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Genetic Epidemiology

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Handbook of Epidemiology

Abstract

Genetic epidemiology both emanates from and combines the scientific disciplines of human genetics and epidemiology as well as biometry. Strong interdisciplinary relationships exist among others with the fields of molecular genetics and medicine/medical care. Some overlap exists with molecular epidemiology (see Chap. III.6 of this handbook).

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References

  • Botstein D, White RL, Skolnick M, Davis RW (1980) Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet 32:314–331

    Google Scholar 

  • Clerget-Darpoux F, Bonaïti-Pellié C (1992) Strategies based on marker information for the study of human diseases. Ann Hum Genet 56:145–153

    Google Scholar 

  • Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA (1993) Genetic dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late-onset families. Science 261:921–923

    Article  Google Scholar 

  • Day NE, Simons MJ (1976) Disease susceptibility genes — their identification by multiple case family studies. Tissue Antigens 8:109–119

    Google Scholar 

  • Devlin B, Risch N (1995) A comparison of linkage disequilibrium measures for fine-scale mapping. Genomics 29:311–322

    Article  Google Scholar 

  • Devlin B, Roeder K (1999) Genomic control for association studies. Biometrics 55:997–1004

    Article  MATH  Google Scholar 

  • Elston RC (1998) Methods of linkage analysis — and the assumptions underlying them. Am J Hum Genet 63:931–934

    Article  Google Scholar 

  • Elston RL, Stewart J (1971) A general model for genetic analysis of pedigree data. Hum Hered 21:523–542

    Google Scholar 

  • Evans DGR, Harris R (1992) Heterogeneity in genetic conditions. Q J Med 84:563–565

    Google Scholar 

  • Excoffier L, Slatkin M (1995) Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol Biol Evol 12:921–927

    Google Scholar 

  • Falk CT, Rubinstein P (1987) Haplotype relative risks: an easy reliable way to construct a proper control sample for risk calculations. Ann Hum Genet 51:227–233

    Google Scholar 

  • Haldane JBS (1919) The combination of linkage values and the calculation of distances between the loci of linked factors. J Genet 8:299–309

    Google Scholar 

  • Hall JM, Lee MK, Newman B, Morrow JE, Anderson LA, Huey B, King MC (1990) Linkage of early-onset familial breast cancer to chromosome 17q21. Science 250:1684–1689

    Article  Google Scholar 

  • Hardy GH (1908) Mendelian proportions in mixed populations. Science 28:49–50

    Article  Google Scholar 

  • Hill WG, Robertson A (1968) Linkage disequilibrium in finite populations. Theor Appl Genet 38:226–231

    Article  Google Scholar 

  • Holmans P (1993) Asymptotic properties of affected-sib-pair linkage analysis. Am J Hum Genet 52:362–374

    Google Scholar 

  • IGES (2003) International Genetic Epidemiology Society (http://www.biostat.wustl.edu/~genetics/iges/) Accessed June 03, 2004

    Google Scholar 

  • Khoury MJ, Beaty TH, Cohen BH (1993) Fundamentals of genetic epidemiology. Oxford University Press, New York

    Google Scholar 

  • Knapp M, Seuchter SA, Baur MP (1993) The haplotype-relative-risk (HRR) method for analysis of association in nuclear families. Am J Hum Genet 52:1085–1093

    Google Scholar 

  • Lalouel JM, Rao DL, Morton NE, Elston RL (1984) A unified model for complex segregation analysis. Am J Hum Genet 26:484–603

    Google Scholar 

  • Lander ES, Schork NJ (1994) Genetic dissection of complex traits. Science 265:2037–2048, Published erratum, Science 1994, 266:353

    Article  Google Scholar 

  • Lewontin RC (1964) The interaction of selection and linkage. I. General considerations; heterotic models. Genetics 49:49–67

    Google Scholar 

  • Maynard Smith J (1989) Evolutionary genetics. Oxford University Press, New York

    Google Scholar 

  • McKusick VA (1998) Mendelian inheritance in man. Catalogs of Human Genes and Genetic Disorders 12th edn. Johns Hopkins University Press, Baltimore

    Google Scholar 

  • Mendel GJ (1865) Versuche über Pflanzenhybriden. Verhandlungen des Naturforschenden Vereins, Brünn

    Google Scholar 

  • Morton NE (1955) Sequential tests for the detection of linkage. Am J Hum Genet 7:277–318

    Google Scholar 

  • Morton NE, MacLean CL (1974) Analysis of familial resemblance. III. Complex segregation analysis of quantitative traits. Am J Hum Genet 26:484–503

    Google Scholar 

  • Newman B, Austin MA, Lee M, King MC (1988) Inheritance of human breast cancer: evidence for autosomal dominant transmission in high-risk families. Proc Natl Acad Sci, USA 85:3044–3048

    Article  Google Scholar 

  • Online Mendelian Inheritance in Man, OMIMTM (2000) McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University (Baltimore, MD) and National Center for Biotechnology Information, National Library of Medicine (Bethesda, MD) (http://www.ncbi.nlm.nih.gov/omim/) Accessed June 03, 2004

