Abstract
Neurologic and psychiatric disorders encompass a diverse range of disabling conditions. Collectively these diseases are increasingly recognized as disorders of the brain’s neural connections. Brain disorders are currently estimated to affect as many as 1.5 billion people worldwide—a number that is expected to grow as life expectancy increases (Gooch et al., Ann Neurol 81:479–484, 2017). Treatment of these chronic conditions involves long-term use of multiple pharmacologic agents, raising the concern of side effects and possible drug interactions with medications used during the delivery of dental care. There is much overlap between the types of medications used to treat both neurologic and psychiatric diseases. Appropriate preoperative assessment of dental patients should always include obtaining a thorough medical history that includes a current complete list of medications. It is incumbent on the oral healthcare practitioner that an analysis of possible drug interactions be done prior to the administration or prescription of any drugs used during the provision of dental care. This chapter provides an update of the current drug therapies used for patients with psychiatric diagnoses as well as Parkinson’s disease, Alzheimer’s disease, and seizure disorders and discusses potential drug interactions of clinical importance to the oral healthcare provider.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Aarsland D, Larsen JP, Lim NG, Janvin C, Karlsen K, Tandberg E, Cummings JL. Range of neuropsychiatric disturbances in patients with Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1999;67(4):492–6.
Aarsland D, Marsh L, Schrag A. Neuropsychiatric symptoms in Parkinson’s disease. Mov Disord. 2009;24(15):2175–86.
Abdallah C. Considerations in perioperative assessment of valproic acid coagulopathy. J Anaesthesiol Clin Pharmacol. 2014;30(1):7.
Alda M. Lithium in the treatment of bipolar disorder: pharmacology and pharmacogenetics. Mol Psychiatry. 2015;20(6):661.
Alz.org. Alzheimer’s disease & dementia|Alzheimer’s Association. [online]. 2018. https://www.alz.org/alzheimers_disease_what_is_alzheimers.asp. Accessed 28 May 2018.
Alzheimer’s Association. 2018 Alzheimer’s disease facts and figures. Alzheimers Dement. 2018;14(3):367–429.
Anglin R, Yuan Y, Moayyedi P, Tse F, Armstrong D, Leontiadis GI. Risk of upper gastrointestinal bleeding with selective serotonin reuptake inhibitors with or without concurrent nonsteroidal anti-inflammatory use: a systematic review and meta-analysis. Am J Gastroenterol. 2014;109(6):811.
Anon. [online]. 2018. http://www.ninds.nih.gov/disorders/parkinsons_disease/parkinsons_disease.htm. Accessed 29 May 2018.
Balakrishnan R, Ebenezer VI. Contraindications of vasoconstrictors in dentistry. Biomed Pharmacol J. 2013;6(2):409–14.
Baldessarini RJ. Drug therapy of depression and anxiety disorders. In: Brunton LL, Lazo JS, Parker KL, editors. Goodman and Gilman’s the pharmacological basis of therapeutics. New York: McGraw-Hill; 2006. p. 429–60.
Bauer MS, Mitchner L. What is a “mood stabilizer”? An evidence-based response. Am J Psychiatr. 2004;161(1):3–18.
Becker DE. Psychotropic drugs: implications for dental practice. Anesth Prog. 2008;55(3):89–99.
Bentué-Ferrer D, Tribut O, Polard E, Allain H. Clinically significant drug interactions with cholinesterase inhibitors. CNS Drugs. 2003;17(13):947–63.
Bhat NP, Preethishree P. Depression and its pharmacological management: a critical review. J Drug Deliv Therap. 2015;5(4):54–60.
Bomasang-Layno E, Fadlon I, Murray AN, Himelhoch S. Antidepressive treatments for Parkinson’s disease: a systematic review and meta-analysis. Parkinsonism Relat Disord. 2015;21(8):833–42.
