Abstract
To “win the war” against a continuous development of new and old (“emerging and re-emerging”) drug-resistant and pathogenic bacteria is a problem. Super drug-resistant bacteria are now isolated from patients and the environment in most countries in the world. Overuse and abuse of antibacterial agents in treatment and growth promotional activity have led to more resistant bacteria being transferred to animal and fish production, and vice versa, and may be included in the food chain. In addition, increased mobility, climatic changes, overcrowding, war and disasters, poor hygiene and poor infection control are accelerating this chain reaction. Modern infection prevention efforts must be directed towards detection, reduction and removal of unfortunate use of antibacterial agents. Central to this work is proper hygiene and good infection control both for humans and animals. This chapter is focused on practical measures to control overuse and abuse of antibacterial agents and to prevent drug resistance.
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References
WHO. The evolving threat of antibacterial resistance. Options for action. Geneva: World Health Organization; 2012.
Peirano G, Bradford PA, Kazmierczak KM, et al. Global incidence of carbapenemase-producing Escherichia coli ST131. Emerg Infect Dis. 2014;20:1928–31.
CDC. Antibiotic resistance threats in the United States. Atlanta: CDC; 2013.
National strategy for combating antibiotic resistant bacteria. The White House, Washington; September 2014.
O’Fallon E, Kandell R, Schreiber R, D’Agata EM. Acquisition of multidrug resistant gram negative bacteria; incidence and risk factors within a long term care population. Infect Control Hosp Epidemiol. 2010;31:1148–53.
Bucket CL, Besser RE. Combating antimicrobial resistance: intervention programs to promote appropriate antibiotic use. Inf Med. 2002;19:160–73.
Interagency task force on antimicrobial resistance: a public health action plan to combat antimicrobial resistance. Available at http://www.cdc.gov/drugresistance/actionplan/html/index.htm. Accessed June 22, 2004.
ECDC. European antibiotic awareness day, a European health initiative. Summary of latest data on antibiotic resistance in the European Union. EARS-Net results; 2013.
Friedman CR, Whitney CG. It’s time for a change in practice: reduction of antibiotic use can alter antibiotic resistance. J Infect Dis. 2008;197:1082–3.
Bronzwaer SLAM, Cars O, Buchholz U, et al. A European study on the relationship between antimicrobial use and antimicrobial resistance. Emerg Infect Dis. 2002;8:278–82.
Boucher HW, Talbot GH, Bradley JS et al. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Disease Society of America. Clin Infect Dis 2009; 48: 1–12.
Antibiotic use in the United States. Progress and opportunities. Atlanta, GA. CDC 2017.
The Board of Global Health and Institute of Medicine. Ending the war metaphor: the changing agenda for unraveling the host-microbe relationship - workshop summary. Washington, DC: The National Academies Press; 2006.
Breedlove B, Cohen ML. After the resistance: the Alamo today. Emerg Infect Dis. 2014;20:1268–9.
Fleming SA. Nobel lecture: penicillin. 1945. Stockholm: Nobel Media AB; 2013.
Andersen BM. Microbiology and infection protection. Handbook of hygiene and infection control in hospitals. Fagbokforlaget; 2014.
Andersen BM. Food infection is a neglected problem. Aftenposten Knowledge; Oct 28, 2014.
Paterson GK, Larsen J, Harrison EM, et al. First detection of livestock-associated methicillin-resistant Staphylococcus aureus CC398 in bulk tank milk in the United Kingdom, January to July 2012. Euro Surveill. 2012;17:20337.
Casey JA, Curriero FC, Cosgrove SE, Nachman KE, Schwartz BS. High-density livestock operations. Crop field application of manure, and risk of community-associated methicillin-resistant Staphylococcus aureus infection in Pennsylvania. JAMA Intern Med. 2013;173(21):1980–90.
ECDC Surveillance reports. Summary of the latest data on antibiotic resistance in Europe; 2017.
WHO. Antimicrobial resistance 2014. Geneva: World Health Organization; 2014.
Lee HW, Koh YM, Kim J, et al. Capacity of multidrug resistant clinical isolates of Acinetobacter baumannii to form biofilm and adhere to epithelial cell surfaces. Clin Microbiol Infect. 2008;14:49–54.
Litleskare I, Blix S. Total usage in humans, animals and fish, measured in weight of active substance. NORM/NORM-VET 2015;(1):27.
Grave K. Usage of antimicrobial agents in animals. NORM/NORM-VET 2015;(1):24.
ECDC: point prevalence survey of healthcare-associated infections and antimicrobial use in European hospitals 2011-2012. ECDC, Surveillance Report; 2 July 2013.
Eveillard M, Schmit JL, Eb F. Antimicrobial use prior to the acquisition of multiresistant bacteria. Infect Control Hosp Epidemiol. 2002;23:155–8.
Grub C, Holberg-Petersen M, Medbø S, Andersen BM, Syversen G, Melby KK. A multi-drug resistant, methicillin-susceptible strain of Staphylococcus aureus from a neonatal intensive care unit in Oslo, Norway. Scand J Infect Dis. 2010;42:148–51.
Gutierrez D, Delgado S, Vasquez-Sanches D, et al. Incidence of Staphylococcus aureus and analysis of associated bacterial communities on food industry surfaces. Appl Environ Microbiol. 2012;78:8547–54.
NORM/NORM-VET. Usage of antimicrobial agents and occurrence of antimicrobial resistance in Norway. Tromsø/Oslo 2013, 2014 and 2015.
ECDC Surveillance reports. Summary of the latest data on antibiotic consumption in the European Union; 2017.
Sievert DM, Ricks P, Edwards JR, et al. Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the centers of disease control and prevention, 2009-2010. Infect Control Hosp Epidemiol. 2013;34:1–14.
Livermore DM. Defining an extended-spectrum beta-lactamase. Clin Microbiol Infect. 2008;14:3–10.
Harris AD, McGregor JC, Johnson JA, et al. Risk factors for colonization with extended-spectrum beta-lactamase-producing bacteria and intensive care unit admission. Emerg Infect Dis. 2007;13:1144–9.
Olafsen K, Hotvedt R, Andersen BM, Almdahl SM, Sorlie D. Nosocomial infection with resistant Enterobacter cloacae. Tidsskr Nor Legeforen. 1989;109:332–6.
Koeleman JGM, van der Bijl MW, Stove J, Vanderbroucke-Grauls CMJE, Savelkoul PHM. Antibiotic resistance is a major risk factor for epidemic behavior of Acinetobacter baumannii. Infect Control Hosp Epidemiol. 2001;22:284–8.
Pimentel JD, Low J, Styles K, Harris OC, Hughes A, Athan E. Control of an outbreak of multi-drug resistant Acinetobacter baumannii in an intensive care unit and a surgical ward. J Hosp Infect. 2005;59:249–53.
Wybo I, Blommert L, De Beer T, et al. Outbreak of multidrug-resistant Acinetobacter baumannii in a Belgian university hospital after transfer from Greece. J Hosp Infect. 2007;67:374–80.
Bukholm G, Tannæs T, Kjelsberg ABB, Smith-Erichsen N. An outbreak of multidrug-resistant Pseudomonas aeruginosa associated with increased risk of patient death in an intensive care unit. Infect Control Hosp Epidemiol. 2002;23:441–6.
Wang CY, Jerng JS, Cheng KY, et al. Pandrug-resistant Pseudomonas aeruginosa among hospitalized patients; clinical features, risk factors and outcomes. Clin Microbiol Infect. 2006;12:63–8.
Qureshi A, Mooney L, Denton M, Kerr KG. Stenotrophomonas maltophilia in salads. Emerg Infect Dis. 2005;11:1157–8.
Grundmann H, Livermore DM, Giske CG, et al. The CNSE Working Group. Carbapenem-non-susceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts. Euro Surveill. 2010;15:19711. http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19711
Kumarasamy KK, Toleman MA, Walsh TR, et al. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect Dis. 2010;10:597–602.
Rasheed JK, Kitchel B, Zhu W, et al. New Delhi metallo-beta-lactamase-producing Enterobacteriaceae, United States. Emerg Infect Dis. 2013;19:870.
Zachary KC, Bayne PS, Morrison VJ, Ford DS, Silver LC, Hooper DC. Contamination of gowns, gloves, and stethoscopes with vancomycin-resistant enterococci. Infect Control Hosp Epidemiol. 2001;22:560–4.
Byers KE, Anglim AM, Anneski CJ, Farr BM. Duration of colonization with vancomycin-resistant enterococcus. Infect Control Hosp Epidemiol. 2002;23:207–11.
Andersen BM, Seljordslia B, Hochlin K, Rasch M, Syversen G. A predicted outbreak in an overcrowded, administratively neglected and run-down haemodialysis unit as a victim of “new public management” in Norwegian hospitals. J Hosp Admin. 2013;2:1–10.
Sjølund M, Tano E, Blaser MJ, Andersson DI, Engstrand L. Persistence of resistant Staphylococcus epidermidis after single course of clarithromycin. Emerg Infect Dis. 2005;11:1389–93.
WHO. Tuberculosis (TB) WHO monitoring of Xpert MTB/RIF roll-out, 2013. 2017.
Andersen BM. Use of antibacterial agents. In: Handbook in hygiene and infection control in hospitals. Oslo: Ullevål University Hospital; 2008. p. 156–9.
Marshall BM, Levy SB. Food animals and antimicrobials: impacts on human health. Clin Microbiol Rev. 2011;24:718–33.
Andersen BM, Holta Ringertz S, Gullord Petersen T, et al. A three-year survey of nosocomial and community-acquired infections, antibiotic treatment and re-hospitalization in a Norwegian health region. J Hosp Infect. 2000;44:214–23.
Andersen BM, Rasch M, Hochlin K, Tollefsen T, Sandvik L. Hospital-acquired infections before and after healthcare reorganization in a tertiary university hospital in Norway. J Publ Health. 2009;7:1–7.
Vennerød AM, editor. Norwegian Medicines Guide for Health Professionals. Oslo: Association for release by Norwegian Medicines Handbook Oslo; 2015.
Jensenius M, von der Lippe B, Melby KK, Steinbakk M. Brief guide in antibiotic selection. Oslo: Ullevål University Hospital, revised edition; 2000.
Brubakk O, Brørs O, Andersen BM. Treatment suggestions for infections. In: Handbook in hygiene and infection control for hospitals. Oslo: Ullevål University Hospital; 2003. p. 62–4.
Guidelines for antibiotic use in primary care. Antibiotic center for primary care (ASP); 12 Jan 2009.
Andersen BM. Antibacterial agents. In: In: handbook of hygiene and infection control for nursing homes and other long-term care institutions. Oslo: Akademika Forlag; 2013. p. 455–61.
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Andersen, B.M. (2019). Antibacterial Agents and Drug Resistance. In: Prevention and Control of Infections in Hospitals. Springer, Cham. https://doi.org/10.1007/978-3-319-99921-0_4
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DOI: https://doi.org/10.1007/978-3-319-99921-0_4
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