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Chiral Aminal Templates. Diastereo- and enantioselectivity in 1,4 (conjugate) and 1,2 Additions with Organometallic reagents

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Organic Synthesis via Organometallics (OSM 4)

Summary

Chiral diamines, with a C2 axis of symmetry, form very easily aminals. These aminals act as very efficient chiral controller on both 1,4 (conjugate) and 1,2 additions to prochiral substrates. Steric control or chelation control may account of the high diastereoselectivity observed in these reactions, according to the organometallic reagent and to the solvent.

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Author information

Authors and Affiliations

  1. Laboratoire de Chimie des Organoéléments, URA CNRS 473, Université P. et M. Curie, Tour 44-45 E2, 4 Place Jussieu, 75252, Paris Cedex 05, France

    Alex Alexakis, Richard Sedrani, Nathalie Lensen & Pierre Mangency

Authors
  1. Alex Alexakis
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  2. Richard Sedrani
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  3. Nathalie Lensen
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  4. Pierre Mangency
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Editor information

Editors and Affiliations

  1. Institut für Organische Chemie, RWTH Aachen, Professor-Pirlet-Str. 1, D-W 5100, Aachen, Federal Republic of Germany

    Dieter Enders  & Hans-Joachim Gais  & 

  2. Institut für Technische Chemie und Petrochemie, RWTH Aachen, Professor-Pirlet-Str. 1, D-W 5100, Aachen, Federal Republic of Germany

    Wilhelm Keim

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© 1993 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH, Braunschweig/Wiesbaden

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Alexakis, A., Sedrani, R., Lensen, N., Mangency, P. (1993). Chiral Aminal Templates. Diastereo- and enantioselectivity in 1,4 (conjugate) and 1,2 Additions with Organometallic reagents. In: Enders, D., Gais, HJ., Keim, W. (eds) Organic Synthesis via Organometallics (OSM 4). Vieweg+Teubner Verlag. https://doi.org/10.1007/978-3-322-84062-2_1

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  • DOI: https://doi.org/10.1007/978-3-322-84062-2_1

  • Publisher Name: Vieweg+Teubner Verlag

  • Print ISBN: 978-3-528-06481-5

  • Online ISBN: 978-3-322-84062-2

  • eBook Packages: Springer Book Archive

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