Brodie MJ, Besag F, Ettinger AB, Mula M, Gobbi G, Comai S, Aldenkamp AP, Steinhoff BJ. Epilepsy, antiepileptic drugs, and aggression: an evidence-based review. Pharmacol Rev. 2016;68(3):563–602.
Brown RS, Rhodus NL. Epinephrine and local anesthesia revisited. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100(4):401–8.
Casey DA. Pharmacotherapy of neuropsychiatric symptoms of dementia. P T. 2015;40(4):284–7.
Catalani B, Hamilton CS, Herron EW, Urman RD, Fox CJ, Kaye AD. Psychiatric agents and implications for perioperative analgesia. Best Pract Res Clin Anaesthesiol. 2014;28(2):167–81.
Chen JJ. Parkinson disease: a summary of recent evidence-based medicine reviews. Ment Health Clin. 2012;2(2):25–31.
Chen Z, Brodie MJ, Liew D, Kwan P. Treatment outcomes in patients with newly diagnosed epilepsy treated with established and new antiepileptic drugs: a 30-year longitudinal cohort study. JAMA Neurol. 2018;75(3):279–86.
Connolly BS, Lang AE. Pharmacological treatment of Parkinson disease: a review. JAMA. 2014;311(16):1670–83.
Defilippi JL, Crismon ML. Drug interactions with cholinesterase inhibitors. Drugs Aging. 2003;20(6):437–44.
Epilepsy Foundation. About epilepsy: the basics. (online). 2018. https://www.epilepsy.com/learn/about-epilepsy-basics. Accessed 28 May 2018.
Fennema J, Petrykiv S, de Jonge L, Arts M. Efficacy and safety of antidepressants as analgesics in chronic pain: a review. Eur Psychiatry. 2017;41:S234.
Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, Dworkin RH, Gilron I, Haanpää M, Hansson P, Jensen TS, Kamerman PR. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol. 2015;14(2):162–73.
Fishbain D. Evidence-based data on pain relief with antidepressants. Ann Med. 2000;32(5):305–16.
Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Moshé SL, Peltola J, Roulet Perez E, Scheffer IE. Operational classification of seizure types by the international league against epilepsy: position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58(4):522–30.
Friedlander AH, Marder SR. The psychopathology, medical management and dental implications of schizophrenia. J Am Dent Assoc. 2002;133(5):603–10.
Friedlander AH, Norman DC. Late-life depression: psychopathology, medical interventions, and dental implications. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;94(4):404–12.
Friedlander AH, Mahler M, Norman KM, Ettinger RL. Parkinson disease: systemic and orofacial manifestations, medical and dental management. J Am Dent Assoc. 2009;140(6):658–69.
Garrett AR, Hawley JS. SSRI-associated bruxism: a systematic review of published case reports. Neurol Clin Pract. 2018;8(2):135–41.
Gauthier S, Cummings J, Ballard C, Brodaty H, Grossberg G, Robert P, Lyketsos C. Management of behavioral problems in Alzheimer’s disease. Int Psychogeriatr. 2010;22(3):346–72.
Giron MS, Forsell Y, Bernsten C, Thorslund M, Winblad B, Fastbom J. Psychotropic drug use in elderly people with and without dementia. Int J Geriatr Psychiatry. 2001;16(9):900–6.
Glauser T, Shinnar S, Gloss D, Alldredge B, Arya R, Bainbridge J, Bare M, Bleck T, Dodson WE, Garrity L, Jagoda A. Evidence-based guideline: treatment of convulsive status epilepticus in children and adults: report of the guideline committee of the American Epilepsy Society. Epilepsy Curr. 2016;16(1):48–61.
Gooch CL, Pracht E, Borenstein AR. The burden of neurological disease in the United States: a summary report and call to action. Ann Neurol. 2017;81(4):479–84.
Griffin CE III, Kaye AM, Bueno FR, Kaye AD. Benzodiazepine pharmacology and central nervous system–mediated effects. Ochsner J. 2013;13(2):214–23.
