Skip to main content

Grid Computing in Structure Determination of Biological Specimens by Electron Microscope Tomography

  • Conference paper
Grid Computing (AxGrids 2003)

Part of the book series: Lecture Notes in Computer Science ((LNCS,volume 2970))

Included in the following conference series:

  • 391 Accesses

Abstract

The present contribution describes a potential application of Grid Computing in Bioinformatics. High resolution structure determination of biological specimens is critical in BioSciences to understanding the biological function. The problem is computational intensive and distributed computing and Grid Computing are thus becoming essential. This contribution analyzes the use of Grid Computing and its potential benefits in the field of electron microscope tomography of biological specimens.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Baumeister, W.: Electron tomography: towards visualizing the molecular organization of the cytoplasm. Cur. Opi. Struct. Biol. 12, 679–684 (2002)

    Article  Google Scholar 

  2. Medalia, O., Weber, I., Frangakis, A., Nicastro, D., Gerisch, G., Baumeister, W.: Macromolecular architecture in eukaryotic cells visualized by cryoelectron tomography. Science 298, 1209–1213 (2002)

    Article  Google Scholar 

  3. Frank, J.: Three Dimensional Electron Microscopy of Macromolecular Assemblies. Academic Press, London (1996)

    Google Scholar 

  4. Frank, J.: Single-particle imaging of macromolecules by cryo-electron microscopy. Annu. Rev. Biophys. Biomol. Struct. 31, 303–319 (2002)

    Article  Google Scholar 

  5. Rademacher, M.: Weighted Back-Projection Methods. In: Frank, J. (ed.) Electron Tomography. Three-Dimensional Imaging with the Transmission Electron Microscope, pp. 91–115. Plenum Press (1992)

    Google Scholar 

  6. Marabini, R., Herman, G., Carazo, J.: 3D reconstruction in electron microscopy using ART with blobs. Ultramicroscopy 72, 53–56 (1998)

    Article  Google Scholar 

  7. Fernandez, J., Lawrence, R., Garcia, I., Ellisman, C.J.: High performance electron tomography of complex specimens. J. Struct. Biol. 138, 6–20 (2002)

    Article  Google Scholar 

  8. Fernandez, J., Carazo, J., Garcia, I.: Three-dimensional reconstruction of cellular structures by electron microscope tomography and parallel computing. J. Parallel and Distributed Computing (2003) (submitted)

    Google Scholar 

  9. Bilbao-Castro, J., Carazo, J., Garcia, I., Fernandez, J.: Parallel iterative reconstruction methods for structure determination of biological specimens by electron microscopy. In: IEEE Intl. Congress on Image Processing (2003) (submitted)

    Google Scholar 

  10. Perkins, G., Renken, C., Song, J., Frey, T., Young, S., Lamont, S., Martone, M., Lindsey, S., Ellisman, M.: Electron tomography of large, multicomponent biological structures. J. Struc. Biol. 120, 219–227 (1997)

    Article  Google Scholar 

  11. Peltier, S., Lin, A., Lee, D., Mock, S., Lamont, S., Molina, T., Wong, M., Dai, L., Martone, M., Ellisman, M.: The telescience portal for tomography applications. J. Parallel Distributed Computing (2003) (in press)

    Google Scholar 

  12. Foster, I., Kesselman, C., Nick, J., Tuecke, S.: Grid services for distributed system integration. Computer 35, 37–46 (2002)

    Article  Google Scholar 

  13. Foster, C.K.: Globus: A metacomputing infrastructure toolkit. Intl. J. Supercomputer Applications 11, 115–128 (1997)

    Article  Google Scholar 

  14. Wolski, R., Spring, N.T., Hayes, J.: The network weather service: A distributed resource performance forecasting service for metacomputing. Future Generation Computer Systems 15, 757–768 (1999)

    Article  Google Scholar 

  15. Garcia, I., Herman, G.: Global optimization by PCBRS. In: State of art in global optimization: Computational Methods and Applications, pp. 433–455. Kluwer Academic Publishers, Dordrecht (1996)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Fernández, J.J., Bilbao-Castro, J.R., Marabini, R., Carazo, J.M., García, I. (2004). Grid Computing in Structure Determination of Biological Specimens by Electron Microscope Tomography. In: Fernández Rivera, F., Bubak, M., Gómez Tato, A., Doallo, R. (eds) Grid Computing. AxGrids 2003. Lecture Notes in Computer Science, vol 2970. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-24689-3_22

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-24689-3_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-21048-1

  • Online ISBN: 978-3-540-24689-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics