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Literaturverzeichnis

  • Abel, C. (1989) Laufende Dissertation, Universität Hannover

    Google Scholar 

  • Aeschbacher, M.; Reinhardt, CA.; Zbinden, G. (1986) A rapid cell membrane permeability test using fluorescent dyes and flow cytometry, Cell. Biol. Toxicol. 2(2), pp.: 247–255

    Article  CAS  Google Scholar 

  • Agar, D.W.; Bailey, J.E. (1981) Continuous cultivation of fission yeast: classical and flow microfluorometry observations, Biotechnol. Bioeng., 23, pp.: 2217–2229

    Article  CAS  Google Scholar 

  • Agar, D.W.; Bailey, J.E. (1982) Measurements and models of synchronous growth of fission yeast induced by temperature oscillations, Biotechnol. Bioeng., 24, pp.: 217–236

    Article  CAS  Google Scholar 

  • Ahlmann N. (1985) Entwicklung eines On-line-Meßverfahrens für intrazelluläre Penicillin-G- acylase des E. coli 5K(pHM12)-Hybridstammes, Dissertation, Universität Hannover

    Google Scholar 

  • Ahlmann, N., Niehoff, A., Rinas, U., Scheper, T., Schügerl, K. (1986) Continuous on-line monitoring of intracellular enzyme activity, Anal. Chim. Acta, 190, pp.: 221–226

    Article  CAS  Google Scholar 

  • Aizawa, M.; Kato, S.; Suzuki, S. (1977) Immunoresponsive membrane. I. Membrane potential change associated with an immunochemical reaction between membrane-bound antigen and free antibody; J. Membr. Sci., 2, pp.: 125–132

    Article  CAS  Google Scholar 

  • Aizawa, M.; Watanabe, Y.; Suzuki, S. (1979) Biospecific thermal analyzer coupled with a flowthrough immobilized enzyme column, J. Solid Phase Biochem., 4, pp.: 131–141ET

    CAS  Google Scholar 

  • Alberghina, L.; Mariani, L.; Martegani, E.; Vanoni, M. (1983) Analysis of protein distribution in budding yeast, Biotechnol. Bioeng., 25, pp.: 1295–1310

    Article  CAS  Google Scholar 

  • Albery, W.J.; Bartlett, P.N. (1984) Anorganic conductor electrode for the oxidation of NADH, J. Chem. Soc., Chem. Commun., pp.: 234–236

    Google Scholar 

  • Albery, W.J.; Craston, D.H. (1987) Amperometric enzyme electrodes: theory and experiments in: Biosensors - Fundamentals and Applications (eds.: A.P.F. Turner, I. Karube, G.S. Wilson, Oxford Science Publication, Oxford, pp.: 180–210 )

    Google Scholar 

  • Alford, J.S. (1978) Modelling Cell Concentration in Complex Media, Biotechnol. Bioeng., 20, pp.: 1873–1881

    Article  CAS  Google Scholar 

  • Anders, K.-D. (1988) Kulturfluoreszenzmessungen an immobilisierten Zellen, Diplomarbeit, Universität Hannover

    Google Scholar 

  • Anders, K.D. (1989) Laufende Dissertation, Universität Hannover

    Google Scholar 

  • Anders, K.D.; Müller, W.; Scheper, T. (1989) Messung der NADH-abhängigen Kulturfluoreszenz zur Detektion toxischer Verbindungen, GWF Wasser-Abwasser, 130,(3), Biotechnologie pp.: 15–20

    Google Scholar 

  • Andrade, J.D.; Vanwagenen, RA.; Gregonis, D.E.; Newby, K.; Lin, J.-N. (1985) Remote fiberoptic biosensors based on evanescent-excited fluoro-immunoassay: concept and progress, IEEE Transactions on Electon. Dev., 32(7), pp.: 1175–1179

    Article  Google Scholar 

  • Anonymus (1988) Die sensiblen Schnüffler; Wirtschaftswoche, 35, pp.: 82–85

    Google Scholar 

  • Anzai, J.; Ohki, Y.; Osa, T.; Nakajima, H.; Matsuo, T. (1985) Urea sensor based on an ion sensitive field effect transistor. II. Effects of buffer concentration and pH on the Potentiometrie response; Chem. Pharm. Bull., 33 (6), 2556–59

    Article  CAS  Google Scholar 

  • Anzai, J.; Tezuka, S.; Nakjima, H.; Osa, T.; Matsuo, T. (1987) Urea sensor based on an ion sensitive field effect transistor. IV. Determination of urea in human blood; Chem. Pharm. Bull., 35 (2), 693–98

    Article  CAS  Google Scholar 

  • Anzai, J.; Tezuka, S.; Osa, T.; Nakajima, H.; Matsuo, T. (1986) Urea sensor based on an ion sensitive field effect transistor. III. Effects of enzyme load and ionic strength on the Potentio¬metrie response; Chem. Pharm. Bull., 34 (10), 4373–76

    Article  CAS  Google Scholar 

  • Arminger, W.B.; Forro, J.R.; Montalvo, L.M.; Lee, J.F. (1986) The interpretation of on-line process measurements of intracellular NADH in fermentation processes, Chem. Eng. Commun. 45, pp. 197–206

    Article  Google Scholar 

  • Arminger, W.B.; Lee, J.F.; Montalvo, L.M.; Forro, J.R. (1985) Fed batch control based upon the measurement of intracellular NADH, Proceedings: 190th ACS Meeting, Chicago, MBTD 40

    Google Scholar 

  • Arnold, MA., Meyerhoff, M.E. (1988) Recent Advances in the Development and Analytical Applications of Biosensing Probes, CRC Crit. Rev. Anal. Chem. 20(3), pp.: 149–196

    Article  CAS  Google Scholar 

  • Arnold, MA.; Meyerhoff, M.E. (1984) Ion-Selective Electrodes, Anal. Chem., 56, 20R–48R

    Article  CAS  Google Scholar 

  • Arnold, MA.; Meyerhoff. M.E. (1988) Recent advances in the development and analytical application of biosensing probes, CRC Crit. Rev. Anal. Chem., 20(3), pp.: 149–196

    Article  CAS  Google Scholar 

  • Arnold, MA.; Ostler, T.J. (1986) Fiber optic ammonia gas sensing probe, Anal. Chem. 58, pp.: 1137–1140

    Article  CAS  Google Scholar 

  • Arnold, MA.; Rechnitz, GA. (1987) Biosensors based on plant und animal tissue, in: Biosensors - Fundamentals and Applications (eds.: A.P.F. Turner, I. Karube, G.S. Wilson, Oxford Science Publication, Oxford, pp.: 30–59

    Google Scholar 

  • Arnold, MA.; Solsky, R.L. (1986) Ion-Selective Electrodes, Anal. Chem., 58, 84R–101R

    Article  CAS  Google Scholar 

  • Arthur, C.L.; Dhaliwai, G.K.; Thompson, M. (1986) Liquid phase piezoelectric and acoustic transmission studies of interfacial immunochemistry. Nal. Chem. 58, pp.: 1206–1209

    Google Scholar 

  • Arwin, H.; Lundström, I.; Palmquist, A. (1982) Electrode adsorption method for determination of enzymatic activity, Med. Biol. Eng. Comput., 20, pp.: 362–374

    Article  CAS  Google Scholar 

  • Attridge, J.W.; Leaver, K.D.; Cozens, J.R. (1987) Design of a fibre-optic sensor with rapid response, J. Phys. E. Sci. Inst., 20(5), pp.: 548

    Article  CAS  Google Scholar 

  • Axe, D.D.; Bailey, J.E. (1987) Application of P nuclear magnetic resonance spectroscopy to investigate plasmid effects on Escherichia coli metabolism, Biotechnol. Lett. 9(2), pp.: 83–88

    Google Scholar 

  • Bailey, J.E.; Fazel-Madjlessi, J.; McQuitty, D.N.; Lee, L.Y.; Oro, JA. (1978) Measurement of structured microbial population dynamics by flow microfluorometry, AlChE J., 24 (4), pp.: 570–577

    Article  CAS  Google Scholar 

  • Bailey, J.E.; Ollis, D.F. (1986) Biochemical Engineering Fundamentals, 2nd ed., McGraw Hill, New York

    Google Scholar 

  • Ballarin-Denti, A.; den Hollander, JA.; Sanders, D.; Slayman, C.W. (1984) Kinetics and pH-Dependence of Glycine-Proton Symport in Saccharomyces cerevisiae, Biochim. Biophys. Acta, 778, pp.: 1–16

    Article  CAS  Google Scholar 

  • Barker, A.S. (1987) Immobilization of biological components of biosensors, in: Biosensors - Fundamentals and Applications (eds.: A.P.F. Turner, I. Karube, G.S. Wilson, Oxford Science Publication, Oxford, pp.: 85–99

    Google Scholar 

  • Barker, S A. (1987) Immobilization of the biological component of biosensors in: Biosensors - Fundamentals and Applications (eds.: A.P.F. Turner, I. Karube, G.S. Wilson, Oxford Science Publication, Oxford, pp.: 85–99

    Google Scholar 

  • Battye, F.L.; Darling, W.; Beall, J. (1985) A Fast Cell Sampler for Flow Cytometry, Cytometry, 6, pp.: 492–495

    Article  CAS  Google Scholar 

  • Bayer, T. (1987) Reaktionstechnische Untersuchungen zur Produktion von Cephalosporin C im Mammutschlaufenreaktor, Dissertation, Universität Hannover

    Google Scholar 

  • Beisker, W. (1984) Selbstkorrigierende Fluoreszenzdepolarisationsmessung zur Strukturuntersuchung von Nukleinsäuren, Disseration, Universität Hannover, GSF-Bericht AO-415

    Google Scholar 

  • Belghith, H.; Romette, J.-L.; Thomas, D. (1987) An Enzyme electrode for on-line determination of ethanol and methanol, Biotecchnol. Bioeng., 30, 1001–1005

    Article  CAS  Google Scholar 

  • Benaim, N.; Grattan, K.T.V.; Palmer, A.W. (1986) Simple fibre optic pH sensor for use in liquid titrations, Analyst 111, pp.: 1095–1097

    Article  CAS  Google Scholar 

  • Bennetto, H.P.; Box, J.; Delaney, G.M.; Mason, J.R.; Roller, S.D.; Stirling, J.L.; Thurston, C.F. (1987) Redox-Mediated Electrochemistry of Whole Micro-Organisms: From Fuel Cells to Biosensors, in: Biosensors (eds. Turner, A.P.F.; Karube, I.; Wilson, G.S.) pp.: 291–314, Oxford Science Publications, Oxford

    Google Scholar 

  • Berg, P.; Näbauer, T.; Weinauer, T. (1988) Biosensoren, Sensor Magazin, 5, pp.: 16–19

    Google Scholar 

  • Berglund, D.L.; Taffs, R.E.; Robertson, N.P. (1987) A Rapid Analytical Technique for Flow Cytometric Anlysis of Cell Viability Using Calcofluor White M2R, Cytometry 8, pp.: 421–426

    Article  CAS  Google Scholar 

  • Bergmeyer, H.U. (1974) Methoden der enzymatischen Analyse (I und II ), Verlag Chemie, Weinheim

    Google Scholar 

  • Bergveld, P. (1989) Exploiting the dynamic properties of FET-based chemical sensors, J. Phys. E: Sci. Instr., 22, pp.: 678–683

    Article  CAS  Google Scholar 

  • Besch, W.K.; Schmidt, B.W.; Mayer, E. (1987) Toxizitätstest mit Goldorfe und Zebrabärbling zu Durchführung zur Aussagekraft von Toxizitätstests mit der Goldorfe (Levciscus Idus) und dem Zebrabärbling (Brachydanio rerio), Wassergefährdende Stoffe, 5,5. Ergänzung, Kap. 3. 1

    Google Scholar 

  • Betteridge, D.; Courtney, N.G.; Sly, TJ.; Porter, D.G. (1984) Development of a flow injection analyser for post column detection of sugars separated by high performance liquid chromatography, Analyst (London), 109, pp. 19–21

    Article  Google Scholar 

  • Betz, A.; Chance, B. (1965) Influence of inhibitors on the oscillation of reduced pyridine nucleotides in yeast cells, Arch. Biochem. Biophys. 109, pp.: 759–584

    Google Scholar 

  • Beyeler, W.; Einsele, A.; Fiechter, A. (1981) Online measurements of culture fluorescence: method and application, Eur. J. Appl. Microbiol. Biotechnol., 13, pp.: 10–14

    Article  CAS  Google Scholar 

  • Beyeler, W.; Gschwend, K.; Fiechter, A (1983) In-situ Fluorometrie: Eine neue Methode zur Charakterisierung von Bioreaktoren, Chem. Ing. Tech., 55 (5) pp.: 869–871

    CAS  Google Scholar 

  • Bezegh, K.; Petelenz, D.; Bezegh, A.; Janata, J. (1987) Integrated solid state probe for determination of activity of sodium chloride, Anal. Chem., 59, pp.: 1423–1425

    Article  CAS  Google Scholar 

  • Birnbaum, S.; Bülow, L.; Danielsson, B.; Hardy, K.; Mosbach, K. (1986) Rapid automated analysis of human proinsulin produced by Escherichia coli, Anal. Biochem., 157

    Google Scholar 

  • Birou, B.; Marison, I.W.; von Stockar, U. (1987) Calorimetric Investigation of Aerobic Fermentations, Biotechnol. Bioeng. 30, pp.: 650–660

    Article  CAS  Google Scholar 

  • Birou, B.; von Stockar, U. (1989) Application of bench-scale calorimetry to chemostat cultures, Enzyme Microb. Technol., 11, pp.: 12–16

    Article  CAS  Google Scholar 

  • Blackburn, G.F. (1987) Chemically sensitive field effect transistors, in: Biosensors - Fundamentals and Applications (eds.: A.P.F. Turner, I. Karube, G.S. Wilson, Oxford Science Publication, Oxford, pp.: 481–530

    Google Scholar 

  • Blake-Coleman, B.C.; Calder, M.R.; Carr, R J.G.; Moody, S.C. (1986) Determination of Reactor Biomass by Acoustic Resonance Densitometry, Biotechnol. Bioeng. 28, pp.: 1241–1249

    Article  CAS  Google Scholar 

  • Blake-Coleman, B.C.; Calder, M.R.; Carr, RJ.G.; Moody, S.C.; Clarke, DJ. (1984) Direct Monitoring of Reactor Biomass in Fermentation Control, Trends in Anal. Chem., 3 (9), pp.: 229–235

    Article  Google Scholar 

  • Blute, T.; Gillies, R J.; Dale, B.E. (1988) Cell density measurements in hollow fiber bioreactors, Biotechnol. Prog. 4 (4), pp.: 202–209

    Article  Google Scholar 

  • Boisdé, G.; Per6z, JJ. (1987) Miniature chemical optical fiber sensors for pH measurements, SPIE-Int. Soc. Opt. Eng., 798, pp.: 238

    Google Scholar 

  • Borman, S. (1981) Optrodes, Anal. Chem., 53 (14), pp. 1616A–1618A

    Google Scholar 

  • Borman, S . (1987) Optical and piezoelectrical biosensors, Anal. Chem., 59(19), pp.: 1161–1164

    Google Scholar 

  • Bowers, L.D.; Carr, P.W.; Canning, L.M.; Sayers, C.N.; Carr, P.W. (1976) Rapid flow-enthalpimetric determination of urea in serum with use of an immobilized urease reactor, Clin. Chem. 22, pp.: 1314–1318

    Google Scholar 

  • Bowers, L.D.; Carr, P.W. (1976) Immobilized-enzyme flow-enthalpimetric analyzer: application to glucose determination by direct phosphorylation catalyzed by hexokinase, Clin. Chem., 22, pp.: 1427–1433

    CAS  Google Scholar 

  • Boyer, P.M.; Humphrey, A.E. (1988) Fluorometrie behaviour of phenol fermentation, Biotechnol. Let. 2 (3), pp.: 193–198

    Google Scholar 

  • Bradley, J.; Kidd, A J.; Anderson, PA..; Dear, A.M.; Ashby, R.E.; Turner, A.P.F. (1989a) Rapid determination of the glucose content of molasses using a biosensor, Analyst, 114, pp.: 375–379

    Google Scholar 

  • Bradley, J.; Turner, A.P.F.; Schmid, R.D. (1989b) An in situ fermenter probe for bakers yeast propagation monitoirng, in: Biosensors - Applications in medicine, environmental protection and process control (eds.: R.D. Schmid, F. Scheller) GBF-Monographs, 13, Verlag Chemie, Weinheim

    Google Scholar 

  • Brand, U. (1989) Laufende Dissertation, Universität Hannover

    Google Scholar 

  • Brand, U.; Reinhardt, B.; Rüther, F.; Scheper, T.; Schügerl, K. (1989) Development of sensor systems based on enzyme modified field effect transistors for process control in biotechnology; GBF-Monographien (ed. R.D. Schmid), Vol. 13, VCH-Verlag Weinheim, pp.: 127–136

    Google Scholar 

  • Brand, U.; Reinhard, B.; Rüther, F.; Scheper, T.; Schügerl, K. (1989) Development of sensor systems based on enzyme-modified field-effect transistors for process control in biotechnology, GBF-Monographien (eds. R.D. Schmid, F. Scheller ), Vol. 13, 127–136

    Google Scholar 

  • Brand, U.; Scheper, T.; Schügerl, K. (1989) A penicillin G sensor based on penicillin amidase coupled to a field effect transistor; Anal. Chim. Acta, 226, pp.: 87–97

    Article  CAS  Google Scholar 

  • Braunegg, G.; Sonnleitner, B.; Lafferty, R.M.; (1978) A rapid gas chromatographic method for the determination of poly-hydroxybutyric acid in microbial biomass, Eur. J. Appl. Microbiol. Biotechnol., 6, pp.: 25

    Article  Google Scholar 

  • Brodelius, P.; Vogel, H. (1985) A Phosphorus-31 Nuclear Magentic Resonance Study of Phosphate Uptake and Storage in Cultured Catharanthus roseus and Daucus carota plant cells, J. Biol. Chem. 260(6), pp.: 3556–3560

    CAS  Google Scholar 

  • Brooks, S.L.; Ashby, R.E.; Turner, A.P.F.; Calder, M.R.; Clarke, DJ. (1987/88) Development of an online glucose sensor for fermentation monitoring, Biosensors, 3, pp.: 45–56