Gubbins PO, Heldenbrand S. Clinically relevant drug interactions of current antifungal agents. Mycoses. 2010;53(2):95–113.
Han JY, Besser LM, Xiong C, Kukull WA, Morris JC. Cholinesterase inhibitor use and cognitive decline in mild cognitive impairment and mild dementia due to Alzheimer disease. Alzheimers Dement. 2017;13(7):P1054.
Hashimoto R, Hough C, Nakazawa T, Yamamoto T, Chuang DM. Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation. J Neurochem. 2002;80(4):589–97.
Kennedy WK, Jann MW, Kutscher EC. Clinically significant drug interactions with atypical antipsychotics. CNS Drugs. 2013;27(12):1021–48.
Kishi T, Matsunaga S, Oya K, Nomura I, Ikuta T, Iwata N. Memantine for Alzheimer’s disease: an updated systematic review and meta-analysis. J Alzheimers Dis. 2017;60(2):401–25.
Kumar A, Singh A. A review on Alzheimer’s disease pathophysiology and its management: an update. Pharmacol Rep. 2015;67(2):195–203.
Kyrios M. Anxiety disorders in primary care. In: Emmelkamp P, Ehring T, editors. The Wiley handbook of anxiety disorders. Hoboken: Wiley; 2014. p. 58–68.
Loke YK, Trivedi AN, Singh S. Meta-analysis: gastrointestinal bleeding due to interaction between selective serotonin uptake inhibitors and non-steroidal anti-inflammatory drugs. Aliment Pharmacol Ther. 2008;27(1):31–40.
Lopez OL, Živković S, Smith G, Becker JT, Meltzer CC, DeKosky ST. Psychiatric symptoms associated with cortical-subcortical dysfunction in Alzheimer’s disease. J Neuropsychiatry Clin Neurosci. 2001;13(1):56–60.
Löscher W, Klitgaard H, Twyman RE, Schmidt D. New avenues for anti-epileptic drug discovery and development. Nat Rev Drug Discov. 2013;12(10):757.
Malamed SF. Pharmacology of vasoconstrictors. In: Malamed SF, editor. Handbook of local anesthesia-E-book. London: Elsevier Health Sciences; 2014. p. 39–52.
Mansour A, Pearce M, Johnson B, Sey MS, Oda N, Collegala N, Krishnadev U, Bhalerao S. Which patients taking SSRIs are at greatest risk of bleeding? J Fam Pract. 2006;55(3):206–8.
Manu P, Flanagan RJ, Ronaldson KJ, editors. Life-threatening effects of antipsychotic drugs. London: Academic Press; 2016.
Melvin CL, Carey TS, Goodman F, Oldham JM, Williams JW Jr, Ranney LM. Effectiveness of antiepileptic drugs for the treatment of bipolar disorder: findings from a systematic review. J Psychiatr Pract. 2008;14:9–14.
Menza M, Dobkin RD, Marin H, Mark MH, Gara M, Buyske S, Bienfait K, Dicke A. A controlled trial of antidepressants in patients with Parkinson disease and depression. Neurology. 2009;72(10):886–92.
Miyamoto S, Miyake N, Jarskog LF, Fleischhacker WW, Lieberman JA. Pharmacological treatment of schizophrenia: a critical review of the pharmacology and clinical effects of current and future therapeutic agents. Mol Psychiatry. 2012;17(12):1206.
Miyasaki JM, Shannon K, Voon V, Ravina B, Kleiner-Fisman G, Anderson K, Shulman LM, Gronseth G, Weiner WJ. Practice parameter: evaluation and treatment of depression, psychosis, and dementia in Parkinson disease (an evidence-based review) report of the quality standards Subcommittee of the American Academy of Neurology. Neurology. 2006;66(7):996–1002.
Moodley DS. Local anaesthetics in dentistry-part 3: vasoconstrictors in local anaesthetics. S Afr Dent J. 2017;72(4):176–8.
