Abstract
The word “optimal” can have a number of different meanings. It clearly would indicate the best, but to define the best use of antimicrobial drugs is far from simple. What is optimal today may be passé tomorrow. That which is optimal for the moment may be shown to be toxic at some future date. To understand the optimal use of antimicrobial agents, it is necessary to review the indications for which antimicrobial drugs are used (1). Basically there are three forms of antimicrobial drug use. The first is in defined infections in which the pathogenic microorganism has been established by culture or other means of identification such as an unequivocal Gram stain. These infections actually are infrequent. In most situations, antimicrobial use is empiric; that is, the best possible diagnosis of the etiologic pathogens has been made on the basis of clinical and laboratory information available to the physician.
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References
Neu, H. C.: New antibiotics: Areas of appropriate use. Journal of Infectious Diseases 1987, 3: 403–417.
Neu, H. C.: Cephalosporins in the treatment of meningitis. Drugs 1987, 34 (Supplement 2): 135–153.
Scheid, W. M.: Pathogenesis and pathophysiology of pneumococcal meningitis. In: Sande, M. A., Smith, A. L., Root, R. K. (ed.): Bacterial meningitis. Churchill Livingstone, New York, 1985, p. 37–70.
Chodosh, S.: Acute bacterial exacerbations in bronchitis and asthma. American Journal of Medicine 1987, 82 (Supplement 4A): 154–163.
Neu, H. C.: Antimicrobial therapy of gram-negative bacillary pneumonia. In: Respiratory infections. Sande, M. A., Hudson, L. D., Root, R. K. (ed.): Churchill Livingstone, New York, 1986, p. 235–252.
Wilson, W. R., Geraci, J. S.: Treatment of streptococcal infective endocarditis. American Journal of Medicine 1985, 78 (Supplement 6B): 128–137.
Neu, H. C.: Infective endocarditis. In: Cheng, T. O. (ed.): The international textbook of cardiology. Pergamon Press, New York, 1986, p. 788–810.
Gentry, L. O.: Home management of osteomyelitis. Bulletin of the New York Academy of Medicine 1988, 64: 565–569.
Nichols, R. L., Smith, J. W., Klein, D. B.: Risk of infection after penetrating abdominal trauma. New England Journal of Medicine 1984, 311: 1065–1070.
Quintiliani, R., Cooper, B. W., Briceland, L. L., Nightingale, C. H.: Economic impact of streamlining antibiotic administration. American Journal of Medicine 1987, 82 (Supplement 4A): 391–394.
Tolkoff-Rubin, N., Rubin, K. H.: New approaches to the treatment of urinary tract infections. American Journal of Medicine 1987, 82 (Supplement 4A): 270–277.
Andriole, V. T.: Changing treatment patterns in urinary infections. Bulletin of the New York Academy of Medicine 1987, 63: 433–440.
Stamm, W. E.: Problems in the treatment of bacterial sexually transmitted diseases. American Journal of Medicine 1987, 82 (Supplement 4A): 307–310.
Donowitz, M., Wicks, J., Sharp, G. W. G.: Drug therapy for diarrheal disease: a look ahead. Reviews of Infectious Diseases 1986, 8 (Supplement 2): S188–201.
Bennett, J. E.: Rapid diagnosis of candidiasis and aspergillosis. Reviews of Infectious Diseases 1987, 9: 398–402.
Medoff, G.: Controversial areas in antifungal chemotherapy: short course and combination therapy with amphotericin B. Reviews of Infectious Diseases 1987, 7: 403–407.
Meunier, F.: Prevention of mycoses in immunocompromised patients. Reviews of Infectious Diseases 1987, 9:408–416.
Orga, P. L., Volovitz, B.: Diagnosis and treatment of viral infections. Bulletin of the New York Academy of Medicine 1987, 63:475–483.
Kunin, C. M.: Genitourinary tract infections in the patient at risk: extrinsic risk factors. American Journal of Medicine 1984, 76 (Supplement 5A): 131–140.
Neu, H. C.: Chemotherapy of infections. In: Braunwald, E., Isselbacher, K. J., Petersdorf, R. G., Wilson, J. D., Martin, J. B., Fauci, A. S. (ed.): Harrison’s principles of internal medicine. McGraw-Hill, New York, 1987, p. 485–502.
Neu, H. C.: Antimicrobial activity, bacterial resistance, and antimicrobial pharmacology. American Journal of Medicine 1985, 78 (Supplement 6B): 17–22.
Kunin, C. M., Lipton, H. L., Tupsai, T., Sacks, T., Scheckler, W. E., Jivani, A., Goic, A., Martin, R. R., Guerrant, R. L., Thanlikitkul, V.: Social, behavioral, and practical factors affecting antibiotic use worldwide. Reviews of Infectious Diseases. 1987, 9 (Supplement 3): 270–285.
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© 1989 Springer Fachmedien Wiesbaden
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Jackson, G.G., Schlumberger, H.D., Zeiler, H.J. (1989). Optimal Use of Antimicrobial Agents. In: Jackson, G.G., Schlumberger, H.D., Zeiler, H.J. (eds) Perspectives in Antiinfective Therapy. Vieweg+Teubner Verlag, Wiesbaden. https://doi.org/10.1007/978-3-322-86064-4_37
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DOI: https://doi.org/10.1007/978-3-322-86064-4_37
Publisher Name: Vieweg+Teubner Verlag, Wiesbaden
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