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Allergic Conjunctivitis: Clinical Consequences and an Update on Understanding Its Pathophysiology

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Uveitis and Immunological Disorders

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

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References

  1. Abelson MB (ed). Allergic disease of the eye. Philadelphia: Saunders, 2001.

    Google Scholar 

  2. Abelson MB. A review of olopatadine for the treatment of ocular allergy. Expert Opin Pharmacother 2004;5:1979–1994.

    Article  PubMed  CAS  Google Scholar 

  3. Abelson MB, Chambers WA, Smith LM. Conjunctival allergen challenge. A clinical approach to studying allergic conjunctivitis. Arch Ophthalmol 1990;108:84–88.

    PubMed  CAS  Google Scholar 

  4. Abelson MB, Leonardi A, Smith LM, et al. Histaminase activity in patients vernal keratoconjunctivitis. Ophthalmology 1995;102:1958–1963.

    PubMed  CAS  Google Scholar 

  5. Abelson MB, Ferzola NJ, McWhirter CL, Crampton HJ. Efficacy and safety of single-and multiple-dose ketotifen fumarate 0.025% ophthalmic solution in a pediatric population. Pediatr Allergy Immunol 2004;15:551–557.

    Article  PubMed  Google Scholar 

  6. Abu El-Asrar AM, Struyf S, Van Damme J, Geboes K. Role of chemokines in vernal keratoconjunctivitis. Int Ophthalmol Clin 2003;43:33–39.

    PubMed  Google Scholar 

  7. Akpek EK, Dart JK, Watson S, et al. A randomized trial of topical cyclosporin 0.05% in topical steroid-resistant atopic keratoconjunctivitis. Ophthalmology 2004;111:476–482.

    Article  PubMed  Google Scholar 

  8. Allansmith MR, Korb DR, Greiner JV, et al. Giant papillary conjunctivitis in contact lens wearers. Am J Ophthalmol 1977;83:697–708.

    PubMed  CAS  Google Scholar 

  9. Allansmith MR, Korb DR, Greiner JV. Giant papillary conjunctivitis induced by hard or soft contact lens wear: quantitative histology. Ophthalmology 1978;85:766–778.

    PubMed  CAS  Google Scholar 

  10. Anderson DF, Zhang S, Bradding P, et al. The relative contribution of mast cell subsets to conjunctival T(H)2-like cytokines. Invest Ophthalmol Vis Sci 2001;42:995–1001.

    PubMed  CAS  Google Scholar 

  11. Ballow M, Mendelson L, Donshik P, et al. Pollen specific IgE antibodies in tears of patients with allergic-like conjunctivitis. J Allergy Clin Immunol 1984;73:376–380.

    Article  PubMed  CAS  Google Scholar 

  12. BenEzra D, Pe’er J, Brodsky M, Cohen E. Cyclosporine eyedrops for the treatment of severe vernal keratoconjunctivitis. Am J Ophthalmol 1986;101:278–282.

    PubMed  CAS  Google Scholar 

  13. Bielory L, Lien KW, Bigelsen S. Efficacy and tolerability of newer antihistamines in the treatment of allergic conjunctivitis. Drugs 2005;65:215–228.

    Article  PubMed  CAS  Google Scholar 

  14. Bonini S, Bonini S, Vecchione A, et al. Inflammatory changes in conjunctival scrapings after allergen challenge in humans. J Allergy Clin Immunol 1988;82:462–466.

    Article  PubMed  CAS  Google Scholar 

  15. Bonini S, Bonini S, Lambiase A, et al. Vernal keratoconjunctivitis revisited. A case series of 195 patients with long-term follow up. Ophthalmology 2000;107:1157–1163.

    Article  PubMed  CAS  Google Scholar 

  16. Butrus SI, Ochsner KI, Abelson MB, Schwartz LB. The level of triptase in human tears. Ophthalmology 1990;97:1678–1683.

