Skip to main content
SpringerLink
Log in

Perioperative Psychiatric Problems in Organ Transplantation

  • Chapter
  • First Online:
Perioperative Psychiatry

Abstract

This chapter begins with a brief review of the history of organ transplantation and a description of the process of transplantation listing and postsurgical care, which are relevant to understand the patient’s journey through this complex process. We will then present the most important findings regarding prevalence of psychiatric problems in transplant candidates and recipients, followed by a review of the evidence about the impact of psychiatric presentations upon the post specific transplantation outcomes. This chapter will focus on the psychiatric implications of transplantation among recipients and donors of solid organs—specifically, the kidney, pancreas, liver, heart, lung, and intestine. The procedures involving other human tissues (such as the cornea, skin, bone marrow, and vascularized composite allographs) will not be addressed. A separate section in this chapter is dedicated to the most important psychiatric aspects of living organ donors.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. UNOS-History [cited 2018 04/03]. Available from: https://unos.org/transplantation/history/

  2. Anatomical Gift Act. The National Conference of Commissioners on Uniform State Laws [cited 2018 04/03]. 2006. Available from: http://uniformlaws.org/Act.aspx?title=Anatomical%20Gift%20Act%20(2006)

  3. Rao PS, Schaubel DE, Guidinger MK, Andreoni KA, Wolfe RA, Merion RM, et al. A comprehensive risk quantification score for deceased donor kidneys: the kidney donor risk index. Transplantation. 2009;88(2):231–6.

    Article  PubMed  Google Scholar 

  4. Lau T, Ahmad J. Clinical applications of the Model for End-stage Liver Disease (MELD) in hepatic medicine. Hepat Med. 2013;5:1–10.

    PubMed  PubMed Central  Google Scholar 

  5. National Data. Organ Procurement and Transplantation Network. US Department of Health and Human Services [cited 2017 12/07]. 2017. Available from: https://optn.transplant.hrsa.gov/data/view-data-reports/national-data

  6. Need Continues to Grow. Organ Procurement and Transplantation Network. US Department of Health and Human Services [cited 2018 04/03]. Available from: https://optn.transplant.hrsa.gov/need-continues-to-grow

  7. https://www.unos.org/data/

  8. Nahum LH. Transplant psychosis. Conn Med. 1969;33(8):508 passim.

    CAS  PubMed  Google Scholar 

  9. Allen JP, Wurst FM, Thon N, Litten RZ. Assessing the drinking status of liver transplant patients with alcoholic liver disease. Liver Transpl. 2013;19(4):369–76.

    Article  PubMed  Google Scholar 

  10. Everhart JE, Beresford TP. Liver transplantation for alcoholic liver disease: a survey of transplantation programs in the United States. Liver Transpl Surg. 1997;3(3):220–6.

    Article  CAS  PubMed  Google Scholar 

  11. Lentine KL, Lam NN, Xiao H, Tuttle-Newhall JE, Axelrod D, Brennan DC, et al. Associations of pre-transplant prescription narcotic use with clinical complications after kidney transplantation. Am J Nephrol. 2015;41(2):165–76.

    Article  PubMed  Google Scholar 

  12. Levenson JL, Olbrisch ME. Psychosocial evaluation of organ transplant candidates. A comparative survey of process, criteria, and outcomes in heart, liver, and kidney transplantation. Psychosomatics. 1993;34(4):314–23.

    Article  CAS  PubMed  Google Scholar 

  13. Mathurin P, Moreno C, Samuel D, Dumortier J, Salleron J, Durand F, et al. Early liver transplantation for severe alcoholic hepatitis. N Engl J Med. 2011;365(19):1790–800.

    Article  CAS  PubMed  Google Scholar 

  14. Hajifathalian K, Humberson A, Hanouneh MA, Barnes DS, Arora Z, Zein NN, et al. Ohio solid organ transplantation consortium criteria for liver transplantation in patients with alcoholic liver disease. World J Hepatol. 2016;8(27):1149–54.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Zimbrean P, Emre S. Patients with psychotic disorders in solid-organ transplant. Prog Transplant. 2015;25(4):289–96.

    Article  PubMed  Google Scholar 

  16. Gazdag G, Horvath GG, Makara M, Ungvari GS, Gerlei Z. Predictive value of psychosocial assessment for the mortality of patients waiting for liver transplantation. Psychol Health Med. 2016;21(4):525–9.

    Article  PubMed  Google Scholar 

  17. Carnrike CL Jr, McCracken LM, Aikens JE. Social desirability, perceived stress, and PACT ratings in lung transplant candidates: a preliminary investigation. J Clin Psychol Med Settings. 1996;3(1):57–67.

    Article  PubMed  Google Scholar 

  18. Maldonado JR, Sher Y, Lolak S, Swendsen H, Skibola D, Neri E, et al. The Stanford integrated psychosocial assessment for transplantation: a prospective study of medical and psychosocial outcomes. Psychosom Med. 2015;77(9):1018–30.