    Article  CAS  Google Scholar 

  • Brunt, K. (1982) Comparison between the performances of an electrochemical detector flow cell in a Potentiometrie and an amperometric measuring system using glucose as a test compound, Analyst (London), 107, 1261–1263

    Article  CAS  Google Scholar 

  • Busch, M. (1989) Kulturfluoreszenzmessungen an immobilisierten Zellsystemen, Diplomarbeit, Universität Hannover

    Google Scholar 

  • Bückmann, A.F. (1987) A new synthesis of ceenzymatically active water-soluble macromolecular NAD and NADP derivatives, Biocatalysis, 1, pp.: 173

    Article  Google Scholar 

  • Cady, P. (1975) Rapid automated bacterial identification by impedance measurements, in: New approaches to identification of microorganisms (eds.: Heden, C.-G., Illene, T.) John Wiley and Sons, New York, pp.: 73–99

    Google Scholar 

  • Cain, A J. (1947) The use of Nile Blue in the examination of lipoids, Q J.M.S., 88(3), pp.: 383–392

    Google Scholar 

  • Cannings, L.M.; Carr, P.W. (1975) Rapid thermochemical analysis via immobilized enzyme reactors, Anal. Lett., 8(5), pp.: 359–367

    Article  Google Scholar 

  • Caras, S.; Janata, J. (1980) Field-effect transistor sensitive to penicillin; Anal. Chem., 52, 1935–37

    Article  CAS  Google Scholar 

  • Caras, S.; Janata, J. (1985) pH-based enzyme Potentiometrie sensors. Part 3. Penicillin-sensitive field effect transistor; Anal. Chem., 57,1924–25

    Article  CAS  Google Scholar 

  • Caras, S.D.; Petelenz, D.; Janata, J. (1985) pH-based enzyme Potentiometrie sensors. Part 2. Glucose-sensitive field effect transistor; Anal. Chem., 57,1920–23

    Article  CAS  Google Scholar 

  • Cass, A.E.G.; Davis, G.; Francis, G.D.; Hill, H.A.O.; Aston, W.J.; Higgins, IJ.; Plotkin, E.V.; Scott, L.D.L., Turner, A.P.F. (1984) Ferrocene-mediated enzyme electrode for amperometric determination of glucose, Anal. Chem., 56, 667–671

    Article  CAS  Google Scholar 

  • Cass, A.E.G.; Ribbons, D.W.; Rossiter, J.T.; Williams, S.R. (1987) Biotransformation of aromatic compounds, FEBS Lett. 220 (2), pp. 353–357

    Article  CAS  Google Scholar 

  • Chance, B.; Estabrook, R.W.; Gosh, A. (1964) Damped sinusoidal oscillations of cytoplasmic reduced pyridine nucleotide in yeast cells, Proc. Natl. Acad. Sci. 51, pp.: 1244–1251

    Article  CAS  Google Scholar 

  • Chapman, A.G.; Atkinson, D.E. (1977) Adenine Nucleotide Concentrations and Turnover Rates. Their Correlation with Biological Activity in Bacteria and Yeast, in: Advances in Microbial Physiology (eds. Rose, A.H.; Tempest, D.W.), Vol. 15, Academic Press, London, pp.: 253–306

    Google Scholar 

  • Cheung, P.W:; Fleming, D.G.; Neuman, M.R.; Wen, H.K. (1977) Theory, design and biochmical applications of solid state chemical sensors, CRC Press, Palm Beach

    Google Scholar 

  • Chotani, G.; Constantinides, A. (1982) Online glucose analyzer for fermentation applications, Biotechnol. Bioeng. 24, pp.: 2743–2745

    Article  CAS  Google Scholar 

  • Clark, L.L.; Lyons, C. (1962) Electrode system for continuous monitoring in cardiovascular surgery, N.Y. Acad. Sci. 102, pp.: 29–45

    Article  CAS  Google Scholar 

  • Clarke, DJ.; Blake-Coleman, B.C.; Carr, RJ.G.; Calder, M.R.; Atkinson, T. (1986) Monitoring Reactor Biomass, Trends Biotechnol., 4 (7) pp.: 173–178

    Article  CAS  Google Scholar 

  • Clarke, DJ.; Blake-Coleman, B:C.; Calder, M.R. (1987) Principles and potential of piezo-electric transducers and acoustical techniques, in: Biosensors - Fundamentals and Applications (eds.: A.P.F. Turner, I. Karube, G.S. Wilson, Oxford Science Publication, Oxford, pp.: 551–571

    Google Scholar 

  • Clarke, DJ.; Calder, M.R.; Carr, RJ.G.; Blake-Coleman, B.C.; Moody, S.C.; Collinge, TA. (1985) The development and application of biosensing devices for bioreactor monitoring and control, Biosensors, 1, pp.: 213–320

    Article  CAS  Google Scholar 

  • Clarke, DJ.; Kell, D.B.; Morris, J.G.; Burns, A. (1982) The role of ion-selective electrodes in microbial process control, Ion-selective Electorde Rev., 4, pp.: 75–131

    CAS  Google Scholar 

  • Cleland, N.; Enfors, S.O. (1983) Control of glucose-fed batch cultivations of E. coli by means of an oxygen stabilized enzyme electrode, Eur. J. Appl. Microbiol. Biotechnol., 18, pp.: 141–147

    Article  CAS  Google Scholar 

  • Cleland, N.; Enfors, S.O. (1984) Externaly buffered enzyme electrode for determination of glucose, Anal. Chem., 56, pp.: 1880–1884

    Article  CAS  Google Scholar 

  • Collins, S.; Janata, J. (1982) A critical evaluation of the mechanism of potential response of antigen polymer membranes to the corresponding antiserum; Anal. Chim. Acta, 136, pp.: 93–99

    Article  CAS  Google Scholar 

  • Cooney, C.L. (1981) Growth of Microorganisms, in: Biotechnology (eds.: Rehm, HJ.; Reed, G.), Vol. 1, pp.: 73–112, Verlag Chemie, Weinheim

    Google Scholar 

  • Cooney, C.L.; Wang, H.Y.; Wang, D.I.C. (1977) Computer-aided Material Balancing for Prediction of Fermentation Parameters, Biotechnol. Bioeng., 19, pp.: 55–67

    Google Scholar 

  • Cooney, C.L.; Weaver, J.C.; Tannenbaum, S.R.; Faller, D.V.; Shields, A.; Jahnke, M. (1974) The thermal enzyme probe - a novel approach to chemical analysis, in: Enzyme Engineering (eds: E.K. Pye, L.B. Wingard, Jr.), 2, pp.: 411–417, Plenum, New York

    Google Scholar 

  • Coonrod, J.D.; Kunz, L J.; Ferraro, M J. (eds.) (1983) The Direct Detection of Microorganisms in Clinical Samples, Academic Press, London

    Google Scholar 

  • Crissman, HA.; Steinkamp, JA. (1982) Rapid, one step staining procedures for analysis of cellular DNA and protein by single and dual laser flow cytometry, Cytometry, 3 (2), pp.: 84–90

    Article  CAS  Google Scholar 

  • Cryer, D.R.; Eccleshall, R.; Marmur, J. (1975) Isolation of Yeast RNA, Meth. Cell. Biol. 12, pp.: 39–40

    Google Scholar 

  • Cuypers, PA.; Hermens, W.Th, Hemker, H.C. (1978) Ellipsometry as a tool to study protein films at liwuid-solid interfaces, Anal. Biochem. 84, pp.: 56–67

    Article  CAS  Google Scholar 

  • Czaban, J.D. (1985) Electrochemical sensors in clinical chemistry: Yesterday, today, tomorrow, Anal. Chem., 57(2), pp.: 345A–356A

    Google Scholar 

  • Danielsson, B. (1976) Determination of urea with an enzyme thermistor using immobilized urease. Anal. Lett. 9, pp.: 987–1001

    Google Scholar 

  • Danielsson, B.; Gadd, K.; Mattiasson, B.; Mosbach, K. (1977) Enzyme thermistor determination of glucose in serum using immobilized glucose oxidase, Clin. Chim. Acta. 81, pp.: 163–175

    Article  CAS  Google Scholar 

  • Danielsson, B.; Mandenius, C.F.; Winquist, F.; Mattiasson, B- Mosbach, K. (1980) Fermentation monitoring and control by enzyme thermistor, Proc 5 Internat. Fermen. Symp., London, Canada, July 20–25

    Google Scholar 

  • Danielsson, B.; Mattiasson, B.; Mosbach, K. (1981) Enzyme thermistor devices and their analytical applications, Appl. Biochem. Bioeng., 3, pp. 97–143

    CAS  Google Scholar 

  • Danielsson, B.; Mattiasson, B.; Karlsson, R.; Winquist, F. (1979) Use of an enzyme thermistor in continuous measurements and enzyme reactor control, Biotechnol. Bioeng. 21, pp.: 1749–1766

    Article  CAS  Google Scholar 

  • Danielsson, B.; Mosbach, K. (1979) Determination of enzyme activities with the enzyme thermistor unit, FEBS Lett., 101, pp. 47–50

    Article  CAS  Google Scholar 

  • Danielsson, B.; Mosbach, K. (1987) Theory and applications of calorimetric sensors, in: Biosensors - Fundamentals and Applications (eds. A.P.F: Turner, I. Karube, G.S. Wilson), Oxford Science Publications, Oxford, pp.: 575–597

    Google Scholar 

  • Danielsson, B.; Rieke, E.; Mattiasson, B.; Winquist, F.; Mosbach, K. (1981) Determiantion by the enzyme thermistor of cellobiose formed on degradation of cellulose, Appl. Biochem. Biotechnol., 6, pp.: 207–222

    Article  CAS  Google Scholar 

  • Danielsson, B.; Winquist, F. (1987) Biosensors based on semiconductor gas sensors in: Biosensors - Fundamentals and Applications (eds.: A.P.F. Turner, I. Karube, G.S. Wilson, Oxford Science Publication, Oxford, pp.: 531–548

    Google Scholar 

  • de Mola, A.H.; Marx-Figini, M.; Figini, R.V.I. (1975) Molecular weight distribution of native poly-hydroxybutyric acid, Makromol. Chemie, 176, pp.: 1469–1475

    Google Scholar 

  • Decristoforo, G.; Danielsson, B. (1984) Flow injection analysis with enzyme thermistor detector for automated determination of beta-lactams, Anal. Chem. 56, pp.: 263–268

    Article  CAS  Google Scholar 

  • Decristoforo, H. (1988) Flow-injection analysis for automated determination of ß-lactams using immobilized enzyme reactors with thermistor or ultraviolet spectrophotometric detection in Immobilized enzymes and ceils. Part D, Methodes in Enzymology (eds.: S.P. Colowick, N.O. Kaplan), 137, Academic Press, Orlando

    Google Scholar 

  • den Hollander, JA.; Ugurbil, K.; Brown, T.R.; Shulman, R.G. (1981) Phosphorus-31 nuclear magnetic resonance studies of the effect of oxygen upon glycolysis in yeast, Biochemistry 20, pp.: 5871–5880

    Article  Google Scholar 

  • Dennis, K.; Srienc, F.; Bailey, J.E. (1983) Flow Cytometry Analysis of Plasmid Heterogeneity in Escherichia coli Populations, Biotechnol. Bioeng. 25, pp.: 2485–2490

    Google Scholar 

  • Dennis, K.; Srienc, F.; Bailey, J.E. (1985) Ampicillin Effects on Five Recombinant Escherichia coli Strains: Implications for Selection Pressure Design, Biotechnol. Bioeng. 27, pp.: 1490–1494

    Article  CAS  Google Scholar 

  • Dermoun, Z.; Beiaich, J.P. (1979) Microcalorimetric study of Escherichia coli aerobic growth: kinetics and experimental enthalpy associated with growth on succinic acid, J. Bacteriol., 140 (2) pp.: 377–380

    Google Scholar 

  • Djavan, A.; James, A.M. (1980) Determination of the maintenance energy of Klebsiella aerogenes growing in contiuous culture, Biotechnol. Let., 2, pp.: 303–308

    Article  CAS  Google Scholar 

  • Doelle, H.W. (1978) Fermentation, in: Bacterial metabolism, 2nd. edition, Academic Press, New York

    Google Scholar 

  • Doran, P.M.; Bailey, J.E. (1987) Effects of immobilization on the nature of glycolytic oscillations in yeast, Biotechnol. Bioeng., 29, pp.: 892–897

    Article  CAS  Google Scholar 

  • Drake, J.F.; Tsuchiya, H.M. (1973) Differential Counting in Mixed Cultures with Coulter Counters, Appl. Microbiol., 26 (1), pp.: 9–13

    Google Scholar 

  • Drury, D.D. (1988) Oxygen Transfer Properties of a Bioreactor for use within a nuclear magne-tic resonance spectrometer, Biotechnol. Bioeng. 32, pp.: 966–974

    Google Scholar 

  • Dullau, T. (1989) Laufende Doktorarbeit, Universität Hannover

    Google Scholar 

  • Duysens, L.N.M., Amesz, J. (1957) Fluorescence spectrophotometry of reduced phospho- pyridine nucleotide in intact cell in the near-ultraviolet and visible region, Biochim. Biophys. Acta, 24, pp.: 19–26

    Article  CAS  Google Scholar 

  • Eddowes, M J.; Pedley, D.G.; Webb, B.C. (1985) Response of an enzyme-modified pH-sensitive ion-selective device. Experimental study of a glucose oxidase-modified ion-sensitive field effect tranistor in buffered and unbuffered aqueous solution; Sensors and Actuators 7, pp.: 233–244

    Article  CAS  Google Scholar 

  • Edmonds, T.E.; Flatters, N J.; Jones, C.F.; Miller, J.N. (1988) Determination of pH with acid-base indicators: implications for optical fibre probes, Talanta, 35(2), pp.: 103–107

    Article  CAS  Google Scholar 

  • Edmonds, T.E.; Ross, I.D. (1985) Low-cost fibre optic chemical sensors, Anal. Proc., 22, pp.: 206

    Google Scholar 

  • Eghtessadi, Fariba (1989) Laufende Diplomarbeit, Universität Hannover

    Google Scholar 

  • Einsele, A.; Ristroph, D.L.; Humphrey, A.E. (1978) Mixing times and glucose uptake measured with a fluorometer, Biotechnol. Bioeng., 20, pp.: 1487–1492

    Article  CAS  Google Scholar 

  • Einsele, A.; Ristroph, D.L.; Humphrey, A.E. (1979) Substrate uptake mechanisms for yeast cells. A new approach utilizing a fluorometer, Eur. J. Appl. Microbiol. Biotechnol., 6. pp.: 335–339

    Article  CAS  Google Scholar 

  • Eisert, W.G. (1980) Automatische Cytometrie, Habilitationsschrift, GSF-Bericht BT-537

    Google Scholar 

  • Enfors, S.O. (1987) Compensated enzyme-electrodes for in situ process control, in: Biosensors - Fundamentals and Applications (eds.: A.P.F. Turner, I. Karube, G.S. Wilson, Oxford Science Publication, Oxford, pp.: 347–355

    Google Scholar 

  • Enfors, S.O.; Molin, N.L.; Mosbach, K.H.; Nilsson, HJ. (1977) Enzyme electrode, US-Patent, No. 4,024,042,17. May

    Google Scholar 

  • Enfors, S.O.; Nilsson, H. (1979) Design and response characteristics of an enzyme electrode for measurement of penicillin in fermentation broth, Enzyme Microb. Technol., 1, pp.: 260–264

    Article  CAS  Google Scholar 

  • Fazel-Madjlessi, J.; Bailey, J.E. (1979) Analysis of fermentation processes using flow microfluorometry: single parameter observations of batch bacterial growth, Biotechnol. Bioeng., 21, pp.: 1995–2010

    Article  CAS  Google Scholar 

  • Fazel-Madjlessi, J.; Bailey, J.E. (1980) Analysis of fermentation processes using flow microfluorometry: amylase and protease activities in Bacillus subtilis batch cultures, Biotechnol. Bioeng., 22, pp.: 1657–1669

    Article  CAS  Google Scholar 

  • Fazel-Madjlessi, J.; Bailey, J.E.; McQuitty, D.N.; (1980) Flow microfluorometry measurements of multicomponent cell composition during batch bacterial growth, Biotechnol. Bioeng., 22, pp.: 457–462

    Google Scholar 

  • Fenge, C. (1989) Laufende Dissertation, Universität Hannover

    Google Scholar 

  • Fernandez, E J.; Clark, D.S. (1987) N.M.R. Spectroscopy: a Non-invasive Tool for Studying Intracellular Processes, Enzyme Microb. Technol., 9, pp.: 259–271

    Article  CAS  Google Scholar 

  • Fernandez, E J.; Mancuso, A.; Clark, D.S. (1988) NMR spectroscopy studies of hybridoma metabolism in a simple membrane reactor, Biotechnol. Prog. 4(3), pp.: 173–183

    Article  CAS  Google Scholar 

  • Fiechter, A. (1981) Regulatory aspects in yeast metabolism, Adv. biotechnol (eds.: Moo-Young, Campbell und Vezina), Pergamon Press, Toronto, Vol. 1, pp.: 261–266

    Google Scholar 

  • Fiechter, A.; Fuhrmann, G.F.; Kaeppeli, O. (1981) Regulation of glucose metabolism in growing yeast cells, Adv. Microb. Physiol., 22, pp.: 123–184

    Google Scholar 

  • Finguerut, J.; Guarda, E.T.L.; Camargo, E. (1978) Influence of the Growth on the Spectrophotometric Determination of the Yeast Concentration in Liquid Hydrocarbon Fermentations, Biotechnol. Bioeng., 20, pp.: 1285–1286

    Article  CAS  Google Scholar 

  • Finkeldey, T. (1987) Entwicklung eines Fließinjektionssystems zur Analyse biotechnologischer Medien, Diplomarbeit, Universität Hannover

    Google Scholar 

  • Firley, A. (1983) Kultivierung von Escherichia coli 5K (pHM12) zur Bildung von Penicillin-G- acylase, Diplomarbeit, Universität Hannover

    Google Scholar 

  • Fischer, W. (1989) Entwicklung eines Toxin-Guard-Systems auf der Basis eines Enzym-thermistors, Diplomarbeit, Universität Hannover

    Google Scholar 

  • Fleischaker, R J.; Weaver, J.C.; Sinskey, A J. (1981) Instrumentation for Process Control in Cell Culture, Advances in Applied Microbiol., 27, pp.: 137–167

    Article  CAS  Google Scholar 

  • Forro, J.R.; Maenner, G.F.; Armiger, W.B. (1984) Monitoring cell activity by use of the culture fluorescence, Proceedings: 188th ACS National Meeting, Philadelphia, MBTD 79

