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Bioanorganische Chemie pp 291–307Cite as

Katalyse und Regulation bioenergetischer Prozesse durch die Erdalkalimetallionen Mg2+ und Ca2+

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Zusammenfassung

Unter den vier nicht zu den Spurenelementen gerechneten Bio-Metallkationen nimmt Mg2+ aufgrund seines geringen lonenradius eine Sonderstellung ein (vgl. Tab. 13.1; Martin; Black, Huang, Cowan). Dieses Ion bevorzugt wegen des relativ kleinen Verhältnisses Radius/Ladung und der daraus folgenden Lewis-Acidität mehrfach negativ geladene Liganden, insbesondere Polyphosphate; im Gegensatz zum verwandten und in der katalytischen Funktion teilweise ähnlichen Zn2+ ist Mg2+ jedoch eindeutig ein “hartes” Elektrophil (vgl. Abb. 2.6), welches mit einfachen N- und S-Liganden wie His oder Cys− keine inerten Komplexe mehr bildet. Darüber hinaus bevorzugt Mg2+ sehr stark die Koordinationszahl sechs mit weitgehend oktaedrischer Konfiguration, während die sonst in der biologischen Funktion vergleichbaren Ionen entweder zu niedrigeren (Zn2+) oder höheren Koordinationszahlen neigen (Ca2+). Daß jedoch von dieser Regel unter dem “entatischen Streß” durch ein Enzymprotein auch abgewichen werden kann, zeigt das Beispiel der Enolase (14.9).

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  1. Universität Stuttgart, Stuttgart, Deutschland

    Prof. Dr.phil. nat. Wolfgang Kaim & Brigitte Schwederski Ph. D.

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  1. Prof. Dr.phil. nat. Wolfgang Kaim
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  2. Brigitte Schwederski Ph. D.
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© 1995 B. G. Teubner Stuttgart

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Kaim, W., Schwederski, B. (1995). Katalyse und Regulation bioenergetischer Prozesse durch die Erdalkalimetallionen Mg2+ und Ca2+ . In: Bioanorganische Chemie. Teubner Studienbücher Chemie. Vieweg+Teubner Verlag. https://doi.org/10.1007/978-3-322-91893-2_14

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  • DOI: https://doi.org/10.1007/978-3-322-91893-2_14

  • Publisher Name: Vieweg+Teubner Verlag

  • Print ISBN: 978-3-519-13505-0

  • Online ISBN: 978-3-322-91893-2

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