    Google Scholar 

  • Ott J (1999) Analysis of human genetic linkage, 3rd edn. Johns Hopkins University Press, Baltimore

    Google Scholar 

  • Penrose LS (1953) The general sib-pair linkage test. Annals of Eugenics 18:120–144

    Google Scholar 

  • Pritchard JK, Stephens M, Rosenberg NA, Donnelly P (2000) Association mapping in structured populations. Am J Hum Genet 67:170–181

    Article  Google Scholar 

  • Qian D, Beckmann L (2002) Minimum-recombinant haplotyping in pedigrees. Am J Hum Genet 70:1434–1445

    Article  Google Scholar 

  • Rhode K, Fürst R (2001) Haplotyping and estimation of haplotype frequencies for closely linked biallelic multilocus genetic phenotypes including nuclear family information. Human Mutation 14:289–295

    Article  Google Scholar 

  • Risch N (1983) A general model for disease-marker association. Ann Hum Genet 47:245–252

    MATH  Google Scholar 

  • Risch N (1991) A note on multiple testing procedures in linkage analysis. Am J Hum Genet 48:1058–1064

    Google Scholar 

  • Schaid DJ (1999) Likelihoods and TDT for the case-parents design. Genet Epidemiol 16:250–260

    Article  Google Scholar 

  • Schaid DJ, Sommer SS (1994) Comparison of statistics for candidate-gene association studies using cases and parents. Am J Hum Genet 55:402–409

    Google Scholar 

  • Sham P (1998) Statistics in human genetics. Wiley, New York

    Google Scholar 

  • Shute NC, Ewens WJ (1988) A resolution of the ascertainment sampling problem. II. Generalizations and numerical results. Am J Hum Genet 43:374–386

    Google Scholar 

  • Spielman RS, Ewens WJ (1998) A sibship test for linkage in the presence of association: The sib transmission/disequilibrium test. Am J Hum Genet 62:450–458

    Article  Google Scholar 

  • Spielman RS, McGinnis RE, Ewens JW (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506–516

    Google Scholar 

  • Suarez BK, Hampe CL (1994) Linkage and association. Am J Hum Genet 54:554–559

    Google Scholar 

  • Tamarin RH (1986) Principles of genetics, 2nd edn. Prindle, Weber & Schmidt, Boston

    Google Scholar 

  • Terwilliger JD, Ott J (1992) A haplotype-based ‘haplotype relative risk’ approach to detecting allelic association. Hum Hered 42:337–346

    Article  Google Scholar 

  • Terwilliger JD, Ott J (1994) Handbook of human genetic linkage. Johns Hopkins University Press, Baltimore

    Google Scholar 

  • Thompson EA (1986) Genetic epidemiology: a review of the statistical basis. Statistics in Medicine 5:291–302

    Article  Google Scholar 

  • Thomson G (1983) Investigation of the mode of inheritance of the HLA associated diseases by the method of antigen genotype frequencies among diseased individuals. Tissue Antigens 21:81–104

    Article  Google Scholar 

  • Vogel W (2000) Genetische Epidemiologie oder zur Spezifität von Subdisziplinen der Humangenetik. Med Genet 4:395–399

    Google Scholar 

  • Weinberg W (1908) über den Nachweis der Vererbung beim Menschen. Jahreshefte des Vereins für vaterländische Naturkunde in Württemberg 64:368–383

    Google Scholar 

  • Weiss KM (1993) Genetic variation and human disease. Principles and evolutionary approaches. University Press, Cambridge

    Google Scholar 

  • Whittaker JC, Morris AP (2001) Family-based tests of association and/or linkage. Ann Hum Genet 65:407–419

    Article  Google Scholar 

  • Whittemore AS, Tu IP (1998) Simple, robust linkage tests for affected sibs. Am J Hum Genet 62:1228–1242

    Article  Google Scholar 

  • Woolf B (1955) On estimating the relation between blood group and disease. Ann Hum Genet 19:251–253

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Genetic Epidemiology, University of Göttingen, Medical School, Humboldtallee 32, 37073, Göttingen, Germany

    Heike Bickeböller

Authors
  1. Heike Bickeböller
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Editor information

Editors and Affiliations

  1. Division of Epidemiological Methods and Ethiologic Research, Bremen Institute for Prevention Research and Social Medicine (BIPS), Linzer Str. 10, 28359, Bremen, Germany

    Wolfgang Ahrens  & Iris Pigeot  & 

  2. Division of Biometrie and Data Management, Bremen Institute for Prevention Research and Social Medicine (BIPS), Linzer Str. 10, 28359, Bremen, Germany

    Wolfgang Ahrens  & Iris Pigeot  & 

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© 2005 Springer-Verlag Berlin Heidelberg

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Bickeböller, H. (2005). Genetic Epidemiology. In: Ahrens, W., Pigeot, I. (eds) Handbook of Epidemiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-26577-1_29

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