    Google Scholar 

  • Forsberg, C.W.; Lam, K. (1977) Use of Adenosine 5’-Triphosphate as an Indicator of Microbiota Biomass in Rumen Contents, Appl. Env. Microbiol., 33 (3) pp.: 528–537

    CAS  Google Scholar 

  • Fowler, S.D.; Greenspan, P. (1985) Application of Nile Red, a fluorescent hydrophobic probe for the detection of neutral lipid deposits in tissue sections, J. Histochem. Cytochm., 33, pp.: 833–836

    Google Scholar 

  • Foxall, D.L.; Cohen, J.S. (1983) NMR studies of perfused cells, J. Mag. Res. 52, pp. 346–349

    CAS  Google Scholar 

  • Freitag, R. (1989) Entwicklung und Automatisierung immunchemischer Nachweisverfahren zur On-line-Detektion hochmolekularer Medienkomponenten in Fermentationsprozessen, Dissertation, Universität Hannover

    Google Scholar 

  • Fuh, M.R.S. (1987) Single fibre optic fluorescence pH probe, Analyst 112, pp.: 1159–1162

    Article  CAS  Google Scholar 

  • Fuh, M.R.S.; Burgess, L.W.; Christian, G.D. (1988) Single Fiber-optic fluorescence enzyme-based sensor, Anal. Chem. 60, pp.: 433–435

    Google Scholar 

  • Fulton, S.P.; Cooney, C.L. Weaver, J.C. (1980) Thermal enzyme probe differential temperature measurements in a laminar flow-through cell. Anal. Chem, 52, pp.: 505–508

    Article  CAS  Google Scholar 

  • Gadian, D.G. (1982) Nuclear Magnetic Resonance and Its Applications to Living Systems, Oxford University Press, London

    Google Scholar 

  • Galazzo, J.L.; Shanks, J.Yt; Bailey, J.E. (1987) Comparison of Suspended and Immobilized Yeast Metabolism using P Nuclear Magnetic Resonance Spectroscopy, Biotechnol. Techniques, 1 (1), pp.: 1–6

    Article  CAS  Google Scholar 

  • Gallazzo, J.L.; Bailey, J.E. (1989) In vivo nuclear magnetic resonance analysis of immobilization effects on glucose metabolism of yeast Saccharomyces cerevisiae, Biotechnol. Bioeng. 33, pp. 1283–1289

    Article  Google Scholar 

  • Garn, M.; Gisin, M.; Thommen, C.; Cevey, P. (1989) A flow injection analysis system for fermentation monitoring and control, Biotechnol. Bioeng., 34, pp.: 423–428

    Article  CAS  Google Scholar 

  • Gebauer, A.; Scheper, T.; Schügerl, K. (1987) Growth of E. coli in a stirred tank in an airlift tower reactor with an outer loop, Bioprocess Eng., 2. pp.: 13–23

    Article  Google Scholar 

  • Gencer, MA.; Mutharasan, R. (1979) Determination of Biomass Concentration by Capacity Measurement, Biotechnol. Bioeng., 21, pp.: 1097–1103

    Google Scholar 

  • Geppert, G.; Asperger, L. (1987a) Automatic on-line measurement of substrates in fermentation liquids with enzyme electrodes, Studia Biophys., 119 (1-3), pp.: 159–162

    CAS  Google Scholar 

  • Geppert, G.; Asperger, L. (1987b) Automatic on-line measurement of substrates in fermentation liquids with enzyme electrodes, Bioelectrochem. Bioenerg. (a section of J. Electroanal. Chem., 231) 17, pp.: 399–407

    Google Scholar 

  • Gesellschaft Berliner Ingenieure (1988) Toxalarm-Bakterientoximeter, Firmenprospekt

    Google Scholar 

  • Gilbert, M.F.; McQuitty, D.N.; Bailey, J.E. (1978) Flow microfluorometry study of diauxic batch growth of Saccharomyces cerevisiae, Appl. Environ. Microbiol., 36 (4), pp.: 615–617

    Google Scholar 

  • Gillies, RJ.; MacKenzie, N.E.; Dale, B.E. (1989) Analyses of Bioreactor Performance by Nuclear Magnetic Resonance Spectroscopy, Bio/Technology, 7, pp.: 50–54

    Article  CAS  Google Scholar 

  • Gillies, R J.; Ogino, T.; Shulman, R.G.; Ward, D.C. (1982) 31P Nuclear Magnetic Evidence for the Regulation of Intracellular pH by Ehrlich Ascites Tumor Cells, J. Cell Biol., 95 (10), pp.: 24–28

    Article  CAS  Google Scholar 

  • Gnanasekaran, R.; Mottola, HA. (1985) Flow injection determination of penicillins using immobilized penicillinase in a single bead string reactor, Anal. Chem., 57, pp.: 1005–1009

    Article  CAS  Google Scholar 

  • Goldfinch, M J.; Lowe, C.R. Solid phase optoelectronic sensors for biochemical analysis. Anal, biochem., 138, pp.: 430

    Google Scholar 

  • Gonzalez-Mendez, R.; Wemmer, G.; Hahn, G.; Wade-Jardetzky, N.; Jardetzky, O. (1982) Continuous-Flow NMR Culture System for Mammalian Cells, Biochim. Biophys. Acta, 720, pp.: 274–280

    Article  CAS  Google Scholar 

  • Gosmann, B.; Rehm,H.J. (1986) Oxygen uptake of microorganisms entrapped in Ca-alginate, Appl. Microbiol. Biotechnol., 23, pp.: 163–167

    Google Scholar 

  • Gotoh, M.; Tamiya, E.; Karube, J.; Kagawa, Y. (1986) A microsensor for adenosines-triphosphate based on pH-sensitive field effect transistors; Anal. Chem. Acta, 187, 287–91

    Article  CAS  Google Scholar 

  • Gottschalk, G. (1979) Bacterial Metabolism, Springer Verlag, Berlin

    Book  Google Scholar 

  • Gottschalk, G. (1986) Bacterial Fermentations, in: Bacterial Metabolism, 2nd Edition, Springer Verlag, Berlin, New York, pp.: 208–282

    Google Scholar 

  • Graf, H. (1989) Untersuchungen zur Automatisierung eines Perfusionssystems zur Kultivierung von tierischen Zellen, Dissertation, Universität Hannover

    Google Scholar 

  • Graham, A.; Moo-Young, M. (1985) Biosensors: recent trends, Biotech. Advs., 3, pp.: 209–218

    Article  CAS  Google Scholar 

  • Grattan, K.T.V.; Mouaziz, Z.; Palmer, A.W. (1987/88) Dual wavelength optical fibre sensor for pH measurement, Biosensors, 3, pp.: 17–25

    Google Scholar 

  • Grattan, K.T.V.; Mouaziz, Z.; Selli, R.K. (1987) pH sensor using a LED source in a fibre optic device, Proc. SPIE-Int. Soc, Opt. Eng., 798, pp.: 230

    CAS  Google Scholar 

  • Green, MJ, (1987) New approaches to electrochemical immunoassay, in: Biosensors - Fundamentals and Applications (eds.: A.P.F. Turner, I. Karube, G.S. Wilson, Oxford Science Publication, Oxford, pp.: 61–70

    Google Scholar 

  • Greenspan, P.; Fowler, S.D. (1985) Biological applications of the fluorescent lipid probe Nile Red, Kodak Bulletin, 56(3), pp.: 1–8

    Google Scholar 

  • Greenspan, P.; Mayer, E,P.; Fowler, S.D. (1985) Nile Red: A selective fluorescent stain for in-tracellular lipid droplets, J. Cell Biol, 100, pp.: 965–973

    Article  CAS  Google Scholar 

  • Groom, CA; Luong, J.H.T.; Mulchandani, A, (1988) On-line culture fluorescence measuring during the batch cultivation of poly-hydroxybutyrate producing Alcaligenes eutrophus, J. Biotechnol., 8, pp,: 271–278

    Article  CAS  Google Scholar 

  • Gründig, B.; Krabisch, Ch. (1989) Electron mediator-modified electrode for the determination of glucose in fermentation media, Anal. Chim. Acta, 222, pp.: 75–81

    Google Scholar 

  • Gschwend, K.; Beyeler, W.; Fiechter, A, (1983) Detection of reactor nonhomogenities by measuring culture fluorescence, Biotechnol. Bioeng., 25, pp.: 2789–2793

    Article  CAS  Google Scholar 

  • Guilbault, G, G.; Lubrano, G J. (1973) An enzyme electrode for amperometric determination of glucose, Anal.Chim, Acta, 64, pp.: 439–455

    Article  CAS  Google Scholar 

  • Guilbault, G.G. (1980) Use of the piezoelectric crystal detector in analytical chemistry, Ion. Selec, Elc. Rev., 2(1), pp.: 3–17

    CAS  Google Scholar 

  • Guilbault, G.G. (1982) Determination of formaldehyde with an enzyme-coated piezoelectric crystal detector. ANal. Chera, 55, pp.: 1682–1684

    Google Scholar 

  • Guilbault, G.G. (1982) Immobilized enzymes as analytical reagents, Appl. Biochem. and Biotechnol, 7, pp.; 85–98

    Article  CAS  Google Scholar 

  • Guilbault, G.G. (1982) Ion-selective electrodes applied to enzyme systems, Ion-selective Electrode Rev, (1982), 4, pp.: 187–231

    CAS  Google Scholar 

  • Guilbault, G.G.; Danielsson, B.; Mandenius, C.F.; Mosbach, K. (1983) A comparison of enzyme electrode and thermistor probes for assay of alcohols using alcohol oxidase, Anal. Chem., 55, pp,: 1582–1585

    Article  CAS  Google Scholar 

  • Guilbault, G.G.; Luong, J,H, (1988) Gas phase biosensors, J. of Biotechnol., 9, pp.: 1–10

    Article  CAS  Google Scholar 

  • Guilbault, G.G.; Luong, J,H, (1989) Biosensors: currcnt status and future possibilities, Selctive Electrode Rev., 11, pp,: 346

    Google Scholar 

  • Guilbault, G.G.; Mascini, M. (eds.) (1988) Analytical uses of immobilized biological compounds for detection, medical and industrial uses, NATO ASI Series, Vol. 226, Reidel Publishing Company, Dordrecht

    Google Scholar 

  • Guilbault, G.G.; Ngeh-Ngwainbi, J. (1987) Use of protein coatings on piezoelectric crystals for assay of gaseous pollutants in: Analytical uses of immobilized biological compounds for detection, medical ana industrial uses (eds.: G.G. Guilbault, M, Mascini), NATO ASI Series, Vol. 226, Reidel Publishing Company, Dordrecht, pp,: 187–194

    Google Scholar 

  • Gupta, R.K.; Gupta, P.; Moore, R.D, (1984) NMR Studies of Intracellular metal ions in intact cells and tissues, Ann. Rev, Biophys. Bioeng, 13, pp.: 221–246

    Article  CAS  Google Scholar 

  • Guske, C, (1989) Laufende Dissertation, California Institute of Technology, Pasadena

    Google Scholar 

  • Hall, E. (1986) The developing biosensor arena, Enzyme Microb. Technol. 8(11), pp.: 651–658

    Article  CAS  Google Scholar 

  • Hall, E. (1988) Entwicklungen in der Biosensor-Technologie, BioEngineering, 1/88, pp.: 21–28

    Google Scholar 

  • Hamori, E,; Arndt-Jovin, DJ/, Grimwade, B.G.; Jovin, T.M, (1980) Selection of Viable Cells with Known DNA Content, Cytometry, 1 (2), pp.: 132–135

    Article  CAS  Google Scholar 

  • Hanazato, Y.; Nakako, M.; Maeda, M.; Shiono, S. (1987) Glucose sensor based on a field-effect tranistor with a photolithographically patterned glucose oxidase membrane; Anal. Chim. Acta, 193, 87–96

    Article  CAS  Google Scholar 

  • Hanazato, Y.; Nakako, M.; Shiono, S. (1986) Multi-enzyme electrode using hydrogen-ion-sensitive field-effect transistors; IEEE Trans. Electron Dev., Vol ED-33, No. 1

    Google Scholar 

  • Hanazato, Y.; Shino, S (1983) Bioelectrode using two hydrogen ion sensitive field effect transistors and a platinium wire pseudo reference electrode, in: Chemical sensors. Proceedings of international meeting on chemical sensors, (eds.: Seiyama, K.; Fueki, K.; Shiokawa, J.; Suzuki, S.) Fukuoda, Japan, September 19–22, 1983; Anal. Chem. Sym. Ser., 17, Elsevier, Amsterdam, pp.: 513–518

    Google Scholar 

  • Hancher, C.W.; Thacker, L.H.; Phares, E.F. (1974) A Fiber-Optic Retroreflective Turbidimeter for Continuously Monitoring Cell Concentration During Fermentation, Biotechnol. Bioeng., 16, pp.: 475–484

    Article  CAS  Google Scholar 

  • Haran, N.; Kahana, Z.E.; Lapidot, A. (1983) In vivo 15N NMR studies of regulation of nitrogen assimilation and amino acid production by Brevibacterium lactofermentum, J. Biol. Chem. 258 (21), pp. 12929–12933

    CAS  Google Scholar 

  • Harima, T.; Humphrey, A.E. (1980) Estimation of Trichoderma QM 9414 Biomass and Growth Rate by Indirect Means, Biotechnol. Bioeng., 22, pp.: 821–831

    Article  CAS  Google Scholar 

  • Harris, C.M.; Kell, D.B. (1985) The Estimation of Microbial Biomass, Biosensors, 1, pp.: 17–84

    Article  CAS  Google Scholar 

  • Harris, C.M.; Todd, R.W.; Bungard, S.J.; Lovitt, R.W.; Morris, J.G.; Kell, D.B. (1987) Dielectric Permittivity of Microbial Suspensions at Radio Frequencies: a Novel Method for the Real-time Estimation of Microbial Biomass, Enzyme Microbiol. Technol., 9, pp.: 181–186

    Article  CAS  Google Scholar 

  • Harris, R.K. (1986) Nuclear Magnetic Resonance: A Physiochemical View, Longman House, Harlow, England

    Google Scholar 

  • Harrison, D.E.F.; Chance, B. (1970) Fluorometric technique for monitoring changes in the level of reduced nicotinamide nucleotides in continuous cultures of microorganisms, Appl. Microbiol., 19 (3) pp.: 446–450

    CAS  Google Scholar 

  • Hartmeyer, W. (1986) Immobilisierte Biokatalysatoren, Springer Verlag, Berlin

    Google Scholar 

  • Hatch, R.T.; Wilder, C.; Cadman, T.W. (1979) Analysis and Control of Mixed Cultures, Biotechnol. Bioeng. Symp., 9, pp.: 25–37

    Google Scholar 

  • Heden, C.G.; Illény, T. (1975) (eds.) for: New Approaches to the Identification of Micro-organisms, John Wiley and Sons, New York

    Google Scholar 

  • Heijnen, J J.; Roels, JA.; Stouthamer, A.H. (1979) Application of Balancing Methods in Modelling the Penicillin Fermentation, Biotechnol. Bioeng., 21, pp.: 2175–2201

    Article  CAS  Google Scholar 

  • Heinzle, E.; Goldschmidt, B.; Moes, J.; Dunn, I J. (1986) Modelling of mixing phenomena ob-served in Bacillus subtilis batch cultivations, Proceedings: 5th Yugoslavian-Austrian-Italian Chem. Eng. Conf., Portoroz, Yugoslavia, pp.: 525–534

    Google Scholar 

  • Heinzle, E.; Lunden, M.; Dunn, I J. (1985) Analysis of Biomass and Metabolites Using Pyrolysis Mass Spectrometry, Proceedings: Modelling and Control of Biotechnological Processes, Pergamon Press, 1st IFAC Symposium, Noorwijkerhout, The Netherlands, 11-13 December

    Google Scholar 

  • Hendy, NA.; Gray, P.P. (1979) Use of ATP as an Indicator of Biomass Concentration in Trichoderma viride Fermentation, Biotechnol. Bioeng., 21 pp.: 153–156

    Article  CAS  Google Scholar 

  • Herrero, AA.; Gomez, R.F.; Roberts, M.F. (1985) 31P NMR studies of Clostridium thermocellum, J. Biol. Chem. 260(12), pp.: 7442–7451

    Google Scholar 

  • Hiddessen, R. (1987) Entwicklung und Einsatz eines Automatisierungssystems zur On-line Überwachung und Steuerung prozeßgekoppelter Bioreaktoren, Dissertation, Universität Hannover

    Google Scholar 

  • Hikuma, M.; Kubo, T.; Yasuda, T.; Karube, I.; Suzuki, S. (1979) Amperometric determination of acetic acid with immobilized Trichosporon brassicae, Anal. Chim. Acta, 109, 33–37

    Article  CAS  Google Scholar 

  • Hikuma, M.; Kubo, T.; Yasuda, T.; Karube, I.; Suzuki, S. (1979) Microbial electrode sensor for alcohols, Biotechnol. Bioeng., 21, pp.: 1845–1853

    Article  CAS  Google Scholar 

  • Hikuma, M.; Obana, H.; Yasuda, T.; Karube,.; Suzuki, S. (1980a) A Potentiometrie microbial sensor based on immobilized Escherichia coli for glutamic acid, Anal. Chim. Acta, 116, pp.: 61–67

    Article  CAS  Google Scholar 

  • Hikuma, M.; Obana, H.; Yasuda, T.; Karube, I.; Suzuki, S. (1980b) Amperometric determination of total assimilable sugars in fermentation broth with use of immobilized whole cells, Enzyme Microb. Technol., 2, 234–238

    Article  CAS  Google Scholar 

  • Hjortso, M.A.; Dennis, K.E.; Bailey, J.E. (1985) Quantitative Charakterization of Plasmid In-stability in Saccharomyces cerevisiae Using Flow Cytometry-Cell Sorting, Biotechnol. Lett., 7 (1), pp.: 21–24

    Article  CAS  Google Scholar 

  • Holst, O.; Hankanson, H.; Miyabayashi, A.; Mattiasson, B. (1988) Monitoring of glucose in fermentation processes using a commercial glucose analyzer, Appl. Microbiol. Biotechnol., 28, 32–36

    Article  CAS  Google Scholar 

  • Home, P.D.; Alberti, K.G.M.M. (1987) Biosensors in medicine: the clinician’s requirements in: Biosensors - Fundamentals and Applications (eds.: A.P.F. Turner, I. Karube, G.S. Wilson, Oxford Science Publication, Oxford, pp.: 723–736