    PubMed  CAS  Google Scholar 

  17. Calder VL, Jolly G, Hingorani M, et al. Cytokine production and mRNA expression by conjunctival T cell lines in chronic allergic eye diseases. Clin Exp Allergy 1999;29:1214–1222.

    Article  PubMed  CAS  Google Scholar 

  18. Ciprandi G, Buscaglia S, Catrullo A, et al. Azelastine eye drops reduce and prevent allergic conjunctival reaction and exert anti-allergic activity. Clin Exp Allergy 1997;27:182–191.

    Article  PubMed  CAS  Google Scholar 

  19. Cook EB, Stahl JL, Lowe L, et al. Simultaneous measurement of multiple cytokines in a single sample of human tears using microparticle-based flow cytometry. J Immunol Methods 2001;254:109–118.

    Article  PubMed  CAS  Google Scholar 

  20. Cook EB, Stahl JL, Barney NP, Graziano FM. Mechanisms of antihistamines and mast cell stabilizers in ocular allergic inflammation. Curr Drug Targets Inflamm Allergy 2002;1:167–180.

    Article  PubMed  CAS  Google Scholar 

  21. Foster CS, Calonge M. Atopic keratoconjunctiuvitis. Ophthalmology 1990;97:992–100.

    PubMed  CAS  Google Scholar 

  22. Greiner J. Giant papillary conjunctivitis. In: Abelson MB, ed. Allergic disease of the eye. Philadelphia: Saunders, 2001.

    Google Scholar 

  23. Hingorani M, Calder VL, Buckley RJ, Lightman S. The immunomodulatory effect of topical cyclosporin A in atopic keratoconjunctivitis. Invest Ophthalmol Vis Sci 1999;40:392–399.

    PubMed  CAS  Google Scholar 

  24. Irani AA, Butrus SI, Tabbara KF, Schwartz LB. Human conjunctival mast cells: distribution of MCT and MCTC cells in vernal conjunctivitis and giant papillary conjunctivitis. J Allergy Clin Immunol 1990;86:34–39.

    Article  PubMed  CAS  Google Scholar 

  25. Irkec MT, Orhan M, Erdener U. Role of tear inflammatory mediators in contact lens-associated giant papillary conjunctivitis in soft contact lens wearers. Ocul Immunol Inflamm 1999;7:35–38.

    Article  PubMed  CAS  Google Scholar 

  26. Key B. Allergy and allergic diseases. Part I. N Engl J Med 2001;344:30–37.

    Article  Google Scholar 

  27. Leonardi A. Vernal keratoconjunctivitis: pathogenesis and treatment. Prog Ret Eye Res 2002;21:319–339.

    Article  CAS  Google Scholar 

  28. Leonardi A, Battista MC, Gismondi M, et al. Antigen sensitivity evaluated by tear-specific and serum-specific IgE, skin tests, and conjunctival and nasal provocation tests in patients with ocular allergic diseases. Eye 1993;7:461–464.

    PubMed  Google Scholar 

  29. Leonardi A, Borghesan F, Faggian D, et al. Eosinophil cationic protein in tears of normal subjects and patients affected by vernal keratoconjunctivitis. Allergy 1995;50:610–613.

    PubMed  CAS  Google Scholar 

  30. Leonardi A, Borghesan F, DePaoli M, et al. Procollagens and inflammatory cytokine concentrations in tarsal and limbal vernal keratoconjunctivitis. Exp Eye Res 1998;67:105–112.

    Article  PubMed  CAS  Google Scholar 

  31. Leonardi A, DeFranchis G, Zancanaro F, et al. Identification of local Th2 and Th0 lymphocytes in vernal conjunctivitis by cytokine flow cytometry. Invest Ophthalmol Vis Sci 1999;40:3036–3040.

    PubMed  CAS  Google Scholar 

  32. Leonardi A, Borghesan F, Faggian D, et al. Tear and serum soluble leukocyte activation markers in conjunctival allergic diseases. Am J Ophthalmol 2000;129:151–158.

