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Diet in Experimental Atherosclerosis

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Book cover Clinical Implications of Recent Research Results in Arteriosclerosis

Part of the book series: Abhandlungen der Rheinisch-Westfälischen Akademie der Wissenschaften ((ARAW,volume 70))

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Abstract

Experimental induction of atherosclerosis has been attempted in a wide variety of animals and each experimental modality can be subjected to some valid criticism (1, 2). The principal question raised about cholesterol-induced atherosclerosis in the rabbit (3) is whether it may be a manifestation of a cholesterol storage syndrome in a herbivore. In 1958 Lambert et al. (4) demonstrated that atherosclerotic lesions could be induced in rabbits by feeding saturated fat. The mechanism was thought to involve essential fatty acid deficiency. However, collation of the existing literature in 1964 (5) showed that saturated fat added to stock diet never gave rise to atherosclerosis whereas addition to a semipurified diet invariably did. We showed further that the essential fatty acid content of stock diet did not protect rabbits from atherosclerosis but the fiber content did (6, 7). We devised a semipurified diet which is hyperlipoproteinemic and atherogenic for rabbits. The diet contains 40% carbohydrate, usually sucrose; 25% protein, usually casein; 15% cellulose; 14% saturated fat, usually coconut oil; 5% salt mix and 1% vitamin mix. The carbohydrate, protein and fat represent 41.5%, 25.9%, and 32.6% of calories, respectively. A major advantage of this diet is that it can be used to test nutrients within one dietary class or it can be used to examine interactions of nutrients.

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Authors and Affiliations

  1. The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, USA

    D. Kritchevsky

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© 1983 Westdeutscher Verlag GmbH, Opladen

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Kritchevsky, D. (1983). Diet in Experimental Atherosclerosis. In: Clinical Implications of Recent Research Results in Arteriosclerosis. Abhandlungen der Rheinisch-Westfälischen Akademie der Wissenschaften, vol 70. VS Verlag für Sozialwissenschaften, Wiesbaden. https://doi.org/10.1007/978-3-322-98699-3_16

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  • DOI: https://doi.org/10.1007/978-3-322-98699-3_16

  • Publisher Name: VS Verlag für Sozialwissenschaften, Wiesbaden

  • Print ISBN: 978-3-322-98700-6

  • Online ISBN: 978-3-322-98699-3

  • eBook Packages: Springer Book Archive

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