    Google Scholar 

  • Hong, K.; Tanner, R.D.; Malaney, G.W.; Wilson, DJ. (1987) A Spectrophotometric Method for Estimating the Yeast Cell Concentration in a Semi-Solid State Fermentation, Process Biochem., pp.: 149–153

    Google Scholar 

  • Horan, P.K.; Wheeless Jr.; L.L. (1977) Quantitative Single Cell Analysis and Sorting, Science, 198, pp.: 149–157

    Article  CAS  Google Scholar 

  • Huang, T.-L.; Han, Y.W.; Callihan, C.D. (1971) Application of the Lowry Method for Determination of Cell Concentration in Fermentation of Waste Cellulosics, J. Ferment. Technol., 49 (6), pp.: 574–576

    CAS  Google Scholar 

  • Hundeck, H.G. (1987) Untersuchungen über die Einsatzbereiche eines Enzymthermistors als universeller Biosensor, Diplomarbeit, Universität Hannover

    Google Scholar 

  • Hundeck, H.G. ( 1989 ) Laufende Dissertation, Universität Hannover

    Google Scholar 

  • Hübner, U. (1987) Reaktionstechnische Untersuchungen zum dynamischen Verhalten der Hefe Saccharomyces cerevisiae - Einfluß abnehmender Sauerstoffkonzentrationen -, Diplomarbeit, Universität Hannover

    Google Scholar 

  • Hübner, U. (1989) Laufende Disseration, Universität Hannover

    Google Scholar 

  • Hysert, D.W.; Knudsen, F.B.; Morrison, N.N.M.; van Gheluwe, G.; Lom, T. (1979) Application of a Bioluminescence ATP Assay, in: Brewery Wastewater Treatment Studies, 21, pp.: 1301–1314

    Google Scholar 

  • Ishikawa, Y.; Shoda, M. (1983) Calorimetric Analysis of Escherichia coli on Continuous Culture, Biotechnol. Bioeng.; 25, pp.: 1817–1827

    Google Scholar 

  • Ishikawa, Y.; Shoda, M.; Maruyama, H. (1981) Design and performance of a new micro-calorimetric system for aerobic cultivation of microorganisms, Biotechnol. Bioeng., 23, pp.: 2692–2640

    Google Scholar 

  • Ishimori, Y.; Karube, I.; Suzuki, S. (1981) Determination of Microbial Populations with Piezo-electric Membranes, Appl. Envir. Microbiol., 42 (4), pp.: 632–637

    CAS  Google Scholar 

  • Jakobi, G.; Lohr, A. (1987) Detergents and textile washing, VCH Verlagsgesellschaft, Weinheim

    Google Scholar 

  • Janata, J.; Huber, R J. (1985) Solid state chemical sensors, Academic Press, New York

    Google Scholar 

  • Jämmrich, U. (1988) Mechanische Beanspruchung von Süspensionszellen und ihre Charakterisierung, Diplomarbeit, Universität Hannover

    Google Scholar 

  • Jenkinson, D.S.; Ladd, J.N. (1981) Microbial Biomass in Soil: Measurement and Turnover, in: Soil Biochemistry (eds.: Paul, EA., Ladd, J.N.), Vol. 5, pp.: 415–471, Dekker, New York

    Google Scholar 

  • Jones, T.P.; Porter, M.D. (1988) Optical pH sensor based on the chemical modification of a porous polymer film, Anal. Chem., 60, pp.: 404–406

    Google Scholar 

  • Juhnke, I.; Lüdemann, H. (1978) Ergebnisse der Untersuchung von 200 chemischen Verbindungen auf akute Fischtoxizität mit der Goldorfe, Z.F. Naturforsch. 5, pp.: 161–169

    Google Scholar 

  • Junker, B.H.; Wang, D.I.C.; Hatton, TA. (1988) Fluorescence sensing of fermentation parameters using fiber optics, Biotechnol. Bioeng., 32, pp.: 55–63

    Article  CAS  Google Scholar 

  • Jüttner, R.R.; Lafferty, R.M.; Knackmuss, HJ. (1975) A simple method for the determination of poly-hydroxybutyric acid in microbial biomass, Eur. J. Appl. Microbiol, biotechnol. 1, pp.: 233–237

    Google Scholar 

  • Kanamori, K.; Roberts, J.D. (1983) N-15 NMR Studies of Biological Systems, Acc. Chem. Res. 16, pp.: 35–41

    Article  CAS  Google Scholar 

  • Kang, SJ.; Pugh, L.B.; Borchardt, JA. (1983) ATP as a Measure of Active Biomass Concentration and Inhibition in Biological Wastewater Treatment Processes, Proc. Ind. Waste. Conf., pp.: 751–759

    Google Scholar 

  • Karczmar, G.S.; Kortesky, A.P.; Bisseil, M.J.; Klein, M.P.; Wiener, M.W. (1983) A device for maintaining viable cells at high densities for NMR studies, J. Mag. Res. 53, pp. 123–128

    CAS  Google Scholar 

  • Karl, D.M. (1986) Determination of in situ Microbial Biomass, Viability, Metabolism, and Growth, in: Poindexter, J.S., Leadbetter, E.R. (Eds.), Bacteria in Nature, Vol. 2, New York: Plenum Press, pp.: 85–176

    Google Scholar 

  • Karrer, D. (1972) Der total gefüllte Bioreaktor, Dissertation, ETH Zürich, Nr. 6254 Karube, I. (1987) Micro-organism based sensors, in: Biosensors - Fundamentals and Applications (eds.: A.P.F. Turner, I. Karube, G.S. Wilson, Oxford Science Publication, Oxford, pp.: 13–29

    Google Scholar 

  • Karube, I. (1988) Immunosensors, In: Guilbault, G.G., Mascini, M. (eds.), Analytical Uses of Immobilized Biological Compounds for Detection, Medical and Industrial Uses, Norwell, MA: D. Reidel Pub. Co, pp.: 267–279

    Google Scholar 

  • Karube, I. Mitsuda, S.; Suzuki, S. (1979) Glucose sensor using immobilized whole cells of Pseudomonas fluorescence, Europ J. Appl. Microbiol. Biotechnol., 7, pp.: 343–351

    Google Scholar 

  • Karube, I.; Gotoh, M. (1987) Immunosensors in: Analytical uses of immobilized biological compounds for detection, medical and industrial uses, NATO ASI Series, Vol. 226, Reidel Publishing Company, Dordrecht, pp.: 267–280

    Google Scholar 

  • Karube, I.; Sode, K.; Tamiya, E. (1989) Current trends in microbiosensor development, SwissBiotech, 7(4), pp.:25–32

    Google Scholar 

  • Karube, I.; Suzuki, S. (1983) Application of biosensor in fermentation processes; Annual Reports on Ferment. Technol., 6, pp.: 203–233

    CAS  Google Scholar 

  • Karube, I.; Tamiya, E.; Dicks, J.M.; Gotoh, M. (1986) A microsensor for urea based on an ion- selective field-effect transistor; Anal. Chim. Acta, 185, 195–200

    Article  Google Scholar 

  • Karube, J. (1988) Immunosensors, in: Analytical uses of immobilized biological compounds for detection, medical and industrial uses (eds.: G.G. Guilbault; M. Mascini ), D. Reidel Pub. Co., pp.: 267–279

    Google Scholar 

  • Karube, J.; Suzuki, M. (1986) Novel immunosensors, Biosensors, 2(6), pp.: 353–354

    Article  Google Scholar 

  • Kawabata, Y-; Imasaka, T.; Ishibashi, N. (1986) Fiber optic pH sensor based on laser fluorometry, OFS’86 TOKYO, pp.: 139–142

    Google Scholar 

  • Kawabata, Y.; Tahara, R.; Imasaka, T.; Ishibashi, N. (1988) Fiber-optic calcium (II) sensor with reversible response, Anal. Chim. Acta 212, pp.: 267–271

    Article  CAS  Google Scholar 

  • Kawabata, Y.; Tsuchida, K.; Imasaka, T.; Ishabashi, N. (1987) Fiber-optic pH sensor with monolayer indicator, Anal. Sci. 3(1), pp.: 7

    Google Scholar 

  • Kawabata, Y; Kamichika, T.; Imasaka, T.; Nobuhiko, I. (1989) Fiber-optic sensor dor carbon dioxide with a pH indicator dispersed in a poly(ethylene glycol)membrane, Anal. Chim. Acta 219, pp.: 223–229

    Article  CAS  Google Scholar 

  • Keating, M.Y.; Rechnitz, G.A. (1984) Potentiometrie digoxin antibody measurements with antigen-ionophore based membrane electrodes. Anal. Chem., 36, pp.: 801–803

    Google Scholar 

  • Kell, D.B. (1987) Forces, Fluxes and the Control of Microbial Growth and Metabolism, J. of General Microbiol., 133, p.: 1651–1665

    CAS  Google Scholar 

  • Kernevez, J.P.; Konante, L.; Romette, J.L. (1983) Determination of substrate concentrations by a computerized enzyme electrode, Biotechnol. Bioeng., 25, pp.: 845–855

    Article  CAS  Google Scholar 

  • Kiba, N.; Tomiyasu, T.; Furusawa, M. (1984) Flow enthalpimetric determination of glucose based on oxidation by 1,4-benzoquinone with use of immobilized glucose oxidase column, Tantala, 31, pp.: 131–132

    Article  CAS  Google Scholar 

  • Kieber, D.J.; Vaughan, G.M.; Mopper, K. (1988) Determination of formiate in natural waters by a coupled enzymatic/high-performance liquid chromatographic technique. Aanl. Chem., 60, pp.: 1654

    Article  CAS  Google Scholar 

  • Kilburn, D.G. Fitzpatrick, P.; Blake-Coleman, B.C.; Clarke, DJ.; Griffiths, J.B. (1989) On-line Monitoring of cell mass in mammalian cell cultures by acoustic densitometry, Biotechnol. Bioeng., 33, pp.: 1379–1384

    Article  CAS  Google Scholar 

  • Kimura, J.; Kuriyama, T.; Kawana, Y. (1986) An integrated SOS/FET multi-biosensor; Sensors and Actuators, 9, 373–87

    Article  CAS  Google Scholar 

  • King, W.H. (1964) Piezoelectric surface mass sensor devices, Anal. Chem., 36, pp.: 1735–1739

    Article  CAS  Google Scholar 

  • Kingdon, C.F.M.; Stolzenburg, M. (1988) Biosensoren, Sensormagazin, 4, pp.: 22–24

    Google Scholar 

  • Kirkbright, G.F.; Narayanaswamy, R.; Welti, N.A. (1984) Studies with immobilized chemical reagents using a flow-cell for the development of chemically sensitive fibre-optic devices, Analyst, 109, pp.: 15

    Article  CAS  Google Scholar 

  • Kittstein-Eberle, R.; Ogbomo, I.; Schmidt, H.-L. (1989) Biosensing devices for the semi-automated control of dehydrogenase substrates in fermentations, Biosensors, 4, pp.: 75–85

    Article  Google Scholar 

  • Klein, J. (1980) Trägerfixierung von Mikroorganismen in polymerer Matrix, Kontakte, 3, pp.: 24–36

    Google Scholar 

  • Klein, J. (1981) Heterogene Biokatalyse mit polymerfixierten Mikroorganismen, Nachr. Chem. Tech. Lab., 29 (12), pp. 850

    Article  CAS  Google Scholar 

  • Klein, M. (1986) Ionenselektiver Feldeffekttransistor mit Natrium-Aluminium-Silikatschicht zur Messung der Na+-Konzentration in wäßrigen Lösungen NTG FAchberichte, 93, pp.: 66–72

    Google Scholar 

  • Klein, M.; Kuisl, M. (1984) Ionenselektiver Feldeffekttransistor mit Ta205-Schicht für den Einsatz bei pH-Messungen, VDI-Berichte, 509, pp.: 275–279

    CAS  Google Scholar 

  • Klingenberg, M. (1974) in: Methoden der enzymatischen Analyse (ed.: H.U. Bergmeyer), Verlag Chemie, Weinheim, pp.: 2094

    Google Scholar 

  • Knop, R.H.; Chen, C.-W.; Mitchell J.B.; Russo, A.; McPherson, S.; Cohen, J.S. (1984) Metabolie studies of mammalian cells by P-NMR using a continuous perfusion technique, Biochim. Biophys. Acta, 804, pp.: 275–284

    Article  CAS  Google Scholar 

  • Knöpfel, H.P. (1972) Der Zum Crabtree-Effekt bei Saccharomyces cerevisiae und Candida tropicalis, Dissertation, ETH Zürich, Nr. 4906

    Google Scholar 

  • Koch, A.L. (1970) Turbidity measurements of bacterial cultures in some available commercial instruments, Anal. Biochem., pp.: 252–259

    Google Scholar 

  • Kok, R.; Hogan, P. (1987/88) The development of an in situ fermentation electrode calibrator. Biosensors, 3 pp.: 89–100

    Article  Google Scholar 

  • Koliander, B.; Hampel, W.; Roehr, M. (1984) Indirect Estimation of Biomass by Rapid Ribo-nucleic Acid Determination, Appl. Microbiol. Biotechnol., 19, pp.: 272–276

    Article  CAS  Google Scholar 

  • Kracke-Helm, HA. (1989) Kultivierung rekombinanter, temperatursensitiver Escherichi coli in einem Air-lift-Schlaufenreaktor

    Google Scholar 

  • Kretzmer, G. (1989) Entwicklung von Methoden zur kontrollierten mechanischen Belastung adhärenter Zellen am Beispiel der BHK 21cl3, Dissertation, Universität Hannover

    Google Scholar 

  • Kroner, K.-H.; Kula, M.R. (1984) On-line measurement of extracellular enzymes during fer-mentation by using membrane techniques. Anal. Chim. Acta, 163, pp. 3–11

    Article  CAS  Google Scholar 

  • Kruth, H.S. (1982) Flow Cytometry: rapid biochemical analysis of single cells, Anal. Biochem., 125, pp.: 225–242

    Article  CAS  Google Scholar 

  • Kuan, S.S.; Guilbault, G.G. (1987) Ion-selective electrodes and biosensors based on ISEs, in: Biosensors - Fundamentals and Applications (eds.: A.P.F. Turner, I. Karube, G.S. Wilson, Ox-ford Science Publication, Oxford, pp.: 135–152

    Google Scholar 

  • Kubitschek, H.E. (1958) Electronic Counting and Sizing of Bacteria, Nature (London), 182 (4630), pp.: 234–235

    Article  CAS  Google Scholar 

  • Kubitschek, H.E. (1969) Counting and Sizing Micro-organisms with the Coulter Counter, Methods in Microbiology (eds.: Norris, J.R.; Ribbons, D.W.) Academic Press, London and New York, pp.: 593–604

    Google Scholar 

  • Kuchenbecker, D.; Bley, T.; Schmidt, A. (1981) Short-Periodic oscillations of culture fluorescence in yeast cell populations, Stud. Biophys., 86 (2), pp.: 92–96

    Google Scholar 

  • Kuhlmann, W.; Kroner, K.H. (1986) Continuous Sampling Device for Bioprocess Control, Eng. Found. Conference, Upsalla, 14–16. 05. 1986

    Google Scholar 

  • Kula, M.-R. (1982) Enzyme, in: Handbuch der Biotechnologie (eds.: Präve, P.; Faust, U.; Sittig, W.; Sukatsch, DA. ), Akademische Verlagsgesellschaft, Wiesbaden

    Google Scholar 

  • Kulp, TJ.; Camins, I.; Angel, S.M.; Munkholm, C.; Walt, D.R. (1987) Polymer immobilized enzyme optrodes for the detection of penicillin, Anal. Chem. 59, pp.: 2849–2853

    Article  CAS  Google Scholar 

  • Kuriyama, T.; Kimura, J.; Kawana, Y. (1985) Development of biosensrs with immobilized enzyme; Chem. Economy & Eng. Rev., 17(7–8), No. 190

    Google Scholar 

  • Kutzenbach, C.; Rauenbusch, E. (1974) Preparation and general properties of crystalline penicillin acylase from Escherichia coli ATCC 11105, Z. Physiol. Chem., 354, pp.: 45–53

    Google Scholar 

  • Küenzi, M. (1970) Über den Reservekohlenstoffwechsel von Saccharomyces cerevisiae, Dissertation, ETH Zürich, Nr. 4544

    Google Scholar 

  • Laerum, O.D.; Farsund, T. (1981) Clinical Application of Flow Cytometry: A Review, Cytometry, 2 (1), pp.: 1–23

    Article  CAS  Google Scholar 

  • Lauks, I.; Sansen, W. (1985) Transducers 85, Proceedings 3rd International Conference on Solid State Sensors and Actuators, 11-14. June 1985, Philadelphia, IEEE Press, pp.: 125–127

    Google Scholar 

  • Lee, C.; Lim, H. (1980) New Device for Continuously Monitoring the Optical Density of Concentrated Microbial Cultures, Biotechnol. Bioeng., 22, pp.: 639–642

    Article  Google Scholar 

  • Lee, L.G.; Berry, G.M.; Chen, C.-H. (1989) Vita Blue: A New 633-nm Excitable Fluorescent Dye for Cell Analysis, Cytometry 10, pp.: 151–164

    Article  Google Scholar 

  • Lee, Y.H. (1981) Pulsed Light Probe for Cell Density Measurement, Biotechnol. Bioeng., 23, pp.: 1903–1906

    Google Scholar 

  • Leist, C.; Meyer, H.P.; Fiechter, A. (1986) Process control during the suspension culture of a human melanoma cell line in a mechanically stirred loop bioreactor, J. Biotechnol., 4, pp.: 235–246

    Article  CAS  Google Scholar 

  • Lemoigne, M (1926) Produits de lácide ß-oxybutyrique, Bull. Soc. Chim. Biol., 8, pp.: 770–782

    CAS  Google Scholar 

  • Lenz, R.; Boelcke, C.; Peckman, U.; Reuß, M. (1985) A New Automatic Sampling Device for Determination of Filtration Characteristics and the Coupling of an HPLC to Fermentors, Proceedings: Modelling and Control of Biotechnological Processes, Pergamon Press (ed. Johnson, A.), IFAC-publications, Pergamon Fress, 1st IFAC Symposium, Noordwijkerhout, 11–13 December 1985

    Google Scholar 

  • Li, J.; Humphrey, A.E. (1989) Kinetic and fluorometric behavior of a phenol fermentation, Biotechnol. Let. 11 (3), pp. 177–182