Mulsant BH, Sink K, Holden K, Yaffe K. Pharmacotherapy provides minimal improvements in the neuropsychiatric symptoms of dementia. Evid Based Ment Health. 2005;8(3):83.
Nimh.nih.gov. NIMH: mental illness. (online). 2018a. http://www.nimh.nih.gov/health/statistics/prevalence/any-mental-illness-ami-among-adults.shtml. Accessed 1 Jun 2018.
Nimh.nih.gov. NIMH: schizophrenia. (online). 2018b. https://www.nimh.nih.gov/health/statistics/schizophrenia.shtml. Accessed 26 May 2018.
Nimh.nih.gov. NIMH: bipolar disorder. (online). 2018c. http://www.nimh.nih.gov/health/statistics/prevalence/bipolar-disorder-among-adults.shtml. Accessed 26 May 2018.
Nimh.nih.gov. NIMH: major depression. (online). 2018d. http://www.nimh.nih.gov/health/statistics/prevalence/major-depression-among-adults.shtml. Accessed 26 May 2018.
Nimh.nih.gov. NIMH: any anxiety disorder. (online). 2018e. http://www.nimh.nih.gov/health/statistics/prevalence/any-anxiety-disorder-among-adults.shtml. Accessed 26 May 2018.
Noetzli M, Eap CB. Pharmacodynamic, pharmacokinetic and pharmacogenetic aspects of drugs used in the treatment of Alzheimer’s disease. Clin Pharmacokinet. 2013;52(4):225–41.
Nussbaum RL, Ellis CE. Alzheimer’s disease and Parkinson’s disease. N Engl J Med. 2003;348(14):1356–64.
Olin JT, Schneider LS, Katz IR, Meyers BS, Alexopoulos GS, Breitner JC, Bruce ML, Caine ED, Cummings JL, Devanand DP, Krishnan KR. Provisional diagnostic criteria for depression of Alzheimer disease. Am J Geriatr Psychiatry. 2002;10(2):125–8.
Orgeta V, Tabet N, Nilforooshan R, Howard R. Efficacy of antidepressants for depression in Alzheimer’s disease: systematic review and meta-analysis. J Alzheimers Dis. 2017;58(3):725–33.
Ozeki Y, Fujii K, Kurimoto N, Yamada N, Okawa M, Aoki T, Takahashi J, Ishida N, Horie M, Kunugi H. QTc prolongation and antipsychotic medications in a sample of 1017 patients with schizophrenia. Prog Neuro-Psychopharmacol Biol Psychiatry. 2010;34(2):401–5.
Pasqualetti G, Tognini S, Calsolaro V, Polini A, Monzani F. Potential drug–drug interactions in Alzheimer patients with behavioral symptoms. Clin Interv Aging. 2015;10:1457.
Patsalos PN, Perucca E. Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs. Lancet Neurol. 2003;2(8):473–81.
Perucca E. Clinically relevant drug interactions with antiepileptic drugs. Br J Clin Pharmacol. 2006;61(3):246–55.
Pringsheim T, Jette N, Frolkis A, Steeves TD. The prevalence of Parkinson’s disease: a systematic review and meta-analysis. Mov Disord. 2014;29(13):1583–90.
Rabkin JU, Quitkin F, Harrison WI, Tricamo E, McGRATH PA. Adverse reactions to monoamine oxidase inhibitors. Part I. A comparative study. J Clin Psychopharmacol. 1984;4(5):270–8.
Robbins MR. Dental management of special needs patients who have epilepsy. Dent Clin North Am. 2009;53(2):295–309.
Ropacki SA, Jeste DV. Epidemiology of and risk factors for psychosis of Alzheimer’s disease: a review of 55 studies published from 1990 to 2003. Am J Psychiatr. 2005;162(11):2022–30.
Salerno SM, Browning R, Jackson JL. The effect of antidepressant treatment on chronic back pain: a meta-analysis. Arch Intern Med. 2002;162(1):19–24.
