Skip to main content
SpringerLink
Log in

Endothelial Injury and Repair

  • Chapter
Clinical Implications of Recent Research Results in Arteriosclerosis

Part of the book series: Abhandlungen der Rheinisch-Westfälischen Akademie der Wissenschaften ((ARAW,volume 70))

  • 21 Accesses

Abstract

Endothelial injury has been proposed as the initiating event in the process of atherosclerosis. In this review we discuss the pathophysiology of endothelial injury and its assessment with respect to the complex events underlying atherogenesis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Awbrey, B.J., Hoak, J.C., and Owen, W.G. (1979): Binding of human thrombin to cultured human endothelial cells. Journal of Biological Chemistry, 254: 4092–4095.

    PubMed  CAS  Google Scholar 

  • Bjorkerud, S., Bondjers, G. (1971): Arterial repair and atherosclerosis after mechanical injury. I. Permeability and light microscopic characteristics of endothelium in nonatherosclerotic and atherosclerotic lesions. Atherosclerosis, 13: 355–364.

    Article  PubMed  CAS  Google Scholar 

  • Bondjers, G., Brattsand, R., Bylock, A., Hansson, G.K., and Bjorkerud, S. (1977): Endothelial integrity and atherogenesis in rabbits with moderate hypercholesterolemia. Artery, 3: 395–408.

    Google Scholar 

  • Bornstein, P., Sage, H. (1980): Structurally distinct collagen types. American Review of Biochemistry, 49: 957–1003.

    Article  CAS  Google Scholar 

  • Bunting, S., Gryglewski, R., Moncada, S., and Vane, J.R. (1976): Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation. Prostaglandins, 12: 897–913.

    PubMed  CAS  Google Scholar 

  • Buonassisi, V. (1973): Sulfated mucopolysaccharide synthesis and secretion in endothelial cell cultures. Experimental Cell Research, 76: 393–368.

    Article  Google Scholar 

  • Chien, S. (1978): Transport across arterial endothelium. Progress in Hemostasis and Thrombosis, 4: 1–36.

    PubMed  CAS  Google Scholar 

  • Davies, P., and Ross, R. (1978): Mediation of pinocytosis in cultured arterial smooth muscle and endothelial cells by platelet-derived growth factor. Journal of Cell Biology, 79: 663–671.

    Article  PubMed  CAS  Google Scholar 

  • Davies, P.F., Seiden, S.C., III, and Schwartz, S.M. (1980): Enhanced rates of fluid pinocytosis during exponential growth and monolayer regeneration by cultured arterial endothelial cells. Journal of Cell Physiology, 102: 119–127.

    Article  CAS  Google Scholar 

  • DeBruijn, W.L., Van Nourik, W., and Bosveld, I.J. (1974): Cell border demarcation in the scanning electron microscope by silver stain. Journal of Cell Science, 16: 221–239.

    CAS  Google Scholar 

  • Duguid, J.B. (1949): Pathogenesis of arteriosclerosis. Lancet, 257: 925–927.

    Article  Google Scholar 

  • Fielding, C.J., Vlodavsky, I., Fielding, P.E., and Gospodarowicz, D. (1979): Characteristics of chylomicron binding and lipid uptake by endothelial cells in culture. Journal of Biological Chemistry, 254: 8861–8868.

    PubMed  CAS  Google Scholar 

  • Fischer-Dzoga, K., Fraser, R., Wissler, R.W. (1976): Stimulation of proliferation in stationary primary cultures of monkey and rabbit aortic smooth muscle cells: I. Effects of lipoprotein fractions of hyperlipemic serum and lymph. Experimental Molecular Pathology, 24: 346–359.

    Article  CAS  Google Scholar 

  • Florentin, R.W., Nam, S.C., Lee, K.T., and Thomas, W.A. (1969): Increased 3H-thymidine incorporation into endothelial cells of swine fed cholesterol for 3 days. Experimental Molecular Pathology, 10: 250–255.

    Article  CAS  Google Scholar 

  • Fry, G.L., Czervionke, R.L., Hoak, J.C., Smith, J.B., and Haycraft, D.L. (1980): Platelet adherence to cultured vascular cells: Influence of prostacyclin (PGI2). Blood, 55: 271–275.

    PubMed  CAS  Google Scholar 

  • Gaynor, E. (1971): Increased mitotic activity in rabbit endothelium after endotoxin. An autoradiographic study. Laboratory Investigation, 24: 318–320.

    PubMed  CAS  Google Scholar 

  • Gerrity, R.G., Richardson, M., Caplan, B.A., Cade, J.F., Hirsh, J., and Schwartz, C.J. (1976): Endotoxin-induced vascular endothelial injury and repair. II. Focal injury, en face morphology, 3H thymidine uptake and circulating endothelial cells in the dog. Experimental Molecular Pathology, 24: 59–69.

    Article  CAS  Google Scholar 

  • Gimbrone, M.A., Jr., and Fareed, G.C (1976): Transformation of cultured human vascular endothelium by SV40 DNA. Cell 9: 685–693.