    Article  CAS  Google Scholar 

  • Liedberg, B.; Nylander, C.; Lundström, I. (1983) Surface plasmon resonance for gas detection and biosensing. Sens, and Act. 4, pp.: 199–304

    Article  Google Scholar 

  • Lima Filho, J.L.; Ledingham, W.M. (1987) Continuous Measurement of Biomass Concentration in Laboratory-Scale Fermenters Using a LED-Electrode System, Biotechnol. Techniques, 1 (3), pp.: 145–150

    CAS  Google Scholar 

  • Linek,V; Benes, P.; Sinkula, J.; Holecek, O.; Maly, V. (1980) Oxidation of D-glucose in the presence of glucose oxidase and catalase, Biotechnol. Bioeng., 22, pp.: 2515–2527

    Article  CAS  Google Scholar 

  • Linz, F. (1987) Untersuchungen von Fermentationsproben mit einem Laser-Durchflußcytometer, Diplomarbeit, Universität Hannover

    Google Scholar 

  • Linz, F. (1989) Durchflußcytometrie zur Prozeßbeobachtung in der Biotechnologie, Dissertation, Universität Hannover

    Google Scholar 

  • Lippitsch, M.E.; Pustenhofer, J.; Leiner, MJ.P.; Wolfbeis, O.S. (1988) Fibre-optic oxygen sensor with the fluorescence decay time as the information carrier, Anal. Chim. Acta 205, pp.: 1–11

    Article  CAS  Google Scholar 

  • London, J.; Knight, M. (1966) Concentrations of nicotinamide nucleotide coenzymes in microorganisms, J.Gen. Microbiol., 44, pp. 241–254

    CAS  Google Scholar 

  • Lowe, C.R. (1984) Biosensors, Trends in Biotechnolgy, 2(3), pp.: 59–65

    Article  CAS  Google Scholar 

  • Luo, S.; Walt, D.R. (1989) Avidin-Biotin coupling as a general method for preparing enzyme-based fibre-optic sensors, Anal. Chem. 61, pp.: 1069–1072

    Article  CAS  Google Scholar 

  • Luo, S.; Walt, D.R. (1989) Fibre-optic sensors based on reagent delivery with controlled-release polymers, Anal. Chem., 61, pp.: 174–177

    Article  CAS  Google Scholar 

  • Luong, J.H.T.; Carrier, DJ.; (1986) On-line measurement of culture fluorescence during cultivation of Methylomonas mucosa, Appl. Microbiol. Biotechnol., 24 (1), pp.: 65–70

    Article  CAS  Google Scholar 

  • Luong, J.H.T.; Mulchandani, A.; Guilbault, G.G. (1988) Developments and applications of biosensors, TIBTECH, 6, pp.: 310–316

    Article  CAS  Google Scholar 

  • Luong, J.H.T.; Volesky, B. (1980) Determination of the heat of some aerobic fermentations, Can. J. Chem. Eng., 58, pp.: 497–504

    Article  CAS  Google Scholar 

  • Luong, J.H.T.; Volesky, B. (1982) Indirect Determination of Biomass Concentration in Fermentation Processes, Can. J. Chem. Eng., 60, pp.: 163–167

    Article  CAS  Google Scholar 

  • Luong, J.H.T.; Volesky, B. (1983) Heat evolution during the microbial process-estimation, measurement and applications, Adv. Biochem. Eng. Biotechnol., 28, 1–40

    Google Scholar 

  • Luong, J.H.T.; Yerushalmi, L.; Volesky, B. (1983) Estimating the Maintenance Energy and Biomass Concentration of Saccharomyces cerevisiae by Continuous Calorimetry, Enzyme Microb. Technol., 5, pp.: 291–297

    Article  CAS  Google Scholar 

  • MacBride, W.R.; Magae, J.A.; Armiger, W.B.; Zabriskie, D.W. (1986) Optical apparatus and method for measuring the characteristics of materials by their fluorescence, US-patent, 4577110

    Google Scholar 

  • MacMichael, G.; Armiger, W.B.; Lee, J.F.; Mutharasan, R. (1987) On-line measurement of hybridoma growth by culture fluorescence, Biotechnol. Techn., 1 (4), pp.: 213–218

    Article  Google Scholar 

  • Malin-Berdel, J.; Valet, C. (1980) Flow Cytometric Determination of Esterase and Phosphatase Activities and Kinetics in Hematopoietic Cells with Fluorogenic Substrates, Cytometry, 1 (3), pp.: 222–228

    Article  CAS  Google Scholar 

  • Mandenius, C.F.; Welin, S.; Danielsson, B.; Lundström, I.; Mosbach, K. (1984) The interaction of proteins and cells with affinity ligands covalently coupled to silion surfaces as monitored by ellipsometry. Anal. Biochem., 137, pp.: 106–114

    Article  CAS  Google Scholar 

  • Mandenius, C.F. (1988) Controlling fermentation of lignocellulose hydrolysates in a continuous hollow-fiber reactor using biosensors, Biotechnol. Bioeng., 32, pp.: 123–129

    Article  CAS  Google Scholar 

  • Mandenius, C.F.; Bülow, L.; Danielsson, B.; Mosbach, K. (1985) Monitoring and control of enzymic sucrose hydrolysis using on-line biosensors. Appl. Microbiol. Biotechnol. 21, pp.: 135–142

    Article  CAS  Google Scholar 

  • Mandenius, C.F.; Danielsson, B.; Mattiasson, B. (1980) Enzyme thermistor control of the sucrose concentration at a fermentation with immobilized yeast, Acta Chem. Scand. B34(6), pp.: 463–465

    Article  Google Scholar 

  • Mandenius, C.F.; Danielsson, B.; Mattiasson, B. (1984) Evaluation of a dialysis probe for continuous sampling in fermentors and in complex media, Anal. Chim. Acta, 163, pp.: 135–141

    Article  CAS  Google Scholar 

  • Maneshin, S.K.; Arevshatyan, A A. (1972) Change in the fluorescence intensity of NADH2 in Candida guilliermondii in the transition from an anaerobic to an aerobic state, Appl. Biochem. Microbiol., 8, pp.: 273–275

    Google Scholar 

  • Marconi, W. (1978) Biomedical applications of enzymatic fibres, in: Enzyme Engineering (eds.: G.B. Broun, G. Manecke, L.B. Wingard, Jr.) Plenum Press, New York, Vol.4, pp.: 179–186

    Google Scholar 

  • Marison, I.W.; von Stockar, U. (1986) The Application of a Novel Heat Flux Calorimeter for Studying Growth of Escherichia coli W in Aerobic Batch Culture, Biotechnol. Bioeng., 28, pp.: 1780–1793

    Article  CAS  Google Scholar 

  • Marison, I.W.; von Stockar, U. (1987) A Calorimetric Investigation of the Aerobic Cultivation of Kluyveromyces fragilis on various substrates, Enzyme Microbiol. Technol., 9, pp.: 33–43

    Google Scholar 

  • Matsunaga, T.; Karube, I.; Suzuki, S. (1979) Electrode System for the Determination of Microbial Populations, Appl. Env. Microbiol., 37 (1), pp.: 117–121

    CAS  Google Scholar 

  • Matsunaga, T.; Karube, I.; Suzuki, S. (1980) Electrochemical determination of cell populations, European J. Appl. Microbiol Biotechnol., 10, pp.: 125–132

    Google Scholar 

  • Mattiasson, B, Danielsson, B.; Winquist, F.; Nilson, H.; Mosbach, K. (1981) Enzyme thermistor analysis of penicillin in standard solutions and in fermentation broths, Appl Environ. Microbiol., 41, pp.: 903–908

    CAS  Google Scholar 

  • Mattiasson, B.; Borrebaeck, C.; Sanfridson, B.; Mosbach, K. (1977) Thermometric enzyme linked immunosorbent assay: TELISA, Biochim. Biophys. Acta, 483, pp.: 221–227

    CAS  Google Scholar 

  • Mattiasson, B.; Danielsson, B. (1982) Calorimetric analysis of sugars and sugar derivatives with aid of an enzyme thermistor. Carbohydr. Res., 102, pp.: 273–282

    Article  CAS  Google Scholar 

  • Mattiasson, B.; Danielsson, B.; Hermansson, C.; Mosbach, K. (1988) Enzyme thermistro analysis of heavy metal ions with immobilized urease, FEBS Lett. 85(2), pp.: 203–220

    Article  Google Scholar 

  • Mattiasson, B.; Mandenius, C.F.; Axelsson, J.P.; Danielsson, B.; Hagander, P. (1983) Computer control of fermentation with biosensors, Ann. N.Y. Acad. Sci., 413, pp.: 193–196

    Google Scholar 

  • Mattiasson, B.; Rieke, E.; Mannecke, D. Mosbach, K. (1979) Enzymatic analysis of organophosphate insecticides using an enzyme thermistor, J. Sol. Phase Biochem. 4(4), pp.: 263–270

    Article  CAS  Google Scholar 

  • Mattiasson, B.; Winquist, F.; Nilsson, H.; Mosbach, K. (1981) Enzyme thermistor analysis of penicillin in standard solutions and in fermentation broths, Appl. Environ. Microbiol. 41, pp.: 903–908

    Google Scholar 

  • Mayer, H.; Collins, J.; Wagner, F. (1980) Cloning of the penicillin-G-acylase gene of Escherichia coli ATCC 11105 on multicopy plasmids, Enzyme Engineering, Vol. 5, p. 61, Plenum Press, New York

    Google Scholar 

  • McCapra, F. (1987) Potential applications of bioluminescence and chemiluminescence in biosensors, in: Biosensors - Fundamentals and Applications (eds.: A.P.F. Turner, I. Karube, G.S. Wilson, Oxford Science Publication, Oxford, pp.: 617–637

    Google Scholar 

  • McGlothlin, C.D:; Jordan, J. (1975) Enzymatic enthalpimetry, a new approach to clinical analysis: glucose determination by hexokinase catalyzed phosphorlytaion, Anal. Chem. 47, pp.: 786. 790

    Google Scholar 

  • McLaughlin, J.K.; Meyer, C.L.; Papoutsakis, E.T. (1985) Gas chromatography and gateway sensors for on-line state estimation of complex fermentations (butanol-Acetone Fermentatin), Biotechnol. Bioeng., 27, pp.: 1246–1257

    Article  CAS  Google Scholar 

  • Meadows, D.; Schultz, J.S.; Fiber-optic biosensors based on fluorescence energy transfer, Talanta 35(2), pp.: 145–150

    Google Scholar 

  • Merten, O.-W.; Palfi, G.E.; Stäheli, J.; Steiner, J. (1987) Invasive Infrared Sensor for the Determination of Cell Number in a Continous Fermentation of Hybridomas, Developments in Biological Standardization (eds.: Spier, R., Hennessen, W.), 66, pp.: 357–360

    Google Scholar 

  • Merten, O.-W.; Palfi, G.E.; Steiner, J. (1986) On-line Determination of Biochemical/Physiological Parameters in the Fermentation of Animal Cells in a Continuous or Discontinuous Mode, Advances in Biotechnological Processes, 6, pp.: 111–178

    Google Scholar 

  • Metz, H. (1981) Kontinuierliche Trübungsmessung in Bioreaktoren, Chemie-Technik, 10, pp.: 691–696

    Google Scholar 

  • Meyer, C.; Beyeler, W. (1984) Control strategies for continuous bioprocess based on biological activities, Biotechnol. Bioeng.; 26, pp.: 916–925

    Article  CAS  Google Scholar 

  • Meyer, E.R.; Scheper, T. Hitzmann, B.; Schügerl, K. (1988) Immobilization of enzymes in liquid membranes for enantioselective hydrolysis, Biotechn. Tech., 2, pp.: 127–132

    Article  CAS  Google Scholar 

  • Meyer, H.-P.; Beyeler, W.; Fiechter, A. (1984) Experiences with the on-line measurement of culture fluorescence during cultivation of Bacillus subtilis, Escherichia coli, Sporotrichum thermophile, J. Biotechnol., 1. pp.: 341–349

    Google Scholar 

  • Milanovich, F.P.; Hirschfeld, T.B.; Wang, F.T.; Klainer, S.M.; Walt, D. (1984) Clinical measurement using fiber optics and optrodes, SPIE, 494, pp.: 18–24

    CAS  Google Scholar 

  • Miyahara, Y.; Moriizumi, T. (1985) Monolithic Multifunction EnFET Biosensors; in:Transducers 85. Proc. 3rd International Conference on Solid-state Sensors and Actuators. June 11–14,1985, Philadelphia; IEEE Press, pp.: 148–151

    Google Scholar 

  • Miyahara, Y.; Matsu, F.; Morizumi, T. (1983) Micro enzyme sensors using semiconductor and enzyme immobilization techniques; in: Chemical sensors. Proceedings of international meeting on chemical sensors, (eds.: Seiyama, K.; Fueki, K.; Shiokawa, J.; Suzuki, S.) Fukuoda, Japan, September 19–22,1983; Anal. Chem. Sym. Ser., 17, Elsevier, Amsterdam, pp.: 501–506

    Google Scholar 

  • Miyahara, Y.; Morizumi, T.; Ichimura, K. (1985) Integrated enzyme FETs for simultaneous detections of urea and glucose; Sensors and Actuators, 7, 1–10

    Article  CAS  Google Scholar 

  • Miyaki, Y; Einaga, Y.; Hirosye, T.; Fujita, H. (1977) Solution properties of PHB. Light scattering and viscosity in trifluoroethanol and behaviour of highly expanded polymer coils, Macromolecules, 10, pp.: 1356–1364

    Article  CAS  Google Scholar 

  • Mohan, R.R.; Li, N.N. (1974) Reduction and separation of nitrate and nitrite by liquid membranes-encapsulated enzymes, biotechnol. Bioeng., 16, pp.: 513–523

    Google Scholar 

  • Monici, M.; Boniforti, R.; Buzzigoli, G.; De Rossi, D.; Nannini, A. (1987) Fibre-optic pH sensor for seawater monitoring, SPIE VOl. 798, pp.: 294–300

    CAS  Google Scholar 

  • Montague, G A.; Morris, A J.; Them, M.T. (1988) Adaptive Inferential Estimation and its Application to Biomass Control, Proceedings: 4th Int. Cong, on Computer Appl. in Ferment. Technology (eds. Fish, N.M.; Fox, R.J. )

    Google Scholar 

  • Moreira, A.R.; Dale, B.E.; Doremus, M.G. (1982) Utilization of the fermentor off-gases from an acetone-butanol fermentation, Biotechnol. Bioeng. Symp. Ser., 12, pp.: 263–277

    Google Scholar 

  • Moreira, A.R.; Phillips, JA.; Humphrey, A.E. (1978) Method for Determining the Con-centration of Adsorbed Protein and Cell Biomass in Cellulose Fermentations, Biotechnol. Bioeng., 20, pp.: 1501–1505

    Article  CAS  Google Scholar 

  • Moreira, A.R.; Phillips, JA.; Humphrey, A.E. (1981) Utilization of carbohydrates by Thermomonospora sp. grown on glucose, cellobiose, and cellulose, Biotechnol. Bioeng., 23 (6), pp.: 1325–1338

    Article  CAS  Google Scholar 

  • Moreno, M.C.; Martinez, A.; Millan, P.; Camara, C. (1986) Study of a pH sensitive optical fibre sensor based on the use of cresol red, J. Mol. Struct., 143, pp.: 553

    Google Scholar 

  • Mosbach, K. (ed.) (1987) Immobilized enzymes and cells. Part C, in: Methodes in Enzymology (eds.: S.P. Colowick, N.O. Kaplan ), 136, Academic Press, Orlando

    Google Scholar 

  • Mosbach, K. (ed.) (1988) Immobilized enzymes and cells. Part D, in: Methodes in Enzymology (eds.: S.P. Colowick, N.O. Kaplan ), 137, Academic Press, Orlando

    Google Scholar 

  • Mosbach, K.; Danielsson, B. (1974) An enzyme thermistor, Biochim. Biophys. Acta, 364, pp.: 140–145

    Google Scholar 

  • Mosbach, K.; Gestrelius, S.; Srere, PA.; Danielsson, B. (1974) Theoretical and practical aspects of immobilized multi-step enzyme systems, in: Enzyme Engineering (eds. E.K. Pye, L.B. Wingard, Jr.), 2, pp. 151–162, Plenum, New York

    Google Scholar 

  • Mosbach, K.; Mandenius, C.F.; Danielsson, B. (1983) New biosensor devices, proceedings: Bio-Tech’83, First World Conference and Exhibition on the Commercial Applications and Implications of Biotechnology, pp.: 665–678

    Google Scholar 

  • Mou, D.G.; Cooney, C.L. (1976) Application of dynamic calorimetry for monitoring fermentation processes, Biotechnol. Bioeng., 18, pp.: 1371–1392

    Article  CAS  Google Scholar 

  • Mou, D.G.; Cooney, C.L. (1983) Growth Monitoring and Control Through Computer-Aided On-line Mass Balancing in a fed-batch Penicillin Fermentation, Biotechnol. Bioeng., 25, pp.: 225–255

    Article  CAS  Google Scholar 

  • Möller, J. (1983) FIA - neue Techniken und Anwendungen, LaborPraxis, 7(3), pp.: 78–93

    Google Scholar 

  • Möller, J. (1987) Penicillin-Produktion mit einem Hochleistungsstamm von Pénicillium chrysogenum - Chromatographische Methoden zur Prozeßkontrolle, Dissertation, Universität Hannover

    Google Scholar 

  • Munkholm, C.; Walt, D.R.; Milanovich, F.P.; Klainer, S.M. (1986) Polymer modification of fiber optical chemical sensors as a method of enhancing fluorescence signal for pH measurement, Anal. Chem, 58, pp.: 1427–1430

    CAS  Google Scholar 

  • Munkholm, C.; Walt, D.R:; Milanovich, F.P. (1988) A fiber-optic sensor for CO2 measurement, Talanta 35(2), pp.: 109–112

    Google Scholar 

  • Munoz, E.F.; Silverman, M.P. (1979) Rapid, single-step most-probable-number method for enumerating fecal coliforms in effluents from sewage treatment plants, Appl. and Env. Microbiol., 37 (3), pp.: 527–530

    CAS  Google Scholar 

  • Muramatsu, H.; Dicks, J.M.; Karube, I. (1987) Integrated-circuit bio-calorimetric sensor for glucose. Anal. Chim. Acta, 197, pp.: 347–352

