Abstract
We present a multi-site model describing the alternative use of the RNA splicing sites A3, A4, A5 and A7 in the human immunodeficiency virus HIV-1. Our goal is to integrate experimental data obtained on individual splicing sites into a global model of HIV-1 RNA alternative splicing. We give a qualitative validation of our model, and analyse the possible impact of variations of regulatory protein concentrations on virus multiplication.
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Bockmayr, A., Courtois, A., Eveillard, D., Vezain, M. (2005). Building and Analysing an Integrative Model of HIV-1 RNA Alternative Splicing. In: Danos, V., Schachter, V. (eds) Computational Methods in Systems Biology. CMSB 2004. Lecture Notes in Computer Science(), vol 3082. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-25974-9_5
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DOI: https://doi.org/10.1007/978-3-540-25974-9_5
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