    Article  PubMed  Google Scholar 

  • Haudenschild, C.C., and Schwartz, S.M. (1979): Endothelial regeneration. II. Restitution of endothelial continuity. Laboratory Investigation, 41: 407–418.

    PubMed  CAS  Google Scholar 

  • Hirsch, E.Z., and Robertson, A.L. (1977): Selective acute arterial endothelial injury and repair. I. Methodology and surface characteristics. Atherosclerosis, 28: 271–287.

    Article  PubMed  CAS  Google Scholar 

  • Howard, B.V., Macarak, E.J., Gunson, D., and Kelfalides, N.A. (1976): Characterization of the collagen synthesized by endothelial cells in culture. Proceedings of the National Academy of Science U.S.A., 713: 2361–2364.

    Article  Google Scholar 

  • Iverius, P.H. (1977): Possible role of glycosaminoglycans in the genesis of atherosclerosis. In Atherogene sis Initiating Factors Ciba Symbosium-12, pp. 87. Amsterdam, North Holland: Elsevier.

    Google Scholar 

  • Jaffe, E.A., Minick, C.R., Adelman, B., Becker, C.G., and Nachman, R. (1976): Synthesis of basement membrane collagen by cultured human endothelial cells. Journal of Experimental Medicine, 144: 209–225.

    Article  PubMed  CAS  Google Scholar 

  • Johnson, A.R., and Erdos, E.G. (1977): Metabolism of vasoactive peptides by human endothelial cells in culture. Journal of Clinical Investigation, 59: 684–695.

    Article  PubMed  CAS  Google Scholar 

  • Lieberman, G.E., Lewis, P., and Peters, T.J. (1977): A membrane-bound enzyme in rabbit aorta capable of inhibiting adenosine-diphosphate-induced platelet aggregation. Lancet, 2: 330–332.

    Article  PubMed  CAS  Google Scholar 

  • Lollar, P., and Owen, W.G. (1980): Clearance of thrombin from the circulation by high affinity binding sites on endothelium. Journal of Clinical Investigation, 66: 1222–1230.

    Article  PubMed  CAS  Google Scholar 

  • Loskutoff, D.J., and Edgington, T.S. (1977): Synthesis of a fibrinolytic activator and inhibitor by endothelial cells. Proceedings of the National Academy of Science (U.S.A.), 74: 3903–3907.

    Article  CAS  Google Scholar 

  • Majno, G., and Joris, I. (1978): Endothelium 1977: A review. Advances in Experimental Medical Biology, 104: 169–225.

    Article  CAS  Google Scholar 

  • Minick, C.R., Stemerman, M.B., and Insull, W., Jr. (1977): Effect of regenerated endothelium on lipid accumulation in the arterial wall. Proceedings of the National Academy of Science (U.S.A.), 74: 1724–1728.

    Article  CAS  Google Scholar 

  • Moncada, S., and Vane, J.R. (1979): Arachidonic acid metabolites and the interactions between platelets and blood-vessel walls. New England Journal of Medicine, 300: 1142–1147.

    Article  PubMed  CAS  Google Scholar 

  • Nelson, E., Gertz, S.D., Forbes, M.S., Rennels, M.L., Heald, F.P., Kahn, M.A., Farber, T.M., Miller, E., Husain, M.M., and Earl, F.L. (1976): Endothelial lesions in the aorta of egg yolk-fed minature swine: A study by scanning and transmission electron microscopy. Experimental Molecular Pathology, 25: 208–220.

    Article  CAS  Google Scholar 

  • Reidy, M.A., and Schwartz, S.M. (1981): Endothelial regeneration. III. Time course of intimai changes after small defined injury to rat aortic endothelium. Laboratory Investigation, 44: 301–308.

    PubMed  CAS  Google Scholar 

  • Reidy, M.A., and Bowyer, D.E. (1978): Distortion of endothelial repair. The effect of hypercholesterolemia on regeneration of aortic endothelium following injury by endotoxin. A scanning electron microscope study. Atherosclerosis, 29: 459–466, 1978.

    Article  PubMed  CAS  Google Scholar 

  • Reidy, M.A., and Schwartz, S.M. (1981): Endothelial regeneration. III. Time course of intimai changes after small defined injury to rat aortic endothelium. Laboratory Investigation, 44: 301–308.

    PubMed  CAS  Google Scholar 

  • Ross, R., and Glomset, J. (1976): The pathogenesis of atherosclerosis. New England Journal of Medicine, 295: 369–377.

    Article  PubMed  CAS  Google Scholar 

  • Ross, R., and Harker, L.A. (1976): Hyperlipidemia and atherosclerosis. Chronic hyperlipidemia initiates and maintains lesions by endothelial cell desquamation and lipid accumulation. Science, 193: 1094–1100.