Sansone RA, Sansone LA. Tramadol: seizures, serotonin syndrome, and coadministered antidepressants. Psychiatry (Edgmont). 2009;6(4):17.
Saraghi M, Golden LR, Hersh EV. Anesthetic considerations for patients on antidepressant therapy—part I. Anesth Prog. 2017;64(4):253–61.
Schmidt D, Schachter SC. Drug treatment of epilepsy in adults. BMJ. 2014;348:g254.
Schneider LS, Dagerman K, Insel PS. Efficacy and adverse effects of atypical antipsychotics for dementia: meta-analysis of randomized, placebo-controlled trials. Am J Geriatr Psychiatry. 2006;14(3):191–210.
Selkoe DJ, Schenk D. Alzheimer’s disease: molecular understanding predicts amyloid-based therapeutics. Annu Rev Pharmacol Toxicol. 2003;43(1):545–84.
Serebruany VL. Selective serotonin reuptake inhibitors and increased bleeding risk: are we missing something? Am J Med. 2006;119(2):113–6.
Sink KM, Holden KF, Yaffe K. Pharmacological treatment of neuropsychiatric symptoms of dementia: a review of the evidence. JAMA. 2005;293(5):596–608.
Substance Abuse and Mental Health Services Administration. Results from the 2014 National Survey on Drug Use and Health: mental health findings, NSDUH series H-50, HHS publication no. (SMA) 15-4927. Rockville: Substance Abuse and Mental Health Services Administration; 2015. http://www.samhsa.gov/data/sites/default/files/NSDUH-FRR1-2014/NSDUH-FRR1-2014.pdf. Accessed 1 April 2018.
Suchowersky O, Reich S, Perlmutter J, Zesiewicz T, Gronseth G, Weiner WJ. Practice parameter: diagnosis and prognosis of new onset Parkinson disease (an evidence-based review) report of the quality standards Subcommittee of the American Academy of Neurology. Neurology. 2006;66(7):968–75.
Tysnes OB, Storstein A. Epidemiology of Parkinson’s disease. J Neural Transm. 2017;124(8):901–5.
Vasudev K, Keown P, Gibb I, McAllister-Williams RH. Hematological effects of valproate in psychiatric patients: what are the risk factors? J Clin Psychopharmacol. 2010;30(3):282–5.
Walsh DM, Selkoe DJ. Deciphering the molecular basis of memory failure in Alzheimer’s disease. Neuron. 2004;44(1):181–93.
Wang J, Yu JT, Wang HF, Meng XF, Wang C, Tan CC, Tan L. Pharmacological treatment of neuropsychiatric symptoms in Alzheimer’s disease: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2015;86(1):101–9.
Wirdefeldt K, Adami HO, Cole P, Trichopoulos D, Mandel J. Epidemiology and etiology of Parkinson’s disease: a review of the evidence. Eur J Epidemiol. 2011;26(1):1.
Yagiela JA. Adverse drug interactions in dental practice: interactions associated with vasoconstrictors. J Am Dent Assoc. 1999;130(5):701–9.
Zack MM, Kobau R. National and state estimates of the numbers of adults and children with active epilepsy-United States, 2015. Morb Mortal Wkly Rep. 2017;66(31):821–5.
Zhuo C, Jiang R, Li G, Shao M, Chen C, Chen G, Tian H, Li J, Xue R, Jiang D. Efficacy and tolerability of second and third generation anti-epileptic drugs in refractory epilepsy: a network meta-analysis. Sci Rep. 2017;7(1):2535.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Robbins, M.R. (2019). Pharmacologic Management of Patients with Neurologic Disorders. In: Jeske, A. (eds) Contemporary Dental Pharmacology. Springer, Cham. https://doi.org/10.1007/978-3-319-99852-7_7
Download citation
DOI: https://doi.org/10.1007/978-3-319-99852-7_7
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-99851-0
Online ISBN: 978-3-319-99852-7
eBook Packages: MedicineMedicine (R0)