Abstract
Among the primary risk factors of coronary heart disease hypercholesterolemia, hypertension and nicotine abuse take highest precedence. A total cholesterol level > 300 mg/dl signifies a high atherogenic risk for the individual in question. However, hypercholesterolemia (> 300 mg/dl) is observed in only approx. 25% of all patients with CHD (1). The majority of patients with coronary heart disease exhibit a total cholesterol level between 240 and 300 mg/dl. Corresponding to the results of the Framingham Study the distribution curve for total serum cholesterol in probands who have developed CHD overlaps considerably with that of probands who exhibited no coronary heart disease (1). The average cholesterol value of probands suffering from coronary heart disease was 255 mg/dl (219 mg/dl in probands who did not develop CHD) (1). Taking these results as a basis, it is not possible in an individual case with a total cholesterol level between 150 and 300 mg/dl to make a statement regarding the coronary risk only on the basis of determining the total cholesterol.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Kannel, W.B., Castelli, W.P., Gordon, T.: Cholesterol in the prediction of atherosclerotic disease. New perspective based on Framingham study. Ann. intern. Med. 90, 85–91, 1979.
Friedewald, W.T., Levy, R.I., Fredrickson, D.S.: Estimation of plasma low density lipoprotein cholesterol concentration without use of preparative ultracentrifuge. Clin. Chem. 18, 499–509, 1972.
Miller, G.J., Miller, N.L.: Plasma high density lipoprotein concentration and development of ischemic heart disease. Lancet 1, 16–19, 1979.
Berg, K., Borresen, A., Dahlen, G.: Serum high density lipoprotein and atherosclerotic heart disease. Lancet 1, 499–502, 1976.
Rhoads, G.G., Gulbrandsen, C.L., Kagan, A.: Serum lipoproteins and coronary heart disease in the population study of Hawaii Japanese men. New. Engl. J. Med. 294, 293–298, 1976.
Castelli, W.P., Doyle, J.T., Gordon, T., Harnes, C.G., Hjortland, M.C., Hully, S.B., Kagan, A., Zukel, W.J.: HDL-cholesterol and other lipids in coronary heart disease. The cooperative lipoprotein phenotyping study. Circulation 55, 767–772, 1977.
Gordon, T., Castelli, W.P., Hjortland, M.C., Kannel, W.B., Dawber, T.R.: Diabetes, blood lipids and the role of obesity in coronary disease risk for women. Ann. intern. Med. 87, 393–397,1977.
Wilson, P.W., Garrison, R.J., Castelli, W.P., Feinleib, M., McNamara, W.B., Kannel, W.B.: Prevalence of coronary heart disease in the Framingham offspring study: role of lipoproteins cholesterols. Am. J. Epidem. 46, 649–654, 1980.
Pearson, T.A., Bulkley, B.H., Aschuff, S.C., Kwiterowich, P.O., Gords, L.: The association of low levels of HDL-cholesterol and arteriographically defined artery disease. Am. J. Epidem. 109, 285–295, 1979.
Barboriak, J.J., Anderson, A.J., Hoffmann, R.G.: Irrelationship between coronary artery occlusion, high density cholesterol and alcohol intake. J. Lab. Clin. Med. 94, 348–351, 1979.
Kladetzky, H.G., Assmann, G., Walgenbach, S., Tauchert, P.: Lipid and apoprotein values in coronary angiography patients. Artery 7, 191–205, 1980.
Gordon, T., Castelli, W.P., Hjortland, M.C., Kannel, W.B., Dawber, T.R.: High density lipoprotein as a prospective factor against coronary heart disease. Am. J. Med. 62, 707–714, 1977.
Epstein, F.H.: Role of HDL in individual prediction and community prevention of coronary heart disease. In: Gotto, A.M., Jr., Smith, L.C., Allen, B. (eds.): Atherosclerosis V, Proceedings of the fifth international symposium. Springer, New York 1980, pp. 484–487.
Epstein, F.H.: Estimating the effectiveness of preventive measures to reduce coronary heart disease. In: Carlson, L.A. et al. (eds.): International conference of atherosclerosis. Raven Press, New York 1978, pp. 351–356.
Yaari, S., Goldbouri, U., Even-Zohar, S., Neufeld, H.N.: Association of serum high density lipoprotein and total cholesterol with total cardiovascular, and cancer mortality in 7-year prospective study of 10000 men. Lancet 1, 1011–1015, 1981.
Gordon, I., Castelli, W.P., Hjortland, M.C., Kannel, W.B.: The prediction of coronary heart disease by high density and other lipoproteins an historical perspective. In: Rifkind, B.M., Levy, R.I. (eds.): Hyperlipidemia, Diagnosis and therapy. Grane & Strutton, New York 1977, pp. 71–78.
Gofman, J.W., Young, W., Tandy, R.: Ischemic heart disease, atherosclerosis and longevity. Circulation 34, 679–697, 1966.
Gordon, T.: Epidemiology and high density lipoproteins. In: Gotto, A.M., Jr., Smith, L.C., Allen, B. (eds.): Atherosclerosis V, proceedings of the fifth international symposium. Springer, New York 1980, pp. 495–499.
Gordon, T., Castelli, W.P., Hjortland, M.C., Kannel, W.H., Dawber, T.R.: Predicting coronary heart disease in middle aged and other persons. The Framingham study. J. Am. med. Ass. 238, 497–499, 1977.
Assmann, G., Schriewer, H., Schulte, H., Oberwittler, W.: Der Stellenwert des HDL-Cholesterins als Risikoindikator der koronaren Herzkrankheit. Internist 21, 202–212, 1980.
Assmann, G., Schriewer, H., Oberwittler, W.: Klinik und Pathobiochemie der High-Density-Lipoproteine. Klin. Wschr. 57, 757–765, 1980.
Zilversmith, D.B.: Atherosgenesis: a postprandial phenomenon. Circulation 60, 473–485, 1979.
Assmann, G., Schriewer, H., Funke, H.: Zur Richtigkeit der HDL-Cholesterin- und HDL-Apolipoprotein A-I-Bestimmung nach Phosphorwolframsäure/MgCl-2-Präzipitation Apolipoprotein B-haltiger Lipoproteine. J. Clin. Chem. Clin. Biochem. 19, 273–278, 1981.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1983 Westdeutscher Verlag GmbH, Opladen
About this chapter
Cite this chapter
Assmann, G., Schriewer, H., Juchem, K.H. (1983). The Role of HDL Cholesterol in Preventive Medicine. In: Clinical Implications of Recent Research Results in Arteriosclerosis. Abhandlungen der Rheinisch-Westfälischen Akademie der Wissenschaften, vol 70. VS Verlag für Sozialwissenschaften, Wiesbaden. https://doi.org/10.1007/978-3-322-98699-3_27
Download citation
DOI: https://doi.org/10.1007/978-3-322-98699-3_27
Publisher Name: VS Verlag für Sozialwissenschaften, Wiesbaden
Print ISBN: 978-3-322-98700-6
Online ISBN: 978-3-322-98699-3
eBook Packages: Springer Book Archive