    Article  PubMed  Google Scholar 

  19. Adinolfi LE, Nevola R, Rinaldi L, Romano C, Giordano M. Chronic hepatitis C virus infection and depression. Clin Liver Dis. 2017;21(3):517–34.

    Article  PubMed  Google Scholar 

  20. Doering LV, Chen B, Deng M, Mancini D, Kobashigawa J, Hickey K. Perceived control and health-related quality of life in heart transplant recipients. Eur J Cardiovasc Nurs. 2017;17(6):513–20.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Chilcot J, Hudson JL, Moss-Morris R, Carroll A, Game D, Simpson A, et al. Screening for psychological distress using the Patient Health Questionnaire Anxiety and Depression Scale (PHQ-ADS): initial validation of structural validity in dialysis patients. Gen Hosp Psychiatry. 2018;50:15–9.

    Article  PubMed  Google Scholar 

  22. Mohamed S, Sabki ZA, Zainal NZ. Depression and psychosocial correlates of liver transplant candidates: a systematic review. Asia Pac Psychiatry. 2014;6(4):447–53.

    PubMed  Google Scholar 

  23. Dew MA, Kormos RL, DiMartini AF, Switzer GE, Schulberg HC, Roth LH, et al. Prevalence and risk of depression and anxiety-related disorders during the first three years after heart transplantation. Psychosomatics. 2001;42(4):300–13.

    Article  CAS  PubMed  Google Scholar 

  24. Anvar-Abnavi M, Bazargani Z. Prevalence of anxiety and depression in Iranian kidney transplant recipients. Neurosciences. 2010;15(4):254–7.

    PubMed  Google Scholar 

  25. Annema C, Roodbol PF, Stewart RE, Porte RJ, Ranchor AV. Prevalence of psychological problems and associated transplant-related variables at different time periods after liver transplantation. Liver Transpl. 2015;21(4):524–38.

    Article  PubMed  Google Scholar 

  26. Sirri L, Potena L, Masetti M, Tossani E, Grigioni F, Magelli C, et al. Prevalence of substance-related disorders in heart transplantation candidates. Transplant Proc. 2007;39(6):1970–2.

    Article  CAS  PubMed  Google Scholar 

  27. Evans LD, Stock EM, Zeber JE, Morissette SB, MacCarthy AA, Sako EY, et al. Posttransplantation outcomes in veterans with serious mental illness. Transplantation. 2015;99(8):e57–65.

    Article  PubMed  Google Scholar 

  28. Webzell I, Ball D, Bell J, Sherwood RA, Marsh A, O’Grady JG, et al. Substance use by liver transplant candidates: an anonymous urinalysis study. Liver Transpl. 2011;17(10):1200–4.

    Article  PubMed  Google Scholar 

  29. Osthus TB, Preljevic V, Sandvik L, Dammen T, Os I. Renal transplant acceptance status, health-related quality of life and depression in dialysis patients. J Ren Care. 2012;38(2):98–106.

    Article  PubMed  Google Scholar 

  30. Craven J. Psychiatric aspects of lung transplant. The Toronto Lung Transplant Group. Can J Psychiatr. 1990;35(9):759–64.

    Article  CAS  Google Scholar 

  31. Cheng Y, Zhang G, Shen W, Huang LX, Zhang L, Xie SS, et al. Impact of previous episodes of hepatic encephalopathy on short-term brain function recovery after liver transplantation: a functional connectivity strength study. Metab Brain Dis. 2018;33(1):237–49.

    Article  PubMed  Google Scholar 

  32. van Zwieten A, Wong G, Ruospo M, Palmer SC, Barulli MR, Iurillo A, et al. Prevalence and patterns of cognitive impairment in adult hemodialysis patients: the COGNITIVE-HD study. Nephrol Dial Transplant. 2017;33(7):1197–206.

    Article  Google Scholar 

  33. Burkhalter H, Denhaerynck K, Huynh-Do U, Binet I, Hadaya K, De Geest S. Change of sleep quality from pre- to 3 years post-solid organ transplantation: the Swiss Transplant Cohort Study. PLoS One. 2017;12(10):e0185036.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  34. Adams RJ, Appleton SL, Vakulin A, Hanly PJ, McDonald SP, Martin SA, et al. Chronic kidney disease and sleep apnea association of kidney disease with obstructive sleep apnea in a population study of men. Sleep. 2017;40(1) https://doi.org/10.1093/sleep/zsw015.

  35. Lin Z, Zhao C, Luo Q, Xia X, Yu X, Huang F. Prevalence of restless legs syndrome in chronic kidney disease: a systematic review and meta-analysis of observational studies. Ren Fail. 2016;38(9):1335–46.

    Article  PubMed  Google Scholar 

  36. Stilley CS, Dew MA, Pilkonis P, Bender A, McNulty M, Christensen A, et al. Personality characteristics among cardiothoracic transplant recipients. Gen Hosp Psychiatry. 2005;27(2):113–8.