    Article  CAS  Google Scholar 

  • Muramatsu, H.; Kajiwara, K.; Tamiya, E.; Karube, I. (1986) Piezoelectric immuno sensor for the detection of Candida albicans microbes. Anal. Chim. Acta, 188, pp.: 257–262

    Article  Google Scholar 

  • Musgrove, E.; Rugg, C.; Hedley, D. (1986) Flow Cytometric Measurement of Cytoplasmic pH: A Critical Evaluation of Available Fluorochromes, Cytometry, 7, pp.: 347–355

    Article  CAS  Google Scholar 

  • Müller, W. (1987) Entwicklung eines Meßsystems zur On-line Messung der NADH-abhängigen Kulturfluoreszenz an immobilisierten Hefezellen, Diplomarbeit, Universität Hannover

    Google Scholar 

  • Müller, W.; Anders, K.D.; Scheper, T. (1989) Kulturfluoreszenzmessungen an immobilisierten Hefezellen, Chem. Ing. Techn., 61(7), pp.: 564–565

    Google Scholar 

  • Müller, W.; Wehnert, G.; Scheper, T. (1988) Fluorescence monitoring of immobilized microor-ganisms in cultures, Anal. Chim. Acta, 213, pp.: 47–53

    Article  Google Scholar 

  • Nakako, M.; Hanazato, Y.; Maeda, M.; Shiono, S. (1986) Neutral lipid enzyme electrode based on ion-sensitive field effect transistors, Anal. Chim. Acta, 185, pp.: 179–185

    Google Scholar 

  • Näbauer, A.; Berg, P.; Rüge, I. (1989) Measurement of the accumulation of biomolecules in a solution by means of piezoelectri crystals, in: Biosensors - Applications inmedicine, environmental protection and process control (eds.: R.D. Schmid, F. Scheller) GBF-Monographien, vol. 13, verlag Chemie, Weinheim

    Google Scholar 

  • Nestaas, E.; Wang, D.I.C. (1981a) A New Sensor, The Filtration Probe, for Quantitative Characterization of the Penicillin Fermentation. I. Mycelial Morphology and Culture Activity, Biotechnol. Bioeng., 23, pp.: 2803–2813

    Google Scholar 

  • Nestaas, E.; Wang, D.I.C., (1983) A New Sensor, The Filtration Probe, for Quantitative Characterization of the Penicillin Fermentation. III. An Automatically Operating Probe, Biotechnol. Bioeng., 25, pp.: 1981–1987

    Article  CAS  Google Scholar 

  • Nestaas, E.; Wang, D.I.C.; Suzuki, H.; Evans, L.B. (1981b) A New Sensor, The Filtration Probe, for Quantitative Characterization of the Penicillin Fermentation. II. The Monitor of Mycelial Growth, Biotechnol. Bioeng., 23, pp.: 2815–2824

    Google Scholar 

  • Niçois, S.L.; James, A.M. (1981) A calorimetric determination of maintenance energy requirements during the aerobic growth of Klebsiella aerogenes Biotechnol. Let., 3, pp.: 119–124

    Article  Google Scholar 

  • Nielsen, J.; Nikolajsen, K.; Villadsen, J. (1989) FIA for on-line monitoring of importatn lactic acid fermentation variables, Biotechnol. Bioeng., 33, pp.: 1127–1134

    Google Scholar 

  • Nikolajsen, K.; Nielsen, J.; Villadsen, J. (1988) In-line flow injection analysis for monitoring lactic acid fermentations, Anal. Chim. Acta, 214, pp.: 137–145

    Article  CAS  Google Scholar 

  • Nilsson, H.; Mosbach, K.; Enfors, S.-O.; Molin, N. (1978) An enzyme electrode for measure-ment of penicillin in fermentation broth: a step towar the application of enzyme electrodes in fermentation control, Biotechnol. Bioeng., 20, pp.: 527–539

    Article  CAS  Google Scholar 

  • Nishikawa, S.; Sakai, S.; Karube, I.; Matsunga, T.; Suzuki, S. (1982) Dye-Coupled Electrode System for the Rapid Determination of Cell Populations in Polluted Water, Appl. Env. Microbiol., 43 (4), pp.: 814–818

    CAS  Google Scholar 

  • Noack, U.; Boenisch, J.; Schneider, T. (1989) Algae toximeter - a biosensor for water monitoring, in: Biosensors - Application in medicine, environmental protection and process control (eds.: R.D. Schmid, F. Scheller) GBF-Monographs, 13, Verlag Chemie, Weinheim, pp.:243–246

    Google Scholar 

  • Oehme, F. (1988) Chemische und biochemische Sensoren, Chemie-Technik, 17(4), pp.: 27–33

    CAS  Google Scholar 

  • Offenbacher, H.; Wolfbeis, O.S.; Fürlinger, E. (1986) Fluorescence optical sensors for continuous determination of near-neutral pH-values, Sens. Actuators, 9, pp.: 73–84

    Article  CAS  Google Scholar 

  • Okashi, M.; Watabe, T.; Ishikawa, T.; Watanabe, Y.; Miwa, K.; Shode, M.; Ishikawa, Y.; Ando, T.; Shibata, T.; Kitsunai, T.; Kamiyama, N.; Oikawa, Y. (1979) Sensors and Instrumentation: Steam-Sterilizable Dissolved Oxygen sensors and Cell Mass Sensor for On-line Fermentation System Control, Biotechnol. Bioeng. Symp., 9, pp.: 103–116

    Google Scholar 

  • Olivera, J.R.; Silver, S.P. (1980) Immunoassays for antigens. US Patent No. 4,242,096, Dec. 30

    Google Scholar 

  • Olsson, B.; Ögren, L.; Johansson, G. (1983) An enzymatic flow injection method for the determination of oxygen. Anal. Chim. Acta, 145, pp.: 101–105

    Article  CAS  Google Scholar 

  • Olsson, B.; Lundbäck, H.; Johansson, G. (1985) Galactose determination in an automated flow- injection system containing enzyme reactors and an on-line dialyzer, Anal. Chim. Acta, 167, pp. 123–127

    Article  CAS  Google Scholar 

  • Opitz, N. (1984) Optische Messung von Verfahrensgrößen mit Hilfe fluoreszenzoptischer Verfahren, Chem. Ind. 36, pp.: 742–744

    CAS  Google Scholar 

  • Oriol, E.; Contreras, R.; Raimbault, M. (1987) Use of Microcalorimetry for Monitoring the Solid State Culture of Aspergillus niger, Biotechnol. Techniques, 1 (2), pp.: 79–84

    Article  Google Scholar 

  • Orr, T. (1988) Prospects are bright for expansion of biosensors in bioprocessing arena, Genetic Engineering News, 10/88, pp.: 27, 40

    Google Scholar 

  • Ostle, A.G.; Holt, J.G. (1982) Nile Blue A as a fluorescent stain for poly-hydoxybutyrate, Appl. Environ. Microbiol., 44(1), pp.: 238–241

    CAS  Google Scholar 

  • Owen, V. M. (1987) Commercial aspects of the use of immobilized compounds in: Analytical uses of immobilized biological compounds for detection, medical and industrial uses (eds.: G.G. Guilbault, M. Mascini), NATO ASI Series, Vol. 226, Reidel Publishing Company, Dordrecht, pp.: 329–339

    Google Scholar 

  • Park, S.H.; Hong, K.T.; Lee, J.H.; Bae, J. C. (1983) On-line Estimation of Cell Growth for Glutamic Acid Fermentation System, Eur. J. Appl. Microbiol. Biotechnol., 17, pp.: 168–172

    Google Scholar 

  • Parker, C.P.; Gardell, M.G.; Di Biasio, D. (1986) A complete system for fermentation monitoring, Internat. Biotechnol. Lab., June, pp.: 33

    Google Scholar 

  • Pennington, S.N. (1976) A small volume microcalorimeter for analytical determinations, Anal. Biochem., 72, pp.: 230–237

    Article  CAS  Google Scholar 

  • Perley, C.R.; Swartz, J.R.; Cooney, C.L. (1979) Measurement of Cell Mass Concentration with a Continuous-Flow Viscosimeter, Biotechnol. Bioeng., 21, pp.: 519–523

    Google Scholar 

  • Peterson, J.I.; Fitzgerald, R.V.; Buckhold, D.K. (1984) Fiber-optic probe for in vivo measure-ment of oxygen partial pressure, Anal. Chem. 56, pp.: 62–67

    Article  CAS  Google Scholar 

  • Peterson, J.I.; Goldstein, S.R.; Fitzgerald, R.V.; Buckhold, D.K. (1980) Fiber optic pH probe for physiological use, Anal. Chem. 52, pp.: 864–869

    Article  CAS  Google Scholar 

  • Petitdemage, H.; Cherrier, C.; Raval, G.; Gay, R. (1976) Regulation of the NADH and NADPH-Ferredoxin Oxidoreductases in Clostridia of the butyric group, Biochim. Biophys. Acta, 421, pp.: 334–347

    Article  Google Scholar 

  • Place, J.F.; Sutherland, R.M.; Dähne, C. (1985) Opto-electronic immunosensors: A review of optical immunoassay at continuous surfaces, Biosensors, 1, pp.: 321–353

    Article  CAS  Google Scholar 

  • Plötz, F. (1989) Laufende Doktorarbeit, Universität Hannover

    Google Scholar 

  • Posch, H.E.; Leiner, M J.P.; Wolfbeis, O.S.; Towards a gastric pH sensor: an optrode for the 0-7 range, Fresenius Z. Anal. Chem., 334, pp.: 162–165

    Google Scholar 

  • Preikschat, E. (1987) New Inline Method to Measure Cell Count and Cell Size in Fermentors Using a Focussed Laser Beam, Proc. 4th Eur. Cong. Biotechnol., 3, pp.: 122–125

    Google Scholar 

  • Pschyrembel, W. (1986) Klinisches Wörterbuch, Walter de Gruyter, Berlin

    Google Scholar 

  • Quack, R. (1989) Untersuchungen zum Ansprechverhalten von Enzymmembranen, Diplomarbeit, Universität Hannover

    Google Scholar 

  • Raether, H. (1977) Surface plasmon Oscillations and their applcation. in: Physics of thin films, advances in research and development (eds.: G. Haas; M.H. Francombe) Academic Pres, New York, 9, pp.: 145–261

    Google Scholar 

  • Raether, H. (1980) Excitation of plasmons and interband transitions by electrons, Springer, tracts in modern physics, Springer Verlag, Berlin, Vol. 88

    Google Scholar 

  • Ramsay, G.; Turner, A.P.F. (1988) Development of an Electrochemical Method for the Rapid Determination of Microbial Concentration and Evidence for the Reaction Mechanism, Anal. Chim. Acta, 215, pp.: 61–69

    Article  CAS  Google Scholar 

  • Ramsey, G.; Turner, A.P.F.; Franklin, A.; Higgins, I J. (1985) Rapid Bioelectrochemical Methods for the Detection of Living Microorganisms, Proceedings, Modelling and Control of Biotechnological Processes, Pergamon Press, 1st IFAC Symposium, Noordwijkerhout, 11–13 December

    Google Scholar 

  • Ranzi, B.M.; Compagno, C.; Martegani, E. (1986) Analysis of protein and cell volume distribution in glucose-limited continuous cultures by budding yeast, Biotechnol. Bioeng., 28, pp.: 185–190

    Article  CAS  Google Scholar 

  • Rao, G.; Mutharasan, R. (1987) Directed Metabolic flow and reduction state regulation in ace- tone-butanol-ethanol fermentation with Clostridium acetobutylicum, Proceedings: 194th ACS National Meeting, New Orleans, MBTD 37

    Google Scholar 

  • Rao, G.; Mutharasan, R. (1989) NADH Levels and Solventogenesis in Clostridium aceto-butylicum: New Insights through Culture Fluorescence, Appl. Microbiol. Biotechnol., 30, pp.: 59–66

    CAS  Google Scholar 

  • Reardon, K. (1987) Deactivation and Regeneration kinetics during bioconversions by immobilized Clostridium acetobutylicum, Dissertation, California Institute of technology, Pasadena, California

    Google Scholar 

  • Reardon, K.F.; Scheper, T. (1991) Determination of cell concentration and characterization of cells, Biotechnology - A multi-volume comprehensive treatise, Vol.3, im Druck

    Google Scholar 

  • Reardon, K.F.; Scheper, T.; Bailey, J.E. (1986) In situ fluorescence monitoring of immobilized Clostridium acetobutylicum, Biotechnol. Lett., 8 (11), pp. 817–822

    Google Scholar 

  • Reardon, K.F.; Scheper, T.; Bailey, J.E. (1987) Metabolic pathway rates and culture fluorescence in batch fermentations of Clostridium acetobutylicum, Biotechnology Progress, 3(3), pp.: 153–167

    Article  CAS  Google Scholar 

  • Rechnitz, G A. (1988) Biosensors, C&EN, September 5, pp.: 24–36

    Google Scholar 

  • Rehak, N.N.; Young, D.S. (1978) Prospective applications of calormetry in the clinical laboratory, Clin. Chem. 24, pp.: 1414–1419

    Google Scholar 

  • Reinhardt, B. (1987) Weiterentwicklung eines Fließinjektionssystems zur Analyse biotechnologischer Medien, Diplomarbeit, Universität Hannover

    Google Scholar 

  • Reinhardt, B. (1989) Laufende Dissertation, Universität Hannover

    Google Scholar 

  • Renneberg, R. (1988) Oxygen diffusity of synthetic gels derived from prepolymers, Appl. Microbiol. Biotechnol., 28, pp.: 1–7

    Article  CAS  Google Scholar 

  • Reuß, M. (1987b) Process Computer Coupled Substrate Feeding for Fermentation Processes, Biochemical Engineering (eds.: Chmiel, Hammes, Bailey), Gustav Fischer Verlag, Stuttgart, New York, pp. 149–168

    Google Scholar 

  • Reuß, M.; Boelcke, C.; Lenz, R.; Peckmann, U. (1987a) A New Automatic Sampling Device for Determination of Filtration Characteristics of Biosuspensions and Coupling of Analyzers with Industrial Fermentation Processes, BTF-Biotech-Forum 4, pp. 2–12

    Google Scholar 

  • Rice, T.K. (1980) Methood for the assay of classes of antigen-specific antibodies, US Patent No. 4, 314, 893,2. Dec

    Google Scholar 

  • Rice, T.K. (1982) Sanwich immunoassay using piezoelectric oscillator, US Patent No. 4,314,821, 9. Feb.

    Google Scholar 

  • Rich, S.; Ianiello, R.M.; Jespersen, N.D. (1979) Development and application of a thermistor enzyme probe in the urea-urease system, Anal. Chem. 51, pp.: 204–206

    Article  CAS  Google Scholar 

  • Ridder, C.; Hansen, E.H.; Ruzicka, J. (1982) Flow-injection analysis of glucose in human serum by albumin, Anal. Lett., 15, pp.: 1751–1766

    Article  CAS  Google Scholar 

  • Rieger, M. (1983) Untersuchung zur Regulation von Glycolyse und Atmung in Saccharomyces cerevisiae, Dissertation, ETH Zürich, Diss. ETH 7264

    Google Scholar 

  • Rinas,U. (1984) Kultivierung genetisch modifizierter Escherichia coli Stämme zur Produktion von Penicillin-G-Acylase, Diplomarbeit, Universität Hannover

    Google Scholar 

  • Ristroph, D.L.; Watteeuw, C.M.; Armiger, W.B.; Humphrey, A.E. (1977) Experiences in the use of culture fluorescence for monitoring fermentations, J. Ferment. Technol., 55, pp.: 599–608

    CAS  Google Scholar 

  • Roberts, J.K.M.; Jardetzky, O. (1981) Monitoring of Cellular Metabolism by NMR, Biochim. Biophys. Acta 639, pp.: 53–76

    CAS  Google Scholar 

  • Roederer, J.E.; Baastians, G.J. (1983) Microgravimetric immunoassay with piezoelectric crystals. Anal.Chem. 55, pp.: 2333–2336

    Article  CAS  Google Scholar 

  • Roels, JA. (1980) Application of Macroscopic Principles to Microbial Metabolism, Biotechnol. Bioeng., 22, pp.: 2457–2514

    Article  CAS  Google Scholar 

  • Romette, J.L. (1987) Mammalian cell culture process control: Sampling and sensing, in: Biosensors International Workshop 1987 (ed.: R.D. Schmid), GBF-Monograpiis, Vol. 10, Verlag Chemie, Weinheim, pp.: 81–86

    Google Scholar 

  • Romette, J.L.; Yang, J.S.; Kushabe, H.; Thomas, D. (1983) Enzyme electrode for specific de-termination of L-Lysine, Biotechnol. Bioeng., 25, pp.: 2557–2566

    Article  CAS  Google Scholar 

  • Roos, J.W.; McLaughlin, J.K.M.; Papoutsakis, E.T. (1985) The effect of pH on nitrogen supply, cell lysis, and solvent production in fermentations of Clostridium acetobutylicum, Biotechnol. Bioeng., 27, pp.: 681–694

    Article  CAS  Google Scholar 

  • Roy, D.; Samson, R. (1988) Investigation of Growth and Metabolism of Saccharomyces Cerevisiae (Baker’s Yeast) Using Microcalorimetry and Bioluminometry, J. of Biotechnol., 8, pp. 193–206

    Article  CAS  Google Scholar 

  • Ruzicka, J.; Hansen, E.H. (1979) Flow injection analysis, Chem. Techn., 9, 756–764

    CAS  Google Scholar 

  • Ruzicka, J.; Hansen, E.H. (1980) Flow injection analysis. Principles, applciations and trends, Anal. Chim. Acta, 114, pp. 165–178

    Article  Google Scholar 

  • Ruzicka, J.; Hansen, E.H. (1986) The first decade of low injection analysis: from serial assay to diagnostic tool, Chim. Acta, 179, pp.: 1–58

    Google Scholar 

  • Ruzicka, J.; Hansen, E.H. (1988) Flow Injection Analysis ( 2nd edition ), Wiley & Sons, New York

    Google Scholar 

  • Ruzicka, J.; Hansen, E.H. (1988) Homogenous and Heterogeneous Systems, Flow Injection Analysis Today and Tomorrow, Anal. Chim. Acta 214, pp.: 1–27

    Google Scholar 

  • Ruzicka, J.E.; Hansen, E.H. (1981) Flow injection analysis, J. Wiley & Sons, New York

    Google Scholar 

  • Rüther, F. (1988) Untersuchungen zur Immobilisierung von Enzymen auf Metalloxidschichten, Diplomarbeit, Universität Hannover