    Article  PubMed  CAS  Google Scholar 

  • Schwartz, S.M., and Benditt, E.P. (1976): Clustering of replicating cells in aortic endothelium. Proceedings of the National Academy of Science, 73: 651–653.

    Article  CAS  Google Scholar 

  • Schwartz, S.M., and Benditt, E.P. (1977): Aortic endothelial cell replication. I. Effects of age and hypertension in the rat. Circulation Research, 41: 248–255.

    Article  PubMed  CAS  Google Scholar 

  • Schwartz, S.M., Gajdusek, C.M., Reidy, M.A., Seiden, S.C. III, and Haudenschild, C.C. (1980): Maintenance of integrity in aortic endothelium. Federation Proceedings, 39: 2618–2625.

    PubMed  CAS  Google Scholar 

  • Schwartz, S.M., Haudenschild, C.C., and Eddy, E.M. (1978): Endothelial regeneration. I. Quantitative analysis of initial stages of endothelial regeneration in rat aortic intima. Laboratory Investigation, 38: 568–580.

    PubMed  CAS  Google Scholar 

  • Simionescu, N., Simionescu, M., and Palade, G.E. (1976): Structural-functional correlates in the transendothelial change of water-soluble macromolecules. Thrombosis Research, 8 (Suppl. II): 257–269.

    Article  PubMed  CAS  Google Scholar 

  • Smith, E.B., Staples, E.M., Dietz, H.S., and Smith, R.H. (1979): Role of endothelium in sequestration of lipoprotein and fibrinogen in aortic lesions, thrombi and graft pseudointimas. Lancet, 2: 812–816.

    Article  PubMed  CAS  Google Scholar 

  • Stemermann, M.B., and Ross, R. (1972): Experimental arteriosclerosis. I. Fibrous plaque formation in primates, an electron microscope study. Journal of Experimental Medicine, 136: 769–789.

    Article  Google Scholar 

  • Taylor, K., Glagov, S., Lamberti, J., Veselinovitch, D., and Schaffner, T. (1978): Surface configuration of early atheromatous lesions in controlled-pressure perfusion-fixed monkey aortas. Scanning Electron Microscope, 2: 449–457.

    Google Scholar 

  • Thorgeirsson, G., and Robertson, A.L. (1978): The vascular endothelium — pathobiologic significance. American Journal of Pathology, 93: 803–848.

    PubMed  CAS  Google Scholar 

  • Virchow, R. (1856): Phlogose und Thrombose im Gefäßsystem. Gesammelte Abhandlungen zur Wissenschaftlichen Medicin. Frankfurt: Meidinger Sohn and Company. 458 pp.

    Google Scholar 

  • Vlodavsky, I., Fielding, P.E., Fielding, C.J., and Gospodarowicz, D. (1978): Role of contact inhibition in the regulation of receptor-mediated uptake of low density lipoprotein in cultured vascular endothelial cells. Proceedings of the National Academy of Science (U.S.A.), 75: 356–360.

    Article  CAS  Google Scholar 

  • Wall, R.T., Counts, R.B., Harker, L.A., and Striker, G.E. (1980): Binding and release of Factor VIII/von Willebrand’s factor by human endothelial cells. British Journal of Haematalogy, 46: 287–298.

    Article  CAS  Google Scholar 

  • Weber, G., Fabbrini, I., and Resi, L. (1974): Scanning and transmission electron microscopy observation on the surface lining of aortic intimai plaques in rabbits on a hypercholesterolemic diet. Virchow’s Archiv. A Pathological, Anatomy and Histology, 364: 325–331.

    Article  CAS  Google Scholar 

  • Wight, T.N. (1980): Vessel proteoglycans and thrombogenesis. In Progress in Hemostasis and Thrombosis (Ed.) Spaet, H. Vol. 5, pp. 1–39. New York: Grune & Stratton, Inc.

    Google Scholar 

  • Zetter, B.R., Johnson, L.K., Shuman, M.A., and Gospodarowicz, D. (1978): The isolation of vascular endothelial cell lines with altered cell surface and platelet-binding properties. Cell, 14:501–509.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA

    L. A. Harker

  2. Department of Pathology, University of Washington School of Medicine, Seattle, Washington, USA

    S. M. Schwartz & R. Ross

Authors
  1. L. A. Harker
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. M. Schwartz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Ross
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Westdeutscher Verlag GmbH, Opladen

About this chapter

Cite this chapter

Harker, L.A., Schwartz, S.M., Ross, R. (1983). Endothelial Injury and Repair. In: Clinical Implications of Recent Research Results in Arteriosclerosis. Abhandlungen der Rheinisch-Westfälischen Akademie der Wissenschaften, vol 70. VS Verlag für Sozialwissenschaften, Wiesbaden. https://doi.org/10.1007/978-3-322-98699-3_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-322-98699-3_12

  • Publisher Name: VS Verlag für Sozialwissenschaften, Wiesbaden

  • Print ISBN: 978-3-322-98700-6

  • Online ISBN: 978-3-322-98699-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation