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Cluster Analysis of Multiparametric MR Imaging including ADC Maps and Relaxometry for Spatially High-Resolved Differentiation of Healthy and Ischemic Human Brain Tissue

  • Johannes Bernarding
  • Jürgen Braun
  • Joachim Hohmann
  • Mathias Hoehn-Berlage
  • Christian Stapf
  • Klaus-Jürgen Wolf
  • Thomas Tolxdorff

Abstract

In experimental stroke models and ischemic human brain tissue the apparent diffusion coefficient (ADC) decreases in the acute phase, may normalize after reperfusion or may increase in the chronic stage, suggesting that the ADC may be used to monitor the physiologic state of affected tissue. However, a spatially high-resolved determination of the ADC for human brain tissue, required for the transfer of experimental results, is a complex task: (a) ischemic regions in human brain are often small, heterogeneous or irregularly shaped; (b) examination conditions and the complex human brain anatomy lead to widely scattered ADC values. To improve characterization of healthy and pathologic tissues, navigated diffusion-weighted images and ADC maps were incorporated in a new approach into a multidimensional parameter set of relaxation times (T1, T2) and T1-/T2-weighted images. Volunteers and patients with different neurologic deficits were examined. A supervised histogram-based analysis enabled the segmentation of healthy and pathologie tissue classes and the determination of their mean values and standard deviations. Healthy brain tissue was segmented by incorporating T1 relaxation in the data set. Acute and chronic ischemic regions were best differentiated by combining T2- or diffusion-weighted images with ADC maps. The results support findings that within the first week the mean ADC of human ischemic regions is reduced before approaching or exceeding normal values.

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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH, Braunschweig/Wiesbaden 1999

Authors and Affiliations

  • Johannes Bernarding
    • 1
  • Jürgen Braun
    • 1
  • Joachim Hohmann
    • 1
  • Mathias Hoehn-Berlage
    • 4
  • Christian Stapf
    • 3
  • Klaus-Jürgen Wolf
    • 2
  • Thomas Tolxdorff
    • 1
  1. 1.Departments of Medical Informatics, University Hospital Benjamin FranklinFree University of BerlinGermany
  2. 2.Radiology and Nuclear Medicine, University Hospital Benjamin FranklinFree University of BerlinGermany
  3. 3.Neurology (Stroke Unit), University Hospital Benjamin FranklinFree University of BerlinGermany
  4. 4.Max Planck Institute for Neurological ResearchCologneGermany

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