Abstract
The Control Theory of steady states in “ideal” cells is largely complete. We shall discuss some recent advances in the development of control theory for a more realistic cellular physiology, which includes channelling of metabolites, group relay and signal transduction pathways, as well as hierarchical control systems involving regulated gene expression. With respect to dynamic systems we shall introduce some definitions relevant for the characterization of the control of dynamic systems such as glycolytic oscillations in yeast. These include a control coefficient quantifying the control of the distance from the Hopf bifurcation point, as well as the control exerted by parameters on the amplitudes of the various Fourier components of the sustained oscillations we observe experimentally.
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© 1996 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH, Braunschweig/Wiesbaden
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Westerhoff, H.V. et al. (1996). Control of Dynamics and Steady State: Applications to Multidrug Resistance. In: Ghista, D.N. (eds) Biomedical and Life Physics. Vieweg+Teubner Verlag. https://doi.org/10.1007/978-3-322-85017-1_3
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DOI: https://doi.org/10.1007/978-3-322-85017-1_3
Publisher Name: Vieweg+Teubner Verlag
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Online ISBN: 978-3-322-85017-1
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