    Article  PubMed  CAS  Google Scholar 

  33. Leonardi A, Jose P, Zhan, Calder V. Tear and mucus eotaxin-1 and eotaxin-2 in allergic keratoconjunctivitis. Ophthalmology 2003;110:487–492.

    Article  PubMed  Google Scholar 

  34. Leonardi A. Emerging drugs for ocular allergy. Expert Opin Emerg Drugs 2005;10:505–520.

    Article  PubMed  CAS  Google Scholar 

  35. Leonardi A, Curnow SJ, Zhan H, Calder VL. Multiple cytokines in human tear specimens in seasonal and chronic allergic eye disease and in conjunctival fibroblast cultures. Clin Exp Allergy 2006;36:777–84.

    Article  PubMed  CAS  Google Scholar 

  36. Matsuura N, Uchio E, Nakazawa M, et al. Predominance of infiltrating IL-4-producing T cells in conjunctiva of patients with allergic conjunctival disease. Curr Eye Res 2004;29:235–243.

    Article  PubMed  CAS  Google Scholar 

  37. McGill JI, Holgate ST, Church MK, et al. Allergic eye disease mechanisms. Br J Ophthalmol 1998;82:1203–1214.

    Article  PubMed  CAS  Google Scholar 

  38. Miyazaki D, Nakamura T, Toda M, Cheung-Chau KW, Richardson RM, Ono SJ. Macrophage inflammatory protein-1alpha as a costimulatory signal for mast cell-mediated immediate hypersensitivity reactions. J Clin Invest 2005;115:434–442.

    Article  PubMed  CAS  Google Scholar 

  39. Moeller C, Bjorksten B, Nilsson G, Dreborg S. The precision of the conjunctival provocation test. Allergy 1984;39:37–41.

    Google Scholar 

  40. Montan PG, Hage-Hamsten M. Eosinophil cationic protein in tears in allergic conjunctivitis. Br J Ophthalmol 1996;80:556–560.

    PubMed  CAS  Google Scholar 

  41. Montan PG, Scheynius A, van der Ploeg I. Similar T helper Th2-like cytokine mRNA expression in vernal keratoconjunctivitis regardless of atopic constitution. Allergy 2002;57:436–441.

    Article  PubMed  CAS  Google Scholar 

  42. Ono SJ, Abelson MB. Allergic conjunctivitis: update on pathophysiology and prospects for future treatment. J Allergy Clin Immunol 2005;115:118–122.

    Article  PubMed  CAS  Google Scholar 

  43. Nakamura Y, Sotozono C, Kinoshita S. Inflammatory cytokines in normal human tears. Curr Eye Res 1998;17:673.

    Article  PubMed  CAS  Google Scholar 

  44. Nivenius E, Montan PG, Chryssanthou E, et al. No apparent association between periocular and ocular microcolonization and the degree of inflammation in patients with atopic keratoconjunctivitis. Clin Exp Allergy 2004;34:725–730.

    Article  PubMed  CAS  Google Scholar 

  45. Oldfield WL, Kay AB, Larche M. Allergen-derived T cell peptide-induced late asthmatic reactions precede the induction of antigen-specific hyporesponsiveness in atopic allergic asthmatic subjects. J Immunol 2001;167:1734–1739.

    PubMed  CAS  Google Scholar 

  46. Pucci N, Novembre E, Cianferoni A, et al. Efficacy and safety of cyclosporine eyedrops in vernal keratoconjunctivitis. Ann Allergy Asthma Immunol 2002;89:298–303.

    Article  PubMed  CAS  Google Scholar 

  47. Pucci N, Novembre E, Lombardi E, et al. Atopy and serum eosinophil cationic protein in 110 white children with vernal keratoconjunctivitis: differences between tarsal and limbal forms. Clin Exp Allergy 2003;33:325–330.

