Abstract
Comparative analyses of alternative splicing across species can provide significant biological insight not only to evolution of alternative splicing, but also to its regulation and functional significance. For comprehensive analyses of human and mouse alternatively spliced genes, we developed two databases of the human and the mouse transcriptomes, HumanSDB3 and MouSDB5 respectively. We showed that alternative splicing events in both of the transcriptomes are mainly due to the presence or absence of internal cassette exons. Our databases allow in-depth analyses of alternative and constitutive exons within alternatively spliced genes. Interactive web implementation of our databases brings to end-user the ability to instantly identify orthologous human-mouse gene pairs with their corresponding exons. This is a novel visualization method which provides easy access to conserved alternative splicing data and a tool to explore the evolution of this important biological process.
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Taneri, B., Novoradovsky, A., Snyder, B., Gaasterland, T. (2005). Databases for Comparative Analysis of Human-Mouse Orthologous Alternative Splicing. In: Lagergren, J. (eds) Comparative Genomics. RCG 2004. Lecture Notes in Computer Science(), vol 3388. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-32290-0_10
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DOI: https://doi.org/10.1007/978-3-540-32290-0_10
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