-33397-5_6

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