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HELLP-Syndrom

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Therapiehandbuch Gynäkologie und Geburtshilfe

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Das HELLP-Syndrom stellt eine schwere Verlaufsform der Präeklampsie/ Eklampsie dar. Die aktuelle Literatur beschreibt das HELLP-Syndrom als eine schwere Form der Präeklampsie mit Blutgerinnungsstörungen, obgleich in Vorträgen immer wieder auf die »Entität« HELLP-Syndrom hingewiesen wird, in dessen Verlauf es zu Blutdruckerhöhungen kommen kann. Fred Kubli (1987, mündl. Mitteilung) wies bereits darauf hin, dass das 1982 von Weinstein eingeführte Akronym »HELLP« den klinisch tätigen Geburtshelfern als Syndrom seit langem bekannt war.

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Literatur

  • Barton JR, Sibai BN (2004) Diagnosis and management of hemolysis, elevated liver enzymes, and low platelets syndrome. Clin Perinatol 31: 807–833

    Article  PubMed  Google Scholar 

  • Cunninham FG, Leveno K (2005) Williams Obstetrics, 22. edn. McGraw Hill, New York

    Google Scholar 

  • Cunningham FG, Lowe T, Guss S (1985) Erythrocyte morphology in women with severe preeclampsia and eclampsia. Am J Obstet Gynecol 153: 358

    PubMed  CAS  Google Scholar 

  • Fischer T, Wildt L (1999) Glukokortikoide und HELLP-Syndrom. Gynäkologe 32: 783

    Google Scholar 

  • Frolich MA, Datta S, Corn SB (1998) Thrombopoietin in normal pregnancy and preeclampsia. Am J Obstet Gynecol 179: 100

    Article  PubMed  CAS  Google Scholar 

  • Gamzu R, Rotstein R, Fusman R(2001) Increased erythrocyte adhesiveness and aggregation in peripheral venous blood of women with pregnancy induced hypertension. Obstet Gynecol 98: 307

    Article  PubMed  CAS  Google Scholar 

  • Girardi C (2004) Hellp-eine Albtraumnovelle oder ein Lehr-buch über ein Syndrom. Edition Vabene, Wien

    Google Scholar 

  • Hackenberg H, Rappe N, Wohlers S, Mayer Wittkopf M, Schulz KD (1998) Wertigkeit des C-reaktiven Proteins (CRP) beim HELLP-Syndrom. Geburtsh Frauenheilkunde 58: 508

    Article  Google Scholar 

  • Harlow FH, Brown MA, Brigthon TA (2002) Platelet activation in the hypertensive disorders of pregnancy. Am J Obstet Gynecol 187: 688

    Article  PubMed  Google Scholar 

  • Magann EF, Martin JN (1999) Twelve Stepps to optimal Management of HELLP-Syndrome. Clin Obstet Gynecol 42(3): 532–550

    Article  PubMed  CAS  Google Scholar 

  • Magann EF, Bass D, Chauhan SP, Sullivan DL, Martin RW, Martin JN jr (1994) Antepartum corticosteroids: disease stabiliza-tion in patients with the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP). Am J Obstet Gynecol 171(4): 1148–1153

    PubMed  CAS  Google Scholar 

  • Magee LA, Cham C, Waterman EJ, Ohlson A, Dadelszen P von (2003) Hydralazine for treatment of severe hypertension in pregnancy: metaanalysis. BMJ 3127: 1–10

    Google Scholar 

  • Magpie Trial Collaboration Group(2002) Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate The Magpie Trial: a randomised placebo-controlled trial. Lancet 359: 1877–1890

    Article  Google Scholar 

  • Manas KJ, Welsh JD, Rankin RA(1985) Hepatic hemorrhage without rupture in preeclampsia. N Engl J Med 12: 426

    Google Scholar 

  • Matchaba P, Moodley J (2006) Corticoids for HELLP-syndrome in pregnancy. Cochrane Database 2

    Google Scholar 

  • Rath W (1998) Das geburtshilfliche Vorgehen beim HELLP-Syndromeine aktuelle Kontroverse. Frauenarzt 39: 79

    Google Scholar 

  • Rath W(2002) Das HELLP-Syndrom. In: Heilmann L, Rath W (Hrsg) Schwangerschaftshochdruck. Wissenschaftliche Verlagsanstalt, Stuttgart, S 236–255