    Google Scholar 

  • Rüther, F. (1989) Laufende Dissertation, Universität Hannover

    Google Scholar 

  • Saari, LA.; Seitz, W.R. (1982) pH sensor based on immobilized fluoresceinamine, Anal. Chem. 54, pp.: 821–823

    Google Scholar 

  • Sakato, K.; Tanaka, H.; Samejima, H. (1981) Electrochemical Measurement of Cell Populations, Ann. New York Acad. Sci., 369, pp. 321–334

    Article  CAS  Google Scholar 

  • Samson, R.; Beaumier, D.; Beaulieu, C. (1987) Simultaneous evaluation of on-line micro-calorimetry and fluorometry during batch culture of Pseudomonas putida ATCC 11172 and Saccharomyces cerevisiae ATCC 18824, J. Biotechnol., 6, pp.: 175–190

    Google Scholar 

  • Santos, H.; Turner, D.L. (1986) Characterization of the improved sensitivity obtained using a flow method for oxygenating and mixing cell suspensions in NMR, J. Mag. Res. 68, pp. 345–349

    Google Scholar 

  • Satoh, I.; Danielsson, B.; Mosbach, K. (1981) Triglyceride determination with use of an enzyme thermistor, Anal. Chim. Acta, 131, pp.: 255–262

    Article  CAS  Google Scholar 

  • Sauerbrei (1983) Einsatz eines Enzymthermistors zur Bestimmung gelöster und intrazellulärer Penicillin G-Acylase-Aktivität, Diplomarbeit, Universität Hannover

    Google Scholar 

  • Sauerbrei, A. (1987) Entwicklung und Anwendung eines Enzymthermistors, Dissertation, Universität Hannover

    Google Scholar 

  • Sauerbrey, G,Z, (1959) The sue of oscillators for weighing thin layers and for microweighing. Z. Phys., 155, pp.: 206–211

    Article  CAS  Google Scholar 

  • Schasfoort, R.B.M.; Bergveld, P.; Börner, J.; Kooyman, R.P.H.; Greve, J. (1989) Modulation of the ISFET response by an immunological reaction; Sensors and Actuators, 17, pp.: 531–535

    Article  CAS  Google Scholar 

  • Schatzmann, H. (1975) Anaerobes Wachstum von Saccharomyces cerevisiae, Dissertation, ETH Zürich, Diss. EYTH 5504

    Google Scholar 

  • Scheller, F.; Schubert, F.; Pfeiffer, D. (1985) Biosensoren - Ein Ergebnis der Biotechnologie, Wissenschaft und Fortschritt 35(9), pp.: 249–252

    CAS  Google Scholar 

  • Scheller, F.; Schubert, F.; Pfeiffer, D.; Hintsche, R.; Dransfeld, I.; Renneberg, R.; Wollenberger, U.; Riedel, K.; Pavlova, M.; Kühn, M.; Müller, H.-G.; Tan, P.M.; Hoffmann, W.; Moritz, W. (1989) Research and development of biosensors: A review, Analyst, 114, pp.: 653–662

    Article  CAS  Google Scholar 

  • Scheller, F.W., Schubert, F., Renneberg, R., Müller, H.-G. (1985) Biosensors: Trends and Commercialization, Biosensors 1, pp.: 135–160

    Article  CAS  Google Scholar 

  • Schelp, C. (1989) Entwicklung eines optischen Biosensors, Diplomarbeit, Universität Hannover

    Google Scholar 

  • Schelp, C.; Scheper, T.; Bückmann A.F. (1989) The use of fluorescence sesnors as optical biosensors, GBF-Monographien (eds. R.D. Schmid, F. Scheller ), Vol. 13, 263–266

    Google Scholar 

  • Scheper, T. (1985) Messung zellinterner und zellexterner Parameter zur Fermentationskontrolle, Disseration, Universität Hannover

    Google Scholar 

  • Scheper, T. (1988) Biosensoren - Preiswert, sensibel und selektiv, Achema Magazin, pp.: 78–81

    Google Scholar 

  • Scheper, T.; Anders, K.D.; Freitag, R.; Hundeck, H.G.; Müller, W.; Schelp, C.; Bückmann, A.F.; Reardon K.F. (1989) Biosensor systems for process control in biotechnology, GBF-Monogra- phien (eds. R.D. Schmid, F. Scheller ), Vol. 13, 253–262

    Google Scholar 

  • Scheper, T.; Barenschee, E.R.; Barenschee, T.; Hasler, A.; Schügerl, K. (1989a) A combination of selective mass transport and enzymatic reaction: Enzyme immobilization in liquid surfactant membranes, Ber. Bunsenges. Phys. Chem. 93, pp.: 1034–1038

    CAS  Google Scholar 

  • Scheper, T.; Bückmann, FA. (1990) A fiber optic biosensor based on fluorometric detection using confined macromolecular nictotinamide adenine dinucleotide derivatives, Biosensors and Bioelectronics, 5, in press

    Google Scholar 

  • Scheper, T.; Dullau, T.; Hundeck, H.-G.; Reinhardt, B.; Schügerl, K. (1989b) Immobilisierung von Enzymen auf Oxiran-Polymerträgern für analytische Zwecke, GIT Fachz. Lab. 9, pp.: 799–808

    Google Scholar 

  • Scheper, T.; Gebauer, A.; Sauerbrei, A.; Niehoff, A.; Schügerl, K. (1984) Measurement of bio-logical parameters during fermentation processes, Anal. Chim. Acta, 163, pp.: 111–118

    Google Scholar 

  • Scheper, T.; Gebauer, A.; Schügerl, K. (1987c) Monitoring of NADH-dependent culture fluorescence during cultivation of Escherichia coli, The Chem. Eng. Journal, 34, pp. B7–B12

    Article  CAS  Google Scholar 

  • Scheper, T.; Haiwachs, W.; Schügerl (1984) Production of L-amino acid by continuous enzymatic hydrolysis of D, L-amino acid methyl ester by the liquid surfactant membrane technique, Chem. Eng. J., 29, pp.: B31–B37

    Article  Google Scholar 

  • Scheper, T.; Hitzmann, B.; Rinas, U.; Schügerl, K. (1987d) Flow cytometry of Escherichia coli for process monitoring, J. Biotechnol, 5, pp.: 139–148

    Google Scholar 

  • Scheper, T.; Hoffmann, H.; Schügerl, K. (1987e) Flow Cytometric Studies During Culture of Saccharomyces cerevisiae, Enzyme Microb. Technol. 9, pp. 399–405

    Article  CAS  Google Scholar 

  • Scheper, T.; Likidis, Z.; Makryaleas, K.; Nowottny, C.; Schügerl, K. (1987a) Three different examples of enzymatic byconversion in liquid surfactant membrane reactors, Enzyme Microb. Technol., 9(10), pp.: 625–631

    Google Scholar 

  • Scheper, T.; Lorenz, T.; Schmidt, W.; Schügerl, K. (1986) Measurement of culture fluorescence during the cultivation P. chrysogenum and Z. mobilis, J. of Biotechnol., 3, pp.: 231–238

    Article  CAS  Google Scholar 

  • Scheper, T.; Lorenz, T.; Schmidt, W.; Schügerl, K. (1987a) On-line measurement of culture fluorescence for process control of biotechnological processes, Annals of the New York Acad. Sci., 506, pp.: 431–445

    Article  CAS  Google Scholar 

  • Scheper, T.; Makryaleas, K.; Nowottny, C.; Likidis, Z., Tsikas, D.; Schügerl, K. (1987b) Annal. N.Y. Acad. Sci., 501

    Google Scholar 

  • Scheper, T.; Schügerl, K. (1986a) Characterization of bioreactors by in-situ fluorometry, J. Biotechnol., 3, pp.: 221–229

    Article  CAS  Google Scholar 

  • Scheper, T.; Schügerl, K. (1986b) Culture fluorescence studies on aerobic continuous cultures of S. cerevisiae, Appl. Microbiol. Biotechnol., 23, pp.: 440–444

    Google Scholar 

  • Scheper, T.; Weiss, M.; Schügerl, K. (1986c) Two new fluorogenic substrates for the detection of penicillin-G-acylase activity, Anal. Chim. Acta, 182, pp.: 203–206

    Article  CAS  Google Scholar 

  • Scheper,T (1989) Enzyme immobilization in liquid surfactant membrane emulsions, Adv. Drug. Del. Rev., 2, in press

    Google Scholar 

  • Schindler, J.G.; Schindler, M.M. (1983) Bioelektrochemische Membranelektroden, de Gruyter, Berlin

    Google Scholar 

  • Schlegel, H.G. (1981) Allgemeine Mikrobiologie, 5. Auflage, Georg Thieme Verlag, Stuttgart

    Google Scholar 

  • Schlegel, H.G.; Gottschalk, G.; Bartha, R. (1961) Formation and utilization of poly-ß-hy-droxybutyric acid by knallgasbacteria (Hydrogenomonas), Nature, 191, pp.: 463–465

    Article  CAS  Google Scholar 

  • Schmid R.D. (1987/1988) International workshop at the Gesellschaft für Biotechnologische Forschung (GBF), Brunswick, FRG, 23–26 June, 1987, Biosensors, 3, pp.: 239–249

    Google Scholar 

  • Schmid, R.D. (1988) Biosensoren, Nachr. Chem. Tech. Lab., 35(9), pp.: 910–914

    Article  Google Scholar 

  • Schmid, R.D. (1989) Biosensoren, Nachr. Chem. Tech. Lab., 37(7/8), pp.: 730–733

    Google Scholar 

  • Schmid, R.D.; Guilbault, G.G.; Karube, I.; Schmidt, H.-L.; Wingard, L.B. (eds.) (1987) Biosensors International Workshop 1987, GBF-Monographs, Vol. 10, VCH, Weinheim

    Google Scholar 

  • Schmid, R.D.; Scheller, F. (eds.) (1989) Biosensors Applications in Medicine, environmental protection and process control, GBF-Monographs, Vol. 13, VCH, Weinheim

    Google Scholar 

  • Schmidt, H.-L.; Krisam, G.; Grenner, G. (1976) Microcalorimetric methods for substrate determinations in flow streams with immobilized enzymes, Biochim. Biophys. Acta, 429, pp. 283–290

    CAS  Google Scholar 

  • Schmidt, H.L.; Kittstein-Eberle, R. (1986) Biosensors, Naturwissenschaften, 73(6), pp.: 314–321

    Article  CAS  Google Scholar 

  • Schmidt, W. (1985) Untersuchungen zur on-line Prozeßanalyse bei der satzweisen und kontinuierlichen Ethanolproduktion mit Zymomonas mobilis, Dissertation, Universität Hannover

    Google Scholar 

  • Schneider, K.H. (1989) Laufende Disseration, Universität Göttingen

    Google Scholar 

  • Schultz, J.S. (1987) Design of fibre-optic biosensors based on bioreeeptors, in: Biosensors - Fundamentals and Applications (eds.: A.P.F. Turner, I. Karube, G.S. Wilson, Oxford Science Publication, Oxford, pp.: 638–654

    Google Scholar 

  • Schultz, J.S.; Sims, G. (1987) Affinity sensors for individual metabolites, Biotech. Bioeng. Symp. 9, pp.: 65–71

    Google Scholar 

  • Schügerl, K.; Lübbert, A.; Scheper, T. (1987) Online-Prozeßanalyse in Bioreaktoren, Chem.- Ing.-Tech. 59(9), pp.: 701–714

    Article  Google Scholar 

  • Schwerthöffer, (1988) Trickreiche Sonden, in: Die Zeit, Nr.2,8 Januar

    Google Scholar 

  • Seitz, W.R. (1984) Chemical Sensors based on fiber optics, Anal Chem., 56(1), pp.: 16A–34A.

    Google Scholar 

  • Seitz, W.R. (1987) Optical sensors based on immobilized reagents, in: Biosensors - Fundamentals and Applications (eds.: A.P.F. Turner, I. Karube, G.S. Wilson, Oxford Science Publication, Oxford, pp.: 599–616

    Google Scholar 

  • Senior, P J.; Dawes, EA. (1973) The regulation of PHB metabolism in Azetobacter beijerickii, Biochem. J., 128, pp.: 1193–1201

    Google Scholar 

  • Seo, J.-H.; Bailey, J.E. (1987) Cell cycle analysis of plasmid-containing Escherichia coli HB 101 populations with flow cytometry, Biotechnol. Bioeng., 30, pp.: 297–305

    Article  CAS  Google Scholar 

  • Shanks, J.V.; Bailey, J.E. (19881 Estimation of intracellular sugar phosphate concentrations in Saccharomyces cerevisiae using P nuclear magnetic resonance spectroscopy, Biotechnol. Bioeng. 32, pp. 1138–1152

    Article  CAS  Google Scholar 

  • Shanks, J.V.; Bailey, J.E. (1989) Comparison of wild type and regl mutant Saccharomyces cerevisiae metabolic levels during glucose and galactose metabolism using P NMR, submitted

    Google Scholar 

  • Shapiro, H.M. (1981) Flow cytometric estimation of DNA and RNA content in intact cells stained with Hoechst 33342 and pyronin Y, Cytometry, 2 (3), pp.: 143–150

    Article  CAS  Google Scholar 

  • Shapiro, H.M. (1988) Practical Flow Cytometry, Alan R. Liss, Inc., New York, USA

    Google Scholar 

  • Sharama, A.; Wolfbeis, O.S. (1988) Unusually efficient quenching of the fluorescence of an energy transfer-based optical sensor for oxygen, Anal. Chim. Acta 212, pp.: 261–265

    Article  Google Scholar 

  • Shimmons, B.W.; Svrcek, W.Y.; Zajic, J.E. (1976) Cell Concentration by Viscosity, Biotechnol. Bioeng. 18, pp. 1793–1805

    Article  Google Scholar 

  • Shino, S.; Hanazato, Y; Nakako, M.; Maeda, M. (1987) A flow-through cell for use with an enzyme-modified field effect transistor without polymeric encapsulation and wire bonding, Anal. Chim. Acta, 202, pp.: 131–140

    Article  Google Scholar 

  • Sibbald, A. (1986) Recent advances in field-effect chemical microsensors, J. Mol. Electroncs., 2, pp.: 51–83

    Google Scholar 

  • Sidwell, J.S.; Rechnitz, G. A. (1985) Bananatrode - an electrochemical biosensor for dopamine, Biotkchn. Ltt., 7, pp.: 419–422

    Article  CAS  Google Scholar 

  • Siguta, V.A.; Shilnikova,V. K. (1978) Selective solubility of dyes in lipids of nodule bacteria, Chem. Abstracts, Vol. 89, 176243h

    Google Scholar 

  • Silvennoinen, E.; Koivo, H.N. (1982) Estimation of the Biomass Concentration in the Pekilo- Process from the Filtrate Flow Rate of the Concentrator, in: Halme, A. (Ed.), Modelling and Control of Biotechnical Processes, IFAC-Publications, pp. 219–224

    Google Scholar 

  • Slepecky, RA.; Law, J.H. (1960) A rapid spectrophotometric assay of a, ß - unsaturated acids and ß hydroxy acids, Analyt. Chem., 32, pp.: 1697–1699

    Article  CAS  Google Scholar 

  • Smith, J.L. (1908) On the simultaneous staining of neutral fat and fatty acid by oxazine dyes, J. Path. Bacterid., 12, pp.: 1–4

    Article  Google Scholar 

  • Solomon, B.O.; Erickson, L.E.; Yang, S.S. (1983) Estimation of Biomass Concentration in the Presence of solids for the Purpose of Parameter Estimation, Biotechnol. Bioeng., 25, pp.: 2469–2477

    Article  CAS  Google Scholar 

  • Sonnleitner, B. (1976) Untersuchungen zur Produktion von Poly-ß-hydroxybutyrat durch Alcali- genes eutrophus H 16 in kontinuierlicher Kultur, Diplomarbeit, Technische Universität Graz

    Google Scholar 

  • Spohn, U.; Voß, H. (1989) Probenahmesysteme in der On-line-Bioprozeßanalytik, BTF-Biotech-Forum 6(4), pp.: 274–288

    CAS  Google Scholar 

  • Spreinat, A. (1989) Laufende Dissertation, Universität Göttingen

    Google Scholar 

  • Srienc, F. (1980) Möglichkeiten der genetischen Optimierung der Produktion von PHB mit Alcaligenes eutrophus H16, Dissertation, Technische Universität Graz

    Google Scholar 

  • Srinivas, S.P.; Mutharasan, R. (1987a) Culture fluorescence characteristics and its metabolic significance in batch cultures of Clostridium acetobutylicum, Biotechnol. Lett., 9(2), pp.: 139–142

    Article  CAS  Google Scholar 

  • Srinivas, S.P.; Mutharasan, R. (1987b) Inner filter effects and their interferences in the inter-pretation of culture fluorescence, Biotechnol. Bioeng. 30 (6), pp. 769–774

    Article  CAS  Google Scholar 

  • Steen, H.B.; Boye, E.; Skarstad, K.; Bloom, B.; Godal, T.; Mustafa, S. (1982) Applications of flow cytometry on bacteria: cell cycle kinetics, drug effects, and quantition of antibody binding, Cytometry, 2 (4), pp.: 249–257

    Article  CAS  Google Scholar 

  • Steinkamp, JA. (1984) Flow cytometry, Rev. Sci. Instrum. 55 (9), pp. 1375–1400

    Article  Google Scholar 

  • Stöcklein, W.; Krämer, P.; Schmid, R.D. (1989) Fließinjektionsanalyse zum Nachweis von Pestiziden in Wasser, in: GBF-Monographs 13 (eds.: R.D. Schmid; F. Scheller ), VCH, Weinheim

    Google Scholar 

  • Stöhr, M.; Eipel, H.; Goerttler, K.; Vogt-Schaden, M. (1977) Extended Application of Flow Microfluorometry by Means of a Dual Laser Excitation, Histochem. 51, pp.: 305–313

    Article  Google Scholar 

  • Strässle, C.; Sonnleitner, B.; Fiechter, A. (1989) A predictive model for the spontaneous synchronization of Saccharomyces cerevisiae grown in continuous culture. II Experimental verification, J. Biotechnol., 9, pp.: 191–208

    Article  Google Scholar 

  • Sutherland, R.M.; Dähne, C. (1987) IRS devices for optical immunoassays, in: Biosensors - Fundamentals and Applications (eds.: A.P.F. Turner, I. Karube, G.S. Wilson, Oxford Science Publication, Oxford, pp.: 655–678

