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Cell Mediated Immunity, Immunodeficiency and Microbial Infections

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Perspectives in Antiinfective Therapy

Abstract

Mycobacterium tuberculosis, Listeria monocytogenes and Cryptococcus neoformans are frequent infectious agents of the immunocompromised host. Mycobacteria and listeriae are intracellular bacteria capable of residing inside macrophages, whereas cryptococci are extracellular fungi which evade phagocytosis. Host defence against these microbes depends on macrophages and T lymphocytes. Recent studies suggest that besides interferon-7, inter-leukin 4 and interleukin 5 are also capable of activating antimicrobial macrophage functions, and that besides interleukin secreting helper T lymphocytes, cytolytic T lymphocytes also contribute to resistance. This treatise discusses possible interactions between helper T cells, cytolytic T cells, and macrophages in mechanisms of host resistance to microbial pathogens. Furthermore, possible consequences of immunodeficiencies on infections with these agents are examined.

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Authors and Affiliations

  1. Department of Medical Microbiology and Immunology, University of Ulm, Oberer Eselsberg, D-7900, Ulm, Germany

    S. H. E. Kaufmann & I. E. A. Flesch

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  1. S. H. E. Kaufmann
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  2. I. E. A. Flesch
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G. G. Jackson H. D. Schlumberger H. J. Zeiler

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© 1989 Springer Fachmedien Wiesbaden

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Kaufmann, S.H.E., Flesch, I.E.A. (1989). Cell Mediated Immunity, Immunodeficiency and Microbial Infections. In: Jackson, G.G., Schlumberger, H.D., Zeiler, H.J. (eds) Perspectives in Antiinfective Therapy. Vieweg+Teubner Verlag, Wiesbaden. https://doi.org/10.1007/978-3-322-86064-4_21

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  • DOI: https://doi.org/10.1007/978-3-322-86064-4_21

  • Publisher Name: Vieweg+Teubner Verlag, Wiesbaden

  • Print ISBN: 978-3-528-07979-6

  • Online ISBN: 978-3-322-86064-4

  • eBook Packages: Springer Book Archive

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