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Large-Scale Biological Sequence Assembly and Alignment by Using Computing Grid

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Grid and Cooperative Computing (GCC 2003)

Part of the book series: Lecture Notes in Computer Science ((LNCS,volume 3032))

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Abstract

Large-scale sequence assembly and alignment are fundamental parts of biological computing. However, most of the large-scale sequence assembly and alignment require intensive computing power and normally take very long time to complete. To speedup the assembly and alignment process, this paper parallelizes the Euler sequence assembly and pair-wise/multiple sequence assembly, two important sequence assembly methods, and takes advantage of Computing Grid which has a colossal computing capacity to meet the large-scale biological computing demand.

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References

  1. Carol, A., Robert, D., Strausberg, R.L.: Human Genome Project: Revolutionizing Biology Through Leveraging Technology. In: Proceedings of SPIE - The International Society for Optical Engineering, California, pp. 190–201 (1996)

    Google Scholar 

  2. Eugene, W.M.: Toward Simplifying and Accurately Formulating Fragment Assembly. J. Comp. Bio. 2, 275–290 (1995)

    Article  Google Scholar 

  3. James, L.W., Gene, M.: Whole Genome Shotgun Sequencing. Geno. Res. 7, 401–409 (1997)

    Google Scholar 

  4. Liming, C., David, J., Evgueni, L.: Evolutionary Computation Techniques for Multiple Sequence Alignment. In: Proceedings of the IEEE Conference on Evolutionary Computation, San Diego, vol. 7, pp. 829–835 (2000)

    Google Scholar 

  5. Phil, G.: Documentation for Phrap (1994), http://www.genome.washington.edu/UWGC/analysistools/phrap.html

  6. Xiaoqiu, H., Anup, M.: CAP3: A DNA Sequence Assembly Program. Geno. Res. 9, 868–877 (1999)

    Article  Google Scholar 

  7. James, K.B., Ken, F.S., Rodger, S.: A New DNA Sequence Assembly Program. Nucl. Acids Res. 23, 4992–4999 (1995)

    Article  Google Scholar 

  8. Pavel, A.P., Haixu, T., Smith, W.: An Eulerian Path Approach to DNA Fragment Assembly. In: Proceedings of National Academy of Sciences of the United States of America, vol. 98, pp. 9748–9753 (2001)

    Google Scholar 

  9. Temple, F.S., Michael, S.W.: Identification of Common Molecular Subsequences. J. Mol. Bio. 147, 195–197 (1981)

    Article  Google Scholar 

  10. Julie, D.T., Desmond, G.H., Toby, J.G.: Clustal W: Improving the Sensitivity of Progressive Multiple Sequence Alignment Through Sequence Weighting, Position- Specific Gap Penalties and Weight Matrix Choice. Nucl. Acid Res. 22, 4673–4680 (1994)

    Article  Google Scholar 

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© 2004 Springer-Verlag Berlin Heidelberg

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Shi, W., Zhou, W. (2004). Large-Scale Biological Sequence Assembly and Alignment by Using Computing Grid. In: Li, M., Sun, XH., Deng, Qn., Ni, J. (eds) Grid and Cooperative Computing. GCC 2003. Lecture Notes in Computer Science, vol 3032. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-24679-4_13

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  • DOI: https://doi.org/10.1007/978-3-540-24679-4_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-21988-0

  • Online ISBN: 978-3-540-24679-4

  • eBook Packages: Springer Book Archive

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