    Article  PubMed  CAS  Google Scholar 

  48. Rikkers SM, Holland GN, Drayton GE, Michel FK, Torres MF, Takahashi S. Topical tacrolimus treatment of atopic eyelid disease. Am J Ophthalmol 2003;135:297–302.

    Article  PubMed  CAS  Google Scholar 

  49. Secchi AG, Tognon MS, Leonardi A. Topical use of cyclosporine in the treatment of vernal keratoconjunctivitis. Am J Ophthalmol 1990;110:137–142.

    Google Scholar 

  50. Thomas P, Rueff F, Przybilla B. Severe allergic contact blepharoconjunctivitis from phenylephrine in eyedrops, with corresponding T-cell hyper-responsiveness in vitro. Contact Dermatitis 1998;38:41–43.

    PubMed  CAS  Google Scholar 

  51. Toda M, Ono SJ. Genomics and proteomics of allergic disease. Immunology 2002;106:1–10.

    Article  PubMed  CAS  Google Scholar 

  52. Trocme SD, Aldave AJ. The eye and the eosinophil. Survey Ophthalmol 1994;39:241–252.

    Article  CAS  Google Scholar 

  53. Uchio E, Ono SY, Ikezawa Z, Ohno S. Tear levels of interferon-gamma, interleukin (IL)-2, IL-4 and IL-5 in patients with vernal keratoconjunctivitis, atopic keratoconjunctivitis and allergic conjunctivitis. Clin Exp Allergy 2000;30:103–109.

    Article  PubMed  CAS  Google Scholar 

  54. Uchio E, Matsuura N, Matsumoto S, et al. Histamine release test and measurement of antigen-specific IgE antibody in the diagnosis of allergic conjunctival diseases. J Clin Lab Anal 2001;15:71–75.

    Article  PubMed  CAS  Google Scholar 

  55. Vichyanond P, Tantimongkolsuk C, Dumrongkigchaiporn P, Jirapongsananuruk O, Visitsunthorn N, Kosrirukvongs P. Vernal keratoconjunctivitis: result of a novel therapy with 0.1% topical ophthalmic FK-506 ointment. J Allergy Clin Immunol 2004;113:355–358.

    Article  PubMed  Google Scholar 

  56. Whitcup SM, Bradford R, Lue J, Schiffman RM, Abelson MB. Efficacy and tolerability of ophthalmic epinastine: a randomized, double-masked, parallel-group, active-and vehicle-controlled environmental trial in patients with seasonal allergic conjunctivitis. Clin Ther 2004;26:29–34.

    Article  PubMed  CAS  Google Scholar 

  57. Wilson FM. Allergy to topical medication. Int Ophthalm Clin 2003;43:73–81.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Neuroscience, Ophthalmology Unit, University of Padua, Via Giustiniani 2, 35128, Padova, Italy

    Andrea Leonardi MD

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  1. Andrea Leonardi MD
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Editors and Affiliations

  1. Augenklinik, Charité, Universitätsmedizin Berlin, Campus Virchow Klinikum Augustenburger Platz 1, 13353, Berlin, Germany

    Uwe Pleyer MD (Professor of Ophthalmology) (Professor of Ophthalmology)

  2. Massachusetts Eye Research and Surgery Institute, 5 Cambridge Center, 8th Floor, Cambridge, MA, 02142, USA

    C. Stephen Foster MD (Professor of Ophthalmology) (Professor of Ophthalmology)

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Leonardi, A. (2007). Allergic Conjunctivitis: Clinical Consequences and an Update on Understanding Its Pathophysiology. In: Pleyer, U., Foster, C.S. (eds) Uveitis and Immunological Disorders. Essentials in Ophthalmology. Springer, Berlin, Heidelberg . https://doi.org/10.1007/978-3-540-30798-3_3

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  • DOI: https://doi.org/10.1007/978-3-540-30798-3_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-30797-6

  • Online ISBN: 978-3-540-30798-3

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