    Google Scholar 

  • Rath W, Heilmann L, Faridi A, Wacker J, Klockenbusch W (2002) Empfehlungen zur Diagnostik und Therapie des Bluthoch-drucks in der Schwangerschaft. Frauenarzt 43: 847–851

    Google Scholar 

  • Rosen SA, Merchant SH, Vanderjagt TJ (2003) Spontaneous subcapsular liver hematoma associated with pregbnancy. Arch Pathol Lab Med 127: 1639

    PubMed  Google Scholar 

  • Reubinoff BE, Schenker JG (1991) HELLP-syndrome-a syndrome of hemolysis, elevated liver enzymes and low plate-let count-complicating preeclampsia-eclampsia. Int J Gynecol Obstet 36: 95

    Article  CAS  Google Scholar 

  • Sibai BM, Taslimi MM, El-Nazar A (1986) Maternal-perinatal outcome associated with the syndrome of hemolysis, elevated liver enzymes and low platelets in severe preeclampsia-eclampsia. Am J Obstet Gynecol 155: 501

    PubMed  CAS  Google Scholar 

  • Sibai BM, Ramadan MK, Usta J, Salama M, Mercer BM, Friedman SA (1993) Maternal morbidity and mortality in 442 patients with HELLP-Syndrome. Am J Obstet Gynecol 169: 1000

    PubMed  CAS  Google Scholar 

  • Van Runnard Heimel PJ, Schobben AF, Huisjes AJ, Franx A, Bruinse HW(2005) The transplacental passage of prednisolon in pregnancies complicated by early-onset HELLP-Syndrome. Placenta 26(10): 842–845

    Article  PubMed  CAS  Google Scholar 

  • Virchow R(1856) Gesammelte Abhandlungen zur Wissen-schaftlichen Medizin. Meidinger Sohn, Frankfurt/Main, S 778

    Google Scholar 

  • Visser W, Wallenburg HCS(1995) Temporising management of severe preeclampsia with and without HELLP-syndrome. Br J Obstet Gynecol 102: 111–117

    CAS  Google Scholar 

  • Wacker J (2006) Rezension über Hellp-eine Albtraumnovelle oder ein Lehrbuch über ein Syndrom. Geburtshilfe Frauen-heilkunde 66: 534

    Google Scholar 

  • Wacker J, Schulz M, Chiwora FM, Solomayer E, Bastert G(1998) Seasonal change in the incidence of preeclampsia in Zim-babwe. Acta Obstet Gynecol Scan 77: 712–716

    Article  CAS  Google Scholar 

  • Wacker J, Wagner B, Briese V et al. (2006) Antihypertensive therapy in patients with pre-eclampsia: a prospective ran-domised multicentre study comparing dihydralazine with urapidil. Eur J Obstet Gynecol Reprod Biol 127: 152–157

    Article  CAS  Google Scholar 

  • Weinstein L(1982) Syndrome of hemolysis, elevated liver enzymes and low platelet count: A severe consequence of hypertension in pregnancy. Am J Obstet Gynecol 142: 159

    Google Scholar 

  • Weinstein L(1985) Preeclampsia/eclampsia with hemolysis, elevated liver enzymes and thrombocytopenia. Obstet Gynecol 66: 657

    Google Scholar 

  • Williams K P, Wilson S (1997) Ethnic variation in the incidence of HELLP-syndrome ina hypertensive pregnant population. J Perinat Med 25: 498

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Frauenklinik, Fürst-Stirum-Klinik Bruchsal, Gutleutstr. 1-14, 76646, Bruchsal

    Prof. Dr. med. Jürgen Wacker

  2. Universitätsfrauenklinik, Ernst-Grube-Str. 40, 06120, Halle

    Dr. med. Gregor Seeliger

Authors
  1. Prof. Dr. med. Jürgen Wacker
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  2. Dr. med. Gregor Seeliger
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© 2007 Springer Medizin Verlag Heidelberg

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Wacker, J., Seeliger, G. (2007). HELLP-Syndrom. In: Therapiehandbuch Gynäkologie und Geburtshilfe. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-30098-4_14

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  • DOI: https://doi.org/10.1007/978-3-540-30098-4_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-30097-7

  • Online ISBN: 978-3-540-30098-4

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