Abstract
The ability to control particle size and shape in engineering materials, paved the way for introducing nanostructures with unique properties and broad applications. The small size of nanostructures gives rise to more toxic reactions due to a higher surface area relative to volume and this in turn changes absorption, distribution, metabolism and excretion of nanoparticles (NPs). This also enhances cellular uptake and thus increases the interference with the biological milieu due to large surface area and surface functionalization. Notably, NPs are either degradable nanoparticles such as dendrimers, which can produce unexpected toxic byproducts, or non-degradable ones such as metallic NPs that accumulate in tissues and cells and consequently lead to pernicious effects. The uniqueness of each type of organic and inorganic NPs in addition to the route of administration make their behavior in biological systems more complicated than expected, thus, in vivo and in vitro studies are strongly recommended.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Blasi P, Giovagnoli S, Schoubben A, Ricci M, Rossi C (2007) Solid lipid nanoparticles for targeted brain drug delivery. Adv Drug Deliv Rev 59:454–477
Dobrovolskaia MA, Patri AK, Potter TM, Rodriguez JC, Hall JB, Mcneil SE (2012) Dendrimer-induced leukocyte procoagulant activity depends on particle size and surface charge. Nanomedicine 7:245–256
Graf A, McDowell A, Rades T (2009) Poly (alkycyanoacrylate) nanoparticles for enhanced delivery of therapeutics—is there real potential? Expert Opin Drug Deliv 6:371–387
Greish K, Thiagarajan G, Herd H, Price R, Bauer H, Hubbard D, Burckle A, Sadekar S, Yu T, Anwar A (2012) Size and surface charge significantly influence the toxicity of silica and dendritic nanoparticles. Nanotoxicology 6:713–723
Ilinskaya AN, Dobrovolskaia MA (2013) Nanoparticles and the blood coagulation system. Part II: safety concerns. Nanomedicine 8:969–981
Inoue KI (2011) Promoting effects of nanoparticles/materials on sensitive lung inflammatory diseases. Environ Health Prev Med 16:139–143
Juliano R, Hsu M, Peterson D, Regen S, Singh A (1983) Interactions of conventional or photopolymerized liposomes with platelets in vitro. Exp Cell Res 146:422–427
Malik N, Wiwattanapatapee R, Klopsch R, Lorenz K, Frey H, Weener J, Meijer E, Paulus W, Duncan R (2000) Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labelled polyamidoamine dendrimers in vivo. J Control Release 65:133–148
Mcguinnes C, Duffin R, Brown S, Mills NL, Megson IL, Macnee W, Johnston S, Lu SL, Tran L, Li R (2010) Surface derivatization state of polystyrene latex nanoparticles determines both their potency and their mechanism of causing human platelet aggregation in vitro. Toxicol Sci 119:359–368
Müller RH, Rühl D, Runge S, Schulze-Forster K, Mehnert W (1997) Cytotoxicity of solid lipid nanoparticles as a function of the lipid matrix and the surfactant. Pharm Res 14:458–462
Nadziejko, C., Fang, K., Chen, L., Cohen, B., Karpatkin, M. & Nadas, A. 2002. Effect of concentrated ambient particulate matter on blood coagulation parameters in rats. Research report (Health Effects Institute), 7–29; discussion 31–8
Nemmar A, Hoylaerts MF, Hoet PH, Vermylen J, Nemery B (2003) Size effect of intratracheally instilled particles on pulmonary inflammation and vascular thrombosis. Toxicol Appl Pharmacol 186:38–45
Saiyed M, Patel R, Patel S (2011) Toxicology perspective of nanopharmaceuticals: a critical review. Int J Pharm Sci Nanotechnol 4:1287–1295
Schöler N, Zimmermann E, Katzfey U, Hahn H, Müller R, Liesenfeld O (2000) Effect of solid lipid nanoparticles (SLN) on cytokine production and the viability of murine peritoneal macrophages. J Microencapsul 17:639–650
Stasko NA, Johnson CB, Schoenfisch MH, Johnson TA, Holmuhamedov EL (2007) Cytotoxicity of polypropylenimine dendrimer conjugates on cultured endothelial cells. Biomacromolecules 8:3853–3859
Acknowledgements
The authors are thankful to the Ministry of Education (MOE) Malaysia for funding this work under Transdisciplinary Research Grant Scheme (TRGS) grant no. 6769003 and Universiti Sains Malaysia (USM) for USM-Short Term Research Grant (304/CIPPT/6315073).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Mydin, R.B.S.M.N., Moshawih, S. (2019). Nanoparticles in Nanomedicine Application: Lipid-Based Nanoparticles and Their Safety Concerns. In: Siddiquee, S., Melvin, G., Rahman, M. (eds) Nanotechnology: Applications in Energy, Drug and Food. Springer, Cham. https://doi.org/10.1007/978-3-319-99602-8_10
Download citation
DOI: https://doi.org/10.1007/978-3-319-99602-8_10
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-99601-1
Online ISBN: 978-3-319-99602-8
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)