Abstract
Temperature exposure reliably inhibits tumor cell potential for proliferation at the temperature of not less than 43 °C only. Temperature regimens recommended for clinical treatment (40–42 °С) have no significant impact on the viability of tumor cells. Tumor growth arrest in murine models was observed only in case of preliminary warming of inoculated cells at a temperature more than 42 °С. Heating tumor cells up to 39 °С and their incubation with anticancer drugs in the mean-effective concentrations enhanced tumor cell sensitivity towards cytotoxic action of activated lymphocytes.
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Anisimova, N.Y., Zhubina, I.Z., Donenko, F.V., Dolzhikova, J.I., Kshnaykina, A.V., Kiselevskiy, M.V. (2019). Experimental Basis for Optimal Regimnes of Hyperthermic Peritoneal Chemotherapy. In: Kiselevskiy, M., Abdulaev, A., Davydov, M. (eds) Malignant Mesothelioma and Pseudomyxoma . Springer, Cham. https://doi.org/10.1007/978-3-319-99510-6_5
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