    Article  PubMed  Google Scholar 

  37. Oliver N, Bohorquez H, Anders S, Freeman A, Fine K, Ahmed E, et al. Post-liver transplant delirium increases mortality and length of stay. Ochsner J. 2017;17(1):25–30.

    PubMed  PubMed Central  Google Scholar 

  38. Lee J, Kim DK, Lee JW, Oh KH, Oh YK, Na KY, et al. Rapid correction rate of hyponatremia as an independent risk factor for neurological complication following liver transplantation. Tohoku J Exp Med. 2013;229(2):97–105.

    Article  PubMed  Google Scholar 

  39. Smith PJ, Rivelli SK, Waters AM, Hoyle A, Durheim MT, Reynolds JM, et al. Delirium affects length of hospital stay after lung transplantation. J Crit Care. 2015;30(1):126–9.

    Article  CAS  PubMed  Google Scholar 

  40. Flynn K, Daiches A, Malpus Z, Yonan N, Sanchez M. “A post-transplant person”: narratives of heart or lung transplantation and intensive care unit delirium. Health (London). 2014;18(4):352–68.

    Article  Google Scholar 

  41. Van Sandwijk MS, Ten Berge IJ, Majoie CB, Caan MW, De Sonneville LM, Van Gool WA, et al. Cognitive changes in chronic kidney disease and after transplantation. Transplantation. 2016;100(4):734–42.

    Article  PubMed  CAS  Google Scholar 

  42. Zimbrean P, Crone C, Sher Y, Dew MA, DiMartini A. Transplant psychiatry: psychiatric care of organ donors and recipients. Psychiatr Times. 2016;33: 24F–24H.

    Google Scholar 

  43. Brown ES, Chandler PA. Mood and cognitive changes during systemic corticosteroid therapy. Prim Care Companion J Clin Psychiatry. 2001;3(1):17–21.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Fardet L, Petersen I, Nazareth I. Suicidal behavior and severe neuropsychiatric disorders following glucocorticoid therapy in primary care. Am J Psychiatry. 2012;169(5):491–7.

    Article  PubMed  Google Scholar 

  45. Bolanos SH, Khan DA, Hanczyc M, Bauer MS, Dhanani N, Brown ES. Assessment of mood states in patients receiving long-term corticosteroid therapy and in controls with patient-rated and clinician-rated scales. Ann Allergy Asthma Immunol. 2004;92(5):500–5.

    Article  PubMed  Google Scholar 

  46. Keenan PA, Jacobson MW, Soleymani RM, Mayes MD, Stress ME, Yaldoo DT. The effect on memory of chronic prednisone treatment in patients with systemic disease. Neurology. 1996;47(6):1396–402.

    Article  CAS  PubMed  Google Scholar 

  47. Davis JM, Leach A, Merk B, Janicak PG. Treatment of steroid psychoses. Psychiatr Ann. 1992;22(9):487–91.

    Article  Google Scholar 

  48. Bhat M, Wyse JM, Moodie E, Ghali P, Hilzenrat N, Wong P, et al. Prevalence and predictors of sleep disturbance among liver diseases in long-term transplant survivors. Can J Gastroenterol Hepatol. 2015;29(8):440–4.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Brekke FB, Waldum-Grevbo B, von der Lippe N, Os I. The effect of renal transplantation on quality of sleep in former dialysis patients. Transpl Int. 2017;30(1):49–56.

    Article  PubMed  Google Scholar 

  50. Sommerwerck U, Kleibrink BE, Kruse F, Scherer MJ, Wang Y, Kamler M, et al. Predictors of obstructive sleep apnea in lung transplant recipients. Sleep Med. 2016;21:121–5.

    Article  PubMed  Google Scholar 

  51. Dew MA, DiMartini AF, DeVito Dabbs AJ, Fox KR, Myaskovsky L, Posluszny DM, et al. Onset and risk factors for anxiety and depression during the first 2 years after lung transplantation. Gen Hosp Psychiatry. 2012;34(2):127–38.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Davydow DS, Lease ED, Reyes JD. Posttraumatic stress disorder in organ transplant recipients: a systematic review. Gen Hosp Psychiatry. 2015;37(5):387–98.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Spivey CA, Chisholm-Burns MA, Damadzadeh B, Billheimer D. Determining the effect of immunosuppressant adherence on graft failure risk among renal transplant recipients. Clin Transpl. 2014;28(1):96–104.

    Article  CAS  Google Scholar 

  54. Lieber SR, Volk ML. Non-adherence and graft failure in adult liver transplant recipients. Dig Dis Sci. 2013;58(3):824–34.

    Article  CAS  PubMed  Google Scholar 

  55. Taber DJ, Fleming JN, Fominaya CE, Gebregziabher M, Hunt KJ, Srinivas TR, et al. The impact of health care appointment non-adherence on graft outcomes in kidney transplantation. Am J Nephrol. 2017;45(1):91–8.