    Google Scholar 

  • Sutherland, R.M.; Dähne, C.; Place, J.F.; Ringrose, A.R. (1984b) Immunoassay at a quartz-liquid interface: theory, instrumentation and preliminary application to the fluorescent immunoassay of human immunoglobulin G

    Google Scholar 

  • Sutherland, R.M.; Dähne, C.; Place, J.F.; Ringrose, A.S. (1984a) Optical detection of antibody- antigen reactions at a glass-liquid interface, Clin. Chem. 30(9), pp.: 1533–1538

    CAS  Google Scholar 

  • Tamiya, E.; Seki, A.; Karube, I.; Gotoh, M.; Shimizu, I. (1988) Hypoxanthine sensor based on an amorphous silicon field-effect transistor; Anal. Chim. Acta, 215, pp.: 301–305

    Article  CAS  Google Scholar 

  • Taya, M.; Aoki, N.; Kobayashi, T. (1986) Estimation of Microbial Mass Concentration Based on Fluorometric Measurement of Cell Protein, J. Ferment. Technol. 64(5), pp.: 411–417

    Article  CAS  Google Scholar 

  • Taya, M.; Hegglin, M.; Prensoil, J.E.; Bourne, J.R. (1989) On-line monitoring of cell growth in plant tissue cultures by conductometry, Enzyme Microb. Technol., 11, pp.: 170–176

    Article  CAS  Google Scholar 

  • Terracciano, J.S.; Kashket,E.R. (1986) Intracellular conditions required for initiation of solvent production by Clostridium acetobutylicum, Appl. Environ. Microbiol., 52, pp.: 81–91

    Google Scholar 

  • Thakur, M.S.; Prapulla, S.G.; Karanth, N.G. (1989) Estimation of Intracellular Lipids by the Measurement of Absorbance of Yeast Cells Stained With Sudan Black B, Enzyme Microb. Technol. 11, pp.: 252–254

    Article  CAS  Google Scholar 

  • Thomas, D.C.; Chittur, V.K.; Cagney, J.W.; Lim, H.C. (1985) On-line estimation of mycelial cell mass concentrations with a computer-interfaced filtration probe, Biotechnol. Bioeng., 27, pp. 729–742

    Article  CAS  Google Scholar 

  • Titus, J A.; Haugland,R.; Sharrow, S.O.; Segal, D.M. (1982) Texas Red, a hydrophilic, red-emitting fluorphore for use with fluorescein in dual parameter flow microfluorometric and fluorescence microscopic studies, J. Immuno. Meth. 50, pp.: 193–204

    Article  CAS  Google Scholar 

  • Tran-Minh, C.; Vallin, D. (1978) Enzyme-bound thermistor as an enthalpimetric sensor. Anal. Chem., 50, 1874–1878

    Article  Google Scholar 

  • Trettnak, W.; Leiner, MJ.P.; Wolfbeis, O.S. (1988a) Fiber-optic glucose sensor with a pH optrode as a transducer, Biosensors 4,pp.: 15–26

    Article  CAS  Google Scholar 

  • Trettnak, W.; Leiner, MJ.P.; Wolfbeis, O.S. (1988b) Optical Sensors: Parrt 34 Fibre optic glucose biosensor with an oxygen optrode as the transducer, Analyst 113, pp.: 1519–1523

    Article  CAS  Google Scholar 

  • Turner, A.P.F. (1988) Current trends in biosensor research and development, Sensors and actuators, 17, pp.: 433–450

    Article  Google Scholar 

  • Turner, A.P.F.; Karube, I.; Wilson, G.S. (eds.) (1987) Biosensors - Fundamentals and Applications, Oxford Science Publication, Oxford

    Google Scholar 

  • Turner, A.P.F.; Ramsay, G.; Higgins, I.J. (1982) Applications of electron transfer between biological systems and electrodes, Biochem. Soc. Trans., 11, pp.: 445–448

    Google Scholar 

  • Ugurbil, K; Shulman, R.G.; Zeidler, R.B.; Ghanta, V.K.; Brockmann, R.W.; Schiefer, L.M:; Braunschweiger, P.G. (1979) Biological applications of magnetic resonance, Academic Press, New York

    Google Scholar 

  • Valet, G.; Raffael, A.; Moroder, L.; Wünsch, E.; Ruhenstroth-Bauer, G. (1981) Fast Intracellular pH Determination in Single Cells by Flow-Cytometry, Naturwissenschaften, 68, pp.: 265–266

    Article  CAS  Google Scholar 

  • van Brunt, J. (1987) Biosensors for Bioprocesses, BioTechnology, 5(5), pp.: 437–440

    Article  Google Scholar 

  • van der Schoot, B.H.; Bergveld, P. (1988) ISFET based enzyme sensors; Sensors and Actuators, 3, 161–86

    Google Scholar 

  • van Ginkel, C.G.; Habets-Crützen, A.Q.H.; van der Last, A.R.M.; de Bont, JAM. (1987) A Description of Microbial Growth on Gaseous Alkenes in a Chemostat Culture, Biotechnol. Bioeng., 30, pp.: 799–804

    Article  Google Scholar 

  • Vanous, R.D. (1978) Understanding Nephelometric Instrumentation, American Laboratory, 6, pp.:

    Google Scholar 

  • Vaughan, W.M.; Weber, G. (1970) Oxygen quenching of pyrenebutyric acid fluorescence in water. A dynamic probe for the microenvironment, Biochem. 9, pp.: 464

    Article  CAS  Google Scholar 

  • Verduyn, C.; Zomerdijk, T.P.L.; van Dijken, J.P.; Scheffers, WA. (1984) Continuous measurement of ethanol production by aerobic yeast suspensions with an enzyme electrode, Appl. Microbiol. Biotechnol., 19, pp.: 181–185

    Article  CAS  Google Scholar 

  • Viopor, J.W.M.; Jongeling, A.A.M.; Tanke, H.I. (1979) Intracellular pH-Determination by Fluorescence Measurements, J. Histochem. Cytochem., 27 (1), pp.: 32–35

    Article  Google Scholar 

  • Visser, J.W.M.; Jongeling, A.A.M.; Tanke, H.J. (1979) Intracellular pH-Determination by Fluorescence Measurements, J. Histochem. Cytochem., 27(1), pp.: 32–35

    Article  CAS  Google Scholar 

  • Vogel, H.J.; Brodelius, P. (1984) An In Vivo 31P NMR Comparison of Freely Suspended and Immobilized Catharanthus roseus Plant Cells, J. Biotechnol., 1, pp.: 159–170

    Article  CAS  Google Scholar 

  • von Meyenburg, K. (1969) Katabolitrepression und Sprossungszyklus bei S. cerevisiae, Dissertation, ETH-Zürich

    Google Scholar 

  • Vorlop, K.D.; Klein, J. (1981) New developments in the field of cell immobilization in formation of biocatalysts by ionotrophic gelation, Biotechnol. Lett., 3, pp.: 219–235

    Article  Google Scholar 

  • Walker, C.C.; Dhurjati, P. (1989) Use of culture fluorescence as a sensor for on-line discrimination of host and overproducing recombinant Escherichia coli, Biotechnol. Bioeng. 33, pp.: 500–505

    Article  CAS  Google Scholar 

  • Walters B.S.; Nielsen, T.J.; Arnold, MA. (1988) Fiber-optic biosensor for ethanol, based on an internal enzyme concept, Talanta 35(2), pp.: 151–156

    Article  CAS  Google Scholar 

  • Wang, H.; Wang, D.I.C.; Cooney, C.L. (1978) The application of dynamic calorimetry for monitoring growth of Saccharomyces cerevisiae, Eur. J. Appl. Microbiol. Biotechnol., 5, pp.: 207–214

    Article  Google Scholar 

  • Wang, N.S.; Stephanopoulos, G.N. (1984) Computer Applications to Fermentation Processes, CRC Critical Reviews in Biotechnology, Vol. 2, Issue 1, pp.: 1–103

    Article  Google Scholar 

  • Wangsa, J.; Arnold, MA. (1988) Fiber-optic biosensors based on the fluorometric detection of reduced nicotinamide adenine dinucleotide, Anal. Chem. 60, pp.: 1080–1082

    Article  CAS  Google Scholar 

  • Watanabe, E.; Ogura, T., Toyama, K.; Karube, I.; Matsuoka, H.; Suzuki, S. (1984) Determination of adenosine 5’-monophosphate in fish and shellfish using an enzyme sensor, Enzyme Microb. Technol., 6, pp.: 207–211

    Article  CAS  Google Scholar 

  • Watteeuw,C.; Armiger, W.B.; Ristroph, D.; Humphrey, A.E. (1979) Production of single cell protein from ethanol by fed-batch process, Biotechnol. Bioeng., 21, pp. 1221–1237

    Article  CAS  Google Scholar 

  • Weaver, J.C.; Cooney, C.L.; Fulton, S.P.; Schuler, D.; Tannenbaum, S.R. (1976) Experiments and Calculation concerning a thermal enzyme probe, Biochim. Biophys. Acta, 452, pp.: 285–291

    CAS  Google Scholar 

  • Wehnert, G. (1986) Einsatz eines Enzym thermistors zur on-line Glucosebestimmung in Fermentationsmedien, Diplomarbeit, Universität Hannover

    Google Scholar 

  • Wehnert, G. (1989) Entwicklung einer kombinierten Fluoreszenz-/Streulichtsonde zur on-line und in situ Biomasseabschätzung bei Fermentationsprozessen, Dissertation, Universität Hannover

    Google Scholar 

  • Wehnert, G.; Sauerbrei, A.; Bayer, T.; Scheper, T.; Schügerl, K.; Herold, T. (1987) Application of an enzyme thermistor for the determination of glucose in complex fermentation media, Anal. Chim. Acta, 200, pp.: 73–78

    Article  CAS  Google Scholar 

  • Wehnert, G.; Sauerbrei, A.; Schügerl, K. (1985) Glucose oxidase immobilized on Eupergit C and CPG-10 - A comparison, biotechnol. Lett, 7(11), pp.: 827–830

    Article  CAS  Google Scholar 

  • Wentz, D. (1989) On-line-Prozeßüberwachung im Bioreaktor und Einfluß von Medium-sparametern auf das Wachstum tierischer Zellen, Dissertation, Universität Hannover

    Google Scholar 

  • Wichmann, R.; Wandrey, C.; Bückmann, A.F.; Kula, M.R. (1981) Continuous enzymatic transformation in an enzyme membrane reactro with simultaneous NAD(H) regeneration, Biotechnol. Bioeng. 23, pp.: 2789–2802

    Article  CAS  Google Scholar 

  • Wilhelm, D. (1989) Laufende Dissertation, Universität Hannover

    Google Scholar 

  • Wilkins, J.R. (1978) Use of Platinum Electrodes for the Electrochemical Detection of Bacteria, Appl. Env. Microbiol., 36(5), pp.: 683–687

    CAS  Google Scholar 

  • Wilkins, J.R.; Stoner, G.E.; Boykin, E.H. (1974) Microbial detection method based on sensing molecular hydrogen, Appl. Nicrobiol. 27, pp.: 949–952

    CAS  Google Scholar 

  • Wilkins, J.R.; Young, R.N.; Boykin, E.H. (1978) Multichannel electrochemical microbial detection unit, Appl. Env. Microbiol., 35 (1), pp. 214–215

    CAS  Google Scholar 

  • Wilson, P.D.G. (1987) On-line Estimation of Biomass Using Dynamic Oxygen Balancing, Biotechnol. Techniques, 1 (3), pp. 151–156

    Article  CAS  Google Scholar 

  • Wingard, L.B.; Castner, J. (1987) Potentiometrie biosensors based on redox electrodes, in: Biosensors - Fundamentals and Applications (eds.: A.P.F. Turner, I. Karube, G.S. Wilson, Oxford Science Publication, Oxford, pp.: 153–162

    Google Scholar 

  • Winquist, F.; Danielsson, B.; Malpote, J.-Y.; Persson, L.; Larsson, M.-B. (1985) Enzyme thermistor determination of oxalate with immobilized oxalate oxidase, Anal. Lett. 18, pp.: 573–588

    Article  CAS  Google Scholar 

  • Wittrup, K.D.; Bailey, J.E. (1988) A single-cell assay of ß-galactosidase activity in Saccharomyces cerevisiae, Cytometry, 9, pp.: 394–404

    Article  CAS  Google Scholar 

  • Wittrup, K.D.; Mann, M.B.; Fenton, D.M.; Tsai, L.B.; Bailey, J.E. (1988) Single-Cell Light Scatter as a Probe of Refractile Body Formation in Recombinant Escherichia coli, Bio/Technology, 6,pp.: 423–426

    Article  CAS  Google Scholar 

  • Wolfbeis, O.S. (1985) Acid-base titrations using fluorescent indicators and fiber optical light guides, Fresenius Z. Anal. Chem. 320, pp.: 271–273

    Article  CAS  Google Scholar 

  • Wolfbeis, O.S. (1987) Fibre-optic sensors for chemical parameters of interest in biotechnology, GBF-Monographs, Vol. 10 (eds. R.D. Schmid), pp.: 197–206

    Google Scholar 

  • Wolfbeis, O.S. (1988a) The development of fibre-optic sensors by immobilization of fluorescent probes, in: Analytical uses of immobilized biological compounds for detection, medical and industrial uses, NATO ASI Series, Vol. 226, Reidel Publishing Company, Dordrecht, pp.: 219–226

    Google Scholar 

  • Wolfbeis, O.S. (1988b) Fiber optical fluorosensors in analytical and clinical chemistry, Chem. Anal., 77(Mol. Lumin. Spectrosc., Pt.2), pp.: 129–281

    CAS  Google Scholar 

  • Wolfbeis, O.S.; Marhold, H. (1987) A new group of fluorescent pH-indicators for an extended pH-range, Fresenius Z. Anal. Chem. 327, pp.: 347–350

    Article  CAS  Google Scholar 

  • Wolfbeis, O.S.; Offenbacher, H. (1986) Fluorescence sensor for monitoring ionic strength and physiological pH values, Sens. Actuators 9(1), pp.: 85

    Article  CAS  Google Scholar 

  • Wolfbeis, O.S.; Posch, W.R. (1986) Fibre-optic fluorescing sensor for ammonia, Anal. Chim. Acta, 185, pp.: 321–327

    Article  CAS  Google Scholar 

  • Wolfbeis, O.S.; Trettnak, W. (1989) A new method for determination of enzyme substrates by monitoring the intrinsic fluorescence of immobilized enzymes, in: Biosensors - Applications in medicine, environmental protection and process control (eds. R.D. Schmid, F. Scheller), GBF- Monographs, Vol. 13, pp.: 213–220

    Google Scholar 

  • Wolfbeis, O.S.; Weis, L.J.; Leiner, M.J.L.; Ziegler, W.E. (1988) Fibre-optic fluorosensors for oxygen and carbon dioxide, Anal. Chem. 60, pp.: 2028–2030

    Article  CAS  Google Scholar 

  • Wolfbeis,O.S. (1989) Optochemical Sensors (Optrodes) and their applications, Kontakte (Darmstadt), 2, pp.: 30–34

    Google Scholar 

  • Wong, C.-H.; Whiteside, G.M. (1981) Enzyme-catalyzed organic synthesis, NAD(P)H cofactor regeneration using glucose-6-phosphate and the glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides, J. Am. Chem. Soc., 103, pp.: 4890

    Article  CAS  Google Scholar 

  • Wudtke, M. (1987) Untersuchungen zur Schädigung von tierischen Zellen durch mechanische Beanspruchung, Dissertation, Universität Hannover

    Google Scholar 

  • Wyatt, WA.; Bright, F.V.; Hieftje, G.M. (1987) Characterization and comparison of three fiber-optic sensors for iodide determination based on dynamic fluorescence, Anal. Chem 59, pp.: 2272–2276

    Article  CAS  Google Scholar 

  • Yuan, P.; Walt, D.R. (1987) Calculation for fluorescence modulation by absorbing species and its application to measurements using optical,,fibers, Anal. Chem. 59, pp.: 2391–2394

    Article  CAS  Google Scholar 

  • Zabriskie, D.W. (1979) Use of culture fluorescence for monitoring of fermentation systems, Biotechnol. Bioeng. Symp. 9, pp.: 117–123

    Google Scholar 

  • Zabriskie, D.W.; Armiger, W.B.; Humphrey, A.E. (1975) Estimation of cell biomass and growth rate by measurement of culture fluorescence, Proceedings: ASM Meeting, New York, pp. 195

    Google Scholar 

  • Zabriskie, D.W.; Armiger, W.B.; Humphrey, A.E. (1977) Applications of Computers to the Indirect Measurement of Biomass Concentration and Growth Rate by Component Balancing, in: Workshop Computer Applications in Fermentation Technology, (Ed.: Jefferis, R.P.) GBF Mo-nographien, Verlag Chemie, Weinheim, pp.: 59–72

    Google Scholar 

  • Zabriskie, D.W.; Humphrey, A.E. (1978) Continuous dialysis for the on-line analysis of diffusible components in fermentation broth, Biotechnol. Bioeng., 20, pp.: 1295–1301

    Article  CAS  Google Scholar 

  • Zabriskie, D.W.; Humphrey, A.E. (1978) Estimation of fermentation biomass concentration by measuring culture fluorescence, Appl. Eur. Microbiol., 35(2), pp.: 337–343

    CAS  Google Scholar 

  • Zell, RA. (1986) Biosensoren revolutionieren die Meßtechnik: Ein Stück Leben auf dem Chip, Bild der Wissenschaft, 4, pp.: 100–110

    Google Scholar 

  • Zhujun, Z.; Seitz, W.R. (1984) A fluorescence sensor for quantifiying pH in the range from 6.5 to 8.5, Anal. Chim. Acta, 160, pp.: 47–55

    Article  Google Scholar 

  • Zhujun, Z.; Zhang, Y.; Wangbai, M.; Rüssel, R.; Shakhsher, Z.M. (1989) Poly(vinylalcohol) as a substrate for indicator immobilization for fiber-optic chemical sensors, Anal. Chem., 61, pp.: 202–205

    Article  Google Scholar 

  • Zouh, W. (1989) Cephalosporin-C-Produktion mit einem Hochleistungsstamm von Cephalosporium acremonium, Dissertation, Universität Hannover

    Google Scholar 

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Scheper, T. (1991). Literaturverzeichnis. In: Bioanalytik. Vieweg+Teubner Verlag. https://doi.org/10.1007/978-3-322-83738-7_6

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