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Advances in the Management of Gastric Cancer with Peritoneal Dissemination

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Advances in Peritoneal Surface Oncology

Part of the book series: Resent Results in Cancer Research ((RECENTCANCER,volume 169))

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Abstract

Prognosis of patients with peritoneal carcinomatosis (PC) from gastrointestinal cancer is poor, with a median overall survival of only 3 months [1], [2], and a 5-year survival rate of less than 1% [3]. Furthermore, no survival advantage was found after gastrectomy and lymph node dissection in this context, and therefore simple gastrectomy without additional lymphadenectomy is the optimal strategy for patients with PC [4]. In addition, there is no standard treatment and no effective anticancer drug for peritoneal dissemination. At present, intravenous 5-fluorouracil (5-FU) has been used alone [5] or in combination with other anticancer drugs FAM [6] and FAMTX [7] for chemotherapy of advanced gastric cancer. However, systemic chemotherapy does not improve the survival of patients with peritoneal dissemination [8], [9], because only a small amount of drug reaches the peritoneal cavity after intravenous administration.

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Author information

Authors and Affiliations

  1. Gastric Surgery Division, Shizuoka Cancer Center, 1007 Shimo-Nagakubo Suntou-gun Nagaizumi-Machi, Shizuoka, 411-8777, Japan

    Yutaka Yonemura MD, PhD, Taiichi Kawamura MD, PhD, Etsurou Bandou MD, PhD, Gorou Tsukiyama MD, PhD & Masayuki Nemoto MD

  2. Department of Experimental Therapeutics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan

    Yoshio Endou PhD

  3. Department of Anatomy School of Medicine, Ooita University, Ooita, Japan

    Masahiro Miura PhD

Authors
  1. Yutaka Yonemura MD, PhD
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  2. Taiichi Kawamura MD, PhD
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  3. Etsurou Bandou MD, PhD
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  4. Gorou Tsukiyama MD, PhD
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  5. Masayuki Nemoto MD
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  6. Yoshio Endou PhD
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  7. Masahiro Miura PhD
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Editor information

Editors and Affiliations

  1. Department of Surgical Oncology, Centro Oncológico MD Anderson International España, Calle Gómez Hemans 2, 28033, Madrid, Spain

    Santiago González-Moreno MD, PhD

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© 2007 Springer-Verlag Berlin Heidelberg

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Yonemura, Y. et al. (2007). Advances in the Management of Gastric Cancer with Peritoneal Dissemination. In: González-Moreno, S. (eds) Advances in Peritoneal Surface Oncology. Resent Results in Cancer Research, vol 169. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-30760-0_14

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  • DOI: https://doi.org/10.1007/978-3-540-30760-0_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-30759-4

  • Online ISBN: 978-3-540-30760-0

  • eBook Packages: MedicineMedicine (R0)

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