Skip to main content

Part of the book series: Rheinisch-Westfälische Akademie der Wissenschaften ((VN,volume 300))

  • 40 Accesses

Abstract

As all scientific research begins with a question it is of prime importance to the progress of science that the researcher learns to formulate the right kind of question. This has often been stated, for example by Claude Bernard [1] in 1865 in his Introduction to the study of experimental medicine, and more recently by Lehninger [2] in the introductory chapter of his textbook of biochemistry. Generally speaking, it is one of the characteristics of a ‘right’ question that relevant answers can be found on the basis of existing or newly-developed methodologies. Of questions there are myriads, but questions that can be solved and that are worth while solving are much less plentiful. As Peter Medawar [3] has put it, ‘Research is the art of the soluble’, paraphrasing Bismarck [4], who said ‘Politics is the art of the possible’.

This paper is based on a contribution to ‘Molecular Mechanisms of Biological Recognition’ editor Miriam Balaban, Elsevier, Amsterdam 1979, pages 27–40.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bernard, C., Introduction to the study of experimental medicine, 1965.

    Google Scholar 

  2. Lehninger, A. L., Biochemistry, Second Edition, Worth Publishers Inc., 1975.

    Google Scholar 

  3. Medawar, P. B., The art of the soluble, Methuen Co. Ltd., 1967.

    Google Scholar 

  4. Bismarck, O. v. quoted by G. Büchmann, Geflügelte Worte, Auflage 1972, p. 735, Haude und Spener, Berlin.

    Google Scholar 

  5. Dobjansky, T., Amer. Biol. Teacher 35, 125, 1973.

    Article  Google Scholar 

  6. Szent-Gyórgyi, A. v., Z. Physiol. Chem. 236, 1, 1935, and 244, 105, 1936.

    Article  Google Scholar 

  7. Ball, E. G., Biochem. Z. 295, 262, 1938.

    Google Scholar 

  8. Lardy, H. A., Paetkau, V. and Walter, P., Proc. Nat. Acad. Sci., Wash. 53, 1410, 1965.

    Article  Google Scholar 

  9. Krebs, H. A., Gascoyne,, T. and Notton, B. M., Biochem. J. 102, 275, 1967.

    Google Scholar 

  10. Martius, C. and Knoor, F., Z. Physiol. Chem. 246, 1, 1937; 247, 104, 1937 and 242, 1, 1936.

    Google Scholar 

  11. Krebs, H. A. and Henseleit, K., Z. Physiol. Chem. 210, 33, 1932.

    Article  Google Scholar 

  12. Kossel, A. and Dakin, H. D., Z. Physiol. Chem. 41, 321, 1904 and 42, 181, 1904.

    Article  Google Scholar 

  13. Sutherland, E. W., Posternak, T. and Cori, C. F., J. Biol. Chem. 179, 501, 1949.

    Google Scholar 

  14. Greenwald, I., J. Biol. Chem. 63, 339, 1928.

    Google Scholar 

  15. Benesch, R. and Benesch, R. E., Biochem. Biophys. Res. Commun. 26, 162, 1967; Fed. Proc. 29, 1101, 1970; Trends in Biodiem. Sci., June 1978, p. 124.

    Google Scholar 

  16. Krebs, H. A., Biodiem. J. 29, 1951, 1935.

    Google Scholar 

  17. Van Slyke, D. D., Phillips, R. A., Hamilton, P. B., Archibald, R. M., Futcher, P. H. and Holler, A., J. Biol. Chem. 150, 481, 1943.

    Google Scholar 

  18. Krebs, H. A., Bennett, D. A. H., DE Gasquet, P., Gascoyne, T. and Yoshida, T., Biochem. J. 86, 22, 1963.

    Google Scholar 

  19. Goodman, A. D., Fulsz, R. E. and Cahill, G. F., I. Clin. Invest, 45, 612,. 1966.

    Google Scholar 

  20. Krebs, H. A., Biodiem. J. 29, 1620, 1935.

    Google Scholar 

  21. Chévreul, E. C., J. prakt. Chem. 6, 120, 1835.

    Article  Google Scholar 

  22. Fiske, C. H. and Subbarow, Y., Science 67, 129, 1928.

    Article  Google Scholar 

  23. Eggleton, P. and Eggleton, G. P., J. Physiol. 65, 15, 1928.

    Google Scholar 

  24. Miller, J. F. A. P., Marshall, A. H. E. and White, R. G., Advances in Immunol. 2, 111, 1962.

    Article  Google Scholar 

  25. Wurtman, R. J. and Moskowitz, M., New Engl. J. Med. 296, 1329 and 1383, 1977.

    Google Scholar 

  26. Mothes, K., Österreich. Akad. Wissensch. 181, 1, 1973.

    Google Scholar 

  27. Swain, T., Ann. Rev. Plant Physiol. 25, 470, 1977.

    Google Scholar 

  28. Luckner, M., Secondary metabolites in plants and animals, Chapman and Hall, London, 1977.

    Google Scholar 

  29. Mann, J., Secondary Metabolism, Clarendon/Oxford University Press, 1978.

    Google Scholar 

  30. Olson, R. E. and Suttie, J. W., Vitamins and Hormones 35, 59, 1977.

    Google Scholar 

  31. Suttie, J. W. and Jackson, C. N., Physiol. Rev. 57, 1, 1977.

    Google Scholar 

  32. Martius, C. and Nitz-Litzow, D., Biochim. Biophys. Acta 12, 134, 1953 and 13, 152, 1954.

    Article  Google Scholar 

  33. Stenflo, J., J. Biol. Chem. 249, 5527, 1974.

    Google Scholar 

  34. Magnusson, S., Sottrup-Jensen, L., Petersen, T. E., Morris, H. R. and Dell, A., FEBS Lett. 44, 189, 1974.

    Article  Google Scholar 

  35. Chapman, S. K. and Maren, T. H., Biochim. Biophys. Acta 527, 272, 1978.

    Article  Google Scholar 

  36. Holton, G., The scientific imagination, Cambridge Univ. Press, 1978.

    Google Scholar 

  37. Krebs, H. A. and Shelley, J. H. (ed.), The creative process in science, Proc. C. H. Boehringer Sohn Symp., May 1974, Int. Congress Series 355, Excerpta Medica/Amer. Elsevier.

    Google Scholar 

  38. Weiss, P., Science 101, 101, 1945.

    Article  Google Scholar 

  39. Goethe, J. W. V., Maximen und Reflexionen, 1829, Deutscher Taschenbuch Verlag, p. 46, 1963.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Westdeutscher Verlag GmbH Opladen

About this chapter

Cite this chapter

Krebs, H.A. (1981). On asking the right kind of question in biological research. In: On asking the right kind of question in biological research. Neue Aussichten für die Pflanzenzüchtung: Gen-Übertragung mit dem Ti-Plasmid. Rheinisch-Westfälische Akademie der Wissenschaften, vol 300. VS Verlag für Sozialwissenschaften, Wiesbaden. https://doi.org/10.1007/978-3-322-87853-3_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-322-87853-3_1

  • Publisher Name: VS Verlag für Sozialwissenschaften, Wiesbaden

  • Print ISBN: 978-3-531-08300-1

  • Online ISBN: 978-3-322-87853-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics