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Structural Studies with Coactivators for the Estrogen Receptor

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Estrogen Receptor and Breast Cancer

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Coactivators play essential roles in nuclear receptor-mediated gene transcription. To date, a variety of coactivators have been identified. They can be scaffolding proteins, chromatin remodelers, posttranslational modification enzymes, or RNA splicing factors. Different coactivators are recruited to a nuclear receptor to form large protein complexes at different stages of transcription, and they often act synergistically. Structural analyses on these coactivators and their complex formation with nuclear receptors provide valuable information on understanding nuclear receptor-mediated gene regulation. Here we review recent structural studies on three well-documented nuclear receptor coactivators: steroid receptor coactivators (SRCs), CBP/p300, and CARM1, and their assembly into active DNA-bound estrogen receptor/coactivator complexes for initiation and for the subsequent step of elongation. This review specifically emphasizes the structural interaction within the estrogen receptor (ER) coactivator complex.

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Acknowledgments

This work is supported by NIH grants HD8818 and NIDDK59820 to B.W.O.

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  1. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA

    Ping Yi & Bert W. O’Malley

  2. Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA

    Zhao Wang

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  1. Department of Cancer Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, OH, USA

    Xiaoting Zhang

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Yi, P., Wang, Z., O’Malley, B.W. (2019). Structural Studies with Coactivators for the Estrogen Receptor. In: Zhang, X. (eds) Estrogen Receptor and Breast Cancer. Cancer Drug Discovery and Development. Humana Press, Cham. https://doi.org/10.1007/978-3-319-99350-8_4

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