    Article  PubMed  Google Scholar 

  56. Brocks Y, Zittermann A, Grisse D, Schmid-Ott G, Stock-Giessendanner S, Schulz U, et al. Adherence of heart transplant recipients to prescribed medication and recommended lifestyle habits. Prog Transplant. 2017;27(2):160–6.

    Article  CAS  PubMed  Google Scholar 

  57. Scheel JF, Schieber K, Reber S, Stoessel L, Waldmann E, Jank S, et al. Psychosocial variables associated with immunosuppressive medication non-adherence after renal transplantation. Front Psych. 2018;9:23.

    Article  Google Scholar 

  58. Belaiche S, Decaudin B, Dharancy S, Noel C, Odou P, Hazzan M. Factors relevant to medication non-adherence in kidney transplant: a systematic review. Int J Clin Pharm. 2017;39(3):582–93.

    Article  PubMed  Google Scholar 

  59. Duncan S, Annunziato RA, Dunphy C, LaPointe RD, Shneider BL, Shemesh E. A systematic review of immunosuppressant adherence interventions in transplant recipients: decoding the streetlight effect. Pediatr Transplant. 2018;22(1) https://doi.org/10.1111/petr.13086.

    Article  CAS  Google Scholar 

  60. Constantiner M, Rosenthal-Asher D, Tedla F, Salifu M, Cukor J, Wyka K, et al. Differences in attitudes toward immunosuppressant therapy in a multi-ethnic sample of kidney transplant recipients. J Clin Psychol Med Settings. 2017;25(1):11–9.

    Article  Google Scholar 

  61. Szeifert L, Molnar MZ, Ambrus C, Koczy AB, Kovacs AZ, Vamos EP, et al. Symptoms of depression in kidney transplant recipients: a cross-sectional study. Am J Kidney Dis. 2010;55(1):132–40.

    Article  PubMed  Google Scholar 

  62. Muller HH, Englbrecht M, Wiesener MS, Titze S, Heller K, Groemer TW, et al. Depression, anxiety, resilience and coping pre and post kidney transplantation – initial findings from the Psychiatric Impairments in Kidney Transplantation (PI-KT)-Study. PLoS One. 2015;10(11):e0140706.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  63. Smith PJ, Rivelli S, Waters A, Reynolds J, Hoyle A, Flowers M, et al. Neurocognitive changes after lung transplantation. Ann Am Thorac Soc. 2014;11(10):1520–7.

    Article  PubMed  PubMed Central  Google Scholar 

  64. Dixon BS, VanBuren JM, Rodrigue JR, Lockridge RS, Lindsay R, Chan C, et al. Cognitive changes associated with switching to frequent nocturnal hemodialysis or renal transplantation. BMC Nephrol. 2016;17:12.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Dew MA, DiMartini AF. Psychological disorders and distress after adult cardiothoracic transplantation. J Cardiovasc Nurs. 2005;20(5 Suppl):S51–66.

    Article  PubMed  Google Scholar 

  66. Martinelli V, Fusar-Poli P, Emanuele E, Klersy C, Campana C, Barale F, et al. Getting old with a new heart: impact of age on depression and quality of life in long-term heart transplant recipients. J Heart Lung Transplant. 2007;26(5):544–8.

    Article  PubMed  Google Scholar 

  67. Dew MA, DiMartini AF, Steel J, De Vito DA, Myaskovsky L, Unruh M, et al. Meta-analysis of risk for relapse to substance use after transplantation of the liver or other solid organs. Liver Transpl. 2008;14(2):159–72.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Dumortier J, Dharancy S, Cannesson A, Lassailly G, Rolland B, Pruvot FR, et al. Recurrent alcoholic cirrhosis in severe alcoholic relapse after liver transplantation: a frequent and serious complication. Am J Gastroenterol. 2015;110(8):1160–6. quiz 7.

    Article  PubMed  Google Scholar 

  69. Baguelin-Pinaud A, Moinier D, Fouldrin G, Le Roy F, Etienne I, Godin M, et al. Renal transplantation, anxiety and depressive disorders and quality of life. Encéphale. 2009;35(5):429–35.

    Article  CAS  PubMed  Google Scholar 

  70. Baranyi A, Krauseneck T, Rothenhausler HB. Overall mental distress and health-related quality of life after solid-organ transplantation: results from a retrospective follow-up study. Health Qual Life Outcomes. 2013;11:15.

    Article  PubMed  PubMed Central  Google Scholar 

  71. Burkhalter H, Wirz-Justice A, Cajochen C, Weaver TE, Steiger J, Fehr T, et al. Daytime sleepiness in renal transplant recipients is associated with immunosuppressive non-adherence: a cross-sectional, multi-center study. Clin Transpl. 2014;28(1):58–66.

    Article  Google Scholar 

  72. Calia R, Lai C, Aceto P, Luciani M, Saraceni C, Avolio AW, et al. Psychological risk factors for graft rejection among liver transplant recipients. Transplant Proc. 2011;43(4):1123–7.

    Article  CAS  PubMed  Google Scholar 

  73. Chacko RC, Harper RG, Gotto J, Young J. Psychiatric interview and psychometric predictors of cardiac transplant survival. Am J Psychiatry. 1996;153(12):1607–12.

    Article  CAS  PubMed  Google Scholar 

  74. Corruble E, Barry C, Varescon I, Falissard B, Castaing D, Samuel D. Depressive symptoms predict long-term mortality after liver transplantation. J Psychosom Res. 2011;71(1):32–7.

    Article  PubMed  Google Scholar 

  75. Cukor D, Rosenthal DS, Jindal RM, Brown CD, Kimmel PL. Depression is an important contributor to low medication adherence in hemodialyzed patients and transplant recipients. Kidney Int. 2009;75(11):1223–9.

    Article  PubMed  Google Scholar 

  76. Dobbels F, Skeans MA, Snyder JJ, Tuomari AV, Maclean JR, Kasiske BL. Depressive disorder in renal transplantation: an analysis of Medicare claims. Am J Kidney Dis. 2008;51(5):819–28.

    Article  PubMed  Google Scholar 

  77. Dobbels F, Vanhaecke J, Dupont L, Nevens F, Verleden G, Pirenne J, et al. Pretransplant predictors of posttransplant adherence and clinical outcome: an evidence base for pretransplant psychosocial screening. Transplantation. 2009;87(10):1497–504.

    Article  PubMed  Google Scholar 

  78. Errichiello L, Picozzi D, de Notaris EB. Prevalence of psychiatric disorders and suicidal ideation in liver transplanted patients: a cross-sectional study. Clin Res Hepatol Gastroenterol. 2014;38(1):55–62.

    Article  PubMed  Google Scholar 

  79. Favaro A, Gerosa G, Caforio AL, Volpe B, Rupolo G, Zarneri D, et al. Posttraumatic stress disorder and depression in heart transplantation recipients: the relationship with outcome and adherence to medical treatment. Gen Hosp Psychiatry. 2011;33(1):1–7.

    Article  PubMed  Google Scholar 

  80. Grat M, Lewandowski Z, Grat K, Wronka KM, Krasnodebski M, Barski K, et al. Negative outcomes after liver transplantation in patients with alcoholic liver disease beyond the fifth post-transplant year. Clin Transpl. 2014;28(10):1112–20.

    Article  Google Scholar 

  81. Guimaro MS, Lacerda SS, Aguilar MR, Karam CH, Kernkraut AM, Ferraz-Neto BH. Post-traumatic stress disorders, mood disorders, and quality of life in transplant recipients with acute liver failure. Transplant Proc. 2011;43(1):187–8.

    Article  CAS  PubMed  Google Scholar 

  82. Havik OE, Sivertsen B, Relbo A, Hellesvik M, Grov I, Geiran O, et al. Depressive symptoms and all-cause mortality after heart transplantation. Transplantation. 2007;84(1):97–103.

    Article  PubMed  Google Scholar 

  83. Jin SG, Yan LN, Xiang B, Li B, Wen TF, Zhao JC, et al. Posttraumatic stress disorder after liver transplantation. Hepatobiliary Pancreat Dis Int. 2012;11(1):28–33.

    Article  PubMed  Google Scholar 

  84. Jindal RM, Neff RT, Abbott KC, Hurst FP, Elster EA, Falta EM, et al. Association between depression and nonadherence in recipients of kidney transplants: analysis of the United States renal data system. Transplant Proc. 2009;41(9):3662–6.

    Article  CAS  PubMed  Google Scholar 

  85. Jowsey SG, Cutshall SM, Colligan RC, Stevens SR, Kremers WK, Vasquez AR, et al. Seligman’s theory of attributional style: optimism, pessimism, and quality of life after heart transplant. Prog Transplant. 2012;22(1):49–55.

    Article  PubMed  Google Scholar 

  86. Snipelisky D, Stulak JM, Schettle SD, Sharma S, Kushwaha SS, Dunlay SM. Psychosocial characteristics and outcomes in patients with left ventricular assist device implanted as destination therapy. Am Heart J. 2015;170(5):887–94.

    Article  PubMed  PubMed Central  Google Scholar 

  87. Kugler C, Bara C, von Waldthausen T, Einhorn I, Haastert B, Fegbeutel C, et al. Association of depression symptoms with quality of life and chronic artery vasculopathy: a cross-sectional study in heart transplant patients. J Psychosom Res. 2014;77(2):128–34.

    Article  PubMed  Google Scholar 

  88. Kusleikaite N, Bumblyte IA, Pakalnyte R. Quality of life and depression in renal transplant patients. [Lithuanian]. Medicina (Kaunas, Lithuania). 2007;43(Suppl 1):103–8.

    Google Scholar 

  89. Lamba S, Nagurka R, Desai KK, Chun SJ, Holland B, Koneru B. Self-reported non-adherence to immune-suppressant therapy in liver transplant recipients: demographic, interpersonal, and intrapersonal factors. Clin Transpl. 2012;26(2):328–35.

    Article  Google Scholar 

  90. Madan A, White-Williams C, Borckardt JJ, Burker EJ, Milsom VA, Pelic CM, et al. Beyond rose colored glasses: the adaptive role of depressive and anxious symptoms among individuals with heart failure who were evaluated for transplantation. Clin Transpl. 2012;26(3):E223–31.

    Article  CAS  Google Scholar 

  91. Novak M, Molnar MZ, Szeifert L, Kovacs AZ, Vamos EP, Zoller R, et al. Depressive symptoms and mortality in patients after kidney transplantation: a prospective prevalent cohort study. Psychosom Med. 2010;72(6):527–34.

    Article  PubMed  Google Scholar 

  92. Owen JE, Bonds CL, Wellisch DK. Psychiatric evaluations of heart transplant candidates: predicting post-transplant hospitalizations, rejection episodes, and survival. Psychosomatics. 2006;47(3):213–22.

    Article  PubMed  Google Scholar 

  93. Rice JP, Eickhoff J, Agni R, Ghufran A, Brahmbhatt R, Lucey MR. Abusive drinking after liver transplantation is associated with allograft loss and advanced allograft fibrosis. Liver Transpl. 2013;19(12):1377–86.

    Article  PubMed  Google Scholar 

  94. Rodrigue JR, Nelson DR, Hanto DW, Reed AI, Curry MP. Patient-reported immunosuppression nonadherence 6 to 24 months after liver transplant: association with pretransplant psychosocial factors and perceptions of health status change. Prog Transplant. 2013;23(4):319–28.

    Article  PubMed  PubMed Central  Google Scholar 

  95. Rogal SS, Landsittel D, Surman O, Chung RT, Rutherford A. Pretransplant depression, antidepressant use, and outcomes of orthotopic liver transplantation. Liver Transpl. 2011;17(3):251–60.

    Article  PubMed  PubMed Central  Google Scholar 

  96. Rogal SS, Dew MA, Fontes P, DiMartini AF. Early treatment of depressive symptoms and long-term survival after liver transplantation. Am J Transplant. 2013;13(4):928–35.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  97. Russell CL, Cetingok M, Hamburger KQ, Owens S, Thompson D, Hathaway D, et al. Medication adherence in older renal transplant recipients. Clin Nurs Res. 2010;19(2):95–112.

    Article  PubMed  Google Scholar 

  98. Shapiro PA, Williams DL, Foray AT, Gelman IS, Wukich N, Sciacca R. Psychosocial evaluation and prediction of compliance problems and morbidity after heart transplantation. Transplantation. 1995;60(12):1462–6.

    Article  CAS  PubMed  Google Scholar 

  99. Sharma NC, Kim D. The utility of psychosocial assessment tools in predicting cardiovascular outcomes in post cardiac transplant patients. J Heart Lung Transplant. 2013;1:S197.

    Article  Google Scholar 

  100. Sirri L, Potena L, Masetti M, Tossani E, Magelli C, Grandi S. Psychological predictors of mortality in heart transplanted patients: a prospective, 6-year follow-up study. Transplantation. 2010;89(7):879–86.

    Article  PubMed  Google Scholar 

  101. Smith PJ, Blumenthal JA, Carney RM, Freedland KE, O’Hayer CV, Trulock EP, et al. Neurobehavioral functioning and survival following lung transplantation. Chest. 2014;145(3):604–11.

    Article  PubMed  Google Scholar 

  102. Smith PJ, Blumenthal JA, Hoffman BM, Davis RD, Palmer SM. Postoperative cognitive dysfunction and mortality following lung transplantation. Am J Transplant. 2017;18(3):696–703.

    Article  PubMed  PubMed Central  Google Scholar 

  103. Smith PJ, Snyder LD, Palmer SM, Hoffman BM, Stonerock GL, Ingle KK, et al. Depression, social support, and clinical outcomes following lung transplantation: a single-center cohort study. Transpl Int. 2017;31(5):495–502.

    Article  PubMed  CAS  Google Scholar 

  104. Spaderna H, Mendell NR, Zahn D, Wang Y, Kahn J, Smits JM, et al. Social isolation and depression predict 12-month outcomes in the “waiting for a new heart study”. J Heart Lung Transplant. 2010;29(3):247–54.

    Article  PubMed  Google Scholar 

  105. Tsunoda T, Yamashita R, Kojima Y, Takahara S. Risk factors for depression after kidney transplantation. Transplant Proc. 2010;42(5):1679–81.

    Article  CAS  PubMed  Google Scholar 

  106. Weng FL, Chandwani S, Kurtyka KM, Zacker C, Chisholm-Burns MA, Demissie K. Prevalence and correlates of medication non-adherence among kidney transplant recipients more than 6 months post-transplant: a cross-sectional study. BMC Nephrol. 2013;14:261.

    Article  PubMed  PubMed Central  Google Scholar 

  107. Telles-Correia D, Barbosa A, Mega I, Monteiro E. Predictors of mental health and quality of life after liver transplantation. Psychother Psychosom. 2011;80(1):60–1.

    Article  PubMed  Google Scholar 

  108. Fineberg SK, West A, Na PJ, Oldham M, Schilsky M, Hawkins KA, et al. Utility of pretransplant psychological measures to predict posttransplant outcomes in liver transplant patients: a systematic review. Gen Hosp Psychiatry. 2016;40:4–11.

    Article  PubMed  Google Scholar 

  109. Fireman M, DiMartini AF, Crone CC. Organ transplantation. In: Levenson JLFS, editor. Clinical manual of psychopharmacology in the medically ill. 2nd ed. Arlington: American Psychiatric Association Publishing; 2017. p. 597–631.

    Google Scholar 

  110. Gross CR, Reilly-Spong M, Park T, Zhao R, Gurvich OV, Ibrahim HN. Telephone-adapted mindfulness-based stress reduction (tMBSR) for patients awaiting kidney transplantation. Contemp Clin Trials. 2017;57:37–43.

    Article  PubMed  PubMed Central  Google Scholar 

  111. DeMartini KS, Schilsky ML, Palmer A, Fehon DC, Zimbrean P, O’Malley SS, et al. Text messaging to reduce alcohol relapse in prelisting liver transplant candidates: a pilot feasibility study. Alcohol Clin Exp Res. 2018;42:761.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  112. Chisholm-Burns MA, Spivey CA, Sredzinski E, Butler SL. Intervention toolbox to promote immunosuppressant therapy adherence in adult renal transplant recipients. J Am Pharm Assoc. 2012;52(6):816–22.

    Article  Google Scholar 

  113. Rodrigue JR, Mandelbrot DA, Pavlakis M. A psychological intervention to improve quality of life and reduce psychological distress in adults awaiting kidney transplantation. Nephrol Dial Transplant. 2011;26(2):709–15.

    Article  PubMed  Google Scholar 

  114. Baines LS, Joseph JT, Jindal RM. Prospective randomized study of individual and group psychotherapy versus controls in recipients of renal transplants. Kidney Int. 2004;65(5):1937–42.

    Article  PubMed  Google Scholar 

  115. Baines LS, Joseph JT, Jindal RM. Emotional issues after kidney transplantation: a prospective psychotherapeutic study. Clin Transpl. 2002;16(6):455–60.

    Article  Google Scholar 

  116. Policies. Organ Procurement and Transplantation Network. US Department of Health and Human Services [cited 2018 04/03]. Available from: https://optn.transplant.hrsa.gov/media/1200/optn_policies.pdf#nameddest=Policy_14

  117. Janki S, Dor FJ, JN IJ. Surgical aspects of live kidney donation: an updated review. Front Biosci (Elite Ed). 2015;7:346–65.

    Google Scholar 

  118. Schold JD, Goldfarb DA, Buccini LD, Rodrigue JR, Mandelbrot DA, Heaphy EL, et al. Comorbidity burden and perioperative complications for living kidney donors in the United States. Clin J Am Soc Nephrol. 2013;8(10):1773–82.

    Article  PubMed  PubMed Central  Google Scholar 

  119. Segev DL, Muzaale AD, Caffo BS, Mehta SH, Singer AL, Taranto SE, et al. Perioperative mortality and long-term survival following live kidney donation. JAMA. 2010;303(10):959–66.

    Article  CAS  PubMed  Google Scholar 

  120. Choi SS, Cho SS, Ha TY, Hwang S, Lee SG, Kim YK. Intraoperative factors associated with delayed recovery of liver function after hepatectomy: analysis of 1969 living donors. Acta Anaesthesiol Scand. 2016;60(2):193–202.

    Article  CAS  PubMed  Google Scholar 

  121. Gibney EM, Parikh CR, Garg AX. Age, gender, race, and associations with kidney failure following living kidney donation. Transplant Proc. 2008;40(5):1337–40.

    Article  CAS  PubMed  Google Scholar 

  122. Lam NN, Schnitzler MA, Segev DL, Hess GP, Kasiske BL, Randall HB, et al. Diabetes mellitus in living pancreas donors: use of integrated National Registry and pharmacy claims data to characterize donation-related health outcomes. Transplantation. 2016;101(6):1276–81.

    Article  Google Scholar 

  123. Lentine KL, Lam NN, Axelrod D, Schnitzler MA, Garg AX, Xiao H, et al. Perioperative complications after living kidney donation: a national study. Am J Transplant. 2016;16(6):1848–57.

