Abstract
Modern biological paradigms of invasion in tumour cells cannot be fully explained or described by existing modelling techniques. We present a novel cellular automata model which represents both the nucleus of a cell and its membrane, allowing one to capture the interaction of a cell with its environment, as well as selected theorems for the efficient computation of solutions to such systems. We use this technique to simulate cell-cell binding, single-cellular micro track invasion, and co-injection of MITF\(^{\text {HIGH}}\)(proliferative) and MITF\(^{\text {LOW}}\)(invasive) tumour cells into heterogeneous environments. Results shed new light on emergent phenomena of cellular elongation, filopodial protrusion, and the co-invasion of the local stroma by classically non-invasive cells. We also provide a new modelling framework in which the cellular automaton exhibits non-local interaction within its context.
Supported by l’École Doctorale I2S de l’Université de Montpellier.
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Hodgkinson, A. (2018). A Novel Cellular Automata Modelling Framework for Micro-environmental Interaction and Co-invasion. In: Mauri, G., El Yacoubi, S., Dennunzio, A., Nishinari, K., Manzoni, L. (eds) Cellular Automata. ACRI 2018. Lecture Notes in Computer Science(), vol 11115. Springer, Cham. https://doi.org/10.1007/978-3-319-99813-8_3
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DOI: https://doi.org/10.1007/978-3-319-99813-8_3
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