    Article  CAS  PubMed  Google Scholar 

  124. Mandell MS, Smith AR, Dew MA, Gordon DB, Holtzman S, Howell T, et al. Early postoperative pain and its predictors in the adult to adult living donor liver transplantation cohort study. Transplantation. 2016;100(11):2362–71.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  125. Dew MA, DiMartini AF, DeVito Dabbs AJ, Zuckoff A, Tan HP, McNulty ML, et al. Preventive intervention for living donor psychosocial outcomes: feasibility and efficacy in a randomized controlled trial. Am J Transplant. 2013;13(10):2672–84.

    Article  CAS  PubMed  Google Scholar 

  126. Iacoviello BM, Shenoy A, Hunt J, Filipovic-Jewell Z, Haydel B, LaPointe Rudow D. A prospective study of the reliability and validity of the live donor assessment tool. Psychosomatics. 2017;58(5):519–26.

    Article  PubMed  Google Scholar 

  127. DiMartini A, Crone C, Fireman M, Dew MA. Psychiatric aspects of organ transplantation in critical care. Crit Care Clin. 2008;24(4):949–81, x

    Article  PubMed  PubMed Central  Google Scholar 

  128. Holtzman S, Clarke HA, McCluskey SA, Turcotte K, Grant D, Katz J. Acute and chronic postsurgical pain after living liver donation: incidence and predictors. Liver Transpl. 2014;20(11):1336–46.

    Article  PubMed  Google Scholar 

  129. Bucak N, Begec Z, Erdil F, Toprak HI, Cumurcu BE, Demirtas Y, et al. Postoperative cognitive dysfunction in living liver transplant donors. Exp Clin Transplant. 2014;12(Suppl 1):81–5.

    PubMed  Google Scholar 

  130. Agerskov H, Ludvigsen MS, Bistrup C, Pedersen BD. From donation to everyday life: living kidney donors’ experiences three months after donation. J Ren Care. 2016;42(1):43–52.

    Article  PubMed  Google Scholar 

  131. Heldt J, Torrey R, Han D, Baron P, Tenggardjaja C, McLarty J, et al. Donor smoking negatively affects donor and recipient renal function following living donor nephrectomy. Adv Urol. 2011;2011:929263.

    Article  PubMed  PubMed Central  Google Scholar 

  132. Lentine KL, Schnitzler MA, Xiao H, Axelrod D, Davis CL, McCabe M, et al. Depression diagnoses after living kidney donation: linking U.S. registry data and administrative claims. Transplantation. 2012;94(1):77–83.

    Article  PubMed  PubMed Central  Google Scholar 

  133. Timmerman L, Laging M, Timman R, Zuidema WC, Beck DK, IJzermans JN, et al. The impact of the donors’ and recipients’ medical complications on living kidney donors’ mental health. Transpl Int. 2016;29(5):589–602.

    Article  PubMed  Google Scholar 

  134. Kimura H, Onishi Y, Sunada S, Kishi S, Suzuki N, Tsuboi C, et al. Postoperative psychiatric complications in living liver donors. Transplant Proc. 2015;47(6):1860–5.

    Article  CAS  PubMed  Google Scholar 

  135. Timmerman L, Timman R, Laging M, Zuidema WC, Beck DK, IJzermans JN, et al. Predicting mental health after living kidney donation: the importance of psychological factors. Br J Health Psychol. 2016;21(3):533–54.

    Article  PubMed  Google Scholar 

  136. Ferrando SJ, Levenson JL, Owen JA. Clinical manual of psychopharmacology in the medically ill. Washington, DC: American Psychiatric Publishing, Inc; 2010.

    Google Scholar 

  137. Butt Z, Dew MA, Liu Q, Simpson MA, Smith AR, Zee J, et al. Psychological outcomes of living liver donors from a multi-center, prospective study: results from the Adult to Adult Living Donor Liver Transplantation Cohort Study (A2ALL). Am J Transplant. 2016;17(5):1267–77.

    Article  Google Scholar 

  138. Parikh ND, Ladner D, Abecassis M, Butt Z. Quality of life for donors after living donor liver transplantation: a review of the literature. Liver Transpl. 2010;16(12):1352–8.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Psychiatry and Surgery (Transplant), Yale University School of Medicine, Yale University, New Haven, CT, USA

    Paula C. Zimbrean

  2. Department of Psychiatry, Yale University, New Haven, CT, USA

    Nora Proops

Authors
  1. Paula C. Zimbrean
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nora Proops
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Paula C. Zimbrean .

Editor information

Editors and Affiliations

  1. Department of Psychiatry, New Haven, CT, USA

    Paula C. Zimbrean

  2. Department of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA

    Mark A. Oldham

  3. Department of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA

    Hochang Benjamin Lee

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Zimbrean, P.C., Proops, N. (2019). Perioperative Psychiatric Problems in Organ Transplantation. In: Zimbrean, P., Oldham, M., Lee, H. (eds) Perioperative Psychiatry. Springer, Cham. https://doi.org/10.1007/978-3-319-99774-2_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-99774-2_11

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-99773-5

  • Online ISBN: